SitesBLAST
Comparing WP_092053014.1 NCBI__GCF_900111775.1:WP_092053014.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 11:575/582 of 3ea4A
- active site: Y32 (= Y24), G34 (= G26), G35 (= G27), A36 (≠ T28), S37 (≠ V29), E58 (= E49), T81 (= T72), F120 (= F111), Q121 (= Q112), E122 (= E113), K170 (= K161), M265 (= M256), V292 (= V283), V399 (= V393), G425 (= G419), M427 (= M421), D452 (= D446), N479 (= N473), H481 (≠ F475), L482 (= L476), M484 (= M478), V485 (= V479), W488 (= W482), H557 (≠ R544)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D281), R291 (= R282), W488 (= W482), S567 (≠ A554)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R151), G221 (= G210), G222 (= G211), G223 (= G212), T245 (= T236), L246 (= L237), M247 (= M238), L263 (= L254), G264 (= G255), M265 (= M256), H266 (= H257), G285 (= G276), R287 (= R278), D289 (= D280), R291 (= R282), D309 (= D300), I310 (= I301), G327 (= G318), D328 (= D319), V329 (≠ L320), M404 (= M398), G422 (= G416)
- binding magnesium ion: D452 (= D446), N479 (= N473), H481 (≠ F475)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V393), G400 (= G394), Q401 (= Q395), H402 (= H396), M427 (= M421), G451 (= G445), D452 (= D446), G453 (= G447), S454 (= S448), N479 (= N473), H481 (≠ F475), L482 (= L476), G483 (= G477), M484 (= M478), V485 (= V479)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 11:575/582 of 3e9yA
- active site: Y32 (= Y24), G34 (= G26), G35 (= G27), A36 (≠ T28), S37 (≠ V29), E58 (= E49), T81 (= T72), F120 (= F111), Q121 (= Q112), E122 (= E113), K170 (= K161), M265 (= M256), V292 (= V283), V399 (= V393), G425 (= G419), M427 (= M421), D452 (= D446), N479 (= N473), H481 (≠ F475), L482 (= L476), M484 (= M478), V485 (= V479), W488 (= W482), H557 (≠ R544)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D281), R291 (= R282), W488 (= W482), S567 (≠ A554)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R151), G221 (= G210), G222 (= G211), G223 (= G212), T245 (= T236), L246 (= L237), M247 (= M238), L263 (= L254), G285 (= G276), R287 (= R278), D289 (= D280), R291 (= R282), D309 (= D300), I310 (= I301), G327 (= G318), D328 (= D319), V329 (≠ L320), M404 (= M398), G422 (= G416)
- binding magnesium ion: D452 (= D446), N479 (= N473), H481 (≠ F475)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V393), G400 (= G394), Q401 (= Q395), H402 (= H396), M427 (= M421), G451 (= G445), G453 (= G447), S454 (= S448), N479 (= N473), H481 (≠ F475), L482 (= L476), G483 (= G477), M484 (= M478), V485 (= V479)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), G452 (= G445), D453 (= D446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ F475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), M266 (= M256), H267 (= H257), G286 (= G276), V287 (≠ A277), R288 (= R278), D290 (= D280), R292 (= R282), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416)
- binding magnesium ion: F370 (≠ Y363), D453 (= D446), M458 (= M451), Q461 (= Q454), N480 (= N473), H482 (≠ F475), K533 (≠ P519)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M256), R292 (= R282), M485 (= M478), W489 (= W482), S568 (≠ A554)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 5wj1A
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), M263 (= M253), L264 (= L254), G286 (= G276), R288 (= R278), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416), G424 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M256), D291 (= D281), R292 (= R282), M485 (= M478), W489 (= W482), S568 (≠ A554)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ F475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 5k6tA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H257), R292 (= R282), M485 (= M478), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), G286 (= G276), R288 (= R278), D290 (= D280), R292 (= R282), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), Q404 (= Q397), M405 (= M398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), G452 (= G445), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ F475), L483 (= L476), G484 (= G477)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 5k6rA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R282), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), M266 (= M256), G286 (= G276), R288 (= R278), R292 (= R282), V293 (= V283), D310 (= D300), I311 (= I301), G328 (= G318), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), M458 (= M451), N480 (= N473), H482 (≠ F475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 1z8nA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K125), R161 (= R151), Y191 (= Y181), R194 (vs. gap), D291 (= D281), R292 (= R282), D312 (= D302), W489 (= W482), G569 (= G555)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), G265 (= G255), M266 (= M256), H267 (= H257), G286 (= G276), V287 (≠ A277), R288 (= R278), D290 (= D280), R292 (= R282), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416), G424 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473)
- binding thiamine diphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), G452 (= G445), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ F475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 1yi1A
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D281), R292 (= R282), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), M263 (= M253), L264 (= L254), G265 (= G255), M266 (= M256), H267 (= H257), G286 (= G276), V287 (≠ A277), R288 (= R278), D290 (= D280), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416), G424 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 1yi0A
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D281), R292 (= R282), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), G265 (= G255), M266 (= M256), H267 (= H257), G286 (= G276), V287 (≠ A277), R288 (= R278), D290 (= D280), R292 (= R282), V293 (= V283), D310 (= D300), I311 (= I301), G328 (= G318), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416), G424 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 1yhzA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D281), R292 (= R282), M485 (= M478), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), M266 (= M256), H267 (= H257), G286 (= G276), V287 (≠ A277), R288 (= R278), D290 (= D280), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), Q404 (= Q397), M405 (= M398), G423 (= G416), G424 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 1yhyA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D281), R292 (= R282), V486 (= V479), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), G265 (= G255), M266 (= M256), H267 (= H257), G286 (= G276), V287 (≠ A277), R288 (= R278), D290 (= D280), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), Q404 (= Q397), M405 (= M398), G423 (= G416), G424 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 1ybhA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M256), D291 (= D281), R292 (= R282), M485 (= M478), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), M266 (= M256), H267 (= H257), G286 (= G276), V287 (≠ A277), R288 (= R278), D290 (= D280), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), Q404 (= Q397), M405 (= M398), G423 (= G416), G424 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
48% identity, 99% coverage: 3:562/565 of query aligns to 97:661/670 of P17597
- A122 (≠ T28) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ I30) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E49) binding
- S186 (= S91) binding
- P197 (= P102) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ P104) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q112) binding
- K220 (= K125) binding
- R246 (= R151) binding ; binding
- K256 (= K161) binding
- G308 (= G211) binding
- TL 331:332 (= TL 236:237) binding
- C340 (≠ K245) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 254:257) binding
- GVRFD 371:375 (≠ GARFD 276:280) binding
- DR 376:377 (= DR 281:282) binding
- DI 395:396 (= DI 300:301) binding
- DV 414:415 (≠ DL 319:320) binding
- QH 487:488 (= QH 395:396) binding
- GG 508:509 (= GG 416:417) binding
- GAM 511:513 (≠ GTM 419:421) binding
- D538 (= D446) binding
- DGS 538:540 (= DGS 446:448) binding
- N565 (= N473) binding
- NQHLGM 565:570 (≠ NNFLGM 473:478) binding
- H567 (≠ F475) binding
- W574 (= W482) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ A554) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/583 of 5k3sA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R282), M485 (= M478), W489 (= W482), G569 (= G555)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), M266 (= M256), G286 (= G276), R288 (= R278), D290 (= D280), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ F475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/585 of 5k2oA
- active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E49), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (= E113), K171 (= K161), M266 (= M256), V293 (= V283), V400 (= V393), G426 (= G419), M428 (= M421), D453 (= D446), N480 (= N473), H482 (≠ F475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (= W482), H558 (≠ R544)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M256), R292 (= R282), W489 (= W482), S568 (≠ A554)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), L264 (= L254), G286 (= G276), R288 (= R278), D290 (= D280), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), Q404 (= Q397), M405 (= M398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ F475)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), M428 (= M421), D453 (= D446), G454 (= G447), S455 (= S448), N480 (= N473), H482 (≠ F475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
48% identity, 99% coverage: 3:562/565 of query aligns to 12:576/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M256), R292 (= R282), W489 (= W482), S568 (≠ A554)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V393), G401 (= G394), Q402 (= Q395), H403 (= H396), G426 (= G419), M428 (= M421), G452 (= G445), D453 (= D446), G454 (= G447), S455 (= S448), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G210), G223 (= G211), G224 (= G212), T246 (= T236), L247 (= L237), M248 (= M238), M263 (= M253), L264 (= L254), M266 (= M256), H267 (= H257), G286 (= G276), R288 (= R278), V293 (= V283), D310 (= D300), I311 (= I301), D329 (= D319), V330 (≠ L320), M405 (= M398), G423 (= G416)
- binding magnesium ion: A37 (≠ T28), T82 (= T72), S83 (= S73), Q122 (= Q112), Y381 (≠ F374), D453 (= D446), M458 (= M451), Q461 (= Q454), N480 (= N473), H482 (≠ F475), K533 (≠ P519)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
46% identity, 99% coverage: 3:562/565 of query aligns to 94:658/667 of P09342
- C161 (≠ A69) modified: Disulfide link with 307
- P194 (= P102) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V213) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
47% identity, 99% coverage: 3:562/565 of query aligns to 91:655/664 of P09114
- P191 (= P102) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W482) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
49% identity, 99% coverage: 4:562/565 of query aligns to 9:574/596 of 1t9cA
- active site: Y29 (= Y24), G31 (= G26), G32 (= G27), A33 (≠ T28), I34 (≠ V29), E55 (= E49), T78 (= T72), F117 (= F111), Q118 (= Q112), E119 (= E113), K167 (= K161), R227 (≠ Q220), M263 (= M256), V290 (= V283), V406 (= V393), L431 (= L418), G432 (= G419), M434 (= M421), D459 (= D446), N486 (= N473), E488 (≠ F475), Q489 (≠ L476), M491 (= M478), V492 (= V479), W495 (= W482), L517 (= L505), G522 (= G510), L523 (≠ A511), K556 (≠ R544)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G27), V107 (= V101), P108 (= P102), F117 (= F111), K167 (= K161), D288 (= D281), R289 (= R282), W495 (= W482)
- binding flavin-adenine dinucleotide: R157 (= R151), G216 (= G210), A217 (≠ G211), G218 (= G212), N221 (≠ T214), T243 (= T236), L244 (= L237), Q245 (≠ M238), L261 (= L254), M263 (= M256), H264 (= H257), G283 (= G276), A284 (= A277), R285 (= R278), D287 (= D280), R289 (= R282), V290 (= V283), E316 (≠ D300), V317 (≠ I301), N321 (≠ S305), G334 (= G318), D335 (= D319), A336 (≠ L320), M411 (= M398), G429 (= G416), G430 (= G417)
- binding magnesium ion: D459 (= D446), N486 (= N473), E488 (≠ F475)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
49% identity, 99% coverage: 4:562/565 of query aligns to 9:574/596 of 1t9dA
- active site: Y29 (= Y24), G31 (= G26), G32 (= G27), A33 (≠ T28), I34 (≠ V29), E55 (= E49), T78 (= T72), F117 (= F111), Q118 (= Q112), E119 (= E113), K167 (= K161), R227 (≠ Q220), M263 (= M256), V290 (= V283), V406 (= V393), L431 (= L418), G432 (= G419), M434 (= M421), D459 (= D446), N486 (= N473), E488 (≠ F475), Q489 (≠ L476), M491 (= M478), V492 (= V479), W495 (= W482), L517 (= L505), G522 (= G510), L523 (≠ A511), K556 (≠ R544)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G27), A33 (≠ T28), V107 (= V101), P108 (= P102), F117 (= F111), K167 (= K161), M263 (= M256), D288 (= D281), R289 (= R282), W495 (= W482)
- binding flavin-adenine dinucleotide: R157 (= R151), G216 (= G210), A217 (≠ G211), G218 (= G212), N221 (≠ T214), T243 (= T236), L244 (= L237), Q245 (≠ M238), M260 (= M253), L261 (= L254), H264 (= H257), G283 (= G276), A284 (= A277), R285 (= R278), D287 (= D280), R289 (= R282), V290 (= V283), E316 (≠ D300), V317 (≠ I301), N321 (≠ S305), G334 (= G318), D335 (= D319), A336 (≠ L320), Q410 (= Q397), M411 (= M398), G429 (= G416), G430 (= G417)
- binding magnesium ion: D459 (= D446), N486 (= N473), E488 (≠ F475)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E49), P81 (= P75), Q118 (= Q112), G432 (= G419), M434 (= M421), M464 (= M451)
Query Sequence
>WP_092053014.1 NCBI__GCF_900111775.1:WP_092053014.1
MKKTGSQILLECLRLEGVDTIFGYPGGTVINIYDDLMDSPIKHILTRHEQAAVHAADGYA
RASGKVGVAIATSGPGATNTITGIATAYMDSIPMVIITGQVPTPLIGNDAFQEADVIGIT
RPITKHNYLVKNVNDLARIIKQAFYIARTGRPGPVLVDLPKDVQVATAEFEYPETVELRG
YKPTYSGNVRQIENAAKMIMAARKPVLYVGGGVTLSNTSQELMQLAELIQAPVTTTLMAM
ASFPKKHPLSLGMLGMHGTYYANMAVTNSDLLISVGARFDDRVTGKIATFAPHAKIIHID
IDPTSIKKNVRVDLPIVGDLKDVLKKLVSKLGERKEEIPALVEATEGWRQEINGWKTQHP
MSYKASKTIIKPQFVIEKLRELTRDDAIITTEVGQHQMWTAQFFDFSQPRTFLSSGGLGT
MGYGLPSALGAQAAFRERQVIDISGDGSFQMNSQELATLVQYRLPVKIVILNNNFLGMVR
QWQHLFFHNRYSQTCMELPIDFVKLAEAYGATGLRATKPEEVEEVIRKALETPGPVIMEF
KISREENVMPMVPAGAGLNEMVLAS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory