SitesBLAST
Comparing WP_092483962.1 NCBI__GCF_900115975.1:WP_092483962.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
38% identity, 99% coverage: 6:458/458 of query aligns to 11:466/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P67), G75 (= G69), S76 (≠ A70), G77 (= G71), T78 (= T72), G79 (= G73), L80 (= L74), A83 (≠ G77), C84 (≠ S78), P137 (= P131), G138 (≠ S132), E139 (≠ S133), A142 (≠ C137), T143 (= T138), G146 (= G141), N147 (= N142), S149 (≠ A144), T150 (≠ E145), A152 (= A147), G153 (= G148), E203 (= E198), G204 (= G199), I209 (= I204), E422 (= E414), H423 (= H415)
- binding fe (iii) ion: H377 (= H370), H384 (= H377), E422 (= E414)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), W322 (≠ S325), E413 (= E414), H414 (= H415), N450 (= N451)
- binding lactic acid: R318 (= R321), H369 (= H370), H376 (= H377), H414 (= H415)
- binding manganese (ii) ion: H369 (= H370), H376 (= H377), E413 (= E414)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ G32), P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), W323 (≠ S325), E414 (= E414), H415 (= H415), N451 (= N451)
- binding manganese (ii) ion: H370 (= H370), H377 (= H377), E414 (= E414)
- binding pyruvic acid: R319 (= R321), H370 (= H370), H377 (= H377), H415 (= H415)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R321), W322 (≠ S325), H369 (= H370), H376 (= H377), H414 (= H415)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), W322 (≠ S325), E413 (= E414), N450 (= N451)
- binding manganese (ii) ion: H369 (= H370), H376 (= H377), E413 (= E414)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), H369 (= H370), E413 (= E414), N450 (= N451)
- binding deaminohydroxyvaline: R319 (= R321), H414 (= H415)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R321), H369 (= H370), H376 (= H377), H414 (= H415)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), W322 (≠ S325), E413 (= E414), H414 (= H415), N450 (= N451)
- binding manganese (ii) ion: H369 (= H370), H376 (= H377), E413 (= E414)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ L74), R317 (= R321), W321 (≠ S325), H368 (= H370), H375 (= H377), H413 (= H415)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), W321 (≠ S325), Y322 (≠ T326), E412 (= E414), H413 (= H415), N449 (= N451)
- binding manganese (ii) ion: H368 (= H370), H375 (= H377), E412 (= E414)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), Y324 (≠ T326), H370 (= H370), E414 (= E414), N451 (= N451)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R321), W323 (≠ S325), H415 (= H415)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R321), W323 (≠ S325), H370 (= H370), H415 (= H415)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ A70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ S78), L90 (= L89), P132 (= P131), G133 (≠ S132), A134 (≠ S133), G140 (= G141), M141 (≠ N142), A143 (= A144), T144 (≠ E145), A146 (= A147), S147 (≠ G148), E200 (= E198), G201 (= G199), I206 (= I204), H370 (= H370), E414 (= E414), N451 (= N451)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
35% identity, 100% coverage: 1:456/458 of query aligns to 1:456/456 of 8jdoA