SitesBLAST
Comparing WP_086935559.1 NCBI__GCF_000009265.1:WP_086935559.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4hjhA Iodide sad phased crystal structure of a phosphoglucomutase from brucella melitensis complexed with glucose-6-phosphate
48% identity, 48% coverage: 1:464/963 of query aligns to 3:456/467 of 4hjhA
- binding glucose-6-phosphate: T7 (= T5), S8 (= S6), S101 (= S99), H102 (= H100), E212 (= E214), R243 (= R245), V294 (= V297), G295 (= G298), E314 (= E321), N316 (= N323), R428 (= R436), S430 (= S438), N432 (= N440), R437 (= R445)
- binding magnesium ion: S101 (= S99), D238 (= D240), D240 (= D242), D242 (= D244)
2x65B Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with mannose-1-phosphate. (see paper)
35% identity, 36% coverage: 496:838/963 of query aligns to 5:332/334 of 2x65B
- binding 1-O-phosphono-alpha-D-mannopyranose: H110 (= H607), Y149 (= Y645), G150 (= G646), E170 (= E666), K171 (= K667), N189 (= N685), S190 (= S686), D239 (= D741), W258 (= W760)
- binding phosphate ion: S11 (≠ K502), E13 (≠ T504), R14 (= R505), R326 (≠ G832)
2x65A Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with mannose-1-phosphate. (see paper)
35% identity, 36% coverage: 496:838/963 of query aligns to 5:332/334 of 2x65A
2x60A Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with gtp. (see paper)
35% identity, 36% coverage: 496:838/963 of query aligns to 5:332/333 of 2x60A
- binding guanosine-5'-triphosphate: L7 (≠ M498), A8 (= A499), G9 (= G500), G10 (= G501), G12 (= G503), E13 (≠ T504), R14 (= R505), K25 (= K516), V56 (= V547), E80 (= E573), N85 (= N578), A89 (= A582), A108 (≠ S605)
2x5zA Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with gdp-mannose. (see paper)
35% identity, 36% coverage: 496:838/963 of query aligns to 5:332/333 of 2x5zA
- binding guanosine-5'-diphosphate-alpha-d-mannose: L7 (≠ M498), G9 (= G500), G10 (= G501), V56 (= V547), E80 (= E573), K83 (≠ A576), N85 (= N578), P107 (≠ A604), H110 (= H607), Y149 (= Y645), G150 (= G646), E170 (= E666), K171 (= K667), N189 (= N685), S190 (= S686), D239 (= D741), W258 (= W760), D260 (= D762)
- binding magnesium ion: D109 (= D606), D260 (= D762)
7omlA Bacillus subtilis phosphoglucomutase glmm (metal bound) (see paper)
27% identity, 47% coverage: 3:453/963 of query aligns to 4:426/445 of 7omlA
7ojrA Bacillus subtilis phosphoglucomutase glmm (phosphate bound) (see paper)
27% identity, 47% coverage: 3:453/963 of query aligns to 4:426/445 of 7ojrA
1wqaA Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
25% identity, 48% coverage: 3:464/963 of query aligns to 5:447/455 of 1wqaA
- active site: R11 (= R9), S101 (= S99), H102 (= H100), K111 (= K109), D243 (= D240), D245 (= D242), D247 (= D244), R248 (= R245), G330 (= G325), R340 (= R345)
- binding magnesium ion: S101 (= S99), D243 (= D240), D245 (= D242), D247 (= D244)
P31120 Phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 32% coverage: 3:308/963 of query aligns to 7:317/445 of P31120
- S100 (≠ T97) mutation to A: 2% of wild-type activity.; mutation to T: 20-fold increase in the non-specific phosphoglucomutase activity towards glucose-phosphate substrates (non aminated).
- S102 (= S99) active site, Phosphoserine intermediate; modified: Phosphoserine; by autocatalysis; mutation to A: Loss of activity in the absence or presence of glucosamine-1,6-diP.
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
3i3wA Structure of a phosphoglucosamine mutase from francisella tularensis
24% identity, 47% coverage: 3:456/963 of query aligns to 3:425/441 of 3i3wA
- active site: R9 (= R9), S99 (= S99), H100 (= H100), K109 (= K109), D237 (= D240), D239 (= D242), D241 (= D244), R242 (= R245), H324 (≠ G325)
- binding zinc ion: S99 (= S99), D237 (= D240), D239 (= D242), D241 (= D244)
P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see paper)
33% identity, 12% coverage: 1:115/963 of query aligns to 42:162/581 of P18159
- G162 (= G115) mutation to D: Very low enzymatic activity. Great decrease in biofilm formation. Deformed cell morphology.
Sites not aligning to the query:
- 240 T→I: Impaired enzymatic activity. Great decrease in biofilm formation. Deformed cell morphology.
- 407 G→D: Loss of enzymatic activity. Great decrease in biofilm formation. Deformed cell morphology.
- 418 D→N: Impaired enzymatic activity. Great decrease in biofilm formation. Deformed cell morphology.
6mlwA Crystal structure of x. Citri phosphoglucomutase in complex with 2- fluoro mannosyl-1-methyl-phosphonic acid (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 41:446/449 of 6mlwA
- active site: S98 (= S99), H99 (= H100), K108 (= K109), D238 (= D240), D240 (= D242), D242 (= D244), R243 (= R245), H325 (≠ T330)
- binding 2,6-anhydro-5,7-dideoxy-5-fluoro-7-phosphono-D-glycero-D-manno-heptitol: G303 (= G298), H304 (≠ S299), E321 (≠ L326), S323 (≠ T328), H325 (≠ T330), R415 (= R436), S417 (= S438), N418 (≠ G439), T419 (≠ N440), R424 (= R445)
- binding magnesium ion: S98 (= S99), D238 (= D240), D240 (= D242), D242 (= D244)
Sites not aligning to the query:
5bmpA Crystal structure of phosphoglucomutase from xanthomonas citri complexed with glucose-1-phosphate (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 41:446/449 of 5bmpA
- active site: S98 (= S99), H99 (= H100), K108 (= K109), D238 (= D240), D240 (= D242), D242 (= D244), R243 (= R245), H325 (≠ T330)
- binding 1-O-phosphono-alpha-D-glucopyranose: R281 (vs. gap), G303 (= G298), E321 (≠ L326), S323 (≠ T328), H325 (≠ T330), R415 (= R436), S417 (= S438), N418 (≠ G439), T419 (≠ N440), R424 (= R445)
- binding magnesium ion: S98 (= S99), D238 (= D240), D240 (= D242), D242 (= D244)
Sites not aligning to the query:
6nqhA Xanthomonas citri dephospho-pgm in complex with xylose-1-phosphate
26% identity, 44% coverage: 43:467/963 of query aligns to 40:445/448 of 6nqhA
- active site: S97 (= S99), H98 (= H100), K107 (= K109), D237 (= D240), D239 (= D242), D241 (= D244), R242 (= R245), H324 (≠ T330)
- binding magnesium ion: D237 (= D240), D239 (= D242), D241 (= D244)
- binding 1-O-phosphono-alpha-D-xylopyranose: S97 (= S99), H98 (= H100), K107 (= K109), D239 (= D242), R242 (= R245), R280 (vs. gap), S301 (≠ V297), G302 (= G298), E320 (≠ L326), S322 (≠ T328), H324 (≠ T330), R414 (= R436), S416 (= S438), N417 (≠ G439), T418 (≠ N440), R423 (= R445)
Sites not aligning to the query:
6np8A Xanthomonas citri phospho-pgm in complex with mannose-6-phosphate (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 40:445/448 of 6np8A
- active site: S97 (= S99), H98 (= H100), K107 (= K109), D237 (= D240), D239 (= D242), D241 (= D244), R242 (= R245), H324 (≠ T330)
- binding calcium ion: S97 (= S99), D237 (= D240), D239 (= D242), D241 (= D244)
- binding 6-O-phosphono-alpha-D-mannopyranose: R280 (vs. gap), G302 (= G298), H303 (≠ S299), E320 (≠ L326), S322 (≠ T328), H324 (≠ T330), R414 (= R436), S416 (= S438), N417 (≠ G439), T418 (≠ N440), R423 (= R445)
Sites not aligning to the query:
6nolA Xanthomonas citri dephospho-pgm in complex with mannose-1-phosphate (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 40:445/448 of 6nolA
- active site: S97 (= S99), H98 (= H100), K107 (= K109), D237 (= D240), D239 (= D242), D241 (= D244), R242 (= R245), H324 (≠ T330)
- binding 1-O-phosphono-alpha-D-mannopyranose: G302 (= G298), E320 (≠ L326), S322 (≠ T328), H324 (≠ T330), R414 (= R436), S416 (= S438), N417 (≠ G439), T418 (≠ N440), R423 (= R445)
- binding magnesium ion: S97 (= S99), D237 (= D240), D239 (= D242), D241 (= D244)
Sites not aligning to the query:
6nnpA Xanthomonas citri dephospho-pgm in complex with glucose-6-phosphate (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 40:445/448 of 6nnpA
- active site: S97 (= S99), H98 (= H100), K107 (= K109), D237 (= D240), D239 (= D242), D241 (= D244), R242 (= R245), H324 (≠ T330)
- binding 6-O-phosphono-alpha-D-glucopyranose: R280 (vs. gap), G302 (= G298), H303 (≠ S299), E320 (≠ L326), H324 (≠ T330), R414 (= R436), S416 (= S438), N417 (≠ G439), T418 (≠ N440), R423 (= R445)
- binding magnesium ion: S97 (= S99), D237 (= D240), D239 (= D242), D241 (= D244)
Sites not aligning to the query:
6nn2A Xanthomonas citri pgm apo-phospho (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 40:445/448 of 6nn2A
- active site: S97 (= S99), H98 (= H100), K107 (= K109), D237 (= D240), D239 (= D242), D241 (= D244), R242 (= R245), H324 (≠ T330)
- binding calcium ion: S97 (= S99), D237 (= D240), D239 (= D242), D241 (= D244)
Sites not aligning to the query:
6n1eA Crystal structure of x. Citri phosphoglucomutase in complex with 1- methyl-glucose 6-phosphate (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 40:445/448 of 6n1eA
6mnvA Crystal structure of x. Citri phosphoglucomutase in complex with ch2fg1p (see paper)
26% identity, 44% coverage: 43:467/963 of query aligns to 40:445/448 of 6mnvA
- binding 1-deoxy-1-fluoro-2-O-phosphono-alpha-D-gluco-hept-2-ulopyranose: R280 (vs. gap), G302 (= G298), E320 (≠ L326), S322 (≠ T328), H324 (≠ T330), R414 (= R436), S416 (= S438), N417 (≠ G439), T418 (≠ N440), R423 (= R445)
- binding magnesium ion: S97 (= S99), D237 (= D240), D239 (= D242), D241 (= D244)
Query Sequence
>WP_086935559.1 NCBI__GCF_000009265.1:WP_086935559.1
MKFGTSGLRGLSVDLKGRASALYATAFGKYLLQTGKARAGDVILIGRDFRDSSPEISGNC
AGALAALGFRIFDCGTVPTPALALYGLESNAAGLMVTGSHIPADRNGIKFYRPDGEIDKS
DEAAITALAAEIERTGETVTQAPAETEEHEAICRQLFFERNAALLPQGALSGLKIGVYQH
SSVARDLLVDVLAHYGAEITALGRSESFIPVDTEAVSDETITLMKRWVSEHKFDAIVSTD
GDGDRPLVADETGTPLRGDLLGLVAANFLGAGTVVTPVTSNSGIEAAGSFAVRRTRVGSP
FVISGMEEAVAAGKDHVMGFEANGGLLTATAFDINGRNVRALPTRDCFIPMLAILSLAAT
RKQPLSAVAASYHLPFAAADRLENFPVETSAALMQYLRATDENLSAFLQPIGEVATKSDI
DGLRVTLKDGRIIHFRPSGNAPEMRCYVEAESETAALDLLTAGLTRIRDWAETPAKHATN
TLFSRNPPMTQKIVPVIMAGGKGTRLWPLSRATAPKQFIQFVGDKTLFQETLDRVSNPDL
YEAAIVVTNEEFRFLVAEQARALTIPLAAVLLEPVARNTAAAVAAAATLAGELFGKNTII
QMLASDHEILADETYFDCIRIARDAAADGKLVTFGITPTEPATGYGYIEIGDALKNGAHK
VKRFIEKPALEKAEQMLADGGFYWNSGIFMFPVTELIAELQEYAPDVLKAASKAVSKASR
DLDFTRLDADHFAKSPDISIDYAIMEKTSKAAVVPSPFKWSDMGSWDAVWKSGTRDDNGN
VAAANTTVVNTRNSLVMTHGVHLAVQGMEDVAVIASEDAVYVGPLKDSQNVGQLVKMLAS
SSATAKFAETHPTSYRPWGGYTSIFNGDRFQVKRIFVTPGKKLSLQKHHHRSEHWIVVKG
TAEVTVGENVRMLRENESVYIPLGEVHRLANPGKILLELIEVQTGSYLGEDDIIRIVDEF
GRT
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory