Comparing WP_086509386.1 NCBI__GCF_002151265.1:WP_086509386.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 12 hits to proteins with known functional sites (download)
P9WKJ5 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
30% identity, 79% coverage: 74:572/628 of query aligns to 51:542/575 of P9WKJ5
6ovtA Crystal structure of ilvd from mycobacterium tuberculosis (see paper)
30% identity, 79% coverage: 74:572/628 of query aligns to 38:529/562 of 6ovtA
Q9LIR4 Dihydroxy-acid dehydratase, chloroplastic; AthDHAD; DAD; EC 4.2.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
28% identity, 91% coverage: 3:572/628 of query aligns to 28:574/608 of Q9LIR4
8hs0A The mutant structure of dhad v178w
29% identity, 81% coverage: 63:572/628 of query aligns to 42:536/570 of 8hs0A
B5ZZ34 L-arabinonate dehydratase; ArDHT; D-fuconate dehydratase; Galactonate dehydratase; L-arabonate dehydratase; EC 4.2.1.25; EC 4.2.1.67; EC 4.2.1.6 from Rhizobium leguminosarum bv. trifolii (strain WSM2304) (see 2 papers)
29% identity, 79% coverage: 75:572/628 of query aligns to 47:531/579 of B5ZZ34
5j85A Ser480ala mutant of l-arabinonate dehydratase (see paper)
28% identity, 79% coverage: 75:572/628 of query aligns to 44:528/576 of 5j85A
Q1JUQ1 L-arabonate dehydratase; L-arabinonate dehydratase; EC 4.2.1.25 from Azospirillum brasilense (see paper)
30% identity, 77% coverage: 75:560/628 of query aligns to 44:517/583 of Q1JUQ1
8ej0A Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mg
29% identity, 79% coverage: 75:572/628 of query aligns to 38:520/568 of 8ej0A
8epzA Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mn
29% identity, 79% coverage: 75:572/628 of query aligns to 39:521/569 of 8epzA
5oynA Crystal structure of d-xylonate dehydratase in holo-form (see paper)
30% identity, 67% coverage: 152:572/628 of query aligns to 117:539/589 of 5oynA
Sites not aligning to the query:
Q9A9Z2 D-xylonate dehydratase; XyDHT; Gluconate dehydratase; EC 4.2.1.82; EC 4.2.1.39 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see 2 papers)
30% identity, 67% coverage: 152:572/628 of query aligns to 123:545/595 of Q9A9Z2
Sites not aligning to the query:
7m3kA Crystal structure of galactonate dehydratase from brucella melitensis biovar abortus 2308
26% identity, 66% coverage: 161:572/628 of query aligns to 121:535/587 of 7m3kA
Sites not aligning to the query:
>WP_086509386.1 NCBI__GCF_002151265.1:WP_086509386.1
MARPTALNSTVEQVTERIRERSRGRRKLYEAHMAAQHQQGVHRGELSCGNLAHGFAGCDH
AGDKDRLKLTNSANLAIVSSYNDMLSAHRPFESYPEVIKQAARGMGSTAQFAGGVPAMCD
GVTQGMPGMELSLFSRDVIAMATAVALSHNMFDAALYLGICDKIVPGLFIGAARFGHLPA
VFVPGGPMPSGLPNDEKARIRQLYAEGKVGREELLEAESRSYHSPGTCTFYGTANSNQLM
MEMMGLHLPGASFVNPGTPLREALTRYATEQAIRNTEQSGNYRPFYRQIDERAIVNAMVG
LLASGGSTNHTLHLVAMAAAAGITIDWNDFNDLSAAVPSLTRIYPNGSADVNHFQAAGGM
SLLIRELLDAGLIHGDIPTVFGTDLTAYTQEPFLEDGKLTWREGPTESLDSDVLRPVSNP
FAATGGLVVMEGNLGRGVIKISAVKQANRVVEAPVRIFDDQNQVKAAFESGELDRDVVVV
VRFQGPKANGMPELHKLTPFLGVLQDRGYKVALVTDGRMSGASGKVPAAIHVTPEAVDRG
PLARLRDGDVVRVDAERGELTALVDAAEFASRGIVEPNLERYHFGMGRELFGGFRHLAAG
AEQGAGVFGGFEEEVLSRELEKISQEDQ
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory