SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_086508346.1 NCBI__GCF_002151265.1:WP_086508346.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
36% identity, 86% coverage: 25:233/243 of query aligns to 15:214/214 of 4ymwC

query
sites
4ymwC
Y
 
F
W
 
I
D
 
S
G
 
G
L
 
L
V
 
I
L
 
M
T
 
T
T
 
L
Q
 
K
L
 
L
V
 
T
F
 
F
L
 
L
S
 
A
L
 
V
V
 
T
A
 
I
G
 
G
L
 
V
V
 
L
L
 
M
A
 
G
I
 
L
P
 
F
L
 
I
A
 
A
I
 
L
G
 
M
R
 
K
S
 
M
S
 
S
G
 
S
R
 
I
R
 
K
W
 
P
I
 
I
S
 
K
L
 
L
P
 
V
I
 
A
Y
 
S
V
 
S
Y
 
Y
T
 
I
Y
 
E
V
 
V
F
 
I
R
 
R
G
 
G
T
 
T
P
 
P
L
 
L
L
 
L
I
 
V
Q
 
Q
L
 
L
Y
 
L
I
 
L
I
 
I
Y
 
Y
Y
 
N
G
 
G
V
 
L
V
 
M
F
 
Q
F
 
F
D
 
-
G
 
G
I
 
M
Q
 
N
Q
 
-
T
 
-
F
 
-
L
 
-
W
 
I
P
 
P
I
 
-
L
 
-
R
 
-
E
 
-
A
 
A
F
 
F
Y
 
T
P
 
A
A
 
G
L
 
V
I
 
S
A
 
A
F
 
L
T
 
A
L
 
I
N
|
N
T
 
S
A
 
S
A
 
A
Y
|
Y
T
 
V
T
 
A
E
 
E
I
 
I
F
 
I
R
 
R
G
 
A
A
 
G
I
 
I
K
 
Q
A
 
A
T
 
V
P
 
D
R
 
P
G
 
G
E
 
Q
I
 
N
E
 
E
A
 
A
A
 
A
R
 
R
A
 
S
Y
 
L
G
 
G
M
 
M
S
 
T
Q
 
H
G
 
A
L
 
M
M
 
A
M
 
M
R
 
R
R
 
Y
I
 
V
V
 
I
L
 
I
P
 
P
S
 
Q
A
 
A
F
 
I
R
 
K
R
 
N
A
 
I
L
 
L
P
 
P
A
 
A
Y
 
L
G
 
G
N
 
N
E
|
E
V
 
F
I
 
I
F
 
V
M
 
M
L
 
L
H
 
K
A
x
E
S
 
S
A
 
A
I
 
I
A
 
V
S
 
S
V
 
V
V
 
I
T
 
G
L
 
F
M
 
A
D
 
D
I
 
L
T
 
T
G
 
R
A
 
Q
A
 
A
R
 
D
F
 
I
V
 
I
Y
 
Q
A
 
S
R
 
V
F
 
T
Y
 
Y
A
 
R
P
 
Y
F
 
F
E
 
E
A
 
P
F
 
Y
L
 
I
F
 
I
A
 
I
A
 
A
A
 
A
I
 
I
Y
 
Y
L
 
F
C
 
V
L
 
M
T
 
T
F
 
L
A
 
T
I
 
F
L
 
S
Y
 
K
F
 
L
F
 
L
R
 
S
Y
 
L
L
 
F
E
 
E
K
 
R
K
 
R
L
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
36% identity, 86% coverage: 25:233/243 of query aligns to 15:214/215 of 4ymtC

query
sites
4ymtC
Y
 
F
W
 
I
D
 
S
G
 
G
L
 
L
V
 
I
L
 
M
T
 
T
T
 
L
Q
 
K
L
 
L
V
 
T
F
 
F
L
 
L
S
 
A
L
 
V
V
 
T
A
 
I
G
 
G
L
 
V
V
 
L
L
 
M
A
 
G
I
 
L
P
 
F
L
 
I
A
 
A
I
 
L
G
 
M
R
 
K
S
 
M
S
 
S
G
 
S
R
 
I
R
 
K
W
 
P
I
 
I
S
 
K
L
 
L
P
 
V
I
 
A
Y
 
S
V
 
S
Y
 
Y
T
 
I
Y
 
E
V
 
V
F
 
I
R
 
R
G
 
G
T
 
T
P
|
P
L
|
L
L
 
L
I
 
V
Q
 
Q
L
 
L
Y
 
L
I
 
L
I
 
I
Y
 
Y
Y
 
N
G
 
G
V
 
L
V
 
M
F
 
Q
F
 
F
D
 
-
G
 
G
I
 
M
Q
 
N
Q
 
-
T
 
-
F
 
-
L
 
-
W
 
I
P
 
P
I
 
-
L
 
-
R
 
-
E
 
-
A
 
A
F
 
F
Y
 
T
P
 
A
A
 
G
L
 
V
I
 
S
A
 
A
F
 
L
T
 
A
L
 
I
N
|
N
T
 
S
A
 
S
A
 
A
Y
|
Y
T
 
V
T
 
A
E
 
E
I
 
I
F
 
I
R
 
R
G
 
A
A
 
G
I
 
I
K
 
Q
A
 
A
T
 
V
P
 
D
R
 
P
G
 
G
E
 
Q
I
 
N
E
 
E
A
 
A
A
 
A
R
 
R
A
 
S
Y
 
L
G
 
G
M
 
M
S
 
T
Q
 
H
G
 
A
L
 
M
M
 
A
M
 
M
R
 
R
R
 
Y
I
 
V
V
 
I
L
 
I
P
 
P
S
 
Q
A
 
A
F
 
I
R
 
K
R
 
N
A
 
I
L
 
L
P
 
P
A
 
A
Y
 
L
G
 
G
N
 
N
E
|
E
V
 
F
I
 
I
F
 
V
M
|
M
L
 
L
H
x
K
A
x
E
S
 
S
A
 
A
I
 
I
A
 
V
S
 
S
V
 
V
V
 
I
T
 
G
L
 
F
M
 
A
D
 
D
I
 
L
T
 
T
G
 
R
A
 
Q
A
 
A
R
 
D
F
 
I
V
 
I
Y
 
Q
A
 
S
R
 
V
F
 
T
Y
 
Y
A
 
R
P
 
Y
F
 
F
E
 
E
A
 
P
F
 
Y
L
 
I
F
 
I
A
 
I
A
 
A
A
 
A
I
 
I
Y
 
Y
L
 
F
C
 
V
L
 
M
T
 
T
F
 
L
A
 
T
I
 
F
L
 
S
Y
 
K
F
 
L
F
 
L
R
 
S
Y
 
L
L
 
F
E
 
E
K
 
R
K
 
R
L
 
L

Query Sequence

>WP_086508346.1 NCBI__GCF_002151265.1:WP_086508346.1
MTELTWLNELLAGNRIFTPQTIGYYWDGLVLTTQLVFLSLVAGLVLAIPLAIGRSSGRRW
ISLPIYVYTYVFRGTPLLIQLYIIYYGVVFFDGIQQTFLWPILREAFYPALIAFTLNTAA
YTTEIFRGAIKATPRGEIEAARAYGMSQGLMMRRIVLPSAFRRALPAYGNEVIFMLHASA
IASVVTLMDITGAARFVYARFYAPFEAFLFAAAIYLCLTFAILYFFRYLEKKLLAHLKPQ
SGN

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory