SitesBLAST
Comparing WP_086509739.1 NCBI__GCF_002151265.1:WP_086509739.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
31% identity, 98% coverage: 1:525/537 of query aligns to 6:521/539 of 6lpiB
- active site: I27 (= I23), G29 (= G25), G30 (≠ V26), S31 (≠ H27), I32 (≠ T28), E53 (= E48), C76 (≠ I71), F115 (≠ L112), Q116 (≠ H113), E117 (= E114), K165 (≠ I163), M256 (≠ N251), A283 (≠ D280), V375 (≠ S378), G401 (= G405), M403 (≠ L407), D428 (= D432), N455 (= N459), A457 (≠ G461), L458 (≠ Y462), L460 (vs. gap), V461 (vs. gap), Q464 (≠ I465)
- binding flavin-adenine dinucleotide: R155 (= R153), G212 (= G209), G213 (= G210), G214 (= G211), T236 (= T233), L237 (≠ I234), M238 (≠ N235), L254 (vs. gap), M256 (≠ N251), H257 (≠ A252), G276 (= G271), A277 (≠ T272), R278 (≠ E273), D280 (≠ T277), R282 (≠ Y279), A283 (≠ D280), D300 (= D297), I301 (≠ L298), D319 (= D316), V320 (≠ A317), M380 (vs. gap), G398 (≠ T402)
- binding magnesium ion: D428 (= D432), N455 (= N459)
- binding thiamine diphosphate: E53 (= E48), C76 (≠ I71), P79 (= P74), G376 (vs. gap), Q377 (vs. gap), H378 (vs. gap), G401 (= G405), M403 (≠ L407), G427 (= G431), D428 (= D432), G429 (= G433), S430 (≠ G434), M433 (≠ F437), N455 (= N459), A457 (≠ G461), L458 (≠ Y462), G459 (vs. gap), L460 (vs. gap), V461 (vs. gap)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 22:546/582 of 3ea4A
- active site: Y32 (≠ I23), G34 (= G25), G35 (≠ V26), A36 (≠ H27), S37 (≠ T28), E58 (= E48), T81 (≠ I71), F120 (≠ L112), Q121 (≠ H113), E122 (= E114), K170 (≠ I163), M265 (≠ A250), V292 (vs. gap), V399 (≠ A384), G425 (= G405), M427 (≠ L407), D452 (= D432), N479 (= N459), H481 (≠ G461), L482 (≠ Y462), M484 (vs. gap), V485 (vs. gap), W488 (≠ E463)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D285), R291 (vs. gap), W488 (≠ E463)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R153), G221 (= G209), G222 (= G210), G223 (= G211), T245 (= T233), L246 (≠ I234), M247 (≠ N235), L263 (= L248), G264 (= G249), M265 (≠ A250), H266 (≠ N251), G285 (= G271), R287 (≠ V282), D289 (= D284), R291 (vs. gap), D309 (= D297), I310 (≠ L298), G327 (≠ A315), D328 (= D316), V329 (≠ A317), M404 (vs. gap), G422 (≠ T402)
- binding magnesium ion: D452 (= D432), N479 (= N459), H481 (≠ G461)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ A384), G400 (= G385), Q401 (≠ N386), H402 (= H387), M427 (≠ L407), G451 (= G431), D452 (= D432), G453 (= G433), S454 (≠ G434), N479 (= N459), H481 (≠ G461), L482 (≠ Y462), G483 (vs. gap), M484 (vs. gap), V485 (vs. gap)
Sites not aligning to the query:
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 22:546/582 of 3e9yA
- active site: Y32 (≠ I23), G34 (= G25), G35 (≠ V26), A36 (≠ H27), S37 (≠ T28), E58 (= E48), T81 (≠ I71), F120 (≠ L112), Q121 (≠ H113), E122 (= E114), K170 (≠ I163), M265 (≠ A250), V292 (vs. gap), V399 (≠ A384), G425 (= G405), M427 (≠ L407), D452 (= D432), N479 (= N459), H481 (≠ G461), L482 (≠ Y462), M484 (vs. gap), V485 (vs. gap), W488 (≠ E463)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D285), R291 (vs. gap), W488 (≠ E463)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R153), G221 (= G209), G222 (= G210), G223 (= G211), T245 (= T233), L246 (≠ I234), M247 (≠ N235), L263 (= L248), G285 (= G271), R287 (≠ V282), D289 (= D284), R291 (vs. gap), D309 (= D297), I310 (≠ L298), G327 (≠ A315), D328 (= D316), V329 (≠ A317), M404 (vs. gap), G422 (≠ T402)
- binding magnesium ion: D452 (= D432), N479 (= N459), H481 (≠ G461)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ A384), G400 (= G385), Q401 (≠ N386), H402 (= H387), M427 (≠ L407), G451 (= G431), G453 (= G433), S454 (≠ G434), N479 (= N459), H481 (≠ G461), L482 (≠ Y462), G483 (vs. gap), M484 (vs. gap), V485 (vs. gap)
Sites not aligning to the query:
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
29% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ A250), R292 (vs. gap), W489 (≠ E463)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), G426 (= G405), M428 (≠ L407), G452 (= G431), D453 (= D432), G454 (= G433), S455 (≠ G434), L483 (≠ Y462), G484 (vs. gap), M485 (vs. gap), V486 (vs. gap)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), M263 (vs. gap), L264 (= L248), M266 (≠ A250), H267 (≠ N251), G286 (= G271), R288 (≠ V282), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402)
- binding magnesium ion: A37 (≠ H27), T82 (≠ I71), S83 (≠ T72), Q122 (≠ H113), Y381 (vs. gap), D453 (= D432), M458 (≠ F437), Q461 (≠ S440), N480 (= N459), H482 (≠ G461), K533 (≠ P503)
Sites not aligning to the query:
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/585 of 5k2oA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ A250), R292 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), G286 (= G271), R288 (≠ V282), D290 (= D284), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), Q404 (vs. gap), M405 (vs. gap), G423 (≠ T402)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), M428 (≠ L407), D453 (= D432), G454 (= G433), S455 (≠ G434), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), G484 (vs. gap), M485 (vs. gap), V486 (vs. gap)
Sites not aligning to the query:
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
28% identity, 94% coverage: 13:518/537 of query aligns to 108:632/670 of P17597
- A122 (≠ H27) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ V29) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E48) binding
- S186 (= S90) binding
- P197 (≠ R101) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ D103) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (≠ H113) binding
- K220 (≠ R127) binding
- R246 (= R153) binding ; binding
- K256 (≠ I163) binding
- G308 (= G210) binding
- TL 331:332 (≠ TI 233:234) binding
- C340 (≠ L246) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ LGAN 248:251) binding
- G---------VRFD 371:375 (≠ GTELGETDYDVVFD 271:284) binding
- DR 376:377 (≠ D- 285) binding
- DI 395:396 (≠ DL 297:298) binding
- DV 414:415 (≠ DA 316:317) binding
- QH 487:488 (≠ NH 386:387) binding
- GG 508:509 (≠ TG 402:403) binding
- GAM 511:513 (≠ GTL 405:407) binding
- D538 (= D432) binding
- DGS 538:540 (≠ DGG 432:434) binding
- N565 (= N459) binding
- NQHLGM 565:570 (≠ NQGY-- 459:462) binding
- H567 (≠ G461) binding
- W574 (≠ E463) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
Sites not aligning to the query:
- 653 binding ; S→A: No effect on catalytic activity or sensitivity to herbicides.; S→F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; S→N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; S→T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), G426 (= G405), M428 (≠ L407), G452 (= G431), D453 (= D432), G454 (= G433), S455 (≠ G434), M458 (≠ F437), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), G484 (vs. gap), M485 (vs. gap), V486 (vs. gap)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), M266 (≠ A250), H267 (≠ N251), G286 (= G271), V287 (= V281), R288 (≠ V282), D290 (= D284), R292 (vs. gap), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402)
- binding magnesium ion: F370 (≠ Y362), D453 (= D432), M458 (≠ F437), Q461 (≠ S440), N480 (= N459), H482 (≠ G461), K533 (≠ P503)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ A250), R292 (vs. gap), M485 (vs. gap), W489 (≠ E463)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 5wj1A
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), M263 (vs. gap), L264 (= L248), G286 (= G271), R288 (≠ V282), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402), G424 (= G403)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ A250), D291 (= D285), R292 (vs. gap), M485 (vs. gap), W489 (≠ E463)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), M428 (≠ L407), D453 (= D432), G454 (= G433), S455 (≠ G434), M458 (≠ F437), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), G484 (vs. gap), M485 (vs. gap), V486 (vs. gap)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 5k6tA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ N251), R292 (vs. gap), M485 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), G286 (= G271), R288 (≠ V282), D290 (= D284), R292 (vs. gap), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), Q404 (vs. gap), M405 (vs. gap), G423 (≠ T402)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), G426 (= G405), M428 (≠ L407), G452 (= G431), G454 (= G433), S455 (≠ G434), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), G484 (vs. gap)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 5k6rA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), M266 (≠ A250), G286 (= G271), R288 (≠ V282), R292 (vs. gap), V293 (vs. gap), D310 (= D297), I311 (≠ L298), G328 (≠ A315), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), G426 (= G405), M428 (≠ L407), D453 (= D432), G454 (= G433), S455 (≠ G434), M458 (≠ F437), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), G484 (vs. gap), M485 (vs. gap), V486 (vs. gap)
Sites not aligning to the query:
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/583 of 5k3sA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (vs. gap), M485 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), M266 (≠ A250), G286 (= G271), R288 (≠ V282), D290 (= D284), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), G426 (= G405), M428 (≠ L407), D453 (= D432), G454 (= G433), S455 (≠ G434), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), G484 (vs. gap), M485 (vs. gap), V486 (vs. gap)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 1z8nA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (≠ R127), R161 (= R153), Y191 (≠ R180), R194 (= R183), D291 (= D285), R292 (vs. gap), D312 (= D299), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), G265 (= G249), M266 (≠ A250), H267 (≠ N251), G286 (= G271), V287 (= V281), R288 (≠ V282), D290 (= D284), R292 (vs. gap), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402), G424 (= G403)
- binding magnesium ion: D453 (= D432), N480 (= N459)
- binding thiamine diphosphate: V400 (≠ A384), G401 (= G385), Q402 (≠ N386), H403 (= H387), G426 (= G405), M428 (≠ L407), G452 (= G431), G454 (= G433), S455 (≠ G434), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), G484 (vs. gap), M485 (vs. gap), V486 (vs. gap)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 1yi1A
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D285), R292 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), M263 (vs. gap), L264 (= L248), G265 (= G249), M266 (≠ A250), H267 (≠ N251), G286 (= G271), V287 (= V281), R288 (≠ V282), D290 (= D284), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402), G424 (= G403)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 1yi0A
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D285), R292 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), G265 (= G249), M266 (≠ A250), H267 (≠ N251), G286 (= G271), V287 (= V281), R288 (≠ V282), D290 (= D284), R292 (vs. gap), V293 (vs. gap), D310 (= D297), I311 (≠ L298), G328 (≠ A315), D329 (= D316), V330 (≠ A317), M405 (vs. gap), G423 (≠ T402), G424 (= G403)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 1yhzA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D285), R292 (vs. gap), M485 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), M266 (≠ A250), H267 (≠ N251), G286 (= G271), V287 (= V281), R288 (≠ V282), D290 (= D284), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), Q404 (vs. gap), M405 (vs. gap), G423 (≠ T402), G424 (= G403)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 1yhyA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D285), R292 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G222 (= G209), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), G265 (= G249), M266 (≠ A250), H267 (≠ N251), G286 (= G271), V287 (= V281), R288 (≠ V282), D290 (= D284), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), Q404 (vs. gap), M405 (vs. gap), G423 (≠ T402), G424 (= G403)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
Sites not aligning to the query:
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
28% identity, 94% coverage: 13:518/537 of query aligns to 23:547/582 of 1ybhA
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), S38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ L112), Q122 (≠ H113), E123 (= E114), K171 (≠ I163), M266 (≠ A250), V293 (vs. gap), V400 (≠ A384), G426 (= G405), M428 (≠ L407), D453 (= D432), N480 (= N459), H482 (≠ G461), L483 (≠ Y462), M485 (vs. gap), V486 (vs. gap), W489 (≠ E463)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ A250), D291 (= D285), R292 (vs. gap), M485 (vs. gap), W489 (≠ E463)
- binding flavin-adenine dinucleotide: R161 (= R153), G223 (= G210), G224 (= G211), T246 (= T233), L247 (≠ I234), M248 (≠ N235), L264 (= L248), M266 (≠ A250), H267 (≠ N251), G286 (= G271), V287 (= V281), R288 (≠ V282), D290 (= D284), V293 (vs. gap), D310 (= D297), I311 (≠ L298), D329 (= D316), V330 (≠ A317), Q404 (vs. gap), M405 (vs. gap), G423 (≠ T402), G424 (= G403)
- binding magnesium ion: D453 (= D432), N480 (= N459), H482 (≠ G461)
Sites not aligning to the query:
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
29% identity, 85% coverage: 13:470/537 of query aligns to 105:573/667 of P09342
- C161 (= C68) modified: Disulfide link with 307
- P194 (≠ R101) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (= C212) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
29% identity, 85% coverage: 13:470/537 of query aligns to 102:570/664 of P09114
- P191 (≠ R101) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ Y468) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
6vz8D Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound (see paper)
29% identity, 94% coverage: 13:518/537 of query aligns to 22:520/531 of 6vz8D
- active site: Y32 (≠ I23), G34 (= G25), G35 (≠ V26), A36 (≠ H27), S37 (≠ T28), E58 (= E48), T81 (≠ I71), F120 (≠ L112), Q121 (≠ H113), E122 (= E114), K170 (≠ I163), M256 (≠ A250), V283 (≠ L289), V376 (≠ A384), G402 (= G405), M404 (≠ L407), D429 (= D432), N456 (= N459), H458 (≠ G461), L459 (≠ Y462), M461 (vs. gap), V462 (vs. gap), W465 (≠ E463)
- binding flavin-adenine dinucleotide: G214 (= G209), G215 (= G210), G216 (= G211), T236 (= T233), L237 (≠ I234), L254 (= L248), H257 (≠ N251), R278 (≠ V282), R282 (≠ E288), V283 (≠ L289), I291 (≠ L298), G399 (≠ T402)
- binding magnesium ion: H458 (≠ G461), L459 (≠ Y462), G460 (vs. gap)
- binding thiamine diphosphate: E58 (= E48), P84 (= P74), V376 (≠ A384), G377 (= G385), Q378 (≠ N386), H379 (= H387), G402 (= G405), M404 (≠ L407), G428 (= G431), D429 (= D432), G430 (= G433), S431 (≠ G434), L459 (≠ Y462), G460 (vs. gap), M461 (vs. gap), V462 (vs. gap)
Query Sequence
>WP_086509739.1 NCBI__GCF_002151265.1:WP_086509739.1
MTCGQWLLTLLHERYGVDTVFGIPGVHTVALYRGLEESGVRHVTPRHEQGAGFMADGYAR
ATGRPGVCLIITGPGMTNIATAMGQALADSVPMLVISSVNRRDTLGRGQGRLHELPSQQQ
LMAGVSRFSHTLLDPSALPEVLARAFAVFQGQRPGPVHIEIPIDLFDAPVTSTELPPPAR
LFRPAPDPAGLALAADWLRAAKRPLVLLGGGCVEAPAAARALVERLDAPTVTTINAKGVL
GRAHPLDLGANAALPAVRELAREADVVLAVGTELGETDYDVVFDDGFELRGRLIRIDLDA
QQLVRNQQVALGLVADAGRTLALLAEHFSAPLSRGGAQRTADTLAALNLKGDPAFAPFVP
FYATLGETLPDAILVGDSTAPVYAGNHLVSQPEPRRYFNASTGYGTLGYGLPAALGAQLG
LPGLPVVALVGDGGVMFTLSELATAVEARLPVVVVLWHNQGYEEIRRYMDAHGVTRCGVD
IQAPDFQVVAAGFGCQAVRVSDPAGLTQALASRPLDAPLLVEVNAAAWQQAVTCDLD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory