SitesBLAST
Comparing WP_092056124.1 NCBI__GCF_900111775.1:WP_092056124.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4yi7A Anthranilate bound at active site of anthranilate phosphoribosyl transferase from acinetobacter (anprt; trpd)
43% identity, 99% coverage: 2:347/349 of query aligns to 4:326/331 of 4yi7A
1kgzB Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora (current name, pectobacterium carotovorum) (see paper)
39% identity, 97% coverage: 6:344/349 of query aligns to 6:328/330 of 1kgzB
- binding manganese (ii) ion: S92 (= S105), D222 (= D238), E223 (= E239), E223 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V79 (= V92), G82 (= G95), G83 (= G96), N90 (= N103), I91 (= I104), S92 (= S105), T93 (= T106), K108 (= K121), S118 (= S133)
5nofA Anthranilate phosphoribosyltransferase from thermococcus kodakaraensis (see paper)
40% identity, 98% coverage: 6:348/349 of query aligns to 4:324/325 of 5nofA
4zokA Methylsulfonyl-containing inhibitor bound in the substrate capture site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
45% identity, 95% coverage: 6:336/349 of query aligns to 7:329/342 of 4zokA
- active site: V82 (= V92)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfonyl)phenyl]amino}benzoic acid: P156 (= P166), R163 (≠ K173), A166 (≠ I176), A167 (≠ G177)
- binding magnesium ion: S95 (= S105), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), A116 (≠ S126), A117 (≠ V127), S119 (= S129), G122 (= G132)
4zojA Methylsulfanyl-containing inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
45% identity, 95% coverage: 6:336/349 of query aligns to 7:328/341 of 4zojA
- active site: V82 (= V92)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfanyl)phenyl]amino}benzoic acid: N114 (= N124), A155 (= A165), P156 (= P166), H159 (= H169), Y162 (≠ M172), R169 (= R179), G182 (= G192)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G93), G85 (= G95), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), R115 (= R125), A116 (≠ S126), A117 (≠ V127), S119 (= S129)
4zofA Lobenzarit-like inhibitor bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
45% identity, 95% coverage: 6:336/349 of query aligns to 7:329/342 of 4zofA
- active site: V82 (= V92)
- binding 2-[(2-carboxy-5-nitrophenyl)amino]-3-methylbenzoic acid: G113 (= G123), N114 (= N124), A155 (= A165), H159 (= H169), Y162 (≠ M172), R169 (= R179), G182 (= G192)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G93), G85 (= G95), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), A116 (≠ S126), A117 (≠ V127), S119 (= S129), G122 (= G132)
3r88B Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs145) (see paper)
45% identity, 95% coverage: 6:336/349 of query aligns to 7:330/344 of 3r88B
- active site: V82 (= V92)
- binding 2-amino-4,5-dimethoxybenzoic acid: N114 (= N124), A155 (= A165), P156 (= P166), H159 (= H169), Y162 (≠ M172), R163 (≠ K173), A166 (≠ I176)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V82 (= V92), G83 (= G93), G85 (= G95), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), N114 (= N124), A117 (≠ V127), S118 (= S128), S119 (= S129)
5c1rA Stereoisomer of prpp bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyl (anprt; trpd)
45% identity, 95% coverage: 6:336/349 of query aligns to 7:330/343 of 5c1rA
- active site: V82 (= V92)
- binding 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose: V82 (= V92), G83 (= G93), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), R115 (= R125), A117 (≠ V127), S118 (= S128), S119 (= S129)
- binding magnesium ion: D87 (= D97), V89 (≠ T99), S95 (= S105), E228 (= E239)
4n5vA Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
45% identity, 95% coverage: 6:336/349 of query aligns to 9:333/347 of 4n5vA
- active site: V84 (= V92)
- binding 2-amino-4-fluorobenzoic acid: V84 (= V92), G85 (= G93), H114 (= H122), G115 (= G123), N116 (= N124), A157 (= A165), A157 (= A165), P158 (= P166), H161 (= H169), Y164 (≠ M172), R165 (≠ K173), A168 (≠ I176), R171 (= R179), G184 (= G192)
- binding magnesium ion: S97 (= S105), D229 (= D238), E230 (= E239), E230 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G85 (= G93), G87 (= G95), G88 (= G96), N95 (= N103), S97 (= S105), T98 (= T106), K113 (= K121), A119 (≠ V127), S120 (= S128), S121 (= S129), G124 (= G132)
4n93A Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
45% identity, 95% coverage: 6:336/349 of query aligns to 8:332/346 of 4n93A
- active site: V83 (= V92)
- binding 2-amino-6-methylbenzoic acid: V83 (= V92), G84 (= G93), T85 (= T94), H113 (= H122), N115 (= N124), N115 (= N124), A156 (= A165), P157 (= P166), H160 (= H169), Y163 (≠ M172), A167 (≠ I176), R170 (= R179), G183 (= G192), P184 (= P193)
- binding magnesium ion: S96 (= S105), D228 (= D238), E229 (= E239), E229 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G93), G86 (= G95), G87 (= G96), N94 (= N103), S96 (= S105), T97 (= T106), K112 (= K121), A117 (≠ S126), A118 (≠ V127), S120 (= S129), G123 (= G132)
P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
44% identity, 95% coverage: 6:336/349 of query aligns to 31:356/370 of P9WFX5
- G107 (= G93) binding
- T115 (= T101) binding
- G147 (≠ S133) binding
4owoA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 6-fluoroanthranilate, prpp and magnesium (see paper)
44% identity, 95% coverage: 6:336/349 of query aligns to 9:334/348 of 4owoA
- active site: V84 (= V92)
- binding 2-azanyl-6-fluoranyl-benzoic acid: V84 (= V92), G85 (= G93), T86 (= T94), H114 (= H122), N116 (= N124), N116 (= N124), A157 (= A165), P158 (= P166), H161 (= H169), Y164 (≠ M172), A168 (≠ I176), R171 (= R179), G184 (= G192)
- binding magnesium ion: S97 (= S105), D229 (= D238), E230 (= E239), E230 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V84 (= V92), G85 (= G93), G87 (= G95), G88 (= G96), N95 (= N103), S97 (= S105), T98 (= T106), K113 (= K121), A118 (≠ S126), A119 (≠ V127), S120 (= S128), S121 (= S129), G124 (= G132)
4giuA Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (anprt; trpd). (see paper)
44% identity, 95% coverage: 6:336/349 of query aligns to 8:333/346 of 4giuA
- active site: V83 (= V92)
- binding 2-[(2-carboxy-5-methylphenyl)amino]-3-methylbenzoic acid: G114 (= G123), N115 (= N124), A156 (= A165), H160 (= H169), Y163 (≠ M172), R170 (= R179), G183 (= G192)
- binding magnesium ion: S96 (= S105), D228 (= D238), E229 (= E239), E229 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G93), G86 (= G95), G87 (= G96), N94 (= N103), S96 (= S105), T97 (= T106), K112 (= K121), N115 (= N124), A117 (≠ S126), A118 (≠ V127), S119 (= S128), S120 (= S129), G123 (= G132)
5c7sA Prpp complexed with two mn2+ in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
44% identity, 95% coverage: 6:336/349 of query aligns to 8:331/344 of 5c7sA
- active site: V83 (= V92)
- binding manganese (ii) ion: G84 (= G93), S96 (= S105), D228 (= D238), E229 (= E239), E229 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V83 (= V92), G84 (= G93), G86 (= G95), G87 (= G96), N94 (= N103), S96 (= S105), T97 (= T106), K112 (= K121), N115 (= N124), S120 (= S129)
4owmA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-fluoroanthranilate, prpp and magnesium (see paper)
44% identity, 95% coverage: 6:336/349 of query aligns to 7:332/346 of 4owmA
- active site: V82 (= V92)
- binding 2-azanyl-3-fluoranyl-benzoic acid: P156 (= P166), H159 (= H169), Y162 (≠ M172), R163 (≠ K173), A166 (≠ I176), R170 (≠ K180)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G93), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), A117 (≠ V127), S118 (= S128), S119 (= S129), G122 (= G132)
4gkmA Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (anprt; trpd) (see paper)
44% identity, 95% coverage: 6:336/349 of query aligns to 7:332/346 of 4gkmA
- active site: V82 (= V92)
- binding 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid: N114 (= N124), A155 (= A165), P156 (= P166), Y162 (≠ M172), R163 (≠ K173), A166 (≠ I176), R169 (= R179), R170 (≠ K180)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), A117 (≠ V127), S118 (= S128), S119 (= S129), G122 (= G132)
3r6cA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs179) (see paper)
44% identity, 95% coverage: 6:336/349 of query aligns to 7:332/346 of 3r6cA
- active site: V82 (= V92)
- binding 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid: M62 (= M61), N114 (= N124), A155 (= A165), P156 (= P166), H159 (= H169), Y162 (≠ M172), A166 (≠ I176), R169 (= R179), G182 (= G192), T185 (= T195), R239 (≠ E250), A241 (≠ R252), D246 (≠ K257), V301 (= V312), A310 (= A317), W312 (≠ D319)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G93), G85 (= G95), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), N114 (= N124), R115 (= R125), A116 (≠ S126), A117 (≠ V127), S118 (= S128), S119 (= S129), G122 (= G132), G123 (≠ S133)
3qsaA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor tamu-a7)
44% identity, 95% coverage: 6:336/349 of query aligns to 7:332/346 of 3qsaA
- active site: V82 (= V92)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G93), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), A117 (≠ V127), S118 (= S128), S119 (= S129), G122 (= G132)
- binding 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione: M62 (= M61), N114 (= N124), A155 (= A165), P156 (= P166), H159 (= H169), Y162 (≠ M172), R163 (≠ K173), A166 (≠ I176), G182 (= G192)
3qs8A Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs174) (see paper)
44% identity, 95% coverage: 6:336/349 of query aligns to 7:332/346 of 3qs8A
- active site: V82 (= V92)
- binding 2-benzylbenzoic acid: M62 (= M61), G83 (= G93), N114 (= N124), N114 (= N124), A155 (= A165), A155 (= A165), P156 (= P166), Y162 (≠ M172), Y162 (≠ M172), A166 (≠ I176), R169 (= R179), R169 (= R179), R170 (≠ K180), L181 (= L191), G182 (= G192)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G93), G85 (= G95), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), N114 (= N124), A116 (≠ S126), A117 (≠ V127), S118 (= S128), S119 (= S129), G122 (= G132), E228 (= E239)
3qqsA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs172) (see paper)
44% identity, 95% coverage: 6:336/349 of query aligns to 7:332/346 of 3qqsA
- active site: V82 (= V92)
- binding 2,2'-iminodibenzoic acid: P156 (= P166), H159 (= H169), Y162 (≠ M172), R163 (≠ K173), A166 (≠ I176), R169 (= R179), R170 (≠ K180)
- binding magnesium ion: S95 (= S105), D227 (= D238), E228 (= E239), E228 (= E239)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V82 (= V92), G85 (= G95), G86 (= G96), N93 (= N103), S95 (= S105), T96 (= T106), K111 (= K121), R115 (= R125), A117 (≠ V127), S118 (= S128), S119 (= S129), G122 (= G132)
Query Sequence
>WP_092056124.1 NCBI__GCF_900111775.1:WP_092056124.1
MIKAAIAKIVERKDLTETEMIAVMDQIMGGEATPAQIAAFITALRMKGETVDEITGAARV
MRDRATPIRVGKVLDIDREDINLDQETILDVVGTGGDGTNTFNISTTVSFVVAACGVKVA
KHGNRSVSSLCGSADVLEKLGVNLDVTPEKVEECIRELGIGFLFAPALHGAMKYAIGPRK
EVGIRTIFNILGPLTNPAGADCQVLGVYQEALVEPLAQVLARLGCRRGFVVYGMDGMDEI
TLTGPTRVAEIRDGKVKVFTIEPEDFGLSRCPMSALQGGNAVGNAEIVRSVLQGETSPRR
DVVLLNAAYALVAAGAAEDIPAGLALAREAIDEGRALAKVDALAGMTNE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory