SitesBLAST
Comparing WP_092345415.1 NCBI__GCF_900107645.1:WP_092345415.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 18 hits to proteins with known functional sites (download)
7qyrD Crystal structure of rimk from pseudomonas aeruginosa pao1 (see paper)
76% identity, 97% coverage: 1:292/301 of query aligns to 1:292/293 of 7qyrD
- binding adenosine-5'-diphosphate: V139 (= V139), Y179 (≠ F179), I180 (= I180), D187 (= D187), R211 (= R211), S212 (= S212), L250 (= L250), M259 (= M259)
- binding : S7 (= S7), L12 (= L12), S14 (= S14), R64 (= R64), R189 (= R189), N262 (= N262), S264 (= S264), G266 (= G266)
4iwxA Rimk structure at 2.85a (see paper)
67% identity, 96% coverage: 1:290/301 of query aligns to 3:292/294 of 4iwxA
- binding adenosine-5'-diphosphate: V141 (= V139), K143 (= K141), E180 (= E178), Y181 (≠ F179), I182 (= I180), K183 (= K181), D189 (= D187), R213 (= R211), S214 (= S212), N215 (= N213), M261 (= M259), E262 (= E260)
- binding glutamic acid: R98 (= R96), R104 (= R102), Q107 (= Q105), L108 (= L106), R111 (= R109)
5zctH The crystal structure of the poly-alpha-l-glutamate peptides synthetase rimk at 2.05 angstrom resolution. (see paper)
67% identity, 96% coverage: 1:290/301 of query aligns to 1:290/292 of 5zctH
- binding phosphoaminophosphonic acid-adenylate ester: V139 (= V139), K141 (= K141), Q177 (= Q177), Y179 (≠ F179), I180 (= I180), D187 (= D187), F210 (= F210), R211 (= R211), S212 (= S212), N213 (= N213), R216 (= R216), L250 (= L250), M259 (= M259), E260 (= E260)
- binding magnesium ion: D248 (= D248), E260 (= E260)
5zctA The crystal structure of the poly-alpha-l-glutamate peptides synthetase rimk at 2.05 angstrom resolution. (see paper)
67% identity, 96% coverage: 1:290/301 of query aligns to 1:290/292 of 5zctA
- binding phosphoaminophosphonic acid-adenylate ester: K100 (= K100), K141 (= K141), T146 (= T146), Q147 (= Q147), G148 (= G148), Q177 (= Q177), Y179 (≠ F179), I180 (= I180), R211 (= R211), S212 (= S212), N213 (= N213), L250 (= L250), M259 (= M259)
3vpbB Argx from sulfolobus tokodaii complexed with lysw/glu/adp/mg/zn/sulfate (see paper)
31% identity, 77% coverage: 58:288/301 of query aligns to 47:278/282 of 3vpbB
- binding adenosine-5'-diphosphate: K87 (= K100), I125 (≠ V139), K127 (= K141), S132 (≠ T146), G134 (= G148), V137 (= V151), Q167 (= Q177), Y169 (≠ F179), I170 (= I180), D176 (= D187), R200 (= R211), A201 (≠ S212), N202 (= N213), N249 (≠ M259), E250 (= E260)
- binding glutamic acid: Y190 (≠ M201), R192 (= R203), N202 (= N213), V203 (≠ L214), A204 (≠ H215), E256 (≠ G266), G259 (= G269)
- binding magnesium ion: D237 (= D248), E250 (= E260)
- binding zinc ion: E250 (= E260), N252 (= N262)
Q970U6 Glutamate--LysW ligase ArgX; EC 6.3.2.- from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
31% identity, 77% coverage: 58:288/301 of query aligns to 47:278/282 of Q970U6
- D237 (= D248) binding Mg(2+)
- E250 (= E260) binding Mg(2+); binding Mg(2+)
- N252 (= N262) binding Mg(2+)
3vpdA Lysx from thermus thermophilus complexed with amp-pnp (see paper)
30% identity, 73% coverage: 73:291/301 of query aligns to 62:280/281 of 3vpdA
- binding phosphoaminophosphonic acid-adenylate ester: V127 (= V139), K129 (= K141), W135 (≠ Q147), G136 (= G148), L139 (≠ V151), Q169 (= Q177), V172 (≠ I180), K174 (≠ A183), D178 (= D187), R194 (= R203), W199 (≠ F210), T201 (≠ S212), F239 (≠ L250), E249 (= E260)
- binding butanoic acid: F256 (≠ L267), K257 (≠ E268), N258 (≠ G269), S259 (≠ I270)
Q4JAP9 Alpha-aminoadipate--LysW ligase LysX; AAA--LysW ligase LysX; EC 6.3.2.43 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) (see paper)
29% identity, 68% coverage: 80:283/301 of query aligns to 62:267/276 of Q4JAP9
- NT 253:254 (≠ GI 269:270) mutation to GF: Alters substrate specificity, so that glutamate is preferred over alpha-aminoadipate.
5k2mI Bifunctional lysx/argx from thermococcus kodakarensis with lysw-gamma- aaa (see paper)
28% identity, 73% coverage: 71:291/301 of query aligns to 54:272/273 of 5k2mI
- binding adenosine-5'-diphosphate: K83 (= K100), V120 (= V139), K122 (= K141), S127 (≠ T146), L132 (≠ V151), Q162 (= Q177), V165 (≠ I180), K167 (≠ A183), D171 (= D187), W192 (≠ F210), I193 (≠ R211), T194 (≠ S212), N195 (= N213), F231 (≠ L250), N240 (≠ M259), E241 (= E260)
- binding 2-aminohexanedioic acid: R173 (= R189), N195 (= N213), T196 (≠ L214), A197 (≠ H215), E247 (≠ G266), F248 (≠ L267), N250 (≠ G269)
- binding : F54 (= F71), F125 (≠ E144), W128 (≠ Q147), R130 (≠ I149), N153 (≠ A172), Y156 (≠ L175), N245 (≠ S264)
Sites not aligning to the query:
5k2mG Bifunctional lysx/argx from thermococcus kodakarensis with lysw-gamma- aaa (see paper)
28% identity, 73% coverage: 71:291/301 of query aligns to 54:272/273 of 5k2mG
- binding adenosine-5'-diphosphate: K83 (= K100), V120 (= V139), K122 (= K141), S127 (≠ T146), G129 (= G148), Q162 (= Q177), V165 (≠ I180), K167 (≠ A183), D171 (= D187), W192 (≠ F210), T194 (≠ S212), N195 (= N213), F231 (≠ L250), N240 (≠ M259), E241 (= E260)
- binding magnesium ion: D229 (= D248), E241 (= E260)
- binding : F54 (= F71), F125 (≠ E144), S127 (≠ T146), W128 (≠ Q147), R130 (≠ I149), Y156 (≠ L175), R173 (= R189), R187 (= R203), T196 (≠ L214), A197 (≠ H215), N243 (= N262), P244 (≠ S263), N245 (≠ S264), E247 (≠ G266), F248 (≠ L267), N250 (≠ G269), A251 (≠ I270)
Sites not aligning to the query:
1uc9A Crystal structure of a lysine biosynthesis enzyme, lysx, from thermus thermophilus hb8 (see paper)
29% identity, 71% coverage: 73:285/301 of query aligns to 62:250/256 of 1uc9A
7waeB Trichodesmium erythraeum cyanophycin synthetase 1 (tecpha1) with atpgammas, 4x(beta-asp-arg), and aspartate (see paper)
25% identity, 65% coverage: 99:294/301 of query aligns to 219:487/877 of 7waeB
Sites not aligning to the query:
- binding phosphothiophosphoric acid-adenylate ester: 497, 498, 499, 500, 558, 692, 696, 731, 745, 746, 748, 752, 755
- binding magnesium ion: 500, 522, 558
- binding : 166
7waeD Trichodesmium erythraeum cyanophycin synthetase 1 (tecpha1) with atpgammas, 4x(beta-asp-arg), and aspartate (see paper)
25% identity, 65% coverage: 99:294/301 of query aligns to 219:487/724 of 7waeD
- binding phosphothiophosphoric acid-adenylate ester: K220 (= K100), V259 (= V139), K261 (= K141), G265 (= G145), N266 (≠ T146), H267 (≠ Q147), G268 (= G148), I271 (≠ V151), I273 (≠ L153), E300 (≠ Q177), Y303 (≠ I180), D307 (= D187), E450 (= E260)
- binding arginine: N266 (≠ T146), A453 (≠ S263)
- binding aspartic acid: N394 (vs. gap), R458 (≠ E268)
- binding magnesium ion: N266 (≠ T146), D431 (= D248), E450 (= E260), E450 (= E260), N452 (= N262)
- binding : R309 (= R189), P455 (= P265), G456 (= G266)
Sites not aligning to the query:
7lg5A Synechocystis sp. Utex2470 cyanophycin synthetase 1 with atp (see paper)
34% identity, 35% coverage: 99:203/301 of query aligns to 219:319/871 of 7lg5A
Sites not aligning to the query:
7drnA Structure of atp-grasp ligase psnb complexed with precursor peptide psna2 and amppnp (see paper)
27% identity, 40% coverage: 172:291/301 of query aligns to 197:311/311 of 7drnA
Sites not aligning to the query:
7drpA Structure of atp-grasp ligase psnb complexed with phosphomimetic variant of minimal precursor, mg, and adp (see paper)
27% identity, 40% coverage: 172:291/301 of query aligns to 197:311/312 of 7drpA
- binding adenosine-5'-diphosphate: Q202 (= Q177), E203 (= E178), L205 (≠ I180), D209 (= D187), K269 (≠ L250), L279 (≠ M259), E280 (= E260)
- binding magnesium ion: D267 (= D248), E280 (= E260), E280 (= E260), N282 (= N262)
- binding : V199 (≠ I174), R211 (= R189), N282 (= N262), S284 (= S264), A285 (≠ P265), M286 (≠ G266)
Sites not aligning to the query:
- binding adenosine-5'-diphosphate: 170, 178
- binding : 70, 77, 79, 169, 175, 176, 179, 190, 193, 194
7txuA Cyanophycin synthetase 1 from synechocystis sp. Utex2470 with atp and 16x(asp-arg)
34% identity, 35% coverage: 99:203/301 of query aligns to 219:320/869 of 7txuA
Sites not aligning to the query:
- binding adenosine-5'-triphosphate: 494, 495, 496, 497, 519, 689, 693, 742, 749
- binding magnesium ion: 497, 519, 555
- binding zinc ion: 59, 79, 83
- binding : 14, 16, 17, 18, 19, 57, 58, 86, 87, 90, 96, 97, 99, 100, 164, 165, 166, 202, 203, 450, 597, 604
7lgjA Cyanophycin synthetase 1 from synechocystis sp. Utex2470 with adpcp and 8x(asp-arg)-nh2 (see paper)
34% identity, 35% coverage: 99:203/301 of query aligns to 219:320/869 of 7lgjA
Sites not aligning to the query:
- binding phosphomethylphosphonic acid adenylate ester: 494, 495, 496, 497, 498, 693, 728, 742
- binding magnesium ion: 428, 447, 497, 519, 555
- binding : 164, 165, 166, 187, 202, 203, 214, 450, 453
Query Sequence
>WP_092345415.1 NCBI__GCF_900107645.1:WP_092345415.1
MKIAILSRNPNLYSTRRMVEAGGELGHEMKVIDPLRCYMTIASQRPTINYKGEELTGYDA
LIPRIGASITFYGTAVARQFEMMGVYNINESVAISRSRDKLRSLQLLARKGIGLPVTGFA
HSTQYTNDLIEKVGGAPLVIKLLEGTQGIGVVLAETAKAGQSVIEAFRGLDANILVQEFI
KEADGADIRCLVVGDKVVAAMKRQGKEGEFRSNLHRGGSACIARLTPEERSTAVRAARIM
GLNVAGVDLLRANHGPVVMEVNSSPGLEGIETATGKDVAGMIIKFIEKEAKPGRTKTRGK
G
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory