SitesBLAST
Comparing WP_089302251.1 NCBI__GCF_900188115.1:WP_089302251.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
49% identity, 99% coverage: 6:432/433 of query aligns to 5:428/430 of 3bs8A
- active site: V22 (= V23), Y145 (= Y146), E207 (= E208), D240 (= D241), M243 (= M244), K268 (= K269), G401 (≠ A402)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), H146 (= H147), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), K268 (= K269)
P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
51% identity, 98% coverage: 5:430/433 of query aligns to 1:425/426 of P23893
- K265 (= K269) mutation to R: 2% of wild-type activity.
3k28A Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
50% identity, 94% coverage: 4:411/433 of query aligns to 3:405/423 of 3k28A
- active site: V22 (= V23), Y145 (= Y146), E202 (= E208), D235 (= D241), M238 (= M244), K263 (= K269), G396 (≠ A402)
- binding calcium ion: I103 (= I104), V106 (= V107), P107 (≠ D108), I109 (≠ V110)
- binding pyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), H146 (= H147), G147 (= G148), E202 (= E208), D235 (= D241), V237 (= V243), M238 (= M244), K263 (= K269)
6w80A Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
52% identity, 95% coverage: 7:416/433 of query aligns to 10:417/430 of 6w80A
- active site: V26 (= V23), Y149 (= Y146), D241 (= D241), K269 (= K269)
- binding pyridoxal-5'-phosphate: S121 (= S118), G122 (= G119), T123 (= T120), Y149 (= Y146), H150 (= H147), E208 (= E208), N213 (= N213), D241 (= D241), V243 (= V243), K269 (= K269)
2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
49% identity, 98% coverage: 7:431/433 of query aligns to 5:426/427 of 2gsaB
- active site: V21 (= V23), Y144 (= Y146), E206 (= E208), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A402)
- binding pyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269)
2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
49% identity, 98% coverage: 7:431/433 of query aligns to 5:426/427 of 2gsaA
- active site: V21 (= V23), Y144 (= Y146), E206 (= E208), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A402)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), N211 (= N213), D239 (= D241), V241 (= V243), K267 (= K269)
Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
48% identity, 97% coverage: 5:426/433 of query aligns to 48:467/472 of Q42522
- R92 (≠ S49) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
- G162 (= G119) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.
3usfA Crystal structure of dava-4
49% identity, 98% coverage: 7:431/433 of query aligns to 5:426/427 of 3usfA
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A402)
- binding (4s)-4,5-diaminopentanoic acid: S23 (= S25), V25 (= V27), S157 (= S159), K267 (= K269), E400 (= E401)
- binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), N211 (= N213), D239 (= D241), V241 (= V243), K267 (= K269)
3fq7A Gabaculine complex of gsam (see paper)
49% identity, 98% coverage: 7:431/433 of query aligns to 5:426/427 of 3fq7A
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A402)
- binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: S23 (= S25), V25 (= V27), W61 (= W63), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269), G298 (= G300), T299 (= T301), E400 (= E401)
2hp2A Inter-subunit signaling in gsam (see paper)
49% identity, 98% coverage: 7:431/433 of query aligns to 5:426/427 of 2hp2A
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A402)
- binding (4s)-4,5-diaminopentanoic acid: G298 (= G300), T299 (= T301)
- binding (4r)-5-amino-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S25), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269)
- binding pyridoxal-5'-phosphate: G298 (= G300), T299 (= T301)
2hp1A Inter-subunit signaling in gsam (see paper)
49% identity, 98% coverage: 7:431/433 of query aligns to 5:426/427 of 2hp1A
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A402)
- binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S25), V25 (= V27), W61 (= W63), S116 (= S118), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269), E400 (= E401)
2hozA Inter-subunit signaling in gsam (see paper)
49% identity, 98% coverage: 7:431/433 of query aligns to 5:426/427 of 2hozA
- active site: V21 (= V23), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A402)
- binding (4s)-4,5-diaminopentanoic acid: E141 (≠ A143), G156 (= G158), S157 (= S159), P182 (= P184), N368 (≠ D369), E370 (≠ D371), K373 (≠ R374)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), E206 (= E208), N211 (= N213), D239 (= D241), G298 (= G300), T299 (= T301)
3fqaA Gabaculien complex of gabaculine resistant gsam version (see paper)
49% identity, 98% coverage: 7:431/433 of query aligns to 4:425/426 of 3fqaA
- active site: V20 (= V23), Y143 (= Y146), D238 (= D241), I241 (≠ M244), K266 (= K269), A400 (= A402)
- binding 3-aminobenzoic acid: S22 (= S25), R25 (= R28), W60 (= W63)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G116 (= G119), T117 (= T120), Y143 (= Y146), E205 (= E208), N210 (= N213), D238 (= D241), V240 (= V243), I241 (≠ M244)
P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
48% identity, 98% coverage: 2:426/433 of query aligns to 47:469/474 of P42799
- K314 (= K269) modified: N6-(pyridoxal phosphate)lysine
5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
50% identity, 98% coverage: 5:429/433 of query aligns to 1:419/420 of 5i92F
Sites not aligning to the query:
5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
48% identity, 98% coverage: 2:426/433 of query aligns to 1:423/428 of 5hdmB
- active site: V22 (= V23), Y145 (= Y146), E207 (= E208), D240 (= D241), M243 (= M244), K268 (= K269), A402 (= A402)
- binding pyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), M243 (= M244), K268 (= K269)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), M243 (= M244), K268 (= K269)
5hdmA Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
48% identity, 98% coverage: 2:426/433 of query aligns to 1:423/428 of 5hdmA
- active site: V22 (= V23), Y145 (= Y146), E207 (= E208), D240 (= D241), M243 (= M244), K268 (= K269), A402 (= A402)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), G147 (= G148), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), K268 (= K269)
2e7uA Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
50% identity, 97% coverage: 8:427/433 of query aligns to 6:423/424 of 2e7uA
- active site: V21 (= V23), Y144 (= Y146), E206 (= E208), D238 (= D241), M241 (= M244), K266 (= K269), A401 (= A402)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), N211 (= N213), D238 (= D241), V240 (= V243)
3usfB Crystal structure of dava-4
45% identity, 98% coverage: 7:431/433 of query aligns to 5:401/402 of 3usfB
- active site: V21 (= V23), Y144 (= Y146), E181 (= E208), D214 (= D241), M217 (= M244), K242 (= K269), A376 (= A402)
- binding (4s)-4,5-diaminopentanoic acid: G273 (= G300), T274 (= T301)
- binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), E181 (= E208), N186 (= N213), D214 (= D241), V216 (= V243), M217 (= M244), K242 (= K269)
2hp1B Inter-subunit signaling in gsam (see paper)
45% identity, 98% coverage: 7:431/433 of query aligns to 5:397/398 of 2hp1B
- active site: V21 (= V23), Y144 (= Y146), E177 (= E208), D210 (= D241), M213 (= M244), K238 (= K269), A372 (= A402)
- binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: G269 (= G300), T270 (= T301)
- binding (4s)-4,5-diaminopentanoic acid: S23 (= S25), V25 (= V27), R26 (= R28), W61 (= W63), Y144 (= Y146)
- binding pyridoxal-5'-phosphate: S116 (= S118), G117 (= G119), T118 (= T120), Y144 (= Y146), E177 (= E208), N182 (= N213), D210 (= D241), V212 (= V243), M213 (= M244), K238 (= K269)
Query Sequence
>WP_089302251.1 NCBI__GCF_900188115.1:WP_089302251.1
MSVRIQQSQELFERATSVIPGGVNSPVRAFSSVGGTPRFMVSGEGAYLSDEDGNRYVDLV
SSWGPMILGHSHPAVVEAVRSAAASGLSFGTPVRGEVDLAAEIIRRVDPVEQVRLVNSGT
EATMTAIRLARAFTGRDKIVKFAGCYHGHVDALLVQAGSGVATLGLPTSPGVSDAQAADT
IVLPYNDIEAVRACFAEHAGRIAAVITEAAAGNMGAVAPVPGFNAELRRLTAEDGALLIM
DEVMTGFRVSAAGWYGLDWVAGDLYTFGKVMSGGLPAAAFGGRADVLAMLAPSGSVYQAG
TLAGNPVAAAAGLATLRAADEATYHVLDANAQRLSTMLTEALSAAGVAHTIGQAGNLVSV
FFSEEPVHDYDGARKAESFRYRPFFHALLEQGVFAPPSAFEAWFVNTAMDDNAFEAIEAA
LPAAARAAAEATA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory