SitesBLAST

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
33% identity, 48% coverage: 115:225/232 of query aligns to 66:180/183 of 3nz2C

query
sites
3nz2C

C

C

R

E

I

F

G

G

V

K

N

T

S

I

G

R

I

I

G

G

A

D

F

H

S

T

F

F

I

I

G

N

A

M

-

N

-

V

-

M

-

L

-

D

A

G

G

A

G

P

V

I

D

T

I

I

G

G

N

D

N

H

V

V

I

L

M

I

G

G

Q

P

Y

S

V

T

S

Q

F

F

H
x
Y

S

T

E

A

N

S

H
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H

C

S

F

L

E

-

D

D

T

Y

E

R

R

R

P

R

I

Q

R

A

M

W

Q

E

G

T

V

I

T

C

R

K

Q

P

G

-

I

I

V

V

I

I

E

E

D

D

C

V

W

W

I

I

G
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G

A

G

K

N

V

V

T

V

F

I

L

N

D

Q

G

G

C

V

H

T

I

I

G

G

R

A

G

R

S

S

V

V

I

V

A
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A

G
x
N

A

S

V

V

R
x
N

G

Q

S

D

I

V

P

P

Y

D

S

T

V

L

A

V

V
x
G

G

G

V
x
T

P
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P

A

A

K

R

V

I

I
x
L

K
x
R

S

S

binding acetyl coenzyme *a: Y107 (≠ H150), H111 (= H154), G137 (= G182), A155 (= A200), A156 (= A201), N161 (≠ R206), G171 (≠ V216), T173 (≠ V218), P174 (= P219), L178 (≠ I223), R179 (≠ K224)
binding magnesium ion: N157 (≠ G202), T173 (≠ V218)

3nz2J Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
33% identity, 48% coverage: 115:225/232 of query aligns to 69:183/185 of 3nz2J

query
sites
3nz2J

C

C

R

E

I

F

G

G

V

K

N

T

S

I

G

R

I

I

G

G

A

D

F

H

S

T

F

F

I

I

G

N

A

M

-

N

-

V

-

M

-

L

-

D

A

G

G

A

G

P

V

I

D

T

I

I

G

G

N

D

N

H

V

V

I

L

M

I

G
|
G

Q

P

Y

S

V

T

S

Q

F

F

H
x
Y

S

T

E

A

N

S

H
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H

C

S

F

L

E

-

D

D

T

Y

E

R

R

R

P

R

I

Q

R

A

M

W

Q

E

G

T

V

I

T

C

R

K

Q

P

G

-

I

I

V

V

I

I

E

E

D

D

C

V

W
|
W

I

I

G
|
G

A

G

K

N

V

V

T

V

F

I

L

N

D

Q

G

G

C

V

H

T

I

I

G

G

R

A

G

R

S

S

V

V

I

V

A
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A

G

N

A

S

V

V

R
x
N

G

Q

S

D

I

V

P

P

Y

D

S

T

V

L

A

V

V
x
G

G

G

V
x
T

P
|
P

A

A

K

R

V

I

I

L

K
x
R

S

S

binding acetyl coenzyme *a: G104 (= G144), Y110 (≠ H150), H114 (= H154), W138 (= W180), G140 (= G182), A158 (= A200), A159 (= A201), N164 (≠ R206), G174 (≠ V216), T176 (≠ V218), P177 (= P219), R182 (≠ K224)

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
33% identity, 48% coverage: 115:225/232 of query aligns to 59:173/176 of 3ectA

query
sites
3ectA

C

C

R

E

I

F

G

G

V

K

N

T

S

I

G

R

I

I

G

G

A

D

F

H

S

T

F

F

I

I

G

N

A

M

-

N

-

V

-

M

-

L

-

D

A

G

G

A

G

P

V

I

D

T

I

I

G

G

N

D

N

H

V

V

I

L

M

I

G

G

Q

P

Y

S

V

T

S

Q

F

F

H

Y

S

T

E

A

N

S

H

H

C

S

F

L

E

-

D

D

T

Y

E

R

R

R

P

R

I

Q

R

A

M

W

Q

E

G

T

V

I

T

C

R

K

Q

P

G

-

I

I

V

V

I

I

E

E

D

D

C

V

W

W

I

I

G

G

A

G

K

N

V

V

T

V

F

I

L

N

D

Q

G
|
G

C

V

H

T

I

I

G

G

R

A

G

R

S

S

V

V

I

V

A

A

G

N

A

S

V

V

R

N

G

Q

S
x
D

I

V

P

P

Y

D

S

T

V

L

A

V

V

G

G

G

V

T

P

P

A

A

K

R

V

I

I

L

K

R

S

S

binding calcium ion: G138 (= G190), D156 (≠ S208)

4isxA The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
36% identity, 41% coverage: 135:228/232 of query aligns to 95:186/186 of 4isxA

query
sites
4isxA

V

I

D

E

I

I

G

G

N

D

N

N

V

V

I

M

M

L

G
x
A

Q

P

Y

N

V

V

S

Q

F

I

H

Y

S

T

E

A

N

Y

H

H

C

P

F

I

E

D

D

-

T

-

E

-

R

A

P

Q

I

L

R

R

M

N

Q

S

G

G

V

I

T

E

R

Y

-

G

Q

S

G

P

I

V

V

K

I

I

E

G

D

D

D

N

C

V

W
|
W

I

I

G
|
G

A
x
G

K

G

V

V

T

I

F

I

L

T

D

P

G

G

C

I

H

T

I

I

G

G

R

D

G

N

S

V

V

V

I

I

A

G

A
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A

G

G

A

S

V

V

R

T

G

K

S

D

I

I

P

P

Y

N

S

T

V

V

A

A

V
|
V

G

G

V

N

P

P

A

C

K

R

V

V

I

I

K
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K

S

K

R

I

Q

E

R

E

binding acetyl coenzyme *a: A104 (≠ G144), W138 (= W180), G140 (= G182), G141 (≠ A183), A159 (= A201), V174 (= V216), K182 (= K224)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84

4hurA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with acetyl coenzyme a (see paper)
47% identity, 25% coverage: 173:231/232 of query aligns to 113:169/211 of 4hurA

query
sites
4hurA

I

I

V

E

I

I

E

G

D

N

D

D

C

V

W
|
W

I
|
I

G
|
G

A
x
R

K

D

V

V

T

T

F

I

L
x
M

D

P

G

G

C

V

H

K

I

I

G

G

R

D

G

G

S

A

V

I

I

I

A
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A

G

E

A

A

V

V

R
x
T

G

K

S

N

I

V

P

A

P

P

Y

Y

S

S

V

I

A

V

V
x
G

G

G

V

N

P
|
P

A

L

K

K

V

F

I
|
I

K

-

S

-

R
|
R

Q

K

R

R

Y

F

R

S

D

D

binding acetyl coenzyme *a: W120 (= W180), I121 (= I181), G122 (= G182), R123 (≠ A183), M128 (≠ L188), A140 (= A200), A141 (= A201), T146 (≠ R206), G156 (≠ V216), P159 (= P219), I163 (= I223), R164 (= R226)

Sites not aligning to the query:

binding acetyl coenzyme *a: 51, 67, 68, 69, 79, 80, 110

6x3cE Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
47% identity, 25% coverage: 173:231/232 of query aligns to 113:169/203 of 6x3cE

query
sites
6x3cE

I

I

V

E

I

I

E

G

D

N

D

D

C

V

W
|
W

I

I

G
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G

A

R

K

D

V

V

T

T

F

I

L

M

D

P

G

G

C

V

H

K

I

I

G

G

R

D

G

G

S

A

V

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I

I

A
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A

G

E

A

A

V

V

R

T

G

K

S

N

I

V

P

A

P

P

Y

Y

S

S

V

I

A

V

V

G

G

G

V
x
N

P
|
P

A

L

K

K

V

F

I

I

K

-

S

-

R

R

Q

K

R

R

Y

F

R

S

D

D

binding magnesium ion: N158 (≠ V218), P159 (= P219)
binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (= W180), G122 (= G182), A140 (= A200), A141 (= A201)

Sites not aligning to the query:

4husA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
47% identity, 25% coverage: 173:231/232 of query aligns to 113:169/212 of 4husA

query
sites
4husA

I

I

V

E

I

I

E

G

D

N

D

D

C

V

W

W

I

I

G

G

A

R

K

D

V

V

T

T

F

I

L

M

D

P

G

G

C

V

H

K

I

I

G

G

R

D

G

G

S

A

V

I

I

I

A

A

G

E

A

A

V

V

R

T

G

K

S

N

I

V

P

A

P

P

Y

Y

S

S

V

I

A

V

V

G

G

G

V

N

P

P

A

L

K

K

V

F

I

I

K

-

S

-

R

R

Q

K

R

R

Y

F

R

S

D

D

Sites not aligning to the query:

binding virginiamycin m1: 17, 36, 38

6x3jA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f0224 (46) (see paper)
47% identity, 25% coverage: 173:231/232 of query aligns to 113:169/206 of 6x3jA

query
sites
6x3jA

I

I

V

E

I

I

E

G

D

N

D

D

C

V

W
|
W

I

I

G
|
G

A

R

K

D

V

V

T

T

F

I

L

M

D

P

G

G

C

V

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K

I

I

G

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D

G

G

S

A

V

I

I

I

A

A

G

E

A

A

V

V

R

T

G

K

S

N

I

V

P

A

P

P

Y

Y

S

S

V

I

A

V

V

G

G

G

V

N

P

P

A

L

K

K

V

F

I

I

K

-

S

-

R

R

Q

K

R

R

Y

F

R

S

D

D

binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (= W180), G122 (= G182)

Sites not aligning to the query:

6x3cA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
47% identity, 25% coverage: 173:231/232 of query aligns to 113:169/207 of 6x3cA

query
sites
6x3cA

I

I

V

E

I

I

E

G

D

N

D

D

C

V

W
|
W

I

I

G
|
G

A
x
R

K

D

V

V

T

T

F

I

L
x
M

D

P

G

G

C

V

H

K

I

I

G

G

R

D

G

G

S

A

V

I

I

I

A
|
A

G

E

A

A

V

V

R

T

G

K

S

N

I

V

P

A

P

P

Y

Y

S

S

V

I

A

V

V

G

G

G

V

N

P

P

A

L

K

K

V

F

I

I

K

-

S

-

R

R

Q

K

R

R

Y

F

R

S

D

D

binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (= W180), G122 (= G182), R123 (≠ A183), M128 (≠ L188), A140 (= A200), A141 (= A201)

Sites not aligning to the query:

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
37% identity, 39% coverage: 135:225/232 of query aligns to 95:183/201 of 1krvA

query
sites
1krvA

V

V

D

T

I

I

G

G

N

D

N

N

V

V

I

L

M

I

G
x
A

Q

P

Y

N

V

V

S

T

F

L

H
x
S

S

V

E
x
T

N

G

H

H

C

-

F

-

E

-

D

P

T

V

E

H

R

H

P

E

I

L

R

R

M

K

Q

N

G

G

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T
x
M

R

Y

Q

S

-

F

G

P

I

I

V

T

I

I

E

G

D

N

C

V

W
|
W

I

I

G
|
G

A
x
S

K

H

V

V

T

V

F

I

L
x
N

D

P

G

G

C

V

H

T

I

I

G

G

R

D

G

N

S

S

V

V

I

I

A

G

A
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A

G

G

A

S

V

I

V

V

R

T

G

K

S

D

I

I

P

P

Y

N

S

V

V

V

A

A

V

A

G

G

V

V

P
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P

A

C

K
x
R

V

V

I

I

K
x
R

S

E

binding 4-nitrophenyl beta-D-galactopyranoside: M126 (≠ T169)
binding coenzyme a: A104 (≠ G144), S110 (≠ H150), T112 (≠ E152), W138 (= W180), G140 (= G182), S141 (≠ A183), N146 (≠ L188), A159 (= A201), P177 (= P219), R179 (≠ K221), R182 (≠ K224)

Sites not aligning to the query:

binding 4-nitrophenyl beta-D-galactopyranoside: 16, 25, 70, 82, 84, 90, 92

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
37% identity, 39% coverage: 135:225/232 of query aligns to 95:183/201 of 1kruA

query
sites
1kruA

V

V

D

T

I

I

G

G

N

D

N

N

V

V

I
x
L

M

I

G

A

Q

P

Y

N

V

V

S

T

F

L

H

S

S

V

E

T

N

G

H
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H

C

-

F

-

E

-

D

P

T

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E

H

R

H

P

E

I

L

R

R

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N

G

G

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T
x
M

R

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-

F

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P

I

I

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T

I

I

E

G

D

N

C

V

W
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W

I

I

G
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G

A
x
S

K

H

V

V

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V

F

I

L

N

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P

G

G

C

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G

N

S

S

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V

I

I

A
x
G

A
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A

G

G

A

S

V

I

V

V

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T

G

K

S

D

I

I

P

P

Y

N

S

V

V

V

A

A

V

A

G

G

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P
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P

A

C

K

R

V

V

I

I

K
x
R

S

E

binding coenzyme a: H114 (= H154), W138 (= W180), G140 (= G182), S141 (≠ A183), G158 (≠ A200), A159 (= A201), P177 (= P219), R182 (≠ K224)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: L102 (≠ I142), H114 (= H154), M126 (≠ T169)

Sites not aligning to the query:

binding 1-methylethyl 1-thio-beta-D-galactopyranoside: 16, 22, 25, 62, 70, 82, 82, 84, 90, 92

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
37% identity, 39% coverage: 135:225/232 of query aligns to 96:184/203 of P07464

query
sites
P07464

V

V

D

T

I

I

G

G

N

D

N

N

V

V

I

L

M

I

G

A

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Y

N

V

V

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T

F

L

H

S

S

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N

G

H
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H

C

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F

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E

-

D

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T

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E

H

R

H

P

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I

L

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G

G

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-

F

G

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I

I

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I

I

E

G

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N

C

V

W

W

I

I

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G

A
x
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H

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F

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N

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G

C

V

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T

I

I

G

G

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D

G

N

S

S

V

V

I

I

A

G

A
|
A

G

G

A

S

V

I

V

V

R
x
T

G
x
K

S

D

I

I

P

P

Y

N

S

V

V

V

A

A

V

A

G

G

V

V

P

P

A

C

K
x
R

V

V

I

I

K
x
R

S

E

H115 (= H154) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ A183) binding in other chain
A160 (= A201) binding in other chain
TK 165:166 (≠ RG 206:207) binding
R180 (≠ K221) binding
R183 (≠ K224) binding in other chain

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding
71 binding
85 binding in other chain; binding in other chain
93 binding

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
37% identity, 39% coverage: 135:225/232 of query aligns to 95:183/200 of 1krrA

query
sites
1krrA

V

V

D

T

I

I

G

G

N

D

N

N

V

V

I

L

M
x
I

G
x
A

Q
x
P

Y

N

V

V

S

T

F

L

H

S

S

V

E
x
T

N

G

H
|
H

C

-

F

-

E

-

D

P

T

V

E

H

R

H

P

E

I

L

R

R

M

K

Q

N

G

G

V

E

T

M

R

Y

Q

S

-

F

G

P

I

I

V

T

I

I

E

G

D

N

C

V

W

W

I

I

G
|
G

A
x
S

K

H

V

V

T

V

F

I

L
x
N

D

P

G

G

C

V

H

T

I

I

G

G

R

D

G

N

S

S

V

V

I

I

A
x
G

A
|
A

G

G

A

S

V

I

V

V

R

T

G

K

S

D

I

I

P

P

Y

N

S

V

V

V

A

A

V
x
A

G

G

V

V

P
|
P

A

C

K

R

V

V

I

I

K
x
R

S

E

binding acetyl coenzyme *a: I103 (≠ M143), A104 (≠ G144), P105 (≠ Q145), T112 (≠ E152), H114 (= H154), G140 (= G182), S141 (≠ A183), N146 (≠ L188), G158 (≠ A200), A159 (= A201), A174 (≠ V216), P177 (= P219), R182 (≠ K224)

Sites not aligning to the query:

binding acetyl coenzyme *a: 84

A1ADJ6 Polysialic acid O-acetyltransferase; Capsule O-acetyl transferase; EC 2.3.1.136 from Escherichia coli O1:K1 / APEC (see paper)
30% identity, 51% coverage: 106:224/232 of query aligns to 160:278/307 of A1ADJ6

query
sites
A1ADJ6

G

D

V

I

I

V

S

A

N

T

L

K

G

G

V

S

G

K

C

V

R

I

I

I

G

G

V

R

N

R

S

T

G

T

I

I

G

G

A

A

-

G

F

F

S

E

F

V

I

V

G

T

A

D

A

K

G

C

G

N

V

V

D

T

I

I

G

G

N

H

N

D

V

C

I

M

M

I

G

A

Q

R

Y

D

V

V

S

I

F

L

H

R

-

A

S

S

E

D

N

G

H
|
H

C

P

F

I

E

F

D

D

T

I

E

H

R

S

P

K

I

K

R

R

M

I

Q

N

G

W

V

A

T

-

R

-

Q

K

G

D

I

I

V

I

I

I

E

S

D

S

D

Y

C

V

W
|
W

I

V

G

G

A

R

K

N

V

V

T

S

F

I

L

M

D

K

G

G

C

V

H

S

I

V

G

G

R

S

G

G

S

S

V

V

I

I

A

G

A

Y

G

G

A

S

V

I

V

V

R

T

G

K

S

D

I

V

P

P

P

S

Y

M

S

C

V

A

A

A

V

A

G

G

V

N

P

P

A

A

K

K

V

I

I

I

K

K

H210 (= H154) mutation to A: Loss of activity.
W234 (= W180) mutation to A: Loss of activity.

6u9cA The 2.2 a crystal structure of the type b chloramphenicol acetyltransferase from vibrio cholerae in the complex with acetyl coa
36% identity, 45% coverage: 123:226/232 of query aligns to 58:162/206 of 6u9cA

query
sites
6u9cA

I

I

G

G

A

S

F

F

S

C

F

S

I

I

G

G

A

S

A

-

G

G

G

A

V

V

D

F

I

M

-

M

-

A

G

G

N

N

N

Q

V

G

I

H

M

R

G

S

Q

D

Y

W

V

I

S

S

-

T

-

F

-

P

-

F

F

F

H

Y

S

Q

E

D

N

N

H

D

C

N

F

F

E

A

D

D

T

A

E

R

R

-

P

-

I

-

R

-

M

-

Q

D

G

G

V

F

T

T

R

R

Q

S

G

G

-

D

I

T

V

I

I

I

E

G

D

H

D

D

C

V

W
|
W

I

I

G

G

A

T

K

E

V

A

T

M

F

I

L

M

D

P

G

G

C

V

H

K

I

I

G

G

R

H

G

G

S

A

V

I

I

I

A
|
A

A

S

G

R

A

S

V

V

R

T

G

K

S

D

I

V

P

A

P

P

Y

Y

S

E

V

V

A

V

V

G

G

S

V

N

P

P

A

A

K

K

V

H

I
|
I

K

K

S

F

R

R

binding acetyl coenzyme *a: W116 (= W180), A136 (= A200), I159 (= I223)

6pubA Crystal structure of the type b chloramphenicol acetyltransferase from vibrio cholerae in the complex with crystal violet
36% identity, 45% coverage: 123:226/232 of query aligns to 61:165/210 of 6pubA

query
sites
6pubA

I

I

G

G

A

S

F

F

S

C

F

S

I

I

G

G

A

S

A

-

G

G

G

A

V

V

D

F

I

M

-

M

-

A

G

G

N

N

N

Q

V

G

I

H

M

R

G

S

Q

D

Y

W

V

I

S

S

-

T

-

F

-

P

-

F

F

F

H

Y

S

Q

E

D

N

N

H

D

C

N

F

F

E

A

D

D

T

A

E

R

R

-

P

-

I

-

R

-

M

-

Q

D

G

G

V

F

T

T

R

R

Q

S

G

G

-

D

I

T

V

I

I

I

E

G

D

H

D

D

C

V

W

W

I

I

G

G

A

T

K

E

V

A

T

M

F

I

L

M

D

P

G

G

C

V

H

K

I

I

G

G

R

H

G

G

S

A

V

I

I

I

A

A

A

S

G

R

A

S

V

V

R

T

G

K

S

D

I

V

P

A

P

P

Y

Y

S

E

V

V

A

V

V

G

G

S

V

N

P

P

A

A

K

K

V

H

I

I

K

K

S

F

R

R

Sites not aligning to the query:

binding crystal violet: 4, 7, 9, 10, 11, 36, 37

3dhoA Structure of streptogramin acetyltransferase in complex with an inhibitor
40% identity, 32% coverage: 152:226/232 of query aligns to 99:167/203 of 3dhoA

query
sites
3dhoA

E

E

N

K

H

H

C

M

F

P

E

K

D

L

T

D

E

Q

R

L

P

P

I

I

R

K

M

-

Q

-

G

G

V

D

T

T

R

-

Q

-

G

-

I

-

V

I

I

I

E

G

D

N

D

D

C

V

W

W

I

I

G

G

A

K

K

D

V

V

T

V

F

I

L

M

D

P

G

G

C

V

H

K

I

I

G

G

R

D

G

G

S

A

V
x
I

I

V

A
|
A

A

A

G

N

A

S

V

V

R
x
V

G

K

S

D

I

I

P

A

P

P

Y

Y

S

M

V
x
L

A

A

V
x
G

G

G

V

N

P
|
P

A

A

K

N

V

E

I
|
I

K

K

S

Q

R

R

binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: I139 (≠ V198), A141 (= A200), V147 (≠ R206), L155 (≠ V214), G157 (≠ V216), P160 (= P219), I164 (= I223)

Sites not aligning to the query:

binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: 84

1kk4A Crystal structure of vat(d) in complex with acetyl-coa (see paper)
40% identity, 32% coverage: 152:226/232 of query aligns to 99:167/205 of 1kk4A

query
sites
1kk4A

E

E

N

K

H

H

C

M

F

P

E

K

D

L

T

D

E

Q

R

L

P

P

I

I

R
x
K

M

-

Q

-

G

G

V

D

T

T

R

-

Q

-

G

-

I

-

V

I

I

I

E

G

D

N

D

D

C

V

W
|
W

I

I

G
|
G

A
x
K

K

D

V

V

T

V

F

I

L

M

D

P

G

G

C

V

H

K

I

I

G

G

R

D

G

G

S

A

V

I

I

V

A
|
A

G

N

A

S

V

V

R
x
V

G
x
K

S

D

I

I

P

A

P

P

Y

Y

S

M

V
x
L

A

A

V
x
G

G
|
G

V

N

P
|
P

A

A

K

N

V

E

I
|
I

K

K

S

Q

R

R

binding acetyl coenzyme *a: K111 (≠ R164), W121 (= W180), G123 (= G182), K124 (≠ A183), A141 (= A200), A142 (= A201), V147 (≠ R206), K148 (≠ G207), L155 (≠ V214), G157 (≠ V216), G158 (= G217), P160 (= P219), I164 (= I223)

Sites not aligning to the query:

binding acetyl coenzyme *a: 69, 70

1mrlA Crystal structure of streptogramin a acetyltransferase with dalfopristin (see paper)
40% identity, 32% coverage: 152:226/232 of query aligns to 99:167/204 of 1mrlA

query
sites
1mrlA

E

E

N

K

H

H

C
x
M

F

P

E

K

D

L

T

D

E

Q

R
x
L

P

P

I

I

R

K

M

-

Q

-

G

G

V

D

T

T

R

-

Q

-

G

-

I

-

V

I

I

I

E

G

D

N

D

D

C

V

W

W

I

I

G

G

A

K

K

D

V

V

T

V

F

I

L

M

D

P

G

G

C

V

H

K

I

I

G

G

R

D

G

G

S

A

V

I

I

V

A

A

G

N

A

S

V

V

R

V

G

K

S

D

I

I

P

A

P

P

Y

Y

S

M

V

L

A

A

V

G

G

G

V

N

P

P

A

A

K

N

V

E

I

I

K

K

S

Q

R

R

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: M102 (≠ C155), L108 (≠ R161)

Sites not aligning to the query:

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: 37, 39, 54, 56, 81, 82, 93

Query Sequence

>WP_092999081.1 NCBI__GCF_900102855.1:WP_092999081.1
MAQRAAKIFRGPSYKLDTNVTVTALMGFTIRRAISLLRCILRGLALKPGKWFFVGTSVVL
RNRSFIRFGRGATIGNFVLIDGLSRNGVVIGDGVNIGAYTIIEATGVISNLGVGCRIGVN
SGIGAFSFIGAAGGVDIGNNVIMGQYVSFHSENHCFEDTERPIRMQGVTRQGIVIEDDCW
IGAKVTFLDGCHIGRGSVIAAGAVVRGSIPPYSVAVGVPAKVIKSRQRYRDA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory