Comparing WP_086508980.1 NCBI__GCF_002151265.1:WP_086508980.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 19 hits to proteins with known functional sites (download)
Q5F8J4 NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; NgHSD; EC 1.1.1.3 from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) (see paper)
54% identity, 99% coverage: 1:434/438 of query aligns to 1:433/435 of Q5F8J4
6dzsA Mycobacterial homoserine dehydrogenase thra in complex with NADP
39% identity, 98% coverage: 2:432/438 of query aligns to 3:429/431 of 6dzsA
4pg7A Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
42% identity, 72% coverage: 1:316/438 of query aligns to 2:307/402 of 4pg7A
Sites not aligning to the query:
6a0tB Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
35% identity, 71% coverage: 1:313/438 of query aligns to 1:303/332 of 6a0tB
6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH (see paper)
35% identity, 71% coverage: 1:313/438 of query aligns to 1:303/331 of 6a0sA
2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
35% identity, 71% coverage: 1:313/438 of query aligns to 1:303/331 of 2ejwA
7f4cA The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon sulfurisphaera tokodaii. (see paper)
37% identity, 59% coverage: 61:318/438 of query aligns to 56:298/300 of 7f4cA
Sites not aligning to the query:
5x9dA Crystal structure of homoserine dehydrogenase in complex with l- cysteine and NAD (see paper)
36% identity, 59% coverage: 61:318/438 of query aligns to 56:300/302 of 5x9dA
Sites not aligning to the query:
4xb1A Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
33% identity, 55% coverage: 72:313/438 of query aligns to 86:309/319 of 4xb1A
Sites not aligning to the query:
4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH (see paper)
33% identity, 55% coverage: 72:313/438 of query aligns to 86:309/319 of 4xb2A
Sites not aligning to the query:
3jsaA Homoserine dehydrogenase from thermoplasma volcanium complexed with NAD
30% identity, 54% coverage: 1:236/438 of query aligns to 1:249/321 of 3jsaA
Sites not aligning to the query:
3ingA Crystal structure of homoserine dehydrogenase (np_394635.1) from thermoplasma acidophilum at 1.95 a resolution
31% identity, 34% coverage: 86:232/438 of query aligns to 97:242/319 of 3ingA
Sites not aligning to the query:
O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 56% coverage: 70:316/438 of query aligns to 626:909/916 of O81852
Sites not aligning to the query:
O94671 Probable homoserine dehydrogenase; HDH; EC 1.1.1.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
32% identity, 32% coverage: 71:211/438 of query aligns to 79:239/376 of O94671
P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
33% identity, 27% coverage: 92:211/438 of query aligns to 106:231/359 of P31116
Sites not aligning to the query:
1tveA Homoserine dehydrogenase in complex with 4-(4-hydroxy-3- isopropylphenylthio)-2-isopropylphenol (see paper)
33% identity, 27% coverage: 92:211/438 of query aligns to 105:230/358 of 1tveA
Sites not aligning to the query:
1q7gA Homoserine dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-oxonorvaline (see paper)
33% identity, 27% coverage: 92:211/438 of query aligns to 105:230/358 of 1q7gA
Sites not aligning to the query:
1ebuD Homoserine dehydrogenase complex with NAD analogue and l-homoserine (see paper)
33% identity, 27% coverage: 92:211/438 of query aligns to 105:230/358 of 1ebuD
Sites not aligning to the query:
1ebfA Homoserine dehydrogenase from s. Cerevisiae complex with NAD+ (see paper)
33% identity, 27% coverage: 92:211/438 of query aligns to 105:230/358 of 1ebfA
Sites not aligning to the query:
>WP_086508980.1 NCBI__GCF_002151265.1:WP_086508980.1
MKPVRVGICGLGTVGGGTFNVLTRNADEIARRAGRPIVIEQVALRSTNPECDLTGIKTTN
DVFEVARNPDIDVLVEVLGGYDVPRELVLTAIANGKHVVTANKALIAVHGNEIFQAAHEQ
GVIVAFEAAVAGGIPVIKSLREGLGANRIEWVAGIINGTGNYILTHMRSEGRAFEDVLAE
AQALGYAEADPTFDVEGIDAAHKLTILASIAYGVPLQFEKAYTEGISRVTFDDVEQADNL
GYVIKHLGISKRTEHGLELRVHPTLIPKERLLANVHGVKNAIAIMGDAVGPTLYYGAGAG
SEPTASAVVADLLDVARDIATDHHYRVPYLAFSGIGDDDGGMPILPMEDIVTAYYLRLLA
VDRPGVLARVATILSEQGISIEALVQKEATEGELVPIILLTHRCREKHMNEAIRQIESMA
DIAGPVTRIRVESLDEQE
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory