SitesBLAST
Comparing WP_092345506.1 NCBI__GCF_900107645.1:WP_092345506.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 14 hits to proteins with known functional sites (download)
7cdyA Crystal structure of glucose dehydrogenase
41% identity, 87% coverage: 46:375/379 of query aligns to 10:343/346 of 7cdyA
2g8sA Crystal structure of the soluble aldose sugar dehydrogenase (asd) from escherichia coli in the apo-form (see paper)
38% identity, 88% coverage: 45:378/379 of query aligns to 11:348/348 of 2g8sA
P75804 Aldose sugar dehydrogenase YliI; Asd; Soluble aldose sugar dehydrogenase YliI; EC 1.1.5.- from Escherichia coli (strain K12) (see paper)
38% identity, 88% coverage: 45:379/379 of query aligns to 33:371/371 of P75804
- Q82 (= Q93) binding pyrroloquinoline quinone
- E240 (= E252) binding Ca(2+)
- Y250 (= Y262) binding Ca(2+)
- Y261 (= Y273) binding pyrroloquinoline quinone
7cgzA Glucose dehydrogenase
38% identity, 87% coverage: 46:375/379 of query aligns to 10:318/321 of 7cgzA
2ismB Crystal structure of the putative oxidoreductase (glucose dehydrogenase) (ttha0570) from thermus theromophilus hb8
31% identity, 87% coverage: 41:371/379 of query aligns to 6:319/333 of 2ismB
3dasA Structure of the pqq-bound form of aldose sugar dehydrogenase (adh) from streptomyces coelicolor
30% identity, 86% coverage: 46:371/379 of query aligns to 18:318/334 of 3dasA
- active site: H127 (= H160), E146 (= E179), R189 (= R227), E230 (≠ S268), K232 (≠ G270), G234 (≠ Q272)
- binding alpha-L-arabinopyranose: K199 (≠ Q237), D248 (≠ T297), R268 (= R324), G269 (≠ S325), E270 (≠ K326), K278 (≠ D334), G279 (= G335)
- binding calcium ion: G208 (= G246), Q209 (≠ P247), E214 (= E252), Y224 (= Y262)
- binding pyrroloquinoline quinone: E66 (≠ Q93), H127 (= H160), R189 (= R227), N190 (= N228), Q192 (≠ L230), F207 (≠ M245), S251 (≠ P300), R268 (= R324), R296 (= R349), R298 (= R351), R318 (= R371)
3a9hA Crystal structure of pqq-dependent sugar dehydrogenase holo-form (see paper)
31% identity, 85% coverage: 49:371/379 of query aligns to 16:320/338 of 3a9hA
- active site: H120 (= H163), D139 (≠ E179), R182 (= R227), T224 (≠ S268), K226 (≠ G270), G228 (≠ Q272)
- binding calcium ion: E208 (= E252), Y218 (= Y262)
- binding alpha-D-glucopyranose: G228 (≠ Q272), R229 (≠ Y273), F232 (≠ I276), V233 (≠ P277), D234 (≠ I278)
- binding pyrroloquinoline quinone: E57 (≠ Q93), H120 (= H163), N183 (= N228), Q185 (≠ L230), H201 (≠ M245), V204 (≠ R248), T243 (= T297), L269 (= L323), R270 (= R324), R298 (= R349), R300 (= R351), R320 (= R371)
3a9gA Crystal structure of pqq-dependent sugar dehydrogenase apo-form (see paper)
31% identity, 85% coverage: 49:371/379 of query aligns to 16:320/338 of 3a9gA
- active site: H120 (= H163), D139 (≠ E179), R182 (= R227), T224 (≠ S268), K226 (≠ G270), G228 (≠ Q272)
- binding calcium ion: E208 (= E252), Y218 (= Y262)
- binding alpha-D-glucopyranose: R144 (≠ A184), D148 (≠ S188), G228 (≠ Q272), R229 (≠ Y273), F232 (≠ I276), V233 (≠ P277), D234 (≠ I278)
P13650 Quinoprotein glucose dehydrogenase B; Glucose dehydrogenase B [pyrroloquinoline-quinone]; Soluble glucose dehydrogenase; s-GDH; EC 1.1.5.2 from Acinetobacter calcoaceticus (see paper)
26% identity, 85% coverage: 43:366/379 of query aligns to 47:448/478 of P13650
- Q100 (= Q93) binding D-glucose
- D167 (≠ G159) binding D-glucose
- Q192 (vs. gap) binding D-glucose
- R252 (= R227) binding D-glucose
- G271 (= G246) binding Ca(2+)
- P272 (= P247) binding Ca(2+)
- E277 (= E252) binding Ca(2+)
- Y287 (= Y262) binding Ca(2+)
- A293 (≠ S268) binding Ca(2+)
- Y295 (≠ W269) binding Ca(2+)
- D297 (= D271) binding Ca(2+)
- E333 (≠ H281) binding Ca(2+)
- Y367 (≠ W294) binding pyrroloquinoline quinone
- T372 (= T297) binding pyrroloquinoline quinone
- K401 (≠ R324) binding pyrroloquinoline quinone
1cq1A Soluble quinoprotein glucose dehydrogenase from acinetobacter calcoaceticus in complex with pqqh2 and glucose (see paper)
27% identity, 85% coverage: 43:366/379 of query aligns to 23:418/444 of 1cq1A
- active site: H138 (= H160), D157 (≠ E179), R222 (= R227), A263 (≠ S268), Y265 (≠ W269), D267 (= D271), E303 (≠ H281)
- binding beta-D-glucopyranose: D137 (≠ G159), H138 (= H160), Q162 (vs. gap), Y337 (≠ W294)
- binding calcium ion: G241 (= G246), P242 (= P247), E247 (= E252), Y257 (= Y262), A263 (≠ S268), Y265 (≠ W269), D267 (= D271), E303 (≠ H281)
- binding pyrroloquinoline quinone: Q76 (= Q93), H138 (= H160), R222 (= R227), N223 (= N228), Q240 (≠ M245), Y337 (≠ W294), T342 (= T297), A344 (= A299), L370 (= L323), K371 (≠ R324), R400 (= R349), R402 (= R351)
1c9uA Crystal structure of the soluble quinoprotein glucose dehydrogenase in complex with pqq (see paper)
27% identity, 85% coverage: 43:366/379 of query aligns to 23:418/444 of 1c9uA
- active site: H138 (= H160), D157 (≠ E179), R222 (= R227), A263 (≠ S268), Y265 (≠ W269), D267 (= D271), E303 (≠ H281)
- binding calcium ion: R222 (= R227), G241 (= G246), P242 (= P247), E247 (= E252), Y257 (= Y262), A263 (≠ S268), Y265 (≠ W269), D267 (= D271), E303 (≠ H281)
- binding pyrroloquinoline quinone: Q76 (= Q93), H138 (= H160), R222 (= R227), N223 (= N228), Q240 (≠ M245), Y337 (≠ W294), W340 (vs. gap), T342 (= T297), L370 (= L323), K371 (≠ R324), R400 (= R349), R402 (= R351)
8re0A Quinoprotein glucose dehydrogenase B (see paper)
26% identity, 85% coverage: 43:366/379 of query aligns to 23:424/452 of 8re0A
- binding 3-(3,5-dicarboxy-1~{H}-pyrrol-2-yl)pyridine-2,4,6-tricarboxylic acid: R228 (= R227), Q231 (≠ L230), Q246 (≠ M245), T348 (= T297), L376 (= L323), K377 (≠ R324), R406 (= R349), R408 (= R351)
- binding calcium ion: G247 (= G246), P248 (= P247), E253 (= E252), Y263 (= Y262), A269 (≠ S268), Y271 (≠ W269), D273 (= D271), E309 (≠ H281)
5minB Apo form of the soluble pqq-dependent glucose dehydrogenase from acinetobacter calcoaceticus
26% identity, 85% coverage: 43:366/379 of query aligns to 23:424/453 of 5minB
- active site: H144 (= H160), D163 (≠ E179), R228 (= R227), A269 (≠ S268), Y271 (≠ W269), D273 (= D271), E309 (≠ H281)
- binding calcium ion: E253 (= E252), Y263 (= Y262), A269 (≠ S268), Y271 (≠ W269), D273 (= D271), E309 (≠ H281)
1cruA Soluble quinoprotein glucose dehydrogenase from acinetobacter calcoaceticus in complex with pqq and methylhydrazine (see paper)
26% identity, 85% coverage: 43:366/379 of query aligns to 23:422/448 of 1cruA
- active site: H142 (= H160), D161 (≠ E179), R226 (= R227), A267 (≠ S268), Y269 (≠ W269), D271 (= D271), E307 (≠ H281)
- binding calcium ion: G245 (= G246), P246 (= P247), E251 (= E252), Y261 (= Y262), A267 (≠ S268), Y269 (≠ W269), D271 (= D271), E307 (≠ H281)
- binding methylhydrazine: Y341 (≠ W294), W344 (vs. gap)
- binding pyrroloquinoline quinone: Q76 (= Q93), H142 (= H160), R226 (= R227), N227 (= N228), Q244 (≠ M245), Y341 (≠ W294), T346 (= T297), A348 (= A299), L374 (= L323), K375 (≠ R324), R404 (= R349), R406 (= R351)
Query Sequence
>WP_092345506.1 NCBI__GCF_900107645.1:WP_092345506.1
MQSLRLISYLSLLCLLVSSNAYAWLFGNTIKGNAGSILEYESFGSFNEPWAMTFLPSGNL
LVTEKQGSLLLVDLDDDSKVSVKGLPEVAYSGQGGLGDIVLHPQYKENHWIYLSYAEQDG
AGNRGAVVARAQLDPAATSPHLENFTVIWRQTPKVSGSGHYSHRLAFDPDGYLFITSGER
QKQAPAQSWEQNLGKVIRLNADGTVPPDNPFQDKGELAKTFWSLGHRNLLGIAFDQQGQL
WTHEMGPRHGDEFNLIVAGDNYGWPIVSWGDQYSGIPIPDHDTRPEFHAPEVYWIPTVAP
SGLIIYSGAIFSQWQGNTFIGGLRSKSLIRIQIDGDQAKEVERFAMDQRIREVEQGPEGA
IWVLEDGDDGRLLRLTPKQ
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory