SitesBLAST
Comparing WP_089323166.1 NCBI__GCF_900188395.1:WP_089323166.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
53% identity, 96% coverage: 10:244/244 of query aligns to 5:245/246 of 3osuA
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
53% identity, 96% coverage: 10:244/244 of query aligns to 2:238/239 of 3sj7A
- active site: G12 (= G20), S138 (= S140), Q148 (= Q150), Y151 (= Y153), K155 (= K157)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G16), S10 (≠ T18), R11 (= R19), I13 (= I21), N31 (≠ T39), Y32 (vs. gap), A33 (≠ G40), G34 (≠ T41), S35 (≠ N42), A58 (≠ M60), N59 (= N61), V60 (= V62), N86 (= N88), A87 (= A89), T109 (= T111), S138 (= S140), Y151 (= Y153), K155 (= K157), P181 (= P183), G182 (= G184)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
50% identity, 99% coverage: 3:244/244 of query aligns to 2:245/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G16), S17 (≠ T18), R18 (= R19), I20 (= I21), T40 (= T41), N62 (= N61), V63 (= V62), N89 (= N88), A90 (= A89), I92 (= I91), V139 (≠ I138), S141 (= S140), Y154 (= Y153), K158 (= K157), P184 (= P183), G185 (= G184), I187 (= I186), T189 (= T188), M191 (= M190)
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
51% identity, 98% coverage: 5:244/244 of query aligns to 1:242/244 of 6t77A
- active site: G16 (= G20), S138 (= S140), Y151 (= Y153)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ T18), R15 (= R19), T37 (= T41), L58 (≠ M60), N59 (= N61), V60 (= V62), A87 (= A89), G88 (= G90), I89 (= I91)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
51% identity, 98% coverage: 5:244/244 of query aligns to 1:242/244 of P0AEK2
- GASR 12:15 (≠ GGTR 16:19) binding NADP(+)
- T37 (= T41) binding NADP(+)
- NV 59:60 (= NV 61:62) binding NADP(+)
- N86 (= N88) binding NADP(+)
- Y151 (= Y153) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YSATK 153:157) binding NADP(+)
- A154 (≠ T156) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K157) mutation to A: Defect in the affinity for NADPH.
- I184 (= I186) binding NADP(+)
- E233 (≠ T235) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
51% identity, 98% coverage: 6:244/244 of query aligns to 1:241/243 of 1q7bA
- active site: G15 (= G20), E101 (≠ D104), S137 (= S140), Q147 (= Q150), Y150 (= Y153), K154 (= K157)
- binding calcium ion: E232 (≠ T235), T233 (= T236)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G16), S13 (≠ T18), R14 (= R19), T36 (= T41), N58 (= N61), V59 (= V62), N85 (= N88), A86 (= A89), G87 (= G90), I88 (= I91), S137 (= S140), Y150 (= Y153), K154 (= K157), P180 (= P183), G181 (= G184), I183 (= I186)
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
52% identity, 97% coverage: 9:244/244 of query aligns to 4:241/243 of 7emgB
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
51% identity, 98% coverage: 6:244/244 of query aligns to 1:241/243 of 1q7cA
- active site: G15 (= G20), S137 (= S140), Q147 (= Q150), F150 (≠ Y153), K154 (= K157)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G16), S13 (≠ T18), R14 (= R19), A35 (≠ G40), T36 (= T41), L57 (≠ M60), N58 (= N61), V59 (= V62), G87 (= G90), I88 (= I91)
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
51% identity, 98% coverage: 5:244/244 of query aligns to 1:242/244 of P0A2C9
- M125 (= M127) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (≠ V225) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (= S226) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
50% identity, 99% coverage: 3:244/244 of query aligns to 2:241/243 of 4i08A
- active site: G19 (= G20), N113 (= N112), S141 (= S140), Q151 (= Q150), Y154 (= Y153), K158 (= K157)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G16), S17 (≠ T18), R18 (= R19), I20 (= I21), T40 (= T41), N62 (= N61), V63 (= V62), N89 (= N88), A90 (= A89), G140 (≠ S139), S141 (= S140), Y154 (= Y153), K158 (= K157), P184 (= P183), G185 (= G184), T189 (= T188)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
50% identity, 97% coverage: 7:243/244 of query aligns to 3:245/247 of 4jroC
- active site: G16 (= G20), S142 (= S140), Q152 (= Q150), Y155 (= Y153), K159 (= K157)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ T18), R15 (= R19), G16 (= G20), I17 (= I21), N35 (≠ T39), Y36 (≠ G40), N37 (≠ T41), G38 (≠ N42), S39 (vs. gap), N63 (= N61), V64 (= V62), N90 (= N88), A91 (= A89), I93 (= I91), I113 (≠ T111), S142 (= S140), Y155 (= Y153), K159 (= K157), P185 (= P183), I188 (= I186), T190 (= T188)
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution (see paper)
49% identity, 98% coverage: 5:244/244 of query aligns to 8:252/254 of 4ag3A
- active site: G23 (= G20), S148 (= S140), Y161 (= Y153), K165 (= K157)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G16), S21 (≠ T18), R22 (= R19), G23 (= G20), I24 (= I21), T44 (= T41), L68 (≠ M60), D69 (≠ N61), V70 (= V62), N96 (= N88), A97 (= A89), I146 (= I138), S148 (= S140), Y161 (= Y153), K165 (= K157), P191 (= P183), G192 (= G184), F193 (≠ Y185), I194 (= I186), T196 (= T188), M198 (= M190), T199 (= T191)
P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
50% identity, 97% coverage: 7:243/244 of query aligns to 4:244/247 of P73574
- A14 (≠ G17) mutation to G: 4.2-fold increase in activity on acetoacetyl-CoA.
- P151 (= P148) mutation to F: 2.7-fold increase in activity on acetoacetyl-CoA.; mutation to V: 5.7-fold increase in activity on acetoacetyl-CoA.
- K160 (= K157) mutation to A: Almost no activity on acetoacetyl-CoA.
- F188 (≠ Y185) mutation to Y: 3.3-fold increase in activity on acetoacetyl-CoA.
- N198 (≠ P195) mutation to R: 3.5-fold increase in activity on acetoacetyl-CoA.
6t62A Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
46% identity, 96% coverage: 10:244/244 of query aligns to 6:242/244 of 6t62A
- active site: G16 (= G20), S138 (= S140), Y151 (= Y153)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ T18), R15 (= R19), A36 (≠ G40), T37 (= T41), L58 (≠ M60), D59 (≠ N61), V60 (= V62), N86 (= N88), A87 (= A89), G88 (= G90), I89 (= I91), I136 (= I138), S137 (= S139), S138 (= S140), Y151 (= Y153), K155 (= K157), P181 (= P183), G182 (= G184), I184 (= I186), M188 (= M190)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii (see paper)
46% identity, 96% coverage: 10:244/244 of query aligns to 6:242/244 of 6wprA
- active site: G16 (= G20), S138 (= S140), Y151 (= Y153)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ T18), R15 (= R19), T37 (= T41), L58 (≠ M60), D59 (≠ N61), V60 (= V62), N86 (= N88), A87 (= A89), G88 (= G90), I89 (= I91), I136 (= I138), Y151 (= Y153), K155 (= K157), P181 (= P183)
4dmmB 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
47% identity, 98% coverage: 5:243/244 of query aligns to 1:237/240 of 4dmmB
- active site: G16 (= G20), S142 (= S140), Q152 (= Q150), Y155 (= Y153), K159 (= K157)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ T18), R15 (= R19), G16 (= G20), I17 (= I21), A37 (≠ T41), S38 (≠ N42), S39 (≠ E43), A62 (≠ M60), D63 (≠ N61), V64 (= V62), N90 (= N88), A91 (= A89), L113 (≠ T111), I140 (= I138), S142 (= S140), Y155 (= Y153), K159 (= K157), P185 (= P183), G186 (= G184), I188 (= I186), T190 (= T188), M192 (= M190)
4bo4C Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
48% identity, 98% coverage: 5:244/244 of query aligns to 14:253/255 of 4bo4C
4nbtA Crystal structure of fabg from acholeplasma laidlawii (see paper)
48% identity, 97% coverage: 7:243/244 of query aligns to 3:237/239 of 4nbtA
- active site: G16 (= G20), S132 (= S140), Y145 (= Y153), K149 (= K157)
- binding nicotinamide-adenine-dinucleotide: G12 (= G16), K15 (≠ R19), G16 (= G20), L17 (≠ I21), D36 (≠ T41), L37 (≠ N42), L52 (≠ M60), N53 (= N61), V54 (= V62), N80 (= N88), A81 (= A89), G82 (= G90), I130 (= I138), S132 (= S140), Y145 (= Y153), K149 (= K157), P177 (= P183), G178 (= G184), I180 (= I186), T182 (= T188)
4bnzA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-methyl-n-phenylindole- 3-carboxamide at 2.5a resolution (see paper)
47% identity, 98% coverage: 5:244/244 of query aligns to 3:239/241 of 4bnzA
3tzcA Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg)(y155f) from vibrio cholerae (see paper)
47% identity, 99% coverage: 3:244/244 of query aligns to 2:224/224 of 3tzcA
Query Sequence
>WP_089323166.1 NCBI__GCF_900188395.1:WP_089323166.1
MGRVIDISGKVALVTGGTRGIGKAIAVALKEAGATVYITGTNEEKTKAVAREIGVNGLKM
NVCDREEVKEKVALIVEKEGKIDILVNNAGITRDTLFMRMKDEDWDSVIDTNLNGVYNVT
RQVIPVMMKKRSGCVVNISSVVGFTGNPGQVNYSATKSALIGFTKSLAKEVASRGIRVNT
VAPGYITTDMTEKIPEKVKEALVKSIPMRREGEPSEIADTVLFLVSDMASYITGTTIHVN
GGLF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory