SitesBLAST
Comparing WP_092344299.1 NCBI__GCF_900107645.1:WP_092344299.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 17 hits to proteins with known functional sites (download)
7e1sC Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
39% identity, 96% coverage: 5:350/359 of query aligns to 11:363/366 of 7e1sC
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M89), A129 (= A114), G130 (= G115), L131 (= L116), I150 (= I135), I151 (≠ V136), S152 (= S137), E178 (= E163), H185 (= H171), Y280 (≠ L269), I324 (= I311), L328 (= L315)
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N87), E178 (= E163), S182 (≠ A168), G183 (= G169), G223 (= G211), G224 (= G212), M244 (= M232), A245 (≠ G233), T246 (= T234), L249 (≠ V237), F342 (= F329), T343 (≠ C330)
- binding iron/sulfur cluster: C303 (= C292), N306 (≠ A295), C307 (= C296), V308 (≠ L297), C311 (= C300), G314 (≠ Q303), A317 (≠ R306), C323 (= C310), I324 (= I311)
- binding : L131 (= L116), T133 (≠ L118), N134 (= N119), K155 (= K140), I159 (≠ L144), K162 (≠ R147), R163 (≠ K148), R167 (≠ S152)
7e1sA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
39% identity, 96% coverage: 5:350/359 of query aligns to 11:363/366 of 7e1sA
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M89), A129 (= A114), G130 (= G115), I150 (= I135), I151 (≠ V136), S152 (= S137), E178 (= E163), H185 (= H171), G187 (= G173), Y280 (≠ L269), L328 (= L315)
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N87), L104 (≠ M89), E178 (= E163), G183 (= G169), G223 (= G211), G224 (= G212), Q243 (= Q231), M244 (= M232), A245 (≠ G233), T246 (= T234)
- binding iron/sulfur cluster: C303 (= C292), N306 (≠ A295), C307 (= C296), V308 (≠ L297), C311 (= C300), G314 (≠ Q303), A317 (≠ R306), C323 (= C310), I324 (= I311)
7e1rA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with holo-acp (see paper)
39% identity, 96% coverage: 5:350/359 of query aligns to 11:363/366 of 7e1rA
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N87), L104 (≠ M89), E178 (= E163), G183 (= G169), G224 (= G212), Q243 (= Q231), M244 (= M232), A245 (≠ G233), T246 (= T234), F342 (= F329)
- binding N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide: G128 (= G113), A129 (= A114), G130 (= G115), E178 (= E163), H185 (= H171), G187 (= G173)
- binding iron/sulfur cluster: C303 (= C292), N306 (≠ A295), C307 (= C296), V308 (≠ L297), C311 (= C300), G314 (≠ Q303), A317 (≠ R306), C323 (= C310), I324 (= I311)
7e1qA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori (see paper)
39% identity, 96% coverage: 5:350/359 of query aligns to 11:363/366 of 7e1qA
- binding flavin mononucleotide: G25 (= G19), G26 (= G20), M27 (= M21), G28 (= G22), N102 (= N87), L104 (≠ M89), E178 (= E163), S182 (≠ A168), G183 (= G169), G223 (= G211), G224 (= G212), M244 (= M232), A245 (≠ G233), T246 (= T234), F342 (= F329)
- binding iron/sulfur cluster: P277 (= P266), C303 (= C292), N306 (≠ A295), C307 (= C296), V308 (≠ L297), C311 (= C300), G314 (≠ Q303), A317 (≠ R306), C323 (= C310), I324 (= I311)
7l00C Crystal structure of c. Difficile enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor
26% identity, 96% coverage: 11:356/359 of query aligns to 15:308/315 of 7l00C
- binding flavin mononucleotide: G23 (= G19), G24 (= G20), M25 (= M21), A26 (≠ G22), N74 (= N87), E142 (≠ D164), G146 (≠ A168), G147 (= G169), G174 (= G211), G175 (= G212), Q194 (= Q231), G196 (= G233), T197 (= T234), M281 (≠ F329), S285 (≠ N333)
- binding N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-2-[2-(1H-pyrrol-1-yl)-1,3-thiazol-4-yl]acetamide: A26 (≠ G22), M76 (= M89), G100 (= G113), A101 (= A114), G102 (= G115), V121 (≠ I135), P123 (≠ S137), H149 (= H171), L266 (≠ E307), M281 (≠ F329)
2z6iB Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) (see paper)
28% identity, 75% coverage: 81:351/359 of query aligns to 63:303/321 of 2z6iB
- binding calcium ion: E137 (= E163), H144 (= H171), A158 (≠ K194), I161 (= I203)
- binding flavin mononucleotide: N69 (= N87), E137 (= E163), A141 (= A168), G142 (= G169), G169 (= G211), G170 (= G212), G191 (= G233), T192 (= T234), M281 (≠ F329)
Sites not aligning to the query:
5gvhA Structure of fabk from thermotoga maritima (see paper)
26% identity, 96% coverage: 11:353/359 of query aligns to 11:299/311 of 5gvhA
- binding flavin mononucleotide: G19 (= G19), G20 (= G20), M21 (= M21), A22 (≠ G22), N70 (= N87), I72 (≠ M89), E138 (= E163), S142 (≠ T167), G143 (= G169), G170 (= G211), G171 (= G212), Q190 (= Q231), G192 (= G233), T193 (= T234), M275 (≠ F329), S279 (≠ N333)
2z6jA Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor (see paper)
29% identity, 75% coverage: 81:351/359 of query aligns to 63:290/307 of 2z6jA
- binding calcium ion: A158 (≠ K194), I161 (= I203)
- binding flavin mononucleotide: N69 (= N87), E137 (= E163), A141 (= A168), G142 (= G169), G169 (= G211), G170 (= G212), G191 (= G233), T192 (= T234)
- binding 2-(4-(2-((3-(5-(pyridin-2-ylthio)thiazol-2-yl)ureido)methyl)-1h-imidazol-4-yl)phenoxy)acetic acid: M71 (= M89), L73 (≠ A91), A96 (= A114), G97 (= G115), V116 (≠ I135), P118 (≠ S137), L122 (≠ A141), E137 (= E163), H144 (= H171)
Sites not aligning to the query:
4iqlA Crystal structure of porphyromonas gingivalis enoyl-acp reductase ii (fabk) with cofactors NADPH and fmn (see paper)
28% identity, 94% coverage: 12:350/359 of query aligns to 10:298/313 of 4iqlA
- binding flavin mononucleotide: G18 (= G20), M19 (= M21), V20 (= V23), N68 (= N87), S94 (≠ G113), E136 (= E163), A140 (= A168), G141 (= G169), G170 (= G211), G171 (= G212), Q190 (= Q231), G192 (= G233), T193 (= T234), E277 (≠ F329)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: W21 (≠ R24), W21 (≠ R24), W25 (≠ F28), S44 (≠ G47), M45 (≠ L48), M45 (≠ L48), H46 (= H54), N49 (≠ G57), H52 (≠ E71), H53 (≠ L72), Y73 (≠ V92), P74 (≠ K93), E75 (≠ N94), S202 (≠ D243), K263 (≠ L315), F267 (≠ Q319)
4q4kA Crystal structure of nitronate monooxygenase from pseudomonas aeruginosa pao1 (see paper)
32% identity, 34% coverage: 158:278/359 of query aligns to 171:284/351 of 4q4kA
Sites not aligning to the query:
Q9HWH9 Nitronate monooxygenase; NMO; Propionate 3-nitronate monooxygenase; P3N monooxygenase; EC 1.13.12.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
32% identity, 34% coverage: 158:278/359 of query aligns to 171:284/351 of Q9HWH9
Sites not aligning to the query:
- 21 binding FMN
- 69 binding FMN
2gjnA Crystal structure of 2-nitropropane dioxygenase complexed with fmn and substrate (see paper)
38% identity, 22% coverage: 202:280/359 of query aligns to 168:246/324 of 2gjnA
Sites not aligning to the query:
6e2aA Crystal structure of nadh:quinone reductase pa1024 from pseudomonas aeruginosa pao1 in complex with NAD+ (see paper)
38% identity, 22% coverage: 202:280/359 of query aligns to 169:247/326 of 6e2aA
Sites not aligning to the query:
- binding flavin mononucleotide: 21, 22, 23, 74, 123, 148, 149, 287
- binding nicotinamide-adenine-dinucleotide: 23, 76, 77, 79, 150, 151, 260, 269, 287
Q9I4V0 NADH:quinone reductase; EC 1.6.5.9 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
38% identity, 22% coverage: 202:280/359 of query aligns to 170:248/328 of Q9I4V0
Sites not aligning to the query:
- 22:24 binding FMN
- 75 binding FMN
- 124 binding FMN
- 150 binding FMN
4qiuB Crystal structure of nitroalkane oxidase from pseudomonas aeruginosa in mutant complex form
36% identity, 21% coverage: 204:278/359 of query aligns to 209:283/350 of 4qiuB
Sites not aligning to the query:
- binding flavin mononucleotide: 17, 18, 19, 20, 68, 70, 132, 175, 179, 180, 181, 324
- binding 1-nitropropane: 20, 324
4qitA Crystal structure of nitroalkane oxidase from pseudomonas aeruginosa in mutant complex form
36% identity, 21% coverage: 204:278/359 of query aligns to 210:284/350 of 4qitA
Sites not aligning to the query:
- binding flavin mononucleotide: 18, 19, 20, 21, 69, 71, 133, 176, 180, 181, 325
- binding nitroethane: 71, 182, 183, 325
5lsmA Crystal structure of nitronate monooxygenase (so_0471) from shewanella oneidensis mr-1
30% identity, 33% coverage: 155:274/359 of query aligns to 158:270/339 of 5lsmA
Sites not aligning to the query:
Query Sequence
>WP_092344299.1 NCBI__GCF_900107645.1:WP_092344299.1
MRSGLTIGRHHVPYPVIQGGMGVRISGFRLSGHVALNGGIGIIASAGLALADTHYDGHNF
FKADRLALLEELRKAYEIAPDGVIGVNCMVAVKNYDEVVRTSCEGGAKLIISGAGLPLNL
PKLTADFPDVALVPIVSSVKAAELIVRKWQKSYQRFPDAIVVEDPDTAGGHLGEKMERIG
SGDYDQYETVRGVKAYLNDNWNIAIPVIAAGGIWDRKDLEYALAQGADGVQMGTRFVVTE
ECDADAAFKQAYLDCKQEDIGLIMSPAGLPGRAIKKNIDQVRQRDVDLDVYCPSACLKKC
AYQKSRERFCIVHALDRAQKGDTETGLIFCGSNAWKADRISTVKEVFAELFPQEEQKTG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory