SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_092056230.1 NCBI__GCF_900111775.1:WP_092056230.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
45% identity, 91% coverage: 8:217/230 of query aligns to 7:215/330 of P9WQK5

query
sites
P9WQK5

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K65 (= K66) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
41% identity, 96% coverage: 8:227/230 of query aligns to 5:228/232 of 1f3oA

query
sites
1f3oA

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binding adenosine-5'-diphosphate: Y11 (= Y14), G41 (= G44), G43 (= G46), K44 (= K47), S45 (≠ T48), T46 (= T49)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
41% identity, 96% coverage: 8:227/230 of query aligns to 5:228/230 of 1l2tA

query
sites
1l2tA

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binding adenosine-5'-triphosphate: Y11 (= Y14), S40 (= S43), G41 (= G44), S42 (= S45), G43 (= G46), K44 (= K47), S45 (≠ T48), T46 (= T49), F138 (vs. gap), Q145 (≠ D144), S147 (= S146), G149 (= G148), Q150 (= Q149), H204 (= H203)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
37% identity, 95% coverage: 10:228/230 of query aligns to 9:226/592 of 5lj7A

query
sites
5lj7A

L

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binding adenosine-5'-triphosphate: V22 (≠ A23), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (≠ T48), T48 (= T49), Q92 (= Q93), K136 (≠ R137), Q143 (≠ D144), S145 (= S146), G147 (= G148), Q148 (= Q149)
binding magnesium ion: S47 (≠ T48), Q92 (= Q93)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
37% identity, 95% coverage: 10:228/230 of query aligns to 9:226/615 of 5lilA

query
sites
5lilA

L

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binding adenosine-5'-triphosphate: F13 (≠ Y14), V22 (≠ A23), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (≠ T48), T48 (= T49), Q92 (= Q93), K136 (≠ R137), Q143 (≠ D144), S145 (= S146), G147 (= G148), Q148 (= Q149)
binding magnesium ion: S47 (≠ T48), Q92 (= Q93)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
39% identity, 92% coverage: 12:222/230 of query aligns to 11:220/226 of 5xu1B

query
sites
5xu1B

K

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Y

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V

F

F

Q

Q

G

Q

F

F

N

F

L

L

F

L

P

S

A

K

L

L

T

N

V

A

Y

L

E

Q

N

N

I

V

M

E

L

L

V

P

L

L

K

I

I

Y

K

A

G

G

L

V

T

S

G

S

R

S

A

K

A

R

E

R

D

K

L

L

A

A

R

E

G

E

M

Y

I

L

A

D

E

K

V

V

G

E

L

L

N

T

E

E

R

R

A

S

D

H

F

H

L

L

P

P

R

S

D

E

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

A

V

V

N

E

N

S

P

P

S

L

I

I

I

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

A

L

L

D

D

H

T

V

K

N

T

G

G

K

N

K

Q

V

I

M

M

E

Q

I

L

L

L

R

V

A

D

L

L

A

N

V

K

E

E

Q

-

K

G

K

K

C

T

V

I

V

I

V

M

A

V

T

T

H

H

D

E

N

P

R

E

I

I

E

A

D

A

I

Y

F

A

D

K

R

R

I

Q

L

I

T

V

M

I

E

R

D

D

G

G

R

V

I

I

binding magnesium ion: G45 (= G46), K46 (= K47), S47 (≠ T48)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
41% identity, 88% coverage: 27:228/230 of query aligns to 22:222/223 of 2pclA

query
sites
2pclA

V

I

D

S

L

L

Q

S

L

V

K

K

A

K

G

G

E

E

V

F

V

V

G

S

L

I

F

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

T

S

T

T

L

L

L

L

S

Y

M

I

L

L

G

G

C

L

I

L

L

D

K

A

P

P

T

T

A

E

G

G

S

K

F

V

K

F

L

L

F

E

G

G

H

K

E

E

I

V

F

D

G

Y

L

T

R

N

E

E

K

K

D

E

L

L

P

S

P

L

L

L

R

R

K

N

R

R

Y

K

I

L

S

G

Y

F

I

V

F

F

Q

Q

G

F

F

H

N

Y

L

L

F

I

P

P

A

E

L

L

T

T

V

A

Y

L

E

E

N

N

I

V

M

I

L

V

V

P

L

M

K

L

I

K

K

M

G

G

L

K

T

P

G

K

R

K

A

E

A

A

E

K

D

E

L

R

A

G

R

E

G

Y

M

L

I

L

A

S

E

E

V

L

G

G

L

L

N

G

E

D

R

K

A

L

D

S

F

R

L

K

P

P

R

Y

D

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

A

A

V

N

E

E

S

P

P

I

L

L

I

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

A

G

N

N

L

L

D

D

H

S

V

A

N

N

G

T

K

K

K

R

V

V

M

M

E

D

I

I

L

F

R

L

A

K

L

I

A

N

V

-

E

E

Q

G

K

G

K

T

C

S

V

I

V

V

V

M

A

V

T
|
T

H

H

D

E

N

R

R

E

I

L

E

A

D

E

I

L

F

T

D

H

R

R

I

T

L

L

T

E

M

M

E

K

D

D

G

G

R

K

I

V

V

V

D

G

E

E

R

I

Q

T

R

R

binding magnesium ion: E165 (= E170), P166 (= P171), T167 (= T172), T196 (= T202)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
37% identity, 94% coverage: 10:226/230 of query aligns to 10:225/650 of 5ws4A

query
sites
5ws4A

L

L

G

V

K

R

T

E

Y

F

Q

P

E

A

G

G

K

E

T

S

V

T

V

I

R

Q

A

I

V

L

V

K

D

G

V

I

D

D

L

L

Q

T

L

I

K

Y

A

E

G

G

E

E

V

L

V

V

G

A

L

I

F

V

G

G

P

Q

S
|
S

G
|
G

S

S

G

G

K

K

T
x
S

T

T

L

L

L

M

S

N

M

I

L

L

G

G

C

C

I

L

L

D

K

R

P

P

T

T

A

S

G

G

S

S

F

Y

K

K

L

V

F

N

G

G

H

Q

E

E

I

T

F

G

G

K

L

L

R

E

E

P

K

D

D

Q

L

L

P

A

P

Q

L

L

R

R

K

R

R

E

Y

Y

I

F

S

G

Y

F

I

I

F

F

Q

Q

G

R

F

Y

N

H

L

L

F

L

P

G

A

D

L

L

T

S

V

A

Y

E

E

G

N

N

I

V

M

E

L

V

V

P

L

A

K

V

I

Y

K

A

G

G

L

V

T

T

G

P

R

A

A

D

A

R

E

K

D

Q

L

R

A

A

R

T

G

A

M

L

I

L

A

T

E

E

V

L

G

G

L

L

N

G

E

T

R

K

A

T

D

Q

F

N

L

R

P

P

R

S

D

Q

L

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

A

M

V

N

E

G

S

G

P

D

L

V

I

I

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

A

L

L

D

D

H

S

V

H

N

S

G

G

K

V

K

E

V

V

M

M

E

R

I

I

L

L

R

R

A

E

L

L

A

N

V

A

E

A

Q

G

K

H

K

T

C

I

V

I

V

L

V

V

A

-

T

T

H

H

D

D

N

M

R

Q

I

V

E

A

D

K

I

N

F

A

D

T

R

R

I

I

L

I

T

E

M

I

E

S

D

D

G

G

R

E

I

I

V

I

D

S

E

D

R

R

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S43), G44 (= G44), S48 (≠ T48)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
36% identity, 92% coverage: 12:223/230 of query aligns to 12:222/648 of P75831

query
sites
P75831

K

R

T

S

Y

Y

Q

P

E

A

G

G

K

D

T

E

V

Q

V

V

R

E

A

V

V

L

V

K

D

G

V

I

D

S

L

L

Q

D

L

I

K

Y

A

A

G

G

E

E

V

M

V

V

G

A

L

I

F

V

G

G

P

A

S

S

G

G

S

S

G

G

K
|
K

T

S

T

T

L

L

L

M

S

N

M

I

L

L

G

G

C

C

I

L

L

D

K

K

P

A

T

T

A

S

G

G

S

T

F

Y

K

R

L

V

F

A

G

G

H

Q

E

D

I

V

F

A

G

T

L

L

R

D

E

A

K

D

D

A

L

L

P

A

P

Q

L

L

R

R

K

R

R

E

Y

H

I

F

S

G

Y

F

I

I

F

F

Q

Q

G

R

F

Y

N

H

L

L

F

L

P

S

A

H

L

L

T

T

V

A

Y

E

E

Q

N

N

I

V

M

E

L

V

V

P

L

A

K

V

I

Y

K

A

G

G

L

L

T

E

G

R

R

K

A

Q

A

R

E

L

D

L

L

R

A

A

R

Q

G

E

M

L

I

L

A

Q

E

R

V

L

G

G

L

L

N

E

E

D

R

R

A

T

D

E

F

Y

L

Y

P

P

R

A

D

Q

L

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

S

V

I

A

A

R

R

A

A

L

L

A

M

V

N

E

G

S

G

P

Q

L

V

I

I

L

L

A

A

D
|
D

E

E

P

P

T

T

A

G

N

A

L

L

D

D

H

S

V

H

N

S

G

G

K

E

K

E

V

V

M

M

E

A

I

I

L

L

R

H

A

Q

L

L

A

R

V

-

E

D

Q

R

K

G

K

H

C

T

V

V

V

I

V

I

A

V

T

T

H

H

D

D

N

P

R

Q

I

V

E

A

D

A

I

Q

F

A

D

E

R

R

I

V

L

I

T

E

M

I

E

R

D

D

G

G

R

E

I

I

V

V

K47 (= K47) mutation to L: Lack of activity.
D169 (= D169) mutation to N: Lack of activity.

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
42% identity, 87% coverage: 27:225/230 of query aligns to 20:217/240 of 4ymuJ

query
sites
4ymuJ

V

V

D

T

L

L

Q

K

L

V

K

N

A

K

G

G

E

E

V

V

V

V

G

V

L

I

F

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

L

S

R

M

C

L

I

G

N

C

L

I

L

L

E

K

E

P

P

T

T

A

K

G

G

S

E

F

V

K

F

L

I

F

D

G

G

H

V

E

K

I

I

F

N

G

N

L

G

R

K

E

-

K

V

D

N

L

I

P

N

P

K

L

V

R

R

K

Q

R

K

Y

-

I

V

S

G

Y

M

I

V

F

F

Q

Q

G

H

F

F

N

N

L

L

F

F

P

P

A

H

L

L

T

T

V

A

Y

I

E

E

N

N

I

I

M

T

L

L

V

A

-

P

L

V

K

K

I

V

K

K

G

K

L

M

T

N

G

K

R

K

A

E

A

A

E

E

D

E

L

L

A

A

R

V

G

D

M

L

I

L

A

A

E

K

V

V

G

G

L

L

N

L

E

D

R

K

A

K

D

D

F

Q

L

Y

P

P

R

I

D

K

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

L

A

A

V

I

A

A

R

R

A

A

L

L

A

A

V

M

E

Q

S

P

P

E

L

V

I

M

L

L

A

F

D

D

E
|
E

P

P

T

T

A

S

N

A

L

L

D

D

H

P

V

E

N

M

G

V

K

K

K

E

V

V

M

L

E

N

I

V

L

M

R

K

A

Q

L

L

A

A

V

N

E

E

Q

G

K

M

K

T

C

M

V

V

V

V

V

V

A

T

T
x
H

H

E

D

M

N

G

R

F

I

A

E

R

D

E

I

V

F

G

D

D

R

R

I

V

L

I

T

F

M

M

E

D

D

D

G

G

R

V

I

I

V

V

D

E

E

E

binding adenosine-5'-triphosphate: S36 (= S43), G37 (= G44), S38 (= S45), G39 (= G46), K40 (= K47), S41 (≠ T48), T42 (= T49), E162 (= E170), H194 (≠ T202)
binding magnesium ion: S41 (≠ T48), E162 (= E170)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11, 16

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
38% identity, 94% coverage: 10:225/230 of query aligns to 11:226/233 of P75957

query
sites
P75957

L

L

G

C

K

K

T

R

Y

Y

Q

Q

E

E

G

G

K

S

T

V

V

Q

V

T

R

D

A

V

V

L

V

H

D

N

V

V

D

S

L

F

Q

S

L

V

K

G

A

E

G

G

E

E

V

M

V

M

G

A

L

I

F

V

G
|
G

P

S

S

S

G

G

S

S

G

G

K

K

T

S

T

T

L

L

L

L

S

H

M

L

L

L

G

G

C

G

I

L

L

D

K

T

P

P

T

T

A

S

G

G

S

D

F

V

K

I

L

F

F

N

G

G

H

Q

E

P

I

M

F

S

G

K

L

L

R

S

E

S

K

A

D

A

L

K

P

A

P

E

L

L

R

R

K

N

R

Q

Y

K

I

L

S

G

Y

F

I

I

F

Y

Q

Q

G

F

F

H

N

H

L

L

F

L

P

P

A

D

L

F

T

T

V

A

Y

L

E

E

N

N

I

V

M

A

L

M

V

P

L

L

K

L

I

I

K

G

G

K

L

K

T

K

G

P

R

A

A

E

A

I

E

N

D

S

L

R

A

A

R

L

G

E

M

M

I

L

A

K

E

A

V

V

G

G

L

L

N

D

E

H

R

R

A

A

D

N

F

H

L

R

P

P

R

S

D

E

L

L

S

S

G

G

G

G

Q

E

K

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

A

V

V

N

E

N

S

P

P

R

L

L

I

V

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

H

A

V

R

N

N

G

A

K

D

K

S

V

I

M

F

E

Q

I

L

L

L

R

G

A

E

L

L

A

N

V

R

E

L

Q

Q

K

G

K

T

C

A

V

F

V

L

V

V

A

V

T

T

H

H

D

D

N

L

R

Q

I

L

E

A

D

K

I

R

F

M

D

S

R

R

I

Q

L

L

T

E

M

M

E

R

D

D

G

G

R

R

I

L

V

T

D

A

E

E

G42 (= G41) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
38% identity, 94% coverage: 10:225/230 of query aligns to 8:223/226 of 7mdyC

query
sites
7mdyC

L

L

G

C

K

K

T

R

Y
|
Y

Q

Q

E

E

G

G

K

S

T

V

V

Q

V

T

R

D

A

V

V

L

V

H

D

N

V

V

D

S

L

F

Q

S

L

V

K

G

A

E

G

G

E

E

V

M

V

M

G

A

L

I

F

V

G

G

P

S

S

S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

L

S

H

M

L

L

L

G

G

C

G

I

L

L

D

K

T

P

P

T

T

A

S

G

G

S

D

F

V

K

I

L

F

F

N

G

G

H

Q

E

P

I

M

F

S

G

K

L

L

R

S

E

S

K

A

D

A

L

K

P

A

P

E

L

L

R

R

K

N

R

Q

Y

K

I

L

S

G

Y

F

I

I

F

Y

Q
|
Q

G

F

F

H

N

H

L

L

F

L

P

P

A

D

L

F

T

T

V

A

Y

L

E

E

N

N

I

V

M

A

L

M

V

P

L

L

K

L

I

I

K

G

G

K

L

K

T

K

G

P

R

A

A

E

A

I

E

N

D

S

L

R

A

A

R

L

G

E

M

M

I

L

A

K

E

A

V

V

G

G

L

L

N

D

E

H

R

R

A

A

D

N

F
x
H

L

R

P

P

R

S

D
x
E

L

L

S
|
S

G
|
G

G
|
G

Q

E

K

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

A

V

V

N

E

N

S

P

P

R

L

L

I

V

L

L

A

A

D

D

E
|
E

P

P

T

T

A

G

N
|
N

L

L

D

D

H

A

V

R

N

N

G

A

K

D

K

S

V

I

M

F

E

Q

I

L

L

L

R

G

A

E

L

L

A

N

V

R

E

L

Q

Q

K

G

K

T

C

A

V

F

V

L

V

V

A

V

T

T

H
|
H

D

D

N

L

R

Q

I

L

E

A

D

K

I

R

F

M

D

S

R

R

I

Q

L

L

T

E

M

M

E

R

D

D

G

G

R

R

I

L

V

T

D

A

E

E

binding adp orthovanadate: Y12 (= Y14), G42 (= G44), S43 (= S45), G44 (= G46), K45 (= K47), S46 (≠ T48), T47 (= T49), Q91 (= Q93), H138 (≠ F140), E142 (≠ D144), S144 (= S146), G145 (= G147), G146 (= G148), E168 (= E170), N172 (= N174), H201 (= H203)
binding magnesium ion: S46 (≠ T48), Q91 (= Q93)

9gvkD Cryo-em structure of endogenous atp-bound lolcde with lold-e171q mutations in nanodiscs (see paper)
37% identity, 94% coverage: 10:225/230 of query aligns to 9:224/226 of 9gvkD

query
sites
9gvkD

L

L

G

C

K

K

T

R

Y
|
Y

Q

Q

E

E

G

G

K

S

T

V

V

Q

V

T

R

D

A

V

V

L

V

H

D

N

V

V

D

S

L

F

Q

S

L

V

K

G

A

E

G

G

E

E

V

M

V

M

G

A

L

I

F

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

L

S

H

M

L

L

L

G

G

C

G

I

L

L

D

K

T

P

P

T

T

A

S

G

G

S

D

F

V

K

I

L

F

F

N

G

G

H

Q

E

P

I

M

F

S

G

K

L

L

R

S

E

S

K

A

D

A

L

K

P

A

P

E

L

L

R

R

K

N

R

Q

Y

K

I

L

S

G

Y

F

I

I

F

Y

Q
|
Q

G

F

F

H

N

H

L

L

F

L

P

P

A

D

L

F

T

T

V

A

Y

L

E

E

N

N

I

V

M

A

L

M

V

P

L

L

K

L

I

I

K

G

G

K

L

K

T

K

G

P

R

A

A

E

A

I

E

N

D

S

L

R

A

A

R

L

G

E

M

M

I

L

A

K

E

A

V

V

G

G

L

L

N

D

E

H

R
|
R

A

A

D

N

F
x
H

L

R

P

P

R

S

D
x
E

L

L

S
|
S

G
|
G

G
|
G

Q
x
E

K

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

A

V

V

N

E

N

S

P

P

R

L

L

I

V

L

L

A

A

D

D

E

Q

P

P

T

T

A

G

N

N

L

L

D

D

H

A

V

R

N

N

G

A

K

D

K

S

V

I

M

F

E

Q

I

L

L

L

R

G

A

E

L

L

A

N

V

R

E

L

Q

Q

K

G

K

T

C

A

V

F

V

L

V

V

A

V

T

T

H

H

D

D

N

L

R

Q

I

L

E

A

D

K

I

R

F

M

D

S

R

R

I

Q

L

L

T

E

M

M

E

R

D

D

G

G

R

R

I

L

V

T

D

A

E

E

binding adenosine-5'-triphosphate: Y13 (= Y14), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (≠ T48), T48 (= T49), Q92 (= Q93), R136 (= R137), H139 (≠ F140), E143 (≠ D144), S145 (= S146), G146 (= G147), G147 (= G148), E148 (≠ Q149)
binding magnesium ion: S47 (≠ T48), Q92 (= Q93)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
37% identity, 93% coverage: 10:223/230 of query aligns to 8:221/222 of 7arlD

query
sites
7arlD

L

L

G

C

K

K

T

R

Y

Y

Q

Q

E

E

G

G

K

S

T

V

V

Q

V

T

R

D

A

V

V

L

V

H

D

N

V

V

D

S

L

F

Q

S

L

V

K

G

A

E

G

G

E

E

V

M

V

M

G

A

L

I

F

V

G

G

P

S

S

S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T

T

L

L

L

L

S

H

M

L

L

L

G

G

C

G

I

L

L

D

K

T

P

P

T

T

A

S

G

G

S

D

F

V

K

I

L

F

F

N

G

G

H

Q

E

P

I

M

F

S

G

K

L

L

R

S

E

S

K

A

D

A

L

K

P

A

P

E

L

L

R

R

K

N

R

Q

Y

K

I

L

S

G

Y

F

I

I

F

Y

Q

Q

G

F

F

H

N

H

L

L

F

L

P

P

A

D

L

F

T

T

V

A

Y

L

E

E

N

N

I

V

M

A

L

M

V

P

L

L

K

L

I

I

K

G

G

K

L

K

T

K

G

P

R

A

A

E

A

I

E

N

D

S

L

R

A

A

R

L

G

E

M

M

I

L

A

K

E

A

V

V

G

G

L

L

N

D

E

H

R

R

A

A

D

N

F

H

L

R

P

P

R

S

D

E

L

L

S

S

G

G

G

G

Q

E

K

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

A

V

V

N

E

N

S

P

P

R

L

L

I

V

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

H

A

V

R

N

N

G

A

K

D

K

S

V

I

M

F

E

Q

I

L

L

L

R

G

A

E

L

L

A

N

V

R

E

L

Q

Q

K

G

K

T

C

A

V

F

V

L

V

V

A

V

T

T

H

H

D

D

N

L

R

Q

I

L

E

A

D

K

I

R

F

M

D

S

R

R

I

Q

L

L

T

E

M

M

E

R

D

D

G

G

R

R

I

L

V

T

binding adenosine-5'-diphosphate: G42 (= G44), G44 (= G46), K45 (= K47), S46 (≠ T48)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
37% identity, 94% coverage: 10:225/230 of query aligns to 10:225/229 of 7v8iD

query
sites
7v8iD

L

L

G

C

K

K

T

R

Y

Y

Q

Q

E

E

G

G

K

S

T

V

V

Q

V

T

R

D

A
x
V

V

L

V

H

D

N

V

V

D

S

L

F

Q

S

L

V

K

G

A

E

G

G

E

E

V

M

V

M

G

A

L

I

F

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

L

S

H

M

L

L

L

G

G

C

G

I

L

L

D

K

T

P

P

T

T

A

S

G

G

S

D

F

V

K

I

L

F

F

N

G

G

H

Q

E

P

I

M

F

S

G

K

L

L

R

S

E

S

K

A

D

A

L

K

P

A

P

E

L

L

R

R

K

N

R

Q

Y

K

I

L

S

G

Y

F

I

I

F

Y

Q
|
Q

G

F

F

H

N

H

L

L

F

L

P

P

A

D

L

F

T

T

V

A

Y

L

E

E

N

N

I

V

M

A

L

M

V

P

L

L

K

L

I

I

K

G

G

K

L

K

T

K

G

P

R

A

A

E

A

I

E

N

D

S

L

R

A

A

R

L

G

E

M

M

I

L

A

K

E

A

V

V

G

G

L

L

N

D

E

H

R
|
R

A

A

D

N

F
x
H

L

R

P

P

R

S

D
x
E

L

L

S
|
S

G

G

G
|
G

Q
x
E

K

R

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

L

A

V

V

N

E

N

S

P

P

R

L

L

I

V

L

L

A

A

D

D

E

Q

P

P

T

T

A

G

N

N

L

L

D

D

H

A

V

R

N

N

G

A

K

D

K

S

V

I

M

F

E

Q

I

L

L

L

R

G

A

E

L

L

A

N

V

R

E

L

Q

Q

K

G

K

T

C

A

V

F

V

L

V

V

A

V

T

T

H
|
H

D

D

N

L

R

Q

I

L

E

A

D

K

I

R

F

M

D

S

R

R

I

Q

L

L

T

E

M

M

E

R

D

D

G

G

R

R

I

L

V

T

D

A

E

E

binding phosphoaminophosphonic acid-adenylate ester: V23 (≠ A23), S43 (= S43), G44 (= G44), G46 (= G46), K47 (= K47), S48 (≠ T48), T49 (= T49), Q93 (= Q93), R137 (= R137), H140 (≠ F140), E144 (≠ D144), S146 (= S146), G148 (= G148), E149 (≠ Q149), H203 (= H203)
binding magnesium ion: S48 (≠ T48), Q93 (= Q93)

8g4cB Bceabs atpgs high res tm (see paper)
35% identity, 85% coverage: 27:222/230 of query aligns to 26:221/248 of 8g4cB

query
sites
8g4cB

V

I

D

D

L

I

Q

H

L

I

K

E

A

K

G

G

E

E

V

F

V

V

G

S

L

I

F

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

T
|
T

T

T

L

L

L

L

S

N

M

V

L

L

G

S

C

S

I

I

L

D

K

Q

P

V

T

S

A

H

G

G

S

T

F

I

K

H

L

I

F

N

G

G

H

N

E

D

I

M

F

T

G

A

L

M

R

K

E

E

K

K

D

Q

L

L

P

A

P

E

L

F

R

R

K

K

R

Q

Y

H

I

L

S

G

Y

F

I

I

F

F

Q

Q

G

D

F

Y

N

N

L

L

F

L

P

D

A

T

L

L

T

T

V

V

Y

K

E

E

N

N

I

I

M

L

L

L

V

P

L

L

K

S

I

I

K

T

G

K

L

L

T

S

G

K

R

K

A

E

A

A

E

N

D

R

L

K

A

F

R

E

G

E

M

V

I

A

A

K

E

E

V

L

G

G

L

I

N

Y

E

E

R

L

A

R

D

D

F

K

L

Y

P

P

R

N

D

E

L

I

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

A

I

V

H

E

D

S

P

P

S

L

I

I

I

L

F

A

A

D
|
D

E

E

P

P

T

T

A

G

N

A

L

L

D

D

H

S

V

K

N

S

G

A

K

S

K

D

V

L

M

L

E

N

I

K

L

L

R

S

A

Q

L

L

A

N

V

Q

E

K

Q

R

K

N

K

A

C

T

V

I

V

I

V

M

A

V

T

T

H

H

D

D

N

P

R

V

I

A

E

A

D

S

I

Y

F

C

D

G

R

R

I

V

L

I

T

F

M

I

E

K

D

D

G

G

R

Q

I

M

binding phosphothiophosphoric acid-adenylate ester: S42 (= S43), S44 (= S45), T47 (= T48), D168 (= D169)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 13

7tchB Bceab e169q variant atp-bound conformation (see paper)
35% identity, 85% coverage: 27:222/230 of query aligns to 25:220/245 of 7tchB

query
sites
7tchB

V

I

D

D

L

I

Q

H

L

I

K

E

A

K

G

G

E

E

V

F

V

V

G

S

L

I

F

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

T
|
T

T

T

L

L

L

L

S

N

M

V

L

L

G

S

C

S

I

I

L

D

K

Q

P

V

T

S

A

H

G

G

S

T

F

I

K

H

L

I

F

N

G

G

H

N

E

D

I

M

F

T

G

A

L

M

R

K

E

E

K

K

D

Q

L

L

P

A

P

E

L

F

R

R

K

K

R

Q

Y

H

I

L

S

G

Y

F

I

I

F

F

Q

Q

G

D

F

Y

N

N

L

L

F

L

P

D

A

T

L

L

T

T

V

V

Y

K

E

E

N

N

I

I

M

L

L

L

V

P

L

L

K

S

I

I

K

T

G

K

L

L

T

S

G

K

R

K

A

E

A

A

E

N

D

R

L

K

A

F

R

E

G

E

M

V

I

A

A

K

E

E

V

L

G

G

L

I

N

Y

E

E

R

L

A

R

D

D

F

K

L

Y

P

P

R

N

D
x
E

L

I

S

S

G
|
G

G
|
G

Q

Q

K

K

Q

Q

R

R

V

T

A

S

V

A

A

G

R

R

A

A

L

F

A

I

V

H

E

D

S

P

P

S

L

I

I

I

L

F

A

A

D

D

E

Q

P

P

T

T

A

G

N

A

L

L

D

D

H

S

V

K

N

S

G

A

K

S

K

D

V

L

M

L

E

N

I

K

L

L

R

S

A

Q

L

L

A

N

V

Q

E

K

Q

R

K

N

K

A

C

T

V

I

V

I

V

M

A

V

T

T

H

H

D

D

N

P

R

V

I

A

E

A

D

S

I

Y

F

C

D

G

R

R

I

V

L

I

T

F

M

I

E

K

D

D

G

G

R

Q

I

M

binding adenosine-5'-triphosphate: S41 (= S43), G42 (= G44), S43 (= S45), K45 (= K47), T46 (= T48), E142 (≠ D144), G145 (= G147), G146 (= G148)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12, 19, 21

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
33% identity, 94% coverage: 12:228/230 of query aligns to 11:223/229 of 6z67B

query
sites
6z67B

K

K

T

K

Y
|
Y

Q

D

E

N

G
|
G

K

T

T

T

V
x
A

V

L

R

R

A

G

V

V

V

-

D

-

V

-

D

S

L

V

Q

S

L

V

K

Q

A

P

G

G

E

E

V

F

V

A

G

Y

L

I

F

V

G

G

P

P

S
|
S

G
|
G

S

A

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

I

S

R

M

S

L

L

G

Y

C

R

I

E

L

V

K

K

P

I

T

D

A

K

G

G

S

S

F

L

K

S

L

V

F

A

G

G

H

F

E

N

I

L

F

V

G

K

L

I

R

K

E

K

K

K

D

D

L

V

P

P

P

L

L

L

R

R

K

-

R

R

Y

S

I

V

S

G

Y

V

I

V

F

F

Q

Q

G

D

F

Y

N

K

L

L

F

L

P

P

A

K

L

K

T

T

V

V

Y

Y

E

E

N

N

I

I

M

A

L

Y

V

A

L

M

K

E

I

V

K

I

G

G

L

E

T

N

G

R

R

R

A

N

A

I

E

K

D

R

L

R

A

V

R

M

G

E

M

V

I

L

A

D

E

L

V

V

G

G

L

L

N

K

E

H

R

K

A

V

D

R

F

S

L

F

P

P

R

N

D

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

I

A

A

V

I

A

A

R

R

A

A

L

I

A

V

V

N

E

N

S

P

P

K

L

V

I

L

L

I

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

H

P

V

D

N

N

G

S

K

W

K

E

V

I

M

M

E

N

I

L

L

L

R

E

A

R

L

I

A

N

V

L

E

-

Q

Q

K

G

K

T

C

T

V

I

V

L

V

M

A

A

T

T

H

H

D

N

N

S

R

Q

I

I

E

V

D

N

I

T

F

L

-

R

D

H

R

R

I

V

L

I

T

A

M

I

E

E

D

N

G

G

R

R

I

V

V

V

D

R

E

D

R

E

Q

S

R

K

binding phosphoaminophosphonic acid-adenylate ester: Y13 (= Y14), G16 (= G17), A19 (≠ V20), S39 (= S43), G40 (= G44), G42 (= G46), K43 (= K47), S44 (≠ T48), T45 (= T49)

A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
36% identity, 94% coverage: 13:228/230 of query aligns to 8:222/229 of A5U7B7

query
sites
A5U7B7

T

T

Y

K

Q

Q

E

Y

G

K

K

S

T

S

V

A

V

R

R

P

A

A

V

L

V

D

D

D

V

I

D

N

L

V

Q

K

L

I

K

D

A

K

G

G

E

E

V

F

V

V

G

F

L

L

F

I

G

G

P

P

S

S

G

G

S

S

G

G

K
|
K

T

S

T

T

L

F

L

M

S

R

M

L

L

L

G

L

C

A

I

A

L

E

K

T

P

P

T

T

A

S

G

G

S

D

F

V

K

R

L

V

F

S

G

K

H

F

E

H

I

V

F

N

G

K

L

L

R

R

E

G

K

R

D

H

L

V

P

P

P

K

L

L

R

R

K

Q

R

-

Y

V

I

I

S

G

Y
x
C

I

V

F

F

Q

Q

G

D

F

F

N

R

L

L

F

L

P

Q

A

Q

L

K

T

T

V

V

Y

Y

E

D

N

N

I

V

M

A

L

F

V

A

L

L

K

E

I

V

K

I

G

G

L

K

T

R

G

T

R

D

A

A

A

I

E

N

D

R

L

V

A

V

R

P

G

E

M

V

I

L

A

E

E

T

V

V

G

G

L

L

N

S

E

G

R

K

A

A

D

N

F

R

L

L

P

P

R

D

D

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

V

A

A

V

I

A

A

R

R

A

A

L

F

A

V

V

N

E

R

S

P

P

L

L

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

H

P

V

E

N

T

G

S

K

R

K

D

V

I

M

M

E

D

I

L

L

L

R

E

A

R

L

I

A

N

V

-

E

R

Q

T

K

G

K

T

C

T

V

V

V

L

V

M

A

A

T

T

H

H

D

D

N

H

R

H

I

I

E

V

D

D

-

S

I

M

F

R

D

Q

R

R

I

V

L

V

T

E

M

L

E

S

D

L

G

G

R

R

I

L

V

V

D

R

E

D

R

E

Q

Q

R

R

K42 (= K47) mutation to R: Does not bind ATP. Does not affect dimerization.
C84 (≠ Y90) mutation to A: Does not affect ATPase activity.

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
33% identity, 94% coverage: 12:228/230 of query aligns to 11:223/230 of 6z4wA

query
sites
6z4wA

K

K

T

K

Y
|
Y

Q

D

E

N

G

G

K
x
T

T

T

V
x
A

V

L

R

R

A

G

V

V

V

-

D

-

V

-

D

S

L

V

Q

S

L

V

K

Q

A

P

G

G

E

E

V

F

V

A

G

Y

L

I

F

V

G

G

P

P

S

S

G
|
G

S

A

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

I

S

R

M

S

L

L

G

Y

C

R

I

E

L

V

K

K

P

I

T

D

A

K

G

G

S

S

F

L

K

S

L

V

F

A

G

G

H

F

E

N

I

L

F

V

G

K

L

I

R

K

E

K

K

K

D

D

L

V

P

P

P

L

L

L

R

R

K

-

R

R

Y

S

I

V

S

G

Y

V

I

V

F

F

Q

Q

G

D

F

Y

N

K

L

L

F

L

P

P

A

K

L

K

T

T

V

V

Y

Y

E

E

N

N

I

I

M

A

L

Y

V

A

L

M

K

E

I

V

K

I

G

G

L

E

T

N

G

R

R

R

A

N

A

I

E

K

D

R

L

R

A

V

R

M

G

E

M

V

I

L

A

D

E

L

V

V

G

G

L

L

N

K

E

H

R

K

A

V

D

R

F

S

L

F

P

P

R

N

D

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

I

A

A

V

I

A

A

R

R

A

A

L

I

A

V

V

N

E

N

S

P

P

K

L

V

I

L

L

I

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

H

P

V

D

N

N

G

S

K

W

K

E

V

I

M

M

E

N

I

L

L

L

R

E

A

R

L

I

A

N

V

L

E

-

Q

Q

K

G

K

T

C

T

V

I

V

L

V

M

A

A

T

T

H

H

D

N

N

S

R

Q

I

I

E

V

D

N

I

T

F

L

-

R

D

H

R

R

I

V

L

I

T

A

M

I

E

E

D

N

G

G

R

R

I

V

V

V

D

R

E

D

R

E

Q

S

R

K

binding adenosine-5'-diphosphate: Y13 (= Y14), T17 (≠ K18), A19 (≠ V20), G40 (= G44), G42 (= G46), K43 (= K47), S44 (≠ T48), T45 (= T49)

Query Sequence

>WP_092056230.1 NCBI__GCF_900111775.1:WP_092056230.1
MEHPVVTQGLGKTYQEGKTVVRAVVDVDLQLKAGEVVGLFGPSGSGKTTLLSMLGCILKP
TAGSFKLFGHEIFGLREKDLPPLRKRYISYIFQGFNLFPALTVYENIMLVLKIKGLTGRA
AEDLARGMIAEVGLNERADFLPRDLSGGQKQRVAVARALAVESPLILADEPTANLDHVNG
KKVMEILRALAVEQKKCVVVATHDNRIEDIFDRILTMEDGRIVDERQRSS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory