SitesBLAST
Comparing WP_089322996.1 NCBI__GCF_900188395.1:WP_089322996.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac (see paper)
46% identity, 98% coverage: 3:311/315 of query aligns to 2:306/307 of 6wjaA
- active site: A118 (≠ S120), A119 (= A121), A120 (= A122), F143 (≠ Y144), K147 (= K148)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), D32 (= D33), S34 (= S35), T35 (= T36), G36 (= G37), A55 (≠ V55), L74 (= L76), A75 (= A77), A76 (= A78), S93 (≠ T95), F143 (≠ Y144), K147 (= K148), F170 (= F171), F171 (= F172), I173 (≠ V174)
- binding uridine-diphosphate-n-acetylgalactosamine: V80 (= V82), A120 (= A122), N172 (= N173), G186 (= G187), V187 (= V188), F191 (= F192), T202 (= T208), F204 (= F210), R211 (= R217), L247 (= L253), R270 (= R276), D273 (= D279)
6wj9B Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
46% identity, 98% coverage: 3:311/315 of query aligns to 3:307/308 of 6wj9B
- active site: A119 (≠ S120), A120 (= A121), A121 (= A122), F144 (≠ Y144), K148 (= K148)
- binding nicotinamide-adenine-dinucleotide: G8 (= G8), G11 (= G11), F12 (= F12), I13 (= I13), D32 (= D32), D33 (= D33), S35 (= S35), T36 (= T36), G37 (= G37), D55 (≠ N54), A56 (≠ V55), L75 (= L76), A76 (= A77), A77 (= A78), S94 (≠ T95), A117 (= A118), A119 (≠ S120), F144 (≠ Y144), K148 (= K148), F171 (= F171), F172 (= F172), I174 (≠ V174)
- binding uridine-diphosphate-n-acetylglucosamine: V81 (= V82), N173 (= N173), G187 (= G187), V188 (= V188), F192 (= F192), T203 (= T208), L204 (≠ I209), F205 (= F210), R212 (= R217), L248 (= L253), R271 (= R276), D274 (= D279)
4zrnA Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
43% identity, 97% coverage: 4:310/315 of query aligns to 3:302/309 of 4zrnA
- active site: T117 (≠ S120), G119 (≠ A121), A120 (= A122), Y143 (= Y144), K147 (= K148), Y181 (≠ F182), G185 (= G187)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), N32 (≠ D33), S34 (= S35), S35 (≠ T36), G36 (= G37), S51 (≠ N54), I52 (≠ V55), L73 (= L76), A74 (= A77), A75 (= A78), T92 (= T95), S115 (≠ A118), S116 (= S119), Y143 (= Y144), K147 (= K148), Y170 (≠ F171), V173 (= V174)
- binding uridine-5'-diphosphate-glucose: T117 (≠ S120), G119 (≠ A121), A120 (= A122), Y143 (= Y144), N172 (= N173), G185 (= G187), V186 (= V188), H201 (≠ T208), F203 (= F210), Y208 (≠ Q215), R210 (= R217), V244 (≠ L253), R267 (= R276), D270 (= D279)
6dntA Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
44% identity, 93% coverage: 4:297/315 of query aligns to 6:290/310 of 6dntA
- active site: S120 (= S120), S121 (≠ A121), A122 (= A122), Y144 (= Y144), K148 (= K148), A187 (≠ G187)
- binding (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid: A80 (= A80), S120 (= S120), S121 (≠ A121), Y144 (= Y144), F172 (= F172), N173 (= N173), A187 (≠ G187), V188 (= V188), K191 (≠ I191), V203 (≠ T208), I204 (= I209), Y205 (≠ F210), Q210 (= Q215), R212 (= R217), I246 (≠ L253), R269 (= R276), D272 (= D279)
- binding nicotinamide-adenine-dinucleotide: G10 (= G8), G13 (= G11), F14 (= F12), I15 (= I13), D33 (= D32), N34 (≠ D33), L35 (≠ F34), S36 (= S35), S37 (≠ T36), G38 (= G37), D57 (≠ N54), L58 (≠ V55), L76 (= L76), A77 (= A77), A78 (= A78), A80 (= A80), S118 (≠ A118), S119 (= S119), Y144 (= Y144), K148 (= K148), Y171 (≠ F171), V174 (= V174)
- binding zinc ion: E209 (≠ K214), H275 (= H282)
2p5uA Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
41% identity, 97% coverage: 3:307/315 of query aligns to 2:302/311 of 2p5uA
- active site: T117 (≠ S120), G119 (≠ A121), A120 (= A122), Y143 (= Y144), K147 (= K148), H181 (≠ F182), G185 (= G187)
- binding nicotinamide-adenine-dinucleotide: G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), N32 (≠ D33), L33 (≠ F34), A34 (≠ S35), T35 (= T36), G36 (= G37), D51 (≠ N54), L52 (≠ V55), Q73 (≠ L76), A74 (= A77), A75 (= A78), A77 (= A80), S116 (= S119), Y143 (= Y144), K147 (= K148), V173 (= V174)
1sb8A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
37% identity, 96% coverage: 5:307/315 of query aligns to 20:331/341 of 1sb8A
- active site: S142 (= S120), S143 (≠ A121), S144 (≠ A122), Y166 (= Y144), K170 (= K148), N204 (≠ F182)
- binding nicotinamide-adenine-dinucleotide: G23 (= G8), G26 (= G11), F27 (= F12), I28 (= I13), D47 (= D32), N48 (≠ D33), F49 (= F34), T51 (= T36), G52 (= G37), D78 (vs. gap), I79 (vs. gap), Q98 (≠ L76), A100 (= A78), T117 (= T95), A140 (= A118), A141 (≠ S119), Y166 (= Y144), K170 (= K148), Y193 (≠ F171), N195 (= N173), V196 (= V174)
- binding uridine-diphosphate-n-acetylgalactosamine: S103 (= S81), S142 (= S120), S143 (≠ A121), S144 (≠ A122), Y166 (= Y144), N195 (= N173), A209 (≠ G187), V210 (= V188), W214 (≠ F192), Y225 (≠ E206), I226 (= I207), N227 (≠ T208), R234 (= R217), L271 (= L253), R299 (= R276), D302 (= D279), S306 (= S283)
1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose (see paper)
37% identity, 96% coverage: 5:307/315 of query aligns to 19:330/340 of 1sb9A
- active site: S141 (= S120), S142 (≠ A121), S143 (≠ A122), Y165 (= Y144), K169 (= K148), N203 (≠ F182)
- binding nicotinamide-adenine-dinucleotide: G22 (= G8), G25 (= G11), F26 (= F12), I27 (= I13), D46 (= D32), N47 (≠ D33), F48 (= F34), T50 (= T36), G51 (= G37), D77 (vs. gap), I78 (vs. gap), Q97 (≠ L76), A99 (= A78), T116 (= T95), A139 (= A118), A140 (≠ S119), Y165 (= Y144), K169 (= K148), Y192 (≠ F171), N194 (= N173), V195 (= V174)
- binding uridine-5'-diphosphate-glucose: S141 (= S120), Y165 (= Y144), N194 (= N173), A208 (≠ G187), V209 (= V188), W213 (≠ F192), Y224 (≠ E206), I225 (= I207), N226 (≠ T208), L270 (= L253), R298 (= R276), D301 (= D279)
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
36% identity, 96% coverage: 5:307/315 of query aligns to 20:326/336 of 3ruhA
- active site: S142 (= S120), S143 (≠ A121), S144 (≠ A122), Y166 (= Y144), K170 (= K148), N204 (≠ F182)
- binding nicotinamide-adenine-dinucleotide: G23 (= G8), G26 (= G11), F27 (= F12), I28 (= I13), D47 (= D32), N48 (≠ D33), S50 (= S35), T51 (= T36), G52 (= G37), D78 (≠ N54), I79 (≠ V55), Q98 (≠ L76), A99 (= A77), A100 (= A78), T117 (= T95), A140 (= A118), A141 (≠ S119), S142 (= S120), Y166 (= Y144), K170 (= K148), Y193 (≠ F171), V196 (= V174)
- binding [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl][(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-4,5-bis(oxidanyl)-3-(2-oxidanylidenepropyl)oxan-2-yl] hydrogen phosphate: G102 (≠ A80), S103 (= S81), S142 (= S120), S143 (≠ A121), S144 (≠ A122), Y166 (= Y144), Y193 (≠ F171), N195 (= N173), A209 (≠ G187), V210 (= V188), K213 (≠ I191), W214 (≠ F192), Y225 (≠ E206), I226 (= I207), N227 (≠ T208), R234 (= R217), L271 (= L253), R294 (= R276), D297 (= D279), V298 (≠ I280), S301 (= S283)
3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
36% identity, 96% coverage: 5:307/315 of query aligns to 20:326/336 of 3rufA
- active site: S142 (= S120), S143 (≠ A121), S144 (≠ A122), Y166 (= Y144), K170 (= K148), N204 (≠ F182)
- binding nicotinamide-adenine-dinucleotide: G23 (= G8), G26 (= G11), F27 (= F12), I28 (= I13), D47 (= D32), N48 (≠ D33), S50 (= S35), T51 (= T36), G52 (= G37), D78 (≠ N54), I79 (≠ V55), Q98 (≠ L76), A99 (= A77), A100 (= A78), T117 (= T95), A140 (= A118), Y166 (= Y144), K170 (= K148), Y193 (≠ F171), V196 (= V174)
- binding uridine-5'-diphosphate: N195 (= N173), A209 (≠ G187), V210 (= V188), K213 (≠ I191), W214 (≠ F192), Y225 (≠ E206), I226 (= I207), N227 (≠ T208), R234 (= R217), L271 (= L253), R294 (= R276), D297 (= D279)
3lu1A Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
36% identity, 96% coverage: 5:307/315 of query aligns to 20:326/336 of 3lu1A
- active site: S142 (= S120), S143 (≠ A121), S144 (≠ A122), Y166 (= Y144), K170 (= K148), N204 (≠ F182)
- binding glycine: Q135 (≠ S113), K187 (= K165)
- binding nicotinamide-adenine-dinucleotide: G23 (= G8), G26 (= G11), F27 (= F12), I28 (= I13), D47 (= D32), N48 (≠ D33), S50 (= S35), T51 (= T36), G52 (= G37), D78 (≠ N54), I79 (≠ V55), Q98 (≠ L76), A99 (= A77), A100 (= A78), A140 (= A118), A141 (≠ S119), S142 (= S120), Y166 (= Y144), K170 (= K148), Y193 (≠ F171), N195 (= N173)
- binding uridine-diphosphate-n-acetylgalactosamine: S103 (= S81), S142 (= S120), S143 (≠ A121), S144 (≠ A122), Y166 (= Y144), N195 (= N173), V210 (= V188), W214 (≠ F192), Y225 (≠ E206), I226 (= I207), N227 (≠ T208), R234 (= R217), L271 (= L253), R294 (= R276), D297 (= D279)
6kv9A Moee5 in complex with udp-glucuronic acid and NAD (see paper)
39% identity, 98% coverage: 2:310/315 of query aligns to 1:293/299 of 6kv9A
- active site: S110 (= S120), S111 (≠ A121), S112 (≠ A122), Y133 (= Y144), K137 (= K148)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), R32 (≠ M39), R33 (≠ E40), D47 (≠ N54), L48 (≠ V55), L66 (= L76), A67 (= A77), A68 (= A78), P70 (≠ A80), C85 (≠ T95), A108 (= A118), S109 (= S119), K137 (= K148), F162 (= F171), T164 (≠ N173), V165 (= V174), R171 (≠ D180), M174 (≠ I191)
- binding uridine-5'-diphosphate-glucuronic acid: P70 (≠ A80), R73 (≠ A83), S110 (= S120), S111 (≠ A121), Y133 (= Y144), T164 (≠ N173), R171 (≠ D180), M174 (≠ I191), F175 (= F192), R178 (= R195), E190 (= E206), I191 (= I207), Y192 (≠ F210), Q197 (= Q215), R199 (= R217), V235 (≠ L253), D261 (= D279)
6kvcA Moee5 in complex with udp-glucose and NAD (see paper)
39% identity, 98% coverage: 2:310/315 of query aligns to 1:292/299 of 6kvcA
- active site: S109 (= S120), S110 (≠ A121), S111 (≠ A122), Y132 (= Y144), K136 (= K148)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), R32 (≠ M39), R33 (≠ E40), D46 (≠ N54), L47 (≠ V55), L65 (= L76), A66 (= A77), A67 (= A78), P69 (≠ A80), A107 (= A118), S109 (= S120), K136 (= K148), F161 (= F171), T163 (≠ N173), V164 (= V174), R170 (≠ D180), M173 (≠ I191)
- binding uridine-5'-diphosphate-glucose: P69 (≠ A80), R72 (≠ A83), S109 (= S120), S110 (≠ A121), Y132 (= Y144), T163 (≠ N173), M173 (≠ I191), F174 (= F192), R177 (= R195), E189 (= E206), I190 (= I207), Y191 (≠ F210), Q196 (= Q215), R198 (= R217), D260 (= D279)
Q7BJX9 UDP-N-acetylglucosamine 4-epimerase; UDP-GalNAc 4-epimerase; EC 5.1.3.7 from Plesiomonas shigelloides (Aeromonas shigelloides) (see 2 papers)
35% identity, 96% coverage: 5:307/315 of query aligns to 23:334/345 of Q7BJX9
- GVAGFI 26:31 (≠ GGAGFI 8:13) binding NAD(+)
- DNFSTG 50:55 (≠ DDFSTG 32:37) binding NAD(+)
- DI 81:82 (≠ NV 54:55) binding NAD(+)
- QAA 101:103 (≠ LAA 76:78) binding NAD(+)
- T120 (= T95) binding NAD(+)
- SS 145:146 (≠ SA 120:121) binding substrate
- S147 (≠ A122) mutation to T: No effect on epimerase activity.
- Y169 (= Y144) binding NAD(+)
- K173 (= K148) binding NAD(+)
- YFN 196:198 (≠ FFN 171:173) binding substrate
- V199 (= V174) binding NAD(+)
- VIPK 213:216 (≠ VVSI 188:191) binding substrate
- YIN 228:230 (≠ EIT 206:208) binding substrate
- S236 (≠ T216) mutation to G: No effect on epimerase activity.
- R237 (= R217) binding substrate
- R271 (≠ E250) mutation to G: No effect on epimerase activity.
- RSGD 302:305 (≠ RKGD 276:279) binding substrate
- R307 (≠ K281) mutation to A: No effect on epimerase activity.
- H308 (= H282) mutation to A: No effect on epimerase activity.
- S309 (= S283) mutation to Y: Abolishes epimerase activity.
6bwlA X-ray structure of pal from bacillus thuringiensis (see paper)
37% identity, 82% coverage: 3:260/315 of query aligns to 2:257/313 of 6bwlA
- active site: T122 (≠ S120), C123 (≠ A121), M124 (≠ A122), Y147 (= Y144), K151 (= K148)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), N32 (≠ D33), L33 (≠ F34), N35 (≠ T36), S36 (≠ G37), D57 (≠ N54), I58 (≠ V55), L79 (= L76), A80 (= A77), A81 (= A78), I83 (≠ A80), M120 (≠ A118), K151 (= K148), N176 (= N173), T177 (≠ V174)
- binding uridine-5'-diphosphate: N176 (= N173), G189 (= G187), V190 (= V188), N205 (≠ T208), I206 (= I209), Y207 (≠ F210), Q212 (= Q215), R214 (= R217), I250 (≠ L253)
Sites not aligning to the query:
7ysmA Crystal structure of udp-glucose 4-epimerase (rv3634c) co-crystallized with udp-n-acetylglucosamine from mycobacterium tuberculosis
36% identity, 98% coverage: 3:310/315 of query aligns to 2:306/311 of 7ysmA
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), N32 (≠ D33), T35 (= T36), G36 (= G37), D56 (≠ N54), I57 (≠ V55), L77 (= L76), A78 (= A77), A79 (= A78), I81 (≠ A80), T119 (≠ A118), Y146 (= Y144), K150 (= K148), P173 (≠ F171), N175 (= N173), V176 (= V174)
- binding uridine-diphosphate-n-acetylgalactosamine: I81 (≠ A80), R84 (≠ A83), S121 (= S120), G123 (vs. gap), S124 (≠ A122), Y146 (= Y144), A174 (≠ F172), N175 (= N173), G188 (= G187), V189 (= V188), F193 (= F192), R204 (≠ T208), V205 (≠ I209), F206 (= F210), N211 (≠ Q215), R213 (= R217), D248 (≠ L253), R271 (= R276)
7ys9A Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chaina from mycobacterium tuberculosis
36% identity, 98% coverage: 3:310/315 of query aligns to 2:306/310 of 7ys9A
- binding galactose-uridine-5'-diphosphate: I81 (≠ A80), R84 (≠ A83), S121 (= S120), G123 (vs. gap), Y146 (= Y144), A174 (≠ F172), N175 (= N173), A187 (≠ S186), G188 (= G187), V189 (= V188), F193 (= F192), R204 (≠ T208), F206 (= F210), N211 (≠ Q215), R213 (= R217), D248 (≠ L253), R271 (= R276)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), N32 (≠ D33), A34 (≠ S35), T35 (= T36), G36 (= G37), D56 (≠ N54), I57 (≠ V55), L77 (= L76), A78 (= A77), A79 (= A78), I81 (≠ A80), T119 (≠ A118), Y146 (= Y144), K150 (= K148), P173 (≠ F171), A174 (≠ F172), V176 (= V174)
- binding uridine-5'-diphosphate-glucose: I81 (≠ A80), R84 (≠ A83), S121 (= S120), G123 (vs. gap), Y146 (= Y144), A174 (≠ F172), N175 (= N173), A187 (≠ S186), G188 (= G187), V189 (= V188), F193 (= F192), R204 (≠ T208), F206 (= F210), N211 (≠ Q215), R213 (= R217), D248 (≠ L253), R271 (= R276)
7ystA Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chain b from mycobacterium tuberculosis
36% identity, 98% coverage: 3:310/315 of query aligns to 2:306/312 of 7ystA
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D31 (= D32), N32 (≠ D33), T35 (= T36), G36 (= G37), D56 (≠ N54), I57 (≠ V55), L77 (= L76), A78 (= A77), A79 (= A78), I81 (≠ A80), V96 (≠ T95), T119 (≠ A118), Y146 (= Y144), K150 (= K148), P173 (≠ F171), A174 (≠ F172), N175 (= N173), V176 (= V174)
- binding uridine-5'-diphosphate-glucose: I81 (≠ A80), R84 (≠ A83), S121 (= S120), G123 (vs. gap), Y146 (= Y144), A174 (≠ F172), N175 (= N173), A187 (≠ S186), G188 (= G187), V189 (= V188), F193 (= F192), R204 (≠ T208), V205 (≠ I209), F206 (= F210), R213 (= R217), D248 (≠ L253), R271 (= R276)
6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
32% identity, 98% coverage: 3:310/315 of query aligns to 2:308/321 of 6zllA
- active site: T126 (≠ S120), S127 (≠ A121), S128 (≠ A122), Y149 (= Y144), K153 (= K148)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D32 (= D32), H33 (≠ D33), F34 (= F34), I35 (vs. gap), K43 (≠ S35), D62 (≠ N54), I63 (≠ V55), L81 (= L76), A82 (= A77), A83 (= A78), I124 (≠ A118), T126 (≠ S120), Y149 (= Y144), K153 (= K148), Y176 (≠ F171), V179 (= V174), R185 (≠ D180), M188 (≠ S183)
- binding (2S,3R,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic acid: P85 (≠ A80), V87 (= V82), R88 (≠ A83), T126 (≠ S120), S127 (≠ A121), Y149 (= Y144), T178 (≠ N173), R185 (≠ D180), A189 (≠ P184), R192 (≠ G187), T204 (= T208), F206 (= F210), Q211 (= Q215), R213 (= R217), I250 (≠ L253), E276 (≠ D279)
6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD (see paper)
32% identity, 97% coverage: 3:306/315 of query aligns to 2:304/314 of 6zldA
- active site: T126 (≠ S120), S127 (≠ A121), S128 (≠ A122), Y149 (= Y144), K153 (= K148)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D32 (= D32), H33 (≠ D33), F34 (= F34), I35 (vs. gap), K43 (≠ S35), D62 (≠ N54), I63 (≠ V55), L81 (= L76), A82 (= A77), A83 (= A78), I124 (≠ A118), T126 (≠ S120), K153 (= K148), Y176 (≠ F171), T178 (≠ N173), R185 (≠ D180), M188 (≠ S183)
- binding uridine-5'-diphosphate-glucuronic acid: P85 (≠ A80), R88 (≠ A83), T126 (≠ S120), S127 (≠ A121), S128 (≠ A122), Y149 (= Y144), F177 (= F172), T178 (≠ N173), R185 (≠ D180), M188 (≠ S183), A189 (≠ P184), R192 (≠ G187), T204 (= T208), F206 (= F210), Q211 (= Q215), R213 (= R217), I250 (≠ L253), E276 (≠ D279)
6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD (see paper)
32% identity, 97% coverage: 3:306/315 of query aligns to 2:304/314 of 6zl6A
- active site: T126 (≠ S120), S127 (≠ A121), S128 (≠ A122), Y149 (= Y144), K153 (= K148)
- binding nicotinamide-adenine-dinucleotide: G7 (= G8), G10 (= G11), F11 (= F12), I12 (= I13), D32 (= D32), H33 (≠ D33), F34 (= F34), I35 (vs. gap), K43 (≠ S35), D62 (≠ N54), I63 (≠ V55), L81 (= L76), A82 (= A77), A83 (= A78), I124 (≠ A118), T126 (≠ S120), K153 (= K148), Y176 (≠ F171), T178 (≠ N173), V179 (= V174), R185 (≠ D180), M188 (≠ S183)
- binding uridine-5'-diphosphate: T178 (≠ N173), A189 (≠ P184), R192 (≠ G187), T204 (= T208), F206 (= F210), Q211 (= Q215), R213 (= R217), I250 (≠ L253), E276 (≠ D279)
Query Sequence
>WP_089322996.1 NCBI__GCF_900188395.1:WP_089322996.1
MGKVLVTGGAGFIGSHLVESLLEEGREVVVFDDFSTGKMENLPENSRLTVLKGNVGEKER
VVNLFDSFKFDTVFHLAAVASVAKSVENPEETHRTNFDGTMYLLDCCLKFFVSRFIFASS
AAVYGDLPGLPKKEDDPVKPQTPYAVDKYASERYVLNAFNLYGLKTSALRFFNVFGPRQD
PFSPYSGVVSIFVDRVLRFLNGENVEITIFGDGKQTRDFIYVKDVVKALLLVEKSEAAYG
KVFNTGTGKETSLLDLLKYIENIAGKIPPVKFAPARKGDIKHSCADISNLKKIGFSPSFT
VQEGLKLLFECEMEK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory