SitesBLAST
Comparing WP_089136501.1 NCBI__GCF_002217945.1:WP_089136501.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4amvA E.Coli glucosamine-6p synthase in complex with fructose-6p (see paper)
40% identity, 100% coverage: 2:605/605 of query aligns to 1:608/608 of 4amvA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W74), N98 (= N100), G99 (= G101), Y248 (= Y251), E481 (= E482), K485 (= K486), E488 (= E489), H504 (= H505), K603 (= K600)
- binding fructose -6-phosphate: G301 (= G302), T302 (= T303), S303 (= S304), S347 (= S348), Q348 (= Q349), S349 (= S350), T352 (= T353), S401 (= S401), K485 (= K486), E488 (= E489)
1jxaA Glucosamine 6-phosphate synthase with glucose 6-phosphate (see paper)
40% identity, 100% coverage: 2:605/605 of query aligns to 1:608/608 of 1jxaA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W74), N98 (= N100), G99 (= G101), Y248 (= Y251), E481 (= E482), K485 (= K486), E488 (= E489), H504 (= H505), K603 (= K600)
- binding glucose-6-phosphate: T302 (= T303), S303 (= S304), S347 (= S348), Q348 (= Q349), S349 (= S350), T352 (= T353), S401 (= S401), K485 (= K486), E488 (= E489)
2j6hA E. Coli glucosamine-6-p synthase in complex with glucose-6p and 5-oxo- l-norleucine (see paper)
40% identity, 100% coverage: 2:605/605 of query aligns to 1:608/608 of 2j6hA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W74), N98 (= N100), G99 (= G101), Y248 (= Y251), E481 (= E482), K485 (= K486), E488 (= E489), H504 (= H505), K603 (= K600)
- binding glucose-6-phosphate: T302 (= T303), S347 (= S348), Q348 (= Q349), S349 (= S350), T352 (= T353), V399 (= V399), S401 (= S401), E488 (= E489)
- binding 5-oxo-l-norleucine: C1 (= C2), R73 (= R73), W74 (= W74), T76 (= T76), H86 (= H86), N98 (= N100), G99 (= G101), D123 (= D124)
6r4eA Crystal structure of human gfat-1 in complex with glucose-6-phosphate and l-glu (see paper)
33% identity, 98% coverage: 14:605/605 of query aligns to 19:663/663 of 6r4eA
- active site: R32 (= R27), W95 (= W74), N122 (= N100), G123 (= G101), E536 (= E482), K540 (= K486), E543 (= E489), H559 (= H505), K658 (= K600)
- binding glucose-6-phosphate: T358 (= T303), S359 (= S304), S403 (= S348), Q404 (= Q349), S405 (= S350), T408 (= T353), S456 (= S401), K540 (= K486), E543 (= E489)
- binding glutamic acid: R94 (= R73), W95 (= W74), T97 (= T76), G123 (= G101), D147 (= D124)
Sites not aligning to the query:
6svmA Crystal structure of human gfat-1 in complex with glucose-6-phosphate, l-glu, and udp-galnac (see paper)
33% identity, 98% coverage: 14:605/605 of query aligns to 19:660/660 of 6svmA
- active site: R32 (= R27), W95 (= W74), N122 (= N100), G123 (= G101), E533 (= E482), K537 (= K486), E540 (= E489), H556 (= H505), K655 (= K600)
- binding glucose-6-phosphate: C353 (≠ A301), T355 (= T303), S356 (= S304), S400 (= S348), Q401 (= Q349), S402 (= S350), T405 (= T353), S453 (= S401), K537 (= K486), E540 (= E489)
- binding glutamic acid: R94 (= R73), W95 (= W74), T97 (= T76), H107 (= H86), G123 (= G101), D147 (= D124)
- binding magnesium ion: S434 (= S382), R435 (= R383), T437 (≠ A385)
- binding uridine-diphosphate-n-acetylgalactosamine: Q289 (≠ D240), R322 (≠ L269), G334 (≠ V281), G424 (≠ T372), T426 (= T374), S434 (= S382), T437 (≠ A385), C439 (≠ Y387), G440 (≠ T388), V441 (≠ L389), H442 (≠ L390)
Sites not aligning to the query:
6r4gA Crystal structure of human gfat-1 in complex with udp-glcnac (see paper)
33% identity, 97% coverage: 14:598/605 of query aligns to 19:652/652 of 6r4gA
- active site: R32 (= R27), W95 (= W74), N122 (= N100), G123 (= G101), E532 (= E482), K536 (= K486), E539 (= E489), H555 (= H505)
- binding glucose-6-phosphate: G353 (= G302), T354 (= T303), S355 (= S304), S399 (= S348), Q400 (= Q349), S401 (= S350), T404 (= T353), S452 (= S401), E539 (= E489)
- binding magnesium ion: S433 (= S382), R434 (= R383), T436 (≠ A385)
- binding uridine-diphosphate-n-acetylglucosamine: Q288 (≠ D240), R321 (≠ L269), G333 (≠ V281), G423 (≠ T372), T425 (= T374), S433 (= S382), T436 (≠ A385), C438 (≠ Y387), G439 (≠ T388), V440 (≠ L389), H441 (≠ L390)
Sites not aligning to the query:
1morA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucose 6-phosphate (see paper)
40% identity, 59% coverage: 247:605/605 of query aligns to 2:366/366 of 1morA
- active site: E239 (= E482), K243 (= K486), E246 (= E489), H262 (= H505), K361 (= K600)
- binding 6-O-phosphono-alpha-D-glucopyranose: T60 (= T303), S105 (= S348), Q106 (= Q349), S107 (= S350), T110 (= T353), V157 (= V399), A360 (= A599), K361 (= K600)
1moqA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucosamine 6-phosphate (see paper)
40% identity, 59% coverage: 247:605/605 of query aligns to 2:366/366 of 1moqA