SitesBLAST
Comparing WP_089301544.1 NCBI__GCF_900188115.1:WP_089301544.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3nf4A Crystal structure of acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to flavin adenine dinucleotide (see paper)
61% identity, 99% coverage: 1:378/381 of query aligns to 1:368/369 of 3nf4A
- active site: L127 (= L127), S128 (= S128), G240 (= G243), E354 (= E364), R366 (= R376)
- binding flavin-adenine dinucleotide: Y125 (= Y125), L127 (= L127), S128 (= S128), G133 (= G133), S134 (= S134), W158 (= W158), T160 (= T160), I349 (≠ V359), T356 (= T366), Q358 (= Q368), I359 (= I369)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
44% identity, 98% coverage: 7:380/381 of query aligns to 3:378/378 of 5ol2F
- active site: L124 (= L127), T125 (≠ S128), G241 (= G243), G374 (≠ R376)
- binding calcium ion: E29 (= E33), E33 (≠ A37), R35 (= R39)
- binding coenzyme a persulfide: L238 (= L240), R242 (= R244), E362 (= E364), G363 (= G365)
- binding flavin-adenine dinucleotide: F122 (≠ Y125), L124 (= L127), T125 (≠ S128), P127 (= P130), T131 (≠ S134), F155 (≠ W158), I156 (= I159), T157 (= T160), E198 (= E200), R267 (= R269), F270 (= F272), L274 (≠ I276), F277 (= F279), Q335 (= Q337), L336 (≠ V338), G338 (= G340), G339 (= G341), Y361 (≠ F363), T364 (= T366), E366 (≠ Q368)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
46% identity, 95% coverage: 18:378/381 of query aligns to 12:372/374 of 5lnxD
- active site: L122 (= L127), T123 (≠ S128), G239 (= G243), E358 (= E364), K370 (≠ R376)
- binding flavin-adenine dinucleotide: L122 (= L127), T123 (≠ S128), G128 (= G133), S129 (= S134), F153 (≠ W158), T155 (= T160), R265 (= R269), Q267 (= Q271), F268 (= F272), I272 (= I276), N275 (≠ F279), I278 (= I282), Q331 (= Q337), I332 (≠ V338), G335 (= G341), Y357 (≠ F363), T360 (= T366), E362 (≠ Q368)
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
44% identity, 95% coverage: 20:380/381 of query aligns to 9:369/369 of 3pfdC
- active site: L116 (= L127), S117 (= S128), T233 (≠ G243), E353 (= E364), R365 (= R376)
- binding dihydroflavine-adenine dinucleotide: Y114 (= Y125), L116 (= L127), S117 (= S128), G122 (= G133), S123 (= S134), W147 (= W158), I148 (= I159), T149 (= T160), R259 (= R269), F262 (= F272), V266 (≠ I276), N269 (≠ F279), Q326 (= Q337), L327 (≠ V338), G330 (= G341), I348 (≠ V359), Y352 (≠ F363), T355 (= T366), Q357 (= Q368)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
43% identity, 98% coverage: 7:380/381 of query aligns to 7:381/384 of 1jqiA
- active site: G377 (≠ R376)
- binding acetoacetyl-coenzyme a: L95 (≠ M95), F125 (≠ Y125), S134 (= S134), F234 (≠ L233), M238 (≠ L237), Q239 (≠ D238), L241 (= L240), D242 (≠ A241), R245 (= R244), Y364 (≠ F363), E365 (= E364), G366 (= G365)
- binding flavin-adenine dinucleotide: F125 (≠ Y125), L127 (= L127), S128 (= S128), G133 (= G133), S134 (= S134), W158 (= W158), T160 (= T160), R270 (= R269), F273 (= F272), L280 (≠ F279), Q338 (= Q337), I339 (≠ V338), G342 (= G341), I360 (≠ V359), T367 (= T366), E369 (≠ Q368), I370 (= I369)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
43% identity, 98% coverage: 7:380/381 of query aligns to 34:408/412 of P15651
- 152:161 (vs. 125:134, 70% identical) binding FAD
- S161 (= S134) binding substrate
- WIT 185:187 (= WIT 158:160) binding FAD
- DMGR 269:272 (≠ ASGR 241:244) binding substrate
- R297 (= R269) binding FAD
- QILGG 365:369 (≠ QVLGG 337:341) binding FAD
- E392 (= E364) active site, Proton acceptor
- TSE 394:396 (≠ TNQ 366:368) binding FAD
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
42% identity, 97% coverage: 10:380/381 of query aligns to 6:379/380 of 4l1fA
- active site: L125 (= L127), T126 (≠ S128), G242 (= G243), E363 (= E364), R375 (= R376)
- binding coenzyme a persulfide: T132 (≠ S134), H179 (≠ K180), F232 (≠ L233), M236 (≠ L237), E237 (≠ D238), L239 (= L240), D240 (≠ A241), R243 (= R244), Y362 (≠ F363), E363 (= E364), G364 (= G365), R375 (= R376)
- binding flavin-adenine dinucleotide: F123 (≠ Y125), L125 (= L127), T126 (≠ S128), G131 (= G133), T132 (≠ S134), F156 (≠ W158), I157 (= I159), T158 (= T160), R268 (= R269), Q270 (= Q271), F271 (= F272), I275 (= I276), F278 (= F279), L281 (≠ I282), Q336 (= Q337), I337 (≠ V338), G340 (= G341), I358 (≠ V359), Y362 (≠ F363), T365 (= T366), Q367 (= Q368)
- binding 1,3-propandiol: Q10 (≠ D14)
Sites not aligning to the query:
8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
44% identity, 97% coverage: 8:378/381 of query aligns to 6:379/381 of 8i4rA
- binding acetyl coenzyme *a: S132 (= S134), T134 (≠ A136), R180 (vs. gap), R234 (= R234), L237 (= L237), R238 (≠ D238), L240 (= L240), D241 (≠ A241), R244 (= R244), E365 (= E364), G366 (= G365), R377 (= R376)
- binding flavin-adenine dinucleotide: Y123 (= Y125), L125 (= L127), S126 (= S128), G131 (= G133), S132 (= S134), W156 (= W158), I157 (= I159), T158 (= T160), I360 (≠ V359), T367 (= T366), Q369 (= Q368)
8i4pA Crystal structure of acyl-coa dehydrogenase from thermobifida fusca
44% identity, 97% coverage: 8:378/381 of query aligns to 6:379/381 of 8i4pA
- binding flavin-adenine dinucleotide: Y123 (= Y125), L125 (= L127), S126 (= S128), G131 (= G133), S132 (= S134), W156 (= W158), I157 (= I159), T158 (= T160), I360 (≠ V359), Y364 (≠ F363), T367 (= T366), Q369 (= Q368)
7w0jE Acyl-coa dehydrogenase, tfu_1647
44% identity, 97% coverage: 8:378/381 of query aligns to 7:380/382 of 7w0jE
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: S127 (= S128), W157 (= W158), R270 (= R269), Q272 (= Q271), F273 (= F272), I277 (= I276), F280 (= F279), I283 (= I282), Q339 (= Q337), L340 (≠ V338), G343 (= G341), Y365 (≠ F363), E366 (= E364), T368 (= T366), Q370 (= Q368), I371 (= I369)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
42% identity, 98% coverage: 7:380/381 of query aligns to 7:381/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ A342), T347 (≠ R346), E348 (≠ D347)
- binding flavin-adenine dinucleotide: F125 (≠ Y125), L127 (= L127), S128 (= S128), G133 (= G133), S134 (= S134), W158 (= W158), T160 (= T160), R270 (= R269), F273 (= F272), L280 (≠ F279), V282 (≠ G281), Q338 (= Q337), I339 (≠ V338), G342 (= G341), I360 (≠ V359), Y364 (≠ F363), T367 (= T366), E369 (≠ Q368), I370 (= I369), L373 (≠ M372)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
42% identity, 98% coverage: 7:380/381 of query aligns to 10:384/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ Y125), L130 (= L127), S131 (= S128), G136 (= G133), S137 (= S134), W161 (= W158), T163 (= T160), T214 (= T210), R273 (= R269), F276 (= F272), L280 (≠ I276), L283 (≠ F279), V285 (≠ G281), Q341 (= Q337), I342 (≠ V338), G345 (= G341), I363 (≠ V359), Y367 (≠ F363), T370 (= T366), E372 (≠ Q368), L376 (≠ M372)
8sgsA Human liver mitochondrial short-chain specific acyl-coa dehydrogenase (see paper)
42% identity, 98% coverage: 7:380/381 of query aligns to 4:378/381 of 8sgsA
- binding coenzyme a: S131 (= S134), A133 (= A136), N177 (≠ S179), F231 (≠ L233), M235 (≠ L237), L238 (= L240), I312 (≠ G314), E362 (= E364), G363 (= G365)
- binding flavin-adenine dinucleotide: F122 (≠ Y125), L124 (= L127), S125 (= S128), G130 (= G133), S131 (= S134), W155 (= W158), T157 (= T160), R267 (= R269), F270 (= F272), L274 (≠ I276), L277 (≠ F279), Q335 (= Q337), I336 (≠ V338), G338 (= G340), G339 (= G341), I357 (≠ V359), I360 (= I362), Y361 (≠ F363), T364 (= T366), E366 (≠ Q368)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
42% identity, 98% coverage: 7:380/381 of query aligns to 34:408/412 of P16219
- G90 (= G64) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E78) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 125:134, 70% identical) binding in other chain
- R171 (≠ E144) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (= WIT 158:160) binding in other chain
- A192 (= A165) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G181) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R269) binding FAD
- Q308 (= Q280) binding in other chain
- R325 (= R297) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ T325) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QVLGG 337:341) binding FAD
- R380 (= R352) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ TNQ 366:368) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
43% identity, 94% coverage: 19:378/381 of query aligns to 17:378/378 of 4n5fA
- active site: L126 (= L127), T127 (≠ S128), G243 (= G243), E364 (= E364), R376 (= R376)
- binding dihydroflavine-adenine dinucleotide: L126 (= L127), T127 (≠ S128), G132 (= G133), S133 (= S134), F157 (≠ W158), T159 (= T160), T210 (= T210), Y363 (≠ F363), T366 (= T366), E368 (≠ Q368), M372 (= M372)
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
41% identity, 98% coverage: 7:380/381 of query aligns to 1:368/371 of 2vigB
- active site: L121 (= L127), S122 (= S128), G231 (= G243), E352 (= E364), G364 (≠ R376)
- binding coenzyme a persulfide: S128 (= S134), F221 (≠ L233), M225 (≠ L237), Q226 (≠ D238), L228 (= L240), D229 (≠ A241), R232 (= R244), E352 (= E364), G353 (= G365), I357 (= I369)
- binding flavin-adenine dinucleotide: L121 (= L127), S122 (= S128), G127 (= G133), S128 (= S134), W152 (= W158), T154 (= T160), R257 (= R269), F260 (= F272), L264 (≠ I276), L267 (≠ F279), Q325 (= Q337), I326 (≠ V338), G329 (= G341), I347 (≠ V359), Y351 (≠ F363), T354 (= T366), E356 (≠ Q368)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
42% identity, 97% coverage: 11:378/381 of query aligns to 8:376/379 of 1ukwB
- active site: L124 (= L127), S125 (= S128), T241 (≠ G243), E362 (= E364), R374 (= R376)
- binding cobalt (ii) ion: D145 (≠ E148), H146 (= H149)
- binding flavin-adenine dinucleotide: F122 (≠ Y125), L124 (= L127), S125 (= S128), G130 (= G133), S131 (= S134), W155 (= W158), S157 (≠ T160), K200 (= K202), L357 (≠ V359), Y361 (≠ F363), E362 (= E364), T364 (= T366), E366 (≠ Q368), L370 (≠ M372)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
42% identity, 97% coverage: 11:378/381 of query aligns to 8:376/379 of 1ukwA
- active site: L124 (= L127), S125 (= S128), T241 (≠ G243), E362 (= E364), R374 (= R376)
- binding flavin-adenine dinucleotide: F122 (≠ Y125), L124 (= L127), S125 (= S128), G130 (= G133), S131 (= S134), W155 (= W158), S157 (≠ T160), L357 (≠ V359), Y361 (≠ F363), E362 (= E364), T364 (= T366), E366 (≠ Q368), L370 (≠ M372)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
47% identity, 95% coverage: 20:380/381 of query aligns to 13:370/370 of 2dvlA
- active site: L121 (= L127), T122 (≠ S128), G233 (= G243), E354 (= E364), R366 (= R376)
- binding flavin-adenine dinucleotide: L121 (= L127), T122 (≠ S128), G127 (= G133), S128 (= S134), W152 (= W158), I153 (= I159), T154 (= T160), T356 (= T366), E358 (≠ Q368)
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
43% identity, 94% coverage: 19:378/381 of query aligns to 15:376/376 of 4m9aB
- active site: L124 (= L127), T125 (≠ S128), G241 (= G243), E362 (= E364), R374 (= R376)
- binding dihydroflavine-adenine dinucleotide: F122 (≠ Y125), T125 (≠ S128), G130 (= G133), S131 (= S134), F155 (≠ W158), T157 (= T160), T208 (= T210), Y361 (≠ F363), T364 (= T366), E366 (≠ Q368), M370 (= M372)
Query Sequence
>WP_089301544.1 NCBI__GCF_900188115.1:WP_089301544.1
MPAERTLPNTEAEDLIALAREIAREELAPVAGEFEQAHRFPREQFRLLGKSGLLGLPYPE
RWGGGDVPYEVYLQALEEIASAWMSVGVGMSVHTMSCFALAYYGTEQQRDRWLPDMLSGQ
LLGAYALSEPHAGSDAAALTTRAEPDGEHYVVNGTKAWITHGGEADYYTTMVRTDPDGSK
GISCLLVDAGTDGLSAAPPEQKMGMTASTTAQLVFSDARVERERLIGDEGSGLRIALDSL
ASGRLGIAACSVGLAQAALDEAVAYATQRTQFGTPIIDFQGIEFLLADMAAAVESSRATY
LEAARRKDRGLPFGRQASIAKLVATDSAMKVTTDAVQVLGGAGYTRDFPVERYMREAKVP
QIFEGTNQIQRMVIARELRRG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory