SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_091525027.1 NCBI__GCF_900115115.1:WP_091525027.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
49% identity, 100% coverage: 1:219/220 of query aligns to 3:217/223 of 2pclA

query
sites
2pclA

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binding magnesium ion: E165 (= E166), P166 (= P167), T167 (≠ S168), T196 (= T198)

7mdyC Lolcde nucleotide-bound
46% identity, 99% coverage: 1:218/220 of query aligns to 2:220/226 of 7mdyC

query
sites
7mdyC

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binding adp orthovanadate: Y12 (≠ F11), G42 (= G37), S43 (≠ A38), G44 (= G39), K45 (= K40), S46 (≠ T41), T47 (= T42), Q91 (= Q89), H138 (= H136), E142 (= E140), S144 (= S142), G145 (= G143), G146 (= G144), E168 (= E166), N172 (= N170), H201 (= H199)
binding magnesium ion: S46 (≠ T41), Q91 (= Q89)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
46% identity, 99% coverage: 1:218/220 of query aligns to 5:223/233 of P75957

query
sites
P75957

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G42 (= G34) mutation to D: Loss of lipoprotein release when overexpressed.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
46% identity, 99% coverage: 1:218/220 of query aligns to 2:220/222 of 7arlD

query
sites
7arlD

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binding adenosine-5'-diphosphate: G42 (= G37), G44 (= G39), K45 (= K40), S46 (≠ T41)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
46% identity, 99% coverage: 1:218/220 of query aligns to 4:222/229 of 7v8iD

query
sites
7v8iD

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binding phosphoaminophosphonic acid-adenylate ester: V23 (= V16), S43 (= S36), G44 (= G37), G46 (= G39), K47 (= K40), S48 (≠ T41), T49 (= T42), Q93 (= Q89), R137 (= R133), H140 (= H136), E144 (= E140), S146 (= S142), G148 (= G144), E149 (= E145), H203 (= H199)
binding magnesium ion: S48 (≠ T41), Q93 (= Q89)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
45% identity, 98% coverage: 1:216/220 of query aligns to 3:218/226 of 5xu1B

query
sites
5xu1B

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F

Q

Q

F

Q

H

F

Q

F

L

L

L

L

P

S

E

K

F

L

T

N

A

A

L

L

E

Q

N

N

V

V

C

E

I

L

P

P

A

L

F

I

I

Y

L

A

G

G

K

V

S

S

K

S

T

S

E

K

A

R

E

R

K

K

D

L

A

A

K

E

E

E

L

Y

L

L

D

D

Y

K

L

V

G

E

L

L

S

T

H

E

R

R

I

S

N

H

H

H

F

L

P

P

S

S

E

E

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

V

N

N

K

N

P

P

S

S

V

I

I

I

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

T

T

N

K

S

T

A

G

E

N

N

Q

L

I

H

M

E

Q

L

L

F

L

F

V

K

D

L

L

R

-

D

N

N

K

F

E

G

G

Q

K

T

T

F

I

V

I

I

M

V

V

T

T

H

H

N

E

E

P

E

E

L

I

A

A

N

A

L

Y

A

A

D

K

R

R

K

Q

L

I

V

V

M

I

S

R

D

D

G

G

binding magnesium ion: G45 (= G39), K46 (= K40), S47 (≠ T41)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
46% identity, 94% coverage: 14:219/220 of query aligns to 21:222/648 of P75831

query
sites
P75831

L

V

E

E

V

V

L

L

K

K

N

G

V

I

S

S

L

L

E

D

I

I

K

Y

K

A

G

G

E

E

I

M

V

V

A

A

I

I

V

V

G

G

S

A

S

S

G

G

A

S

G

G

K
|
K

T

S

T

T

L

L

L

M

Q

N

I

I

L

L

G

G

V

C

L

L

D

D

D

-

P

-

E

-

K

K

N

A

T

T

N

S

A

G

K

T

L

Y

T

R

I

V

N

A

D

G

T

Q

D

D

V

V

L

A

S

T

L

L

K

D

D

A

Q

D

Q

A

L

L

A

A

A

Q

F

L

R

R

N

R

K

E

N

H

L

F

G

G

F

F

I

I

F

F

Q

Q

F

R

H

Y

Q

H

L

L

L

L

P

S

E

H

F

L

T

T

A

A

L

E

E

Q

N

N

V

V

C

E

I

V

P

P

A

A

F

V

I

Y

L

A

G

G

K

L

S

E

K

R

T

K

E

Q

A

R

E

L

K

L

D

R

A

A

K

Q

E

E

L

L

L

L

D

Q

Y

R

L

L

G

G

L

L

S

E

H

D

R

R

I

T

N

E

H

Y

F

Y

P

P

S

A

E

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

K

G

P

G

S

Q

V

V

I

I

F

L

A

A

D
|
D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

H

S

S

A

G

E

E

N

E

L

V

H

M

E

A

L

I

F

L

F

H

K

Q

L

L

R

R

D

D

N

R

F

-

G

G

Q

H

T

T

F

V

V

I

I

I

V

V

T

T

H

H

N

D

E

P

E

Q

L

V

A

A

N

A

L

Q

A

A

D

E

R

R

K

V

L

I

V

E

M

I

S

R

D

D

G

G

K

E

F

I

I

V

K47 (= K40) mutation to L: Lack of activity.
D169 (= D165) mutation to N: Lack of activity.

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
42% identity, 95% coverage: 12:219/220 of query aligns to 18:221/592 of 5lj7A

query
sites
5lj7A

N

N

G

R

L

V

E

H

V
|
V

L

L

K

K

N

D

V

I

S

S

L

L

E

S

I

I

K

E

K

R

G

G

E

D

I

F

V

V

A

A

I

I

V

M

G

G

S

Q

S
|
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

M

Q

N

I

I

L

I

G

G

V

C

L

L

D

D

D

T

P

A

E

-

K

-

N

-

T

T

N

G

A

G

K

S

L

S

T

K

I

I

N

D

D

G

T

K

D

E

V

T

L

I

S

E

L

L

K

T

D

N

Q

D

Q

Q

L

L

A

S

A

D

F

L

R

R

N

S

K

Q

N

K

L

F

G

G

F

F

I

I

F

F

Q
|
Q

F

R

H

Y

Q

N

L

L

L

L

P

S

E

S

F

L

T

T

A

A

L

A

E

E

N

N

V

V

C

A

I

L

P

P

A

A

F

I

I

Y

L

A

G

G

K

M

S

P

K

Q

T

S

E

Q

A

R

E

L

K

E

D

R

A

A

K

K

E

Q

L

L

L

L

D

E

Y

K

L

L

G

G

L

L

S

G

H

D

R
x
K

I

W

N

Q

H

N

F

K

P

P

S

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

K

G

P

G

S

E

V

I

I

I

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

H

S

S

A

G

E

E

N

N

L

V

H

M

E

E

L

I

F

L

F

R

K

Q

L

L

R

H

D

E

N

E

F

-

G

G

Q

H

T

T

F

I

V

I

I

M

V

V

T

T

H

H

N

D

E

K

E

H

L

I

A

A

N

A

L

S

A

A

D

N

R

R

K

I

L

I

V

E

M

I

S

K

D

D

G

G

K

E

F

I

I

I

binding adenosine-5'-triphosphate: V22 (= V16), S42 (= S36), G43 (= G37), G45 (= G39), K46 (= K40), S47 (≠ T41), T48 (= T42), Q92 (= Q89), K136 (≠ R133), Q143 (≠ E140), S145 (= S142), G147 (= G144), Q148 (≠ E145)
binding magnesium ion: S47 (≠ T41), Q92 (= Q89)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
42% identity, 95% coverage: 12:219/220 of query aligns to 18:221/615 of 5lilA

query
sites
5lilA

N

N

G

R

L

V

E

H

V
|
V

L

L

K

K

N

D

V

I

S

S

L

L

E

S

I

I

K

E

K

R

G

G

E

D

I

F

V

V

A

A

I

I

V

M

G

G

S

Q

S
|
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

M

Q

N

I

I

L

I

G

G

V

C

L

L

D

D

D

T

P

A

E

-

K

-

N

-

T

T

N

G

A

G

K

S

L

S

T

K

I

I

N

D

D

G

T

K

D

E

V

T

L

I

S

E

L

L

K

T

D

N

Q

D

Q

Q

L

L

A

S

A

D

F

L

R

R

N

S

K

Q

N

K

L

F

G

G

F

F

I

I

F

F

Q
|
Q

F

R

H

Y

Q

N

L

L

L

L

P

S

E

S

F

L

T

T

A

A

L

A

E

E

N

N

V

V

C

A

I

L

P

P

A

A

F

I

I

Y

L

A

G

G

K

M

S

P

K

Q

T

S

E

Q

A

R

E

L

K

E

D

R

A

A

K

K

E

Q

L

L

L

L

D

E

Y

K

L

L

G

G

L

L

S

G

H

D

R
x
K

I

W

N

Q

H

N

F

K

P

P

S

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

K

G

P

G

S

E

V

I

I

I

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

H

S

S

A

G

E

E

N

N

L

V

H

M

E

E

L

I

F

L

F

R

K

Q

L

L

R

H

D

E

N

E

F

-

G

G

Q

H

T

T

F

I

V

I

I

M

V

V

T

T

H

H

N

D

E

K

E

H

L

I

A

A

N

A

L

S

A

A

D

N

R

R

K

I

L

I

V

E

M

I

S

K

D

D

G

G

K

E

F

I

I

I

binding adenosine-5'-triphosphate: V22 (= V16), S42 (= S36), G43 (= G37), G45 (= G39), K46 (= K40), S47 (≠ T41), T48 (= T42), Q92 (= Q89), K136 (≠ R133), Q143 (≠ E140), S145 (= S142), G147 (= G144), Q148 (≠ E145)
binding magnesium ion: S47 (≠ T41), Q92 (= Q89)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
43% identity, 99% coverage: 1:217/220 of query aligns to 1:222/232 of 1f3oA

query
sites
1f3oA

M

M

I

I

K

K

A

L

E

K

N

N

I

V

S

T

K

K

Q

T

F
x
Y

N

K

-

M

G

G

L

E

E

E

V

I

-

I

-

Y

-

A

L

L

K

K

N

N

V

V

S

N

L

L

E

N

I

I

K

K

K

E

G

G

E

E

I

F

V

V

A

S

I

I

V

M

G

G

S

P

S

S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

L

M

L

L

Q

N

I

I

L

I

G

G

V

C

L

L

D

D

D

K

P

P

E

-

K

-

N

-

T

T

N

E

A

G

K

E

L

V

T

Y

I

I

N

D

D

N

T

I

D

K

V

T

L

N

S

D

L

L

K

D

D

D

Q

D

Q

E

L

L

A

T

A

K

F

I

R

R

N

R

K

D

N

K

L

I

G

G

F

F

I

V

F

F

Q

Q

F

Q

H

F

Q

N

L

L

L

I

P

P

E

L

F

L

T

T

A

A

L

L

E

E

N

N

V

V

C

E

I

L

P

P

-

L

-

I

-

F

A

K

F

Y

I

R

L

G

G

A

K

M

S

S

K

G

T

E

E

E

A

R

E

R

K

K

D

R

A

A

K

L

E

E

L

C

L

L

D

K

Y

M

L

A

G

E

L

L

S

E

H

E

R

R

I

F

-

A

N

N

H

H

F

K

P

P

S

N

E

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

A

N

N

K

N

P

P

S

P

V

I

I

I

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

K

S

T

A

G

E

E

N

K

L

I

H

M

E

Q

L

L

F

L

F

K

K

K

L

L

R

N

D

E

N

E

F

D

G

G

Q

K

T

T

F

V

V

V

I

V

V

V

T

T

H

H

N

D

E

I

E

N

L

V

A

A

N

R

L

F

A

G

D

E

R

R

K

I

L

I

V

Y

M

L

S

K

D

D

G

G

K

E

binding adenosine-5'-diphosphate: Y11 (≠ F11), G41 (= G37), G43 (= G39), K44 (= K40), S45 (≠ T41), T46 (= T42)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
43% identity, 99% coverage: 1:217/220 of query aligns to 1:222/230 of 1l2tA

query
sites
1l2tA

M

M

I

I

K

K

A

L

E

K

N

N

I

V

S

T

K

K

Q

T

F
x
Y

N

K

-

M

G

G

L

E

E

E

V

I

-

I

-

Y

-

A

L

L

K

K

N

N

V

V

S

N

L

L

E

N

I

I

K

K

K

E

G

G

E

E

I

F

V

V

A

S

I

I

V

M

G

G

S

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

M

L

L

Q

N

I

I

L

I

G

G

V

C

L

L

D

D

D

K

P

P

E

-

K

-

N

-

T

T

N

E

A

G

K

E

L

V

T

Y

I

I

N

D

D

N

T

I

D

K

V

T

L

N

S

D

L

L

K

D

D

D

Q

D

Q

E

L

L

A

T

A

K

F

I

R

R

N

R

K

D

N

K

L

I

G

G

F

F

I

V

F

F

Q

Q

F

Q

H

F

Q

N

L

L

L

I

P

P

E

L

F

L

T

T

A

A

L

L

E

E

N

N

V

V

C

E

I

L

P

P

-

L

-

I

-

F

A

K

F

Y

I

R

L

G

G

A

K

M

S

S

K

G

T

E

E

E

A

R

E

R

K

K

D

R

A

A

K

L

E

E

L

C

L

L

D

K

Y

M

L

A

G

E

L

L

S

E

H

E

R

R

I
x
F

-

A

N

N

H

H

F

K

P

P

S

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

I

A

N

N

K

N

P

P

S

P

V

I

I

I

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

K

S

T

A

G

E

E

N

K

L

I

H

M

E

Q

L

L

F

L

F

K

K

K

L

L

R

N

D

E

N

E

F

D

G

G

Q

K

T

T

F

V

V

V

I

V

V

V

T

T

H
|
H

N

D

E

I

E

N

L

V

A

A

N

R

L

F

A

G

D

E

R

R

K

I

L

I

V

Y

M

L

S

K

D

D

G

G

K

E

binding adenosine-5'-triphosphate: Y11 (≠ F11), S40 (= S36), G41 (= G37), S42 (≠ A38), G43 (= G39), K44 (= K40), S45 (≠ T41), T46 (= T42), F138 (≠ I134), Q145 (≠ E140), S147 (= S142), G149 (= G144), Q150 (≠ E145), H204 (= H199)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
40% identity, 100% coverage: 1:219/220 of query aligns to 4:222/650 of 5ws4A

query
sites
5ws4A

M

L

I

L

K

E

A

V

E

S

N

N

I

L

S

V

K

R

Q

E

F

F

-

P

-

A

-

G

-

E

N

S

G

T

L

I

E

Q

V

I

L

L

K

K

N

G

V

I

S

D

L

L

E

T

I

I

K

Y

K

E

G

G

E

E

I

L

V

V

A

A

I

I

V

V

G

G

S

Q

S
|
S

G
|
G

A

S

G

G

K

K

T
x
S

T

T

L

L

L

M

Q

N

I

I

L

L

G

G

V

C

L

L

D

D

D

R

P

P

E

-

K

-

N

-

T

T

N

S

A

G

K

S

L

Y

T

K

I

V

N

N

D

G

T

Q

D

E

V

T

L

G

S

K

L

L

K

E

D

P

Q

D

Q

Q

L

L

A

A

A

Q

F

L

R

R

N

R

K

E

N

Y

L

F

G

G

F

F

I

I

F

F

Q

Q

F

R

H

Y

Q

H

L

L

L

L

P

G

E

D

F

L

T

S

A

A

L

E

E

G

N

N

V

V

C

E

I

V

P

P

A

A

F

V

I

Y

L

A

G

G

K

V

S

T

K

P

T

A

E

D

A

R

E

K

K

Q

D

R

A

A

K

T

E

A

L

L

L

L

D

T

Y

E

L

L

G

G

L

L

S

G

H

T

R

K

I

T

N

Q

H

N

F

R

P

P

S

S

E

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

I

M

N

N

K

G

P

G

S

D

V

V

I

I

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

H

S

S

A

G

E

V

N

E

L

V

H

M

E

R

L

I

F

L

F

R

K

E

L

L

R

-

D

N

N

A

F

A

G

G

Q

H

T

T

F

I

V

I

I

L

V

V

T

T

H

H

N

D

E

M

E

Q

L

V

A

A

N

K

L

N

A

A

D

T

R

R

K

I

L

I

V

E

M

I

S

S

D

D

G

G

K

E

F

I

I

I

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S36), G44 (= G37), S48 (≠ T41)

8g4cB Bceabs atpgs high res tm (see paper)
40% identity, 99% coverage: 1:218/220 of query aligns to 3:221/248 of 8g4cB

query
sites
8g4cB

M

I

I

L

K

E

A

A

E

N

N

K

I

I

S

R

K

K

Q

S

F
x
Y

-

G

-

N

-

K

-

L

N

N

G

K

L

Q

E

E

V

V

L

L

K

K

N

G

V

I

S

D

L

I

E

H

I

I

K

E

K

K

G

G

E

E

I

F

V

V

A

S

I

I

V

M

G

G

S

A

S
|
S

G

G

A
x
S

G

G

K

K

T
|
T

T

T

L

L

L

L

Q

N

I

V

L

L

G

S

V

S

L

I

D

D

D

Q

P

V

E

S

K

H

N

G

T

T

N

-

A

-

K

-

L

I

T

H

I

I

N

N

D

G

T

N

D

D

V

M

L

T

S

A

L

M

K

K

D

E

Q

K

Q

Q

L

L

A

A

A

E

F

F

R

R

N

K

K

Q

N

H

L

L

G

G

F

F

I

I

F

F

Q

Q

F

D

H

Y

Q

N

L

L

L

L

P

D

E

T

F

L

T

T

A

V

L

K

E

E

N

N

V

I

C

L

I

L

P

P

A

L

F

S

I

I

L

T

G

K

K

L

S

S

K

K

T

K

E

E

A

A

E

N

K

R

D

K

A

F

K

E

E

E

L

V

L

A

D

K

Y

E

L

L

G

G

L

I

S

Y

H

E

R

L

I

R

N

D

H

K

F

Y

P

P

S

N

E

E

L

I

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

I

I

N

H

K

D

P

P

S

S

V

I

I

I

F

F

A

A

D
|
D

E

E

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

K

S

S

A

A

E

S

N

D

L

L

H

L

E

N

L

K

F

L

F

S

K

Q

L

L

R

N

D

Q

N

K

F

R

G

N

Q

A

T

T

F

I

V

I

I

M

V

V

T

T

H

H

N

D

E

P

E

V

L

A

A

A

N

S

L

Y

A

C

D

G

R

R

K

V

L

I

V

F

M

I

S

K

D

D

G

G

K

Q

F

M

binding phosphothiophosphoric acid-adenylate ester: Y13 (≠ F11), S42 (= S36), S44 (≠ A38), T47 (= T41), D168 (= D165)

7tchB Bceab e169q variant atp-bound conformation (see paper)
39% identity, 99% coverage: 1:218/220 of query aligns to 2:220/245 of 7tchB

query
sites
7tchB

M

I

I

L

K

E

A

A

E

N

N

K

I

I

S

R

K

K

Q

S

F
x
Y

-

G

-

N

-

K

-

L

N

N

G

K

L
x
Q

E

E

V
|
V

L

L

K

K

N

G

V

I

S

D

L

I

E

H

I

I

K

E

K

K

G

G

E

E

I

F

V

V

A

S

I

I

V

M

G

G

S

A

S
|
S

G
|
G

A
x
S

G

G

K
|
K

T
|
T

T

T

L

L

L

L

Q

N

I

V

L

L

G

S

V

S

L

I

D

D

D

Q

P

V

E

S

K

H

N

G

T

T

N

-

A

-

K

-

L

I

T

H

I

I

N

N

D

G

T

N

D

D

V

M

L

T

S

A

L

M

K

K

D

E

Q

K

Q

Q

L

L

A

A

A

E

F

F

R

R

N

K

K

Q

N

H

L

L

G

G

F

F

I

I

F

F

Q

Q

F

D

H

Y

Q

N

L

L

L

L

P

D

E

T

F

L

T

T

A

V

L

K

E

E

N

N

V

I

C

L

I

L

P

P

A

L

F

S

I

I

L

T

G

K

K

L

S

S

K

K

T

K

E

E

A

A

E

N

K

R

D

K

A

F

K

E

E

E

L

V

L

A

D

K

Y

E

L

L

G

G

L

I

S

Y

H

E

R

L

I

R

N

D

H

K

F

Y

P

P

S

N

E
|
E

L

I

S

S

G
|
G

G
|
G

E

Q

Q

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

I

I

N

H

K

D

P

P

S

S

V

I

I

I

F

F

A

A

D

D

E

Q

P

P

S

T

G

G

N

A

L

L

D

D

T

S

N

K

S

S

A

A

E

S

N

D

L

L

H

L

E

N

L

K

F

L

F

S

K

Q

L

L

R

N

D

Q

N

K

F

R

G

N

Q

A

T

T

F

I

V

I

I

M

V

V

T

T

H

H

N

D

E

P

E

V

L

A

A

A

N

S

L

Y

A

C

D

G

R

R

K

V

L

I

V

F

M

I

S

K

D

D

G

G

K

Q

F

M

binding adenosine-5'-triphosphate: Y12 (≠ F11), Q19 (≠ L14), V21 (= V16), S41 (= S36), G42 (= G37), S43 (≠ A38), K45 (= K40), T46 (= T41), E142 (= E140), G145 (= G143), G146 (= G144)

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
38% identity, 99% coverage: 1:218/220 of query aligns to 1:215/222 of P0A9R7

query
sites
P0A9R7

M

M

I

I

K

R

A

F

E

E

N

H

I

V

S

S

K

K

Q

A

F

Y

-

L

N

G

G

G

L

R

E

Q

V

A

L

L

K

Q

N

G

V

V

S

T

L

F

E

H

I

M

K

Q

K

P

G

G

E

E

I

M

V

A

A

F

I

L

V

T

G

G

S

H

S

S

G

G

A

A

G

G

K
|
K

T

S

T

T

L

L

L

L

Q

K

I

L

L

I

G
x
C

V

G

L

I

D

E

D

R

P

P

E

-

K

-

N

-

T

S

N

A

A

G

K

K

L

I

T

W

I

F

N

S

D

G

T

H

D

D

V

I

L

T

S

R

L

L

K

K

D

N

Q

R

Q

E

L

V

A

P

A

-

F

F

R

L

N

R

K

R

N

Q

L

I

G

G

F

M

I

I

F

F

Q

Q

F

D

H

H

Q

H

L

L

L

L

P

M

E

D

F

R

T

T

A

V

L

Y

E

D

N

N

V

V

C

A

I

I

P

P

A

L

F

I

I

I

L

A

G

G

K

A

S

S

K

G

T

D

E

D

A

I

E

R

K

R

D

R

A

V

K

S

E

A

L

A

L

L

D

D

Y

K

L

V

G

G

L

L

S

L

H

D

R

K

I

A

N

K

H

N

F

F

P

P

S

I

E

Q

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

V

A

G

V

I

A

A

R

R

A

A

L

V

I

V

N

N

K

K

P

P

S

A

V

V

I

L

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

N

L

L

D

D

T

D

N

A

S

L

A

S

E

E

N

G

L

I

H

L

E

R

L

L

F

F

F

E

K

E

L

F

R

-

D

N

N

R

F

V

G

G

Q

V

T

T

F

V

V

L

I

M

V

A

T

T

H

H

N

D

E

I

E

N

L

L

-

I

A

S

N

R

L

R

A

S

D

Y

R

R

K

M

L

L

V

T

M

L

S

S

D

D

G

G

K

H

F

L

K41 (= K40) mutation to R: Does not bind ATP.
C49 (≠ G48) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

8w6iD Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
38% identity, 99% coverage: 1:218/220 of query aligns to 1:215/219 of 8w6iD

query
sites
8w6iD

M

M

I

I

K

R

A

F

E

E

N

H

I

V

S

S

K

K

Q

A

F
x
Y

-

L

N

G

G

G

L

R

E

Q

V

A

L

L

K

Q

N

G

V

V

S

T

L

F

E

H

I

M

K

Q

K

P

G

G

E

E

I

M

V

A

A

F

I

L

V

T

G

G

S

H

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

L

Q

K

I

L

L

I

G

C

V

G

L

I

D

E

D

R

P

P

E

-

K

-

N

-

T

S

N

A

A

G

K

K

L

I

T

W

I

F

N

S

D

G

T

H

D

D

V

I

L

T

S

R

L

L

K

K

D

N

Q

R

Q

E

L

V

A

P

A

-

F

F

R

L

N

R

K

R

N

Q

L

I

G

G

F

M

I

I

F

F

Q
|
Q

F

D

H

H

Q

H

L

L

L

L

P

M

E

D

F

R

T

T

A

V

L

Y

E

D

N

N

V

V

C

A

I

I

P

P

A

L

F

I

I

I

L

A

G

G

K

A

S

S

K

G

T

D

E

D

A

I

E

R

K

R

D

R

A

V

K

S

E

A

L

A

L

L

D

D

Y

K

L

V

G

G

L

L

S

L

H

D

R
x
K

I

A

N

K

H

N

F

F

P

P

S

I

E
x
Q

L

L

S
|
S

G
|
G

G
|
G

E
|
E

Q

Q

Q

Q

R

R

V

V

A

G

V

I

A

A

R

R

A

A

L

V

I

V

N

N

K

K

P

P

S

A

V

V

I

L

F

L

A

A

D

D

E

E

P

P

S

T

G

G

N

N

L

L

D

D

T

D

N

A

S

L

A

S

E

E

N

G

L

I

H

L

E

R

L

L

F

F

F

E

K

E

L

F

R

-

D

N

N

R

F

V

G

G

Q

V

T

T

F

V

V

L

I

M

V

A

T

T

H
|
H

N

D

E

I

E

N

L

L

-

I

A

S

N

R

L

R

A

S

D

Y

R

R

K

M

L

L

V

T

M

L

S

S

D

D

G

G

K

H

F

L

binding phosphothiophosphoric acid-adenylate ester: Y11 (≠ F11), S37 (= S36), G38 (= G37), A39 (= A38), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (= T42), Q86 (= Q89), K130 (≠ R133), Q137 (≠ E140), S139 (= S142), G140 (= G143), G141 (= G144), E142 (= E145), H195 (= H199)

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
37% identity, 99% coverage: 1:218/220 of query aligns to 1:215/218 of 8hd0A

query
sites
8hd0A

M

M

I

I

K

R

A

F

E

E

N

H

I

V

S

S

K

K

Q

A

F
x
Y

-

L

N

G

G

G

L
x
R

E

Q

V
x
A

L

L

K

Q

N

G

V

V

S

T

L

F

E

H

I

M

K

Q

K

P

G

G

E

E

I

M

V

A

A

F

I

L

V

T

G

G

S

H

S

S

G

G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

L

Q

K

I

L

L

I

G

C

V

G

L

I

D

E

D

R

P

P

E

-

K

-

N

-

T

S

N

A

A

G

K

K

L

I

T

W

I

F

N

S

D

G

T

H

D

D

V

I

L

T

S

R

L

L

K

K

D

N

Q

R

Q

E

L

V

A

P

A

-

F

F

R

L

N

R

K

R

N

Q

L

I

G

G

F

M

I

I

F

F

Q

Q

F

D

H

H

Q

H

L

L

L

L

P

M

E

D

F

R

T

T

A

V

L

Y

E

D

N

N

V

V

C

A

I

I

P

P

A

L

F

I

I

I

L

A

G

G

K

A

S

S

K

G

T

D

E

D

A

I

E

R

K

R

D

R

A

V

K

S

E

A

L

A

L

L

D

D

Y

K

L

V

G

G

L

L

S

L

H

D

R

K

I

A

N

K

H

N

F

F

P

P

S

I

E

Q

L

L

S
|
S

G

G

G
|
G

E

E

Q

Q

Q

Q

R

R

V

V

A

G

V

I

A

A

R

R

A

A

L

V

I

V

N

N

K

K

P

P

S

A

V

V

I

L

F

L

A

A

D

D

E

Q

P

P

S

T

G

G

N

N

L

L

D

D

T

D

N

A

S

L

A

S

E

E

N

G

L

I

H

L

E

R

L

L

F

F

F

E

K

E

L

F

R

-

D

N

N

R

F

V

G

G

Q

V

T

T

F

V

V

L

I

M

V

A

T

T

H

H

N

D

E

I

E

N

L

L

-

I

A

S

N

R

L

R

A

S

D

Y

R

R

K

M

L

L

V

T

M

L

S

S

D

D

G

G

K

H

F

L

binding adenosine-5'-triphosphate: Y11 (≠ F11), R15 (≠ L14), A17 (≠ V16), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (= T42), S139 (= S142), G141 (= G144)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
34% identity, 100% coverage: 1:219/220 of query aligns to 3:218/230 of 6z4wA

query
sites
6z4wA

M

I

I

I

K

E

A

M

E

R

N

D

I

V

S

V

K

K

Q

K

F
x
Y

-

D

N

N

G

G

L
x
T

E

T

V
x
A

L

L

K

R

N

G

V

V

S

S

L

V

E

S

I

V

K

Q

K

P

G

G

E

E

I

F

V

A

A

Y

I

I

V

V

G

G

S

P

S

S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

I

Q

R

I

-

L

-

G

-

V

S

L

L

D

Y

D

R

P

E

E

V

K

K

N

I

T

D

N

K

A

G

K

S

L

L

T

S

I

V

N

A

D

G

T

F

D

N

V

L

L

V

S

K

L

I

K

K

D

K

Q

K

Q

D

L

V

A

P

A

L

F

L

R

R

N

-

K

R

N

S

L

V

G

G

F

V

I

V

F

F

Q

Q

F

D

H

Y

Q

K

L

L

L

L

P

P

E

K

F

K

T

T

A

V

L

Y

E

E

N

N

V

I

C

A

I

Y

P

A

A

M

F

E

I

V

L

I

G

G

K

E

S

N

K

R

T

R

E

N

A

I

E

K

K

R

D

R

A

V

K

M

E

E

L

V

L

L

D

D

Y

L

L

V

G

G

L

L

S

K

H

H

R

K

I

V

N

R

H

S

F

F

P

P

S

N

E

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

I

A

A

V

I

A

A

R

R

A

A

L

I

I

V

N

N

K

N

P

P

S

K

V

V

I

L

F

I

A

A

D

D

E

E

P

P

S

T

G

G

N

N

L

L

D

D

T

P

N

D

S

N

A

S

E

W

N

E

L

I

H

M

E

N

L

L

F

L

F

E

K

R

L

I

R

-

D

N

N

L

F

Q

G

G

Q

T

T

T

F

I

V

L

I

M

V

A

T

T

H

H

N

N

E

S

E

Q

L

I

A

V

N

N

-

T

L

L

A

R

D

H

R

R

K

V

L

I

V

A

M

I

S

E

D

N

G

G

K

R

F

V

I

V

binding adenosine-5'-diphosphate: Y13 (≠ F11), T17 (≠ L14), A19 (≠ V16), G40 (= G37), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)

A0A0H2ZM82 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
34% identity, 100% coverage: 1:219/220 of query aligns to 3:218/230 of A0A0H2ZM82

query
sites
A0A0H2ZM82

M

I

I

I

K

E

A

M

E

R

N

D

I

V

S

V

K

K

Q

K

F

Y

-

D

N

N

G

G

L

T

E

T

V

A

L

L

K

R

N

G

V

V

S

S

L

V

E

S

I

V

K

Q

K

P

G

G

E

E

I

F

V

A

A

Y

I

I

V

V

G

G

S

P

S

S

G

G

A

A

G

G

K
|
K

T

S

T

T

L

F

L

I

Q

R

I

-

L

-

G

-

V

S

L

L

D

Y

D

R

P

E

E

V

K

K

N

I

T

D

N

K

A

G

K

S

L

L

T

S

I

V

N

A

D

G

T

F

D

N

V

L

L

V

S

K

L

I

K

K

D

K

Q

K

Q

D

L

V

A

P

A

L

F

L

R

R

N

-

K

R

N

S

L

V

G

G

F

V

I

V

F

F

Q

Q

F

D

H

Y

Q

K

L

L

L

L

P

P

E

K

F

K

T

T

A

V

L

Y

E

E

N

N

V

I

C

A

I

Y

P

A

A

M

F

E

I

V

L

I

G

G

K

E

S

N

K

R

T

R

E

N

A

I

E

K

K

R

D

R

A

V

K

M

E

E

L

V

L

L

D

D

Y

L

L

V

G

G

L

L

S

K

H

H

R

K

I

V

N

R

H

S

F

F

P

P

S

N

E

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

I

A

A

V

I

A

A

R

R

A

A

L

I

I

V

N

N

K

N

P

P

S

K

V

V

I

L

F

I

A

A

D
|
D

E
|
E

P

P

S

T

G

G

N

N

L

L

D

D

T

P

N

D

S

N

A

S

E

W

N

E

L

I

H

M

E

N

L

L

F

L

F

E

K

R

L

I

R

-

D

N

N

L

F

Q

G

G

Q

T

T

T

F

I

V

L

I

M

V

A

T

T

H

H

N

N

E

S

E

Q

L

I

A

V

N

N

-

T

L

L

A

R

D

H

R

R

K

V

L

I

V

A

M

I

S

E

D

N

G

G

K

R

F

V

I

V

K43 (= K40) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
D164 (= D165) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
E165 (= E166) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
34% identity, 100% coverage: 1:219/220 of query aligns to 3:218/229 of 6z67B

query
sites
6z67B

M

I

I

I

K

E

A

M

E

R

N

D

I

V

S

V

K

K

Q

K

F
x
Y

-

D

N

N

G
|
G

L

T

E

T

V
x
A

L

L

K

R

N

G

V

V

S

S

L

V

E

S

I

V

K

Q

K

P

G

G

E

E

I

F

V

A

A

Y

I

I

V

V

G

G

S

P

S
|
S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

I

Q

R

I

-

L

-

G

-

V

S

L

L

D

Y

D

R

P

E

E

V

K

K

N

I

T

D

N

K

A

G

K

S

L

L

T

S

I

V

N

A

D

G

T

F

D

N

V

L

L

V

S

K

L

I

K

K

D

K

Q

K

Q

D

L

V

A

P

A

L

F

L

R

R

N

-

K

R

N

S

L

V

G

G

F

V

I

V

F

F

Q

Q

F

D

H

Y

Q

K

L

L

L

L

P

P

E

K

F

K

T

T

A

V

L

Y

E

E

N

N

V

I

C

A

I

Y

P

A

A

M

F

E

I

V

L

I

G

G

K

E

S

N

K

R

T

R

E

N

A

I

E

K

K

R

D

R

A

V

K

M

E

E

L

V

L

L

D

D

Y

L

L

V

G

G

L

L

S

K

H

H

R

K

I

V

N

R

H

S

F

F

P

P

S

N

E

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

I

A

A

V

I

A

A

R

R

A

A

L

I

I

V

N

N

K

N

P

P

S

K

V

V

I

L

F

I

A

A

D

D

E

E

P

P

S

T

G

G

N

N

L

L

D

D

T

P

N

D

S

N

A

S

E

W

N

E

L

I

H

M

E

N

L

L

F

L

F

E

K

R

L

I

R

-

D

N

N

L

F

Q

G

G

Q

T

T

T

F

I

V

L

I

M

V

A

T

T

H

H

N

N

E

S

E

Q

L

I

A

V

N

N

-

T

L

L

A

R

D

H

R

R

K

V

L

I

V

A

M

I

S

E

D

N

G

G

K

R

F

V

I

V

binding phosphoaminophosphonic acid-adenylate ester: Y13 (≠ F11), G16 (= G13), A19 (≠ V16), S39 (= S36), G40 (= G37), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)

Query Sequence

>WP_091525027.1 NCBI__GCF_900115115.1:WP_091525027.1
MIKAENISKQFNGLEVLKNVSLEIKKGEIVAIVGSSGAGKTTLLQILGVLDDPEKNTNAK
LTINDTDVLSLKDQQLAAFRNKNLGFIFQFHQLLPEFTALENVCIPAFILGKSKTEAEKD
AKELLDYLGLSHRINHFPSELSGGEQQRVAVARALINKPSVIFADEPSGNLDTNSAENLH
ELFFKLRDNFGQTFVIVTHNEELANLADRKLVMSDGKFIV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory