SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_090272147.1 NCBI__GCF_900105005.1:WP_090272147.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
45% identity, 100% coverage: 4:649/649 of query aligns to 3:648/648 of P75831

query
sites
P75831

P

P

L

L

I

L

S

E

L

L

E

K

G

D

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K
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S

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N

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C

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L

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E

K47 (= K48) mutation to L: Lack of activity.
D169 (= D170) mutation to N: Lack of activity.

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
43% identity, 100% coverage: 2:649/649 of query aligns to 1:650/650 of 5ws4A

query
sites
5ws4A

N

K

E

Q

P

A

L

L

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S

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L

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N

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L

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V

G

G

A

Q

S
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S

G
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G

S

S

G

G

K

K

S
|
S

T

T

L

L

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M

H

N

L

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L

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C

C

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L

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S

A

R

D

E

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S44), G44 (= G45), S48 (= S49)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
41% identity, 99% coverage: 5:647/649 of query aligns to 3:615/615 of 5lilA

query
sites
5lilA

L

I

I

I

S

E

L

I

E

K

G

Q

I

L

S

N

R

R

T

Y

Y
x
F

R

G

N

E

G

G

E

E

L

N

S

R

T

V

T

H

V
|
V

L

L

H

K

D

D

V

I

A

S

L

L

D

S

I

I

H

E

A

R

G

G

E

D

F

F

V

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A

A

I

I

M

M

G

G

A

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

M

H

N

L

I

L

I

G

G

C

C

L

L

D

D

K

T

P

A

T

T

T

G

G

G

R

S

Y

S

L

K

F

I

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D

G

G

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K

D

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T

A

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R

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L

L

D

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S

N

D

D

Q

Q

L

L

A

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G

D

L

L

R

R

S

S

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Q

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K

F

F

G

G

F

F

I

I

F

F

Q
|
Q

S

R

Y

Y

H

N

L

L

I

L

S

S

S

S

A

L

N

T

A

A

T

A

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E

N

N

V

V

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A

V

L

P

P

A

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I

Y

Y

A

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G

G

L

M

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P

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Q

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R

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L

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R

R

A

A

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K

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Q

L

L

L

L

T

E

G

K

L

L

G

G

L

L

G

G

E

D

R
x
K

L

W

Q

Q

N

N

R

K

P

P

N

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

Q

Q

R

R

V

V

S

S

I

I

A

A

R

R

A

A

L

L

M

M

N

N

D

G

A

G

R

E

I

I

L

I

L

L

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D

D

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Q

P

P

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G

G

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A

L

L

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D

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K

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G

G

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N

V

V

L

M

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L

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L

L

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Q

L

L

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H

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G

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I

I

I

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M

I

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H

D

D

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K

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A

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N

R

R

L

I

I

I

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I

I

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K

D

D

G

G

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I

I

T

I

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S

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D

S

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Q

R

K

K

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Q

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L

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N

P

P

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S

P

V

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F

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K

K

Q

D

G

Q

L

L

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M

A

-

F

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G

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D

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I

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N

-

E

E

A

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F

R

R

M

M

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S

L

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S

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A

L

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H

L

K

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M

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L

L

L

T

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L

M

L

L

G

G

I

I

V

I

I

I

G

G

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I

A

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S

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V

V

V

V

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M

V

L

V

A

A

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G

G

N

N

G

G

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Q

Q

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K

V

I

V

L

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R

N

I

I

S

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D

G

M

I

G

G

T

T

N

N

L

T

L

M

L

T

V

I

R

-

P

-

G

-

A

-

P

-

N

-

T

-

R

-

R

-

S

-

A

-

D

-

G

-

T

-

T

F

N

Q

T

N

L

L

T

K

P

I

E

S

D

D

A

A

V

N

V

T

A

L

S

S

R

K

V

Q

D

S

N

Y

V

I

V

Q

A

S

A

V

V

T

P

P

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N

V

T

D

S

T

S

R

S

A

G

T

I

V

L

R

V

A

V

G

G

N

N

T

K

D

S

-

F

A

T

Q

S

T

A

Q

N

V

L

T

Y

G

G

T

I

T

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A

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D

Q

Y

Y

P

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L

D

A

V

K

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W

L

P

K

L

L

A

K

S

Q

G

G

V

R

F

L

I

L

N

T

D

E

E

D

D

D

N

V

R

D

R

Q

Y

S

A

N

A

Q

V

V

A

V

V

V

I

L

G

D

R

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T

S

V

A

A

K

T

K

N

A

L

I

Y

F

G

A

D

N

A

E

D

N

P

P

L

L

G

G

Q

K

Y

T

M

V

L

I

I

F

R

N

N

K

V

R

P

P

F

F

L

R

I

V

I

I

G

G

V

V

M

V

Q

-

E

-

K

-

G

-

A

-

T

-

P

-

W

-

G

-

Q

S

D

D

Q

Q

D

S

D

L

A

N

V

L

F

Y

V

S

P

P

L

Y

N

S

T

T

A

V

S

L

N

N

R

K

L

I

I

T

G

G

S

G

R

S

H

R

L

I

G

G

S

S

I

I

S

T

V

V

L

K

I

I

D

S

D

D

L

D

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V

L

N

S

S

D

T

A

V

T

A

Q

E

E

K

A

S

V

L

R

T

Q

E

A

L

I

L

M

K

A

S

N

L

H

H

S

-

G

G

I

K

E

K

D

D

F

F

Q

F

I

I

R

M

N

N

M

S

A

D

S

T

L

I

L

K

E

Q

N

T

I

I

A

E

S

N

T

T

Q

T

D

G

T

T

F

M

T

K

V

L

L

L

L

I

G

S

S

S

I

I

A

A

A

F

I

I

S

S

L

L

L

I

V

V

G

G

G

G

I

I

G

G

V

V

M

M

N

N

I

I

M

M

L

L

V

V

N

S

V

V

S

T

E

E

R

R

T

T

R

K

E

E

I

I

G

G

I

V

R

R

M

M

A

A

T

I

G

G

A

A

R

R

T

Q

R

I

N

N

I

I

L

L

Q

Q

Q

Q

F

F

I

L

I

I

E

E

A

A

M

V

V

L

V

I

S

C

A

L

I

I

G

G

G

G

A

V

I

A

G

G

V

I

A

L

V

L

G

S

L

V

G

L

F

I

A

G

A

V

M

L

L

F

Q

N

S

S

F

F

G

I

T

T

-

D

-

F

S

S

I

M

Q

D

F

F

T

S

A

T

G

A

P

S

V

I

L

V

L

T

A

A

F

V

G

L

C

F

A

S

F

T

A

L

T

I

G

G

L

V

I

L

F

F

G

G

F

Y

M

M

P

P

A

A

H

K

K

K

A

A

A

A

H

E

L

L

D

N

P

P

V

I

V

T

A

A

L

L

S

A

binding adenosine-5'-triphosphate: F13 (≠ Y15), V22 (= V24), S42 (= S44), G43 (= G45), G45 (= G47), K46 (= K48), S47 (= S49), T48 (= T50), Q92 (= Q94), K136 (≠ R138), Q143 (= Q145), S145 (= S147), G147 (= G149), Q148 (= Q150)
binding magnesium ion: S47 (= S49), Q92 (= Q94)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
40% identity, 99% coverage: 5:647/649 of query aligns to 3:591/592 of 5lj7A

query
sites
5lj7A

L

I

I

I

S

E

L

I

E

K

G

Q

I

L

S

N

R

R

T

Y

Y

F

R

G

N

E

G

G

E

E

L

N

S

R

T

V

T

H

V
|
V

L

L

H

K

D

D

V

I

A

S

L

L

D

S

I

I

H

E

A

R

G

G

E

D

F

F

V

V

A

A

I

I

M

M

G

G

A

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

M

H

N

L

I

L

I

G

G

C

C

L

L

D

D

K

T

P

A

T

T

T

G

G

G

R

S

Y

S

L

K

F

I

E

D

G

G

E

K

D

E

I

T

A

I

R

E

L

L

D

T

S

N

D

D

Q

Q

L

L

A

S

G

D

L

L

R

R

S

S

R

Q

T

K

F

F

G

G

F

F

I

I

F

F

Q
|
Q

S

R

Y

Y

H

N

L

L

I

L

S

S

S

S

A

L

N

T

A

A

T

A

E

E

N

N

V

V

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A

V

L

P

P

A

A

I

I

Y

Y

A

A

G

G

L

M

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P

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Q

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L

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R

R

A

A

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K

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Q

L

L

L

L

T

E

G

K

L

L

G

G

L

L

G

G

E

D

R
x
K

L

W

Q

Q

N

N

R

K

P

P

N

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

Q

Q

R

R

V

V

S

S

I

I

A

A

R

R

A

A

L

L

M

M

N

N

D

G

A

G

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I

I

L

I

L

L

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A

D

D

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G

G

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A

L

L

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S

S

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G

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N

V

V

L

M

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L

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L

L

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L

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G

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I

I

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L

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D

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K

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Q

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L

-

A

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K

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L

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F

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G

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S

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G

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N

G

G

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Q

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K

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M

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N

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G

G

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D

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N

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L

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M

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N

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M

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M

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F

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S

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C

F

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A

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G

G

L

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I

L

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F

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G

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Y

M

M

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P

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K

K

K

A

A

A

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E

L

L

D

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P

P

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A

A

L

L

S

A

binding adenosine-5'-triphosphate: V22 (= V24), S42 (= S44), G43 (= G45), G45 (= G47), K46 (= K48), S47 (= S49), T48 (= T50), Q92 (= Q94), K136 (≠ R138), Q143 (= Q145), S145 (= S147), G147 (= G149), Q148 (= Q150)
binding magnesium ion: S47 (= S49), Q92 (= Q94)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
53% identity, 35% coverage: 5:228/649 of query aligns to 3:226/226 of 5xu1B

query
sites
5xu1B

L

L

I

I

S

S

L

L

E

K

G

N

I

I

S

F

R

R

T

S

Y

Y

R

R

N

N

G

G

E

D

L

Q

S

E

T

L

T

Q

V

V

L

L

H

K

D

N

V

I

A

N

L

L

D

E

I

V

H

N

A

E

G

G

E

E

F

F

V

V

A

A

I

I

M

M

G

G

A

P

S

S

G

G

S

S

G
|
G

K
|
K

S
|
S

T

T

L

L

M

M

H

N

L

T

L

I

G

G

C

M

L

L

D

D

K

T

P

P

T

T

T

S

G

G

R

E

Y

Y

L

Y

F

L

E

E

G

G

E

Q

D

E

I

V

A

A

R

G

L

L

D

G

S

E

D

K

Q

Q

L

L

A

A

G

K

L

V

R

R

S

N

R

Q

T

Q

F

I

G

G

F

F

I

V

F

F

Q

Q

S

Q

Y

F

H

F

L

L

I

L

S

S

S

K

A

L

N

N

A

A

T

L

E

Q

N

N

V

V

E

E

V

L

P

P

A

L

I

I

Y

Y

A

A

G

G

L

V

P

S

R

S

D

S

V

K

R

R

H

R

A

K

R

L

A

A

E

E

E

E

L

Y

L

L

T

D

G

K

L

V

G

E

L

L

G

T

E

E

R

R

L

S

Q

H

N

H

R

L

P

P

N

S

Q

E

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

V

N

N

D

N

A

P

R

S

I

I

L

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

T

K

K

S

T

G

G

H

N

D

Q

V

I

L

M

E

Q

L

L

L

L

K

V

D

D

L

L

H

N

A

K

R

E

G

G

K

K

T

T

V

I

I

I

V

M

I

V

T

T

H

H

D

E

R

P

E

E

V

I

A

A

N

A

H

Y

A

A

D

K

R

R

L

Q

I

I

E

V

I

I

R

R

D

D

G

G

R

V

I

I

T

S

H

S

D

D

S

S

G

A

R

Q

binding magnesium ion: G45 (= G47), K46 (= K48), S47 (= S49)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
48% identity, 34% coverage: 5:226/649 of query aligns to 1:227/232 of 1f3oA

query
sites
1f3oA

L

M

I

I

S

K

L

L

E

K

G

N

I

V

S

T

R

K

T

T

Y
|
Y

R

K

N

M

G

G

E

E

L

E

S

I

T

I

T

Y

V

A

L

L

H

K

D

N

V

V

A

N

L

L

D

N

I

I

H

K

A

E

G

G

E

E

F

F

V

V

A

S

I

I

M

M

G

G

A

P

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

M

L

H

N

L

I

L

I

G

G

C

C

L

L

D

D

K

K

P

P

T

T

T

E

G

G

R

E

Y

V

L

Y

F

I

E

D

G

N

E

I

D

K

I

T

A

N

R

D

L

L

D

D

S

D

D

D

Q

E

L

L

A

T

G

K

L

I

R

R

S

R

R

D

T

K

F

I

G

G

F

F

I

V

F

F

Q

Q

S

Q

Y

F

H

N

L

L

I

I

S

P

S

L

A

L

N

T

A

A

T

L

E

E

N

N

V

V

E

E

V

L

P

P

A

L

I

I

Y

F

A

K

-

Y

-

R

-

G

G

A

L

M

P

S

R

G

D

E

V

E

R

R

H

R

A

K

R

R

A

A

E

L

E

E

L

C

L

L

T

K

G

M

L

A

G

E

L

L

G

E

E

E

R

R

L

F

Q

A

N

N

-

H

R

K

P

P

N

N

Q

Q

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

A

N

N

D

N

A

P

R

P

I

I

L

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

S

T

G

G

H

E

D

K

V

I

L

M

E

Q

L

L

L

L

K

K

D

K

L

L

H

N

A

E

R

E

-

D

G

G

K

K

T

T

V

V

I

V

V

V

I

V

T

T

H

H

D

D

R

I

E

N

V

V

A

A

N

R

H

F

A

G

D

E

R

R

L

I

I

I

E

Y

I

L

R

K

D

D

G

G

R

E

I

V

T

E

H

R

D

E

S

E

binding adenosine-5'-diphosphate: Y11 (= Y15), G41 (= G45), G43 (= G47), K44 (= K48), S45 (= S49), T46 (= T50)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
48% identity, 34% coverage: 5:226/649 of query aligns to 1:227/230 of 1l2tA

query
sites
1l2tA

L

M

I

I

S

K

L

L

E

K

G

N

I

V

S

T

R

K

T

T

Y
|
Y

R

K

N

M

G

G

E

E

L

E

S

I

T

I

T

Y

V

A

L

L

H

K

D

N

V

V

A

N

L

L

D

N

I

I

H

K

A

E

G

G

E

E

F

F

V

V

A

S

I

I

M

M

G

G

A

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

M

L

H

N

L

I

L

I

G

G

C

C

L

L

D

D

K

K

P

P

T

T

T

E

G

G

R

E

Y

V

L

Y

F

I

E

D

G

N

E

I

D

K

I

T

A

N

R

D

L

L

D

D

S

D

D

D

Q

E

L

L

A

T

G

K

L

I

R

R

S

R

R

D

T

K

F

I

G

G

F

F

I

V

F

F

Q

Q

S

Q

Y

F

H

N

L

L

I

I

S

P

S

L

A

L

N

T

A

A

T

L

E

E

N

N

V

V

E

E

V

L

P

P

A

L

I

I

Y

F

A

K

-

Y

-

R

-

G

G

A

L

M

P

S

R

G

D

E

V

E

R

R

H

R

A

K

R

R

A

A

E

L

E

E

L

C

L

L

T

K

G

M

L

A

G

E

L

L

G

E

E

E

R

R

L
x
F

Q

A

N

N

-

H

R

K

P

P

N

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

A

N

N

D

N

A

P

R

P

I

I

L

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

S

T

G

G

H

E

D

K

V

I

L

M

E

Q

L

L

L

L

K

K

D

K

L

L

H

N

A

E

R

E

-

D

G

G

K

K

T

T

V

V

I

V

V

V

I

V

T

T

H
|
H

D

D

R

I

E

N

V

V

A

A

N

R

H

F

A

G

D

E

R

R

L

I

I

I

E

Y

I

L

R

K

D

D

G

G

R

E

I

V

T

E

H

R

D

E

S

E

binding adenosine-5'-triphosphate: Y11 (= Y15), S40 (= S44), G41 (= G45), S42 (= S46), G43 (= G47), K44 (= K48), S45 (= S49), T46 (= T50), F138 (≠ L139), Q145 (= Q145), S147 (= S147), G149 (= G149), Q150 (= Q150), H204 (= H203)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
44% identity, 34% coverage: 1:223/649 of query aligns to 1:224/233 of P75957

query
sites
P75957

M

M

N

N

E

K

P

I

L

L

I

L

S

Q

L

C

E

D

G

N

I

L

S

C

R

K

T

R

Y

Y

R

Q

N

E

G

G

E

S

L

V

S

Q

T

T

T

D

V

V

L

L

H

H

D

N

V

V

A

S

L

F

D

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G
|
G

A

S

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

M

L

H

H

L

L

L

L

G

G

C

G

L

L

D

D

K

T

P

P

T

T

T

S

G

G

R

D

Y

V

L

I

F

F

E

N

G

G

E

Q

D

P

I

M

A

S

R

K

L

L

D

S

S

S

D

A

Q

A

L

K

A

A

G

E

L

L

R

R

S

N

R

Q

T

K

F

L

G

G

F

F

I

I

F

Y

Q

Q

S

F

Y

H

H

H

L

L

I

L

S

P

S

D

A

F

N

T

A

A

T

L

E

E

N

N

V

V

E

A

V

M

P

P

A

L

I

L

Y

I

A

G

G

K

L

K

P

K

R

P

D

A

V

E

R

I

H

N

A

S

R

R

A

A

E

L

E

E

L

M

L

L

T

K

G

A

L

V

G

G

L

L

G

D

E

H

R

R

L

A

Q

N

N

H

R

R

P

P

N

S

Q

E

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

V

N

N

D

N

A

P

R

R

I

L

L

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

N

L

L

D

D

S

A

K

R

S

N

G

A

H

D

D

S

V

I

L

F

E

Q

L

L

L

L

K

G

D

E

L

L

H

N

A

R

-

L

R

Q

G

G

K

T

T

A

V

F

I

L

V

V

I

V

T

T

H

H

D

D

R

L

E

Q

V

L

A

A

N

K

H

R

A

M

D

S

R

R

L

Q

I

L

E

E

I

M

R

R

D

D

G

G

R

R

I

L

T

T

G42 (= G42) mutation to D: Loss of lipoprotein release when overexpressed.

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
43% identity, 34% coverage: 2:223/649 of query aligns to 1:223/229 of 7v8iD

query
sites
7v8iD

N

N

E

K

P

I

L

L

I

L

S

Q

L

C

E

D

G

N

I

L

S

C

R

K

T

R

Y

Y

R

Q

N

E

G

G

E

S

L

V

S

Q

T

T

T

D

V
|
V

L

L

H

H

D

N

V

V

A

S

L

F

D

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G

G

A

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

H

H

L

L

L

L

G

G

C

G

L

L

D

D

K

T

P

P

T

T

T

S

G

G

R

D

Y

V

L

I

F

F

E

N

G

G

E

Q

D

P

I

M

A

S

R

K

L

L

D

S

S

S

D

A

Q

A

L

K

A

A

G

E

L

L

R

R

S

N

R

Q

T

K

F

L

G

G

F

F

I

I

F

Y

Q
|
Q

S

F

Y

H

H

H

L

L

I

L

S

P

S

D

A

F

N

T

A

A

T

L

E

E

N

N

V

V

E

A

V

M

P

P

A

L

I

L

Y

I

A

G

G

K

L

K

P

K

R

P

D

A

V

E

R

I

H

N

A

S

R

R

A

A

E

L

E

E

L

M

L

L

T

K

G

A

L

V

G

G

L

L

G

D

E

H

R
|
R

L

A

Q

N

N
x
H

R

R

P

P

N

S

Q
x
E

L

L

S
|
S

G

G

G
|
G

Q
x
E

Q

R

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

V

N

N

D

N

A

P

R

R

I

L

L

V

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

A

N

L

L

D

D

S

A

K

R

S

N

G

A

H

D

D

S

V

I

L

F

E

Q

L

L

L

L

K

G

D

E

L

L

H

N

A

R

-

L

R

Q

G

G

K

T

T

A

V

F

I

L

V

V

I

V

T

T

H
|
H

D

D

R

L

E

Q

V

L

A

A

N

K

H

R

A

M

D

S

R

R

L

Q

I

L

E

E

I

M

R

R

D

D

G

G

R

R

I

L

T

T

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V24), S43 (= S44), G44 (= G45), G46 (= G47), K47 (= K48), S48 (= S49), T49 (= T50), Q93 (= Q94), R137 (= R138), H140 (≠ N141), E144 (≠ Q145), S146 (= S147), G148 (= G149), E149 (≠ Q150), H203 (= H203)
binding magnesium ion: S48 (= S49), Q93 (= Q94)

7mdyC Lolcde nucleotide-bound
44% identity, 34% coverage: 5:223/649 of query aligns to 2:221/226 of 7mdyC

query
sites
7mdyC

L

L

I

L

S

Q

L

C

E

D

G

N

I

L

S

C

R

K

T

R

Y
|
Y

R

Q

N

E

G

G

E

S

L

V

S

Q

T

T

T

D

V

V

L

L

H

H

D

N

V

V

A

S

L

F

D

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G

G

A

S

S

S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

H

H

L

L

L

L

G

G

C

G

L

L

D

D

K

T

P

P

T

T

T

S

G

G

R

D

Y

V

L

I

F

F

E

N

G

G

E

Q

D

P

I

M

A

S

R

K

L

L

D

S

S

S

D

A

Q

A

L

K

A

A

G

E

L

L

R

R

S

N

R

Q

T

K

F

L

G

G

F

F

I

I

F

Y

Q
|
Q

S

F

Y

H

H

H

L

L

I

L

S

P

S

D

A

F

N

T

A

A

T

L

E

E

N

N

V

V

E

A

V

M

P

P

A

L

I

L

Y

I

A

G

G

K

L

K

P

K

R

P

D

A

V

E

R

I

H

N

A

S

R

R

A

A

E

L

E

E

L

M

L

L

T

K

G

A

L

V

G

G

L

L

G

D

E

H

R

R

L

A

Q

N

N
x
H

R

R

P

P

N

S

Q
x
E

L

L

S
|
S

G
|
G

G
|
G

Q

E

Q

R

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

V

N

N

D

N

A

P

R

R

I

L

L

V

L

L

A

A

D

D

E
|
E

P

P

T

T

G

G

A
x
N

L

L

D

D

S

A

K

R

S

N

G

A

H

D

D

S

V

I

L

F

E

Q

L

L

L

L

K

G

D

E

L

L

H

N

A

R

-

L

R

Q

G

G

K

T

T

A

V

F

I

L

V

V

I

V

T

T

H
|
H

D

D

R

L

E

Q

V

L

A

A

N

K

H

R

A

M

D

S

R

R

L

Q

I

L

E

E

I

M

R

R

D

D

G

G

R

R

I

L

T

T

binding adp orthovanadate: Y12 (= Y15), G42 (= G45), S43 (= S46), G44 (= G47), K45 (= K48), S46 (= S49), T47 (= T50), Q91 (= Q94), H138 (≠ N141), E142 (≠ Q145), S144 (= S147), G145 (= G148), G146 (= G149), E168 (= E171), N172 (≠ A175), H201 (= H203)
binding magnesium ion: S46 (= S49), Q91 (= Q94)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
44% identity, 34% coverage: 5:223/649 of query aligns to 2:221/222 of 7arlD

query
sites
7arlD

L

L

I

L

S

Q

L

C

E

D

G

N

I

L

S

C

R

K

T

R

Y

Y

R

Q

N

E

G

G

E

S

L

V

S

Q

T

T

T

D

V

V

L

L

H

H

D

N

V

V

A

S

L

F

D

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G

G

A

S

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T

T

L

L

M

L

H

H

L

L

L

L

G

G

C

G

L

L

D

D

K

T

P

P

T

T

T

S

G

G

R

D

Y

V

L

I

F

F

E

N

G

G

E

Q

D

P

I

M

A

S

R

K

L

L

D

S

S

S

D

A

Q

A

L

K

A

A

G

E

L

L

R

R

S

N

R

Q

T

K

F

L

G

G

F

F

I

I

F

Y

Q

Q

S

F

Y

H

H

H

L

L

I

L

S

P

S

D

A

F

N

T

A

A

T

L

E

E

N

N

V

V

E

A

V

M

P

P

A

L

I

L

Y

I

A

G

G

K

L

K

P

K

R

P

D

A

V

E

R

I

H

N

A

S

R

R

A

A

E

L

E

E

L

M

L

L

T

K

G

A

L

V

G

G

L

L

G

D

E

H

R

R

L

A

Q

N

N

H

R

R

P

P

N

S

Q

E

L

L

S

S

G

G

G

G

Q

E

Q

R

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

V

N

N

D

N

A

P

R

R

I

L

L

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

A

N

L

L

D

D

S

A

K

R

S

N

G

A

H

D

D

S

V

I

L

F

E

Q

L

L

L

L

K

G

D

E

L

L

H

N

A

R

-

L

R

Q

G

G

K

T

T

A

V

F

I

L

V

V

I

V

T

T

H

H

D

D

R

L

E

Q

V

L

A

A

N

K

H

R

A

M

D

S

R

R

L

Q

I

L

E

E

I

M

R

R

D

D

G

G

R

R

I

L

T

T

binding adenosine-5'-diphosphate: G42 (= G45), G44 (= G47), K45 (= K48), S46 (= S49)

9gvkD Cryo-em structure of endogenous atp-bound lolcde with lold-e171q mutations in nanodiscs (see paper)
43% identity, 34% coverage: 5:223/649 of query aligns to 3:222/226 of 9gvkD

query
sites
9gvkD

L

L

I

L

S

Q

L

C

E

D

G

N

I

L

S

C

R

K

T

R

Y
|
Y

R

Q

N

E

G

G

E

S

L

V

S

Q

T

T

T

D

V

V

L

L

H

H

D

N

V

V

A

S

L

F

D

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G

G

A

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

H

H

L

L

L

L

G

G

C

G

L

L

D

D

K

T

P

P

T

T

T

S

G

G

R

D

Y

V

L

I

F

F

E

N

G

G

E

Q

D

P

I

M

A

S

R

K

L

L

D

S

S

S

D

A

Q

A

L

K

A

A

G

E

L

L

R

R

S

N

R

Q

T

K

F

L

G

G

F

F

I

I

F

Y

Q
|
Q

S

F

Y

H

H

H

L

L

I

L

S

P

S

D

A

F

N

T

A

A

T

L

E

E

N

N

V

V

E

A

V

M

P

P

A

L

I

L

Y

I

A

G

G

K

L

K

P

K

R

P

D

A

V

E

R

I

H

N

A

S

R

R

A

A

E

L

E

E

L

M

L

L

T

K

G

A

L

V

G

G

L

L

G

D

E

H

R
|
R

L

A

Q

N

N
x
H

R

R

P

P

N

S

Q
x
E

L

L

S
|
S

G
|
G

G
|
G

Q
x
E

Q

R

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

V

N

N

D

N

A

P

R

R

I

L

L

V

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

A

N

L

L

D

D

S

A

K

R

S

N

G

A

H

D

D

S

V

I

L

F

E

Q

L

L

L

L

K

G

D

E

L

L

H

N

A

R

-

L

R

Q

G

G

K

T

T

A

V

F

I

L

V

V

I

V

T

T

H

H

D

D

R

L

E

Q

V

L

A

A

N

K

H

R

A

M

D

S

R

R

L

Q

I

L

E

E

I

M

R

R

D

D

G

G

R

R

I

L

T

T

binding adenosine-5'-triphosphate: Y13 (= Y15), S42 (= S44), G43 (= G45), G45 (= G47), K46 (= K48), S47 (= S49), T48 (= T50), Q92 (= Q94), R136 (= R138), H139 (≠ N141), E143 (≠ Q145), S145 (= S147), G146 (= G148), G147 (= G149), E148 (≠ Q150)
binding magnesium ion: S47 (= S49), Q92 (= Q94)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
43% identity, 34% coverage: 9:228/649 of query aligns to 7:222/223 of 2pclA

query
sites
2pclA

E

E

G

N

I

I

S

K

R

K

T

V

Y

I

R

R

N

G

G

Y

E

E

L

-

S

-

T

-

T

-

V

I

L

L

H

K

D

G

V

I

A

S

L

L

D

S

I

V

H

K

A

K

G

G

E

E

F

F

V

V

A

S

I

I

M

I

G

G

A

A

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

M

L

H

Y

L

I

L

L

G

G

C

L

L

L

D

D

K

A

P

P

T

T

T

E

G

G

R

K

Y

V

L

F

F

L

E

E

G

G

E

K

D

E

I

V

A

D

R

Y

L

T

D

N

S

E

D

K

Q

E

L

L

A

S

G

L

L

L

R

R

S

N

R

R

T

K

F

L

G

G

F

F

I

V

F

F

Q

Q

S

F

Y

H

H

Y

L

L

I

I

S

P

S

E

A

L

N

T

A

A

T

L

E

E

N

N

V

V

E

I

V

V

P

P

A

M

I

L

Y

K

A

M

G

G

L

K

P

P

R

K

D

K

V

E

R

A

H

K

A

E

R

R

A

G

E

E

E

Y

L

L

L

L

T

S

G

E

L

L

G

G

L

L

G

G

E

D

R

K

L

L

Q

S

N

R

R

K

P

P

N

Y

Q

E

L

L

S

S

G

G

G

G

Q

E

Q

Q

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

A

N

N

D

E

A

P

R

I

I

L

L

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

A

N

L

L

D

D

S

S

K

A

S

N

G

T

H

K

D

R

V

V

L

M

E

D

L

I

L

F

K

L

D

K

L

I

H

N

A

E

R

G

G

G

K

T

T

S

V

I

I

V

V

M

I

V

T
|
T

H

H

D

E

R

R

E

E

V

L

A

A

N

E

H

L

A

T

D

H

R

R

L

T

I

L

E

E

I

M

R

K

D

D

G

G

R

K

I

V

T

V

H

G

D

E

S

I

G

T

R

R

binding magnesium ion: E165 (= E171), P166 (= P172), T167 (= T173), T196 (= T202)

8g4cB Bceabs atpgs high res tm (see paper)
41% identity, 33% coverage: 11:222/649 of query aligns to 9:221/248 of 8g4cB

query
sites
8g4cB

I

I

S

R

R

K

T

S

Y
|
Y

R

G

N

N

G

K

E

L

L

N

S

K

T

Q

T

E

V

V

L

L

H

K

D

G

V

I

A

D

L

I

D

H

I

I

H

E

A

K

G

G

E

E

F

F

V

V

A

S

I

I

M

M

G

G

A

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

T

T

L

L

M

L

H

N

L

V

L

L

G

S

C

S

L

I

D

D

K

Q

P

V

T

S

T

H

G

G

R

T

Y

I

L

H

F

I

E

N

G

G

E

N

D

D

I

M

A

T

R

A

L

M

D

K

S

E

D

K

Q

Q

L

L

A

A

G

E

L

F

R

R

S

K

R

Q

T

H

F

L

G

G

F

F

I

I

F

F

Q

Q

S

D

Y

Y

H

N

L

L

I

L

S

D

S

T

A

L

N

T

A

V

T

K

E

E

N

N

V

I

E

L

V

L

P

P

A

L

I

S

Y

I

A

T

G

K

L

L

P

S

R

K

D

K

V

E

R

A

H

N

A

R

R

K

A

F

E

E

E

E

L

V

L

A

T

K

G

E

L

L

G

G

L

I

G

Y

E

E

R

L

L

R

Q

D

N

K

R

Y

P

P

N

N

Q

E

L

I

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

T

S

S

I

A

A

G

R

R

A

A

L

F

M

I

N

H

D

D

A

P

R

S

I

I

L

I

L

F

A

A

D
|
D

E

E

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

S

S

G

A

H

S

D

D

V

L

L

L

E

N

L

K

L

L

K

S

D

Q

L

L

H

N

-

Q

A

K

R

R

G

N

K

A

T

T

V

I

I

I

V

M

I

V

T

T

H

H

D

D

R

P

E

V

V

A

A

A

N

S

H

Y

A

C

D

G

R

R

L

V

I

I

E

F

I

I

R

K

D

D

G

G

R

Q

I

M

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y15), S42 (= S44), S44 (= S46), T47 (≠ S49), D168 (= D170)

7tchB Bceab e169q variant atp-bound conformation (see paper)
40% identity, 33% coverage: 11:222/649 of query aligns to 8:220/245 of 7tchB

query
sites
7tchB

I

I

S

R

R

K

T

S

Y
|
Y

R

G

N

N

G

K

E

L

L

N

S

K

T
x
Q

T

E

V
|
V

L

L

H

K

D

G

V

I

A

D

L

I

D

H

I

I

H

E

A

K

G

G

E

E

F

F

V

V

A

S

I

I

M

M

G

G

A

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

T

T

L

L

M

L

H

N

L

V

L

L

G

S

C

S

L

I

D

D

K

Q

P

V

T

S

T

H

G

G

R

T

Y

I

L

H

F

I

E

N

G

G

E

N

D

D

I

M

A

T

R

A

L

M

D

K

S

E

D

K

Q

Q

L

L

A

A

G

E

L

F

R

R

S

K

R

Q

T

H

F

L

G

G

F

F

I

I

F

F

Q

Q

S

D

Y

Y

H

N

L

L

I

L

S

D

S

T

A

L

N

T

A

V

T

K

E

E

N

N

V

I

E

L

V

L

P

P

A

L

I

S

Y

I

A

T

G

K

L

L

P

S

R

K

D

K

V

E

R

A

H

N

A

R

R

K

A

F

E

E

E

E

L

V

L

A

T

K

G

E

L

L

G

G

L

I

G

Y

E

E

R

L

L

R

Q

D

N

K

R

Y

P

P

N

N

Q
x
E

L

I

S

S

G
|
G

G
|
G

Q

Q

Q

K

Q

Q

R

R

V

T

S

S

I

A

A

G

R

R

A

A

L

F

M

I

N

H

D

D

A

P

R

S

I

I

L

I

L

F

A

A

D

D

E

Q

P

P

T

T

G

G

A

A

L

L

D

D

S

S

K

K

S

S

G

A

H

S

D

D

V

L

L

L

E

N

L

K

L

L

K

S

D

Q

L

L

H

N

-

Q

A

K

R

R

G

N

K

A

T

T

V

I

I

I

V

M

I

V

T

T

H

H

D

D

R

P

E

V

V

A

A

A

N

S

H

Y

A

C

D

G

R

R

L

V

I

I

E

F

I

I

R

K

D

D

G

G

R

Q

I

M

binding adenosine-5'-triphosphate: Y12 (= Y15), Q19 (≠ T22), V21 (= V24), S41 (= S44), G42 (= G45), S43 (= S46), K45 (= K48), T46 (≠ S49), E142 (≠ Q145), G145 (= G148), G146 (= G149)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
39% identity, 34% coverage: 5:222/649 of query aligns to 1:219/343 of P30750

query
sites
P30750

L

M

I

I

S

K

L

L

E

S

G

N

I

I

S

T

R

K

T

V

Y

F

R

H

N

Q

G

G

E

T

L

R

S

T

T

I

T

Q

V

A

L

L

H

N

D

N

V

V

A

S

L

L

D

H

I

V

H

P

A

A

G

G

E

Q

F

I

V

Y

A

G

I

V

M

I

G

G

A

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

H

R

L

C

L

V

G

N

C

L

L

L

D

E

K

R

P

P

T

T

T

E

G

G

R

S

Y

V

L

L

F

V

E

D

G

G

E

Q

D

E

I

L

A

T

R

T

L

L

D

S

S

E

D

S

Q

E

L

L

A

T

G

K

L

A

R

R

S

-

R

R

T

Q

F

I

G

G

F

M

I

I

F

F

Q

Q

S

H

Y

F

H

N

L

L

I

L

S

S

S

S

A

R

N

T

A

V

T

F

E

G

N

N

V

V

E

A

V

L

P

P

A

L

I

E

Y

L

A

D

G

N

L

T

P

P

R

K

D

D

V

E

R

V

H

K

A

R

R

R

A

V

E

T

E

E

L

L

L

L

T

S

G

L

L

V

G

G

L

L

G

G

E

D

R

K

L

H

Q

D

N

S

R

Y

P

P

N

S

Q

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

A

N

S

D

N

A

P

R

K

I

V

L

L

L

L

A

C

D

D

E
|
E

P

A

T

T

G

S

A

A

L

L

D

D

S

P

K

A

S

T

G

T

H

R

D

S

V

I

L

L

E

E

L

L

L

L

K

K

D

D

L

I

H

N

A

R

R

R

-

L

G

G

K

L

T

T

V

I

I

L

V

L

I

I

T

T

H

H

D

E

R

M

E

D

V

V

A

V

N

K

H

R

-

I

A

C

D

D

R

C

L

V

I

A

E

V

I

I

R

S

D

N

G

G

R

E

I

L

40:46 (vs. 44:50, 86% identical) binding ATP
E166 (= E171) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
38% identity, 34% coverage: 5:222/649 of query aligns to 2:220/344 of 6cvlD

query
sites
6cvlD

L

M

I

I

S

K

L

L

E

S

G

N

I

I

S

T

R

K

T

V

Y
x
F

R

H

N
x
Q

G

G

E

T

L

R

S

T

T
x
I

T

Q

V

A

L

L

H

N

D

N

V

V

A

S

L

L

D

H

I

V

H

P

A

A

G

G

E

Q

F

I

V

Y

A

G

I

V

M

I

G

G

A

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

H

R

L

C

L

V

G

N

C

L

L

L

D

E

K

R

P

P

T

T

T

E

G

G

R

S

Y

V

L

L

F

V

E

D

G

G

E

Q

D

E

I

L

A

T

R

T

L

L

D

S

S

E

D

S

Q

E

L

L

A

T

G

K

L

A

R

R

S

-

R

R

T

Q

F

I

G

G

F

M

I

I

F

F

Q

Q

S

H

Y

F

H

N

L

L

I

L

S

S

S

S

A

R

N

T

A

V

T

F

E

G

N

N

V

V

E

A

V

L

P

P

A

L

I

E

Y

L

A

D

G

N

L

T

P

P

R

K

D

D

V

E

R

V

H

K

A

R

R

R

A

V

E

T

E

E

L

L

L

L

T

S

G

L

L

V

G

G

L

L

G

G

E

D

R

K

L

H

Q

D

N

S

R

Y

P

P

N

S

Q
x
N

L

L

S
|
S

G

G

G

G

Q
|
Q

Q

K

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

A

N

S

D

N

A

P

R

K

I

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

A

A

L

L

D

D

S

P

K

A

S

T

G

T

H

R

D

S

V

I

L

L

E

E

L

L

L

L

K

K

D

D

L

I

H

N

A

R

R

R

-

L

G

G

K

L

T

T

V

I

I

L

V

L

I

I

T

T

H
|
H

D

E

R

M

E

D

V

V

A

V

N

K

H

R

-

I

A

C

D

D

R

C

L

V

I

A

E

V

I

I

R

S

D

N

G

G

R

E

I

L

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y15), Q14 (≠ N17), I19 (≠ T22), S41 (= S44), G42 (= G45), A43 (≠ S46), G44 (= G47), K45 (= K48), S46 (= S49), T47 (= T50), N141 (≠ Q145), S143 (= S147), Q146 (= Q150), H200 (= H203)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
39% identity, 32% coverage: 5:209/649 of query aligns to 2:206/344 of 3tuzC

query
sites
3tuzC

L

M

I

I

S

K

L

L

E

S

G

N

I

I

S

T

R

K

T

V

Y
x
F

R

H

N
x
Q

G

G

E

T

L

R

S

T

T

I

T

Q

V

A

L

L

H

N

D

N

V

V

A

S

L

L

D

H

I

V

H

P

A

A

G

G

E

Q

F

I

V

Y

A

G

I

V

M

I

G

G

A

A

S

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

H

R

L

C

L

V

G

N

C

L

L

L

D

E

K

R

P

P

T

T

T

E

G

G

R

S

Y

V

L

L

F

V

E

D

G

G

E

Q

D

E

I

L

A

T

R

T

L

L

D

S

S

E

D

S

Q

E

L

L

A

T

G

K

L

A

R

R

S

-

R

R

T

Q

F

I

G

G

F

M

I

I

F

F

Q

Q

S

H

Y

F

H

N

L

L

I

L

S

S

S

S

A

R

N

T

A

V

T

F

E

G

N

N

V

V

E

A

V

L

P

P

A

L

I

E

Y

L

A

D

G

N

L

T

P

P

R

K

D

D

V

E

R

V

H

K

A

R

R

R

A

V

E

T

E

E

L

L

L

L

T

S

G

L

L

V

G

G

L

L

G

G

E

D

R

K

L

H

Q

D

N

S

R

Y

P

P

N

S

Q

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

A

N

S

D

N

A

P

R

K

I

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

A

A

L

L

D

D

S

P

K

A

S

T

G

T

H

R

D

S

V

I

L

L

E

E

L

L

L

L

K

K

D

D

L

I

H

N

A

R

R

R

-

L

G

G

K

L

T

T

V

I

I

L

V

L

I

I

T

T

H

H

D

E

R

M

E

D

V

V

A

V

N

K

binding adenosine-5'-diphosphate: F12 (≠ Y15), Q14 (≠ N17), G42 (= G45), G44 (= G47), K45 (= K48), S46 (= S49), T47 (= T50)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
39% identity, 32% coverage: 5:209/649 of query aligns to 2:206/344 of 3tuiC

query
sites
3tuiC

L

M

I

I

S

K

L

L

E

S

G

N

I

I

S

T

R

K

T

V

Y
x
F

R

H

N

Q

G

G

E

T

L

R

S

T

T

I

T

Q

V

A

L

L

H

N

D

N

V

V

A

S

L

L

D

H

I

V

H

P

A

A

G

G

E

Q

F

I

V

Y

A

G

I

V

M

I

G

G

A

A

S

S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

H

R

L

C

L

V

G

N

C

L

L

L

D

E

K

R

P

P

T

T

T

E

G

G

R

S

Y

V

L

L

F

V

E

D

G

G

E

Q

D

E

I

L

A

T

R

T

L

L

D

S

S

E

D

S

Q

E

L

L

A

T

G

K

L

A

R

R

S

-

R

R

T

Q

F

I

G

G

F

M

I

I

F

F

Q

Q

S

H

Y

F

H

N

L

L

I

L

S

S

S

S

A

R

N

T

A

V

T

F

E

G

N

N

V

V

E

A

V

L

P

P

A

L

I

E

Y

L

A

D

G

N

L

T

P

P

R

K

D

D

V

E

R

V

H

K

A

R

R

R

A

V

E

T

E

E

L

L

L

L

T

S

G

L

L

V

G

G

L

L

G

G

E

D

R

K

L

H

Q

D

N

S

R

Y

P

P

N

S

Q

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

S

A

I

I

A

A

R

R

A

A

L

L

M

A

N

S

D

N

A

P

R

K

I

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

A

A

L

L

D

D

S

P

K

A

S

T

G

T

H

R

D

S

V

I

L

L

E

E

L

L

L

L

K

K

D

D

L

I

H

N

A

R

R

R

-

L

G

G

K

L

T

T

V

I

I

L

V

L

I

I

T

T

H

H

D

E

R

M

E

D

V

V

A

V

N

K

binding adenosine-5'-diphosphate: F12 (≠ Y15), G42 (= G45), A43 (≠ S46), G44 (= G47), K45 (= K48), S46 (= S49), T47 (= T50)

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
40% identity, 33% coverage: 6:217/649 of query aligns to 4:215/330 of P9WQK5

query
sites
P9WQK5

I

L

S

S

L

I

E

Q

G

N

I

L

S

V

R

V

T

E

Y

Y

R

Y

N

S

G

G

E

G

L

Y

S

A

T

L

T

R

V

P

L

I

H

N

D

G

V

L

A

N

L

L

D

D

I

V

H

A

A

A

G

G

E

S

F

L

V

V

A

M

I

L

M

L

G

G

A

P

S

S

G

G

S

C

G

G

K

K

S

T

T

T

L

L

M

L

H

S

L

C

L

L

G

G

C

G

L

I

D

L

K

R

P

P

T

K

T

S

G

G

R

A

Y

I

L
x
K

F

F

E

D

G

E

E

V

D

D

I

I

A

T

R

T

L

L

D

Q

S

G

D

A

Q

E

L

L

A

A

G

N

L

Y

R

R

S

R

R

N

T

K

F

V

G

G

F

I

I

V

F

F

Q

Q

S

A

Y

F

H

N

L

L

I

V

S

P

S

S

A

L

N

T

A

A

T

V

E

E

N

N

V

V

E

M

V

V

P

P

A

L

I

R

Y

S

A

A

G

G

L

M

P

S

R

R

D

R

V

A

R

S

H

R

A

R

R

R

A

A

E

E

E

E

L

L

L

L

T

A

G

R

L

V

G

N

L

L

G

A

E

E

R

R

L

M

Q

N

N

H

R

R

P

P

N

G

Q

D

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

S

A

I

V

A

A

R

R

A

A

L

I

M

A

N

L

D

D

A

P

R

P

I

L

L

I

L

L

A

A

D

D

E

E

P

P

T

T

G

A

A

H

L

L

D

D

S

F

K

I

S

Q

G

V

H

E

D

E

V

V

L

L

E

R

L

L

L

I

K

R

D

E

L

L

H

A

A

D

R

G

G

E

K

R

T

V

V

V

I

V

V

V

I

A

T

T

H

H

D

D

R

S

E

R

V

M

A

L

N

P

H

M

A

A

D

D

R

R

L

V

I

V

E

E

I

L

K65 (≠ L67) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Query Sequence

>WP_090272147.1 NCBI__GCF_900105005.1:WP_090272147.1
MNEPLISLEGISRTYRNGELSTTVLHDVALDIHAGEFVAIMGASGSGKSTLMHLLGCLDK
PTTGRYLFEGEDIARLDSDQLAGLRSRTFGFIFQSYHLISSANATENVEVPAIYAGLPRD
VRHARAEELLTGLGLGERLQNRPNQLSGGQQQRVSIARALMNDARILLADEPTGALDSKS
GHDVLELLKDLHARGKTVIVITHDREVANHADRLIEIRDGRITHDSGRKPSPAQQLATPP
PRPAPKQGLAAFGDINEAVRMALRALQANLFRTVLTLLGIVIGVASVVVMLAVGNGARQD
VVERISDMGTNLLLVRPGAPNTRRSADGTTNTLTPEDAVVASRVDNVVAAVPEVDTRATV
RAGNTDAQTQVTGTTADYPLAKSWPLASGVFINDEDNRRYAAVAVIGRTVATNLYGDADP
LGQYMLIRNVPFLIIGVMQEKGATPWGQDQDDAVFVPLNTASNRLIGSRHLGSISVLIDD
LSLSDATQEAVRQAIMANHSGIEDFQIRNMASLLENIASTQDTFTVLLGSIAAISLLVGG
IGVMNIMLVNVSERTREIGIRMATGARTRNILQQFIIEAMVVSAIGGAIGVAVGLGFAAM
LQSFGTSIQFTAGPVLLAFGCAFATGLIFGFMPAHKAAHLDPVVALSAD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory