SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_094506961.1 NCBI__GCF_002252445.1:WP_094506961.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8b9zF Drosophila melanogaster complex i in the active state (dm1) (see paper)
69% identity, 97% coverage: 2:421/435 of query aligns to 17:437/441 of 8b9zF

query
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8b9zF

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binding flavin mononucleotide: G69 (= G54), G71 (= G56), K80 (= K65), N98 (= N83), D100 (= D85), G189 (= G173), E191 (= E175), N226 (= N210), A408 (= A392), L409 (= L393)
binding iron/sulfur cluster: P205 (= P189), C361 (= C345), G362 (= G346), Q363 (= Q347), C364 (= C348), C367 (= C351), T405 (= T389), C407 (= C391), L409 (= L393)

8eswV1 NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A (see paper)
69% identity, 97% coverage: 2:421/435 of query aligns to 15:435/439 of 8eswV1

query
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8eswV1

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binding flavin mononucleotide: G67 (= G54), G69 (= G56), K78 (= K65), N96 (= N83), D98 (= D85), E99 (= E86), G187 (= G173), E188 (= E174), N224 (= N210), A406 (= A392)
binding iron/sulfur cluster: I185 (= I171), P203 (= P189), C359 (= C345), Q361 (= Q347), C362 (= C348), C365 (= C351), T403 (= T389), I404 (= I390), C405 (= C391), L407 (= L393)
binding : Y143 (≠ M130), N144 (≠ R131), Q150 (= Q137), D174 (= D160)

7aqrF Cryo-em structure of arabidopsis thaliana complex-i (peripheral arm) (see paper)
71% identity, 94% coverage: 2:408/435 of query aligns to 8:415/434 of 7aqrF

query
sites
7aqrF

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H

T
|
T

I

I

C
|
C

A

A

L
|
L

G

G

D

D

A

A

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

binding flavin mononucleotide: G60 (= G54), R61 (= R55), G62 (= G56), K71 (= K65), N89 (= N83), D91 (= D85), Y177 (= Y170), G180 (= G173), E181 (= E174), E182 (= E175), T216 (≠ N209), N217 (= N210)
binding iron/sulfur cluster: S351 (= S344), C352 (= C345), G353 (= G346), Q354 (= Q347), C355 (= C348), C358 (= C351), T396 (= T389), C398 (= C391), L400 (= L393)

7arcF Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
68% identity, 96% coverage: 2:418/435 of query aligns to 9:426/430 of 7arcF

query
sites
7arcF

L

L

A

R

D

D

K

Q

D

D

R

R

I

I

F

F

T

T

N

N

I

I

Y

Y

G

G

F

R

K

H

D

D

Q

P

S

Y

L

I

K

K

G

G

A

A

M

E

S

A

R

R

G

G

H

D

W

W

D

Y

N

M

T

T

K

K

G

D

F

L

V

V

E

G

K

K

G

G

R

R

D

D

W

W

I

I

I

I

N

D

E

Q

M

I

K

K

A

K

S

S

N

G

L

L

R

R

G
|
G

R
|
R

G

G

G

G

A

A

G

G

F

F

P

A

T

S

G

G

L

L

K
|
K

W

W

S

S

F

F

M

M

P

P

K

K

E

V

V

S

T

D

D

G

R

R

P

P

H

S

Y

Y

L

L

V

V

V

V

N
|
N

A

G

D
|
D

E
|
E

S
|
S

E

E

P

P

G

G

T

T

C

C

K

K

D

D

R

R

E

E

I

I

L

M

R

R

H

H

D

E

P

P

H

H

T

K

L

L

I

V

E

E

G

G

C

C

V

L

I

V

A

A

G

G

C

T

A

A

M

M

S

G

A

A

H

R

T

A

A

G

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M

V

R

N

E

E

R

R

E

K

A

A

L

V

Q

E

A

R

A

A

I

V

D

A

E

E

C

A

Y

Y

D

A

A

K

G

G

L

Y

L

L

G

G

K

K

N

N

N

A

-

C

K

G

C

S

G

G

W

V

D

D

M

F

D

D

I

L

F

F

L

V

H

H

H

Y

G

G

A

A

G

G

A

A

Y
|
Y

I

I

C

C

G
|
G

E
|
E

E

E

T

T

A

A

L

L

L

I

E

E

S

S

L

L

E

E

G

G

K

K

K

Q

G

G

Q

K

P

P

R

R

L

L

K

K

P

P

P

P

F

F

P

P

A

A

N

G

M

M

G

G

L

L

Y

Y

G

G

C

C

P

P

T

T

T

T

V

V

N
x
T

N
|
N

V

V

E

E

S

T

I

V

A

A

V

V

A

S

P

P

T

T

I

I

L

L

R

R

R

R

G

G

G

P

A

E

W

W

F

F

S

S

S

S

I

F

G

G

R

R

P

K

N

N

N

N

V

A

G

G

T

T

K

K

L

L

F

F

Q

A

I

I

S

S

G

G

H

H

V

V

N

N

T

R

P

P

C

V

T

T

V

V

E

E

E

E

S

E

L

M

G

S

I

I

T

P

F

L

R

R

E

E

L

L

I

I

E

E

K

R

H

H

G

A

G

G

G

G

I

V

R

R

G

G

G

G

W

W

D

D

N

N

L

L

L

L

G

A

V

I

I

I

P

P

G

G

G

G

A

S

S

S

C

V

P

P

I

L

I

L

K

P

G

K

E

K

D

M

M

C

M

D

D

D

A

V

I

I

M

M

D

D

F

F

D

D

G

A

M

L

R

R

E

T

K

A

K

Q

S

S

S

G

F

L

G

G

T

T

G

A

G

A

V

V

I

I

V

V

M

M

D

N

K

K

S

D

T

T

D

D

V

V

I

I

K

D

A

A

I

I

A

A

R

R

L

L

A

S

A

Y

F

F

F

Y

K

K

H

H

E

E

S
|
S

C
|
C

G
|
G

Q
|
Q

C
|
C

T

T

P

P

C
|
C

R

R

E

E

G

G

T

T

G

G

W

W

M

L

W

Y

R

D

V

I

M

M

E

S

R

R

M

M

V

R

K

K

G

G

N

D

A

A

Q

R

K

L

R

E

E

E

I

I

D

D

M

M

L

L

L

W

D

E

V

I

T

T

K

K

Q

Q

I

I

E

E

G

G

H

H

T
|
T

I

I

C
|
C

A

A

L
|
L

G

G

D

D

A

A

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

R

R

P

S

E

E

I

M

E

E

K

D

R

R

I

I

D

K

D

N

binding flavin mononucleotide: G61 (= G54), R62 (= R55), K72 (= K65), N90 (= N83), D92 (= D85), E93 (= E86), S94 (= S87), Y178 (= Y170), G181 (= G173), E182 (= E174), T217 (≠ N209), N218 (= N210), L401 (= L393)
binding iron/sulfur cluster: S352 (= S344), C353 (= C345), G354 (= G346), Q355 (= Q347), C356 (= C348), C359 (= C351), T397 (= T389), C399 (= C391), L401 (= L393)

7dgq8 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (see paper)
65% identity, 97% coverage: 2:422/435 of query aligns to 4:425/427 of 7dgq8

query
sites
7dgq8

L

L

A

K

D

D

K

E

D

D

R

R

I

I

F

F

T

T

N

N

I

L

Y

Y

G

G

F

R

K

H

D

D

Q

W

S

R

L

L

K

K

G

G

A

A

M

Q

S

S

R

R

G

G

H

D

W

W

D

Y

N

K

T

T

K

K

G

E

F

I

V

L

E

L

K

K

G

G

R

P

D

D

W

W

I

I

I

L

N

G

E

E

M

V

K

K

A

T

S

S

N

G

L

L

R

R

G

G

R

R

G
|
G

G

G

A

A

G

G

F

F

P

P

T

T

G

G

L

L

K
|
K

W

W

S

S

F

F

M

M

P

N

K

K

E

P

V

S

T

D

D

G

R

R

P

P

H

K

Y

Y

L

L

V

V

V

V

N
|
N

A

A

D
|
D

E
|
E

S
x
G

E

E

P

P

G

G

T

T

C

C

K

K

D

D

R

R

E

E

I

I

L

I

R

R

H

H

D

D

P

P

H

H

T

K

L

L

I

V

E

E

G

G

C

C

V

L

I

V

A

G

G

G

C

R

A

A

M

M

S

G

A

A

H
x
R

T

A

A

A

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M
x
Y

R

N

E

E

R

A

E

S

A

N

L

L

Q
|
Q

A

V

A

A

I

I

D
x
R

E

E

C

A

Y
|
Y

D
x
E

A

A

G

G

L

L

L

I

G

G

K

K

N

N

N

A

-

C

K

G

C

S

G

G

W

Y

D

D

M

F

D

D

I

V

F
|
F

L

V

H

V

H
x
R

G

G

A

A

G

G

A

A

Y

Y

I

I

C
|
C

G
|
G

E

E

E

E

T

T

A

A

L

L

L

I

E

E

S

S

L

I

E

E

G

G

K

K

K

Q

G

G

Q

K

P

P

R

R

L

L

K

K

P

P

P

P

F

F

P

P

A

A

N

D

M

V

G

G

L

V

Y

F

G

G

C

C

P

P

T

T

T

T

V

V

N
x
A

N
|
N

V

V

E

E

S

T

I

V

A

A

V

V

A

S

P

P

T

T

I

I

L

C

R

R

R

R

G

G

G

G

A

A

W

W

F

F

S

A

S

S

I

F

G

G

R

R

P

E

N

R

N

N

V

S

G

G

T

T

K

K

L

L

F

F

Q

N

I

I

S

S

G

G

H

H

V

V

N

N

T

N

P

P

C

C

T

T

V

V

E

E

E

E

S

E

L

M

G

S

I

V

T

P

F

L

R

K

E

E

L

L

I

I

E

E

K

K

H

H

G

A

G

G

G

G

I

V

R

T

G

G

G

G

W

W

D

D

N

N

L

L

L

L

G

A

V

V

I

I

P

P

G

G

G

G

A

S

S

S

C

T

P

P

I

L

I

I

K

P

G

K

E

S

D

V

M

C

M

E

D

T

A

V

I

L

M

M

D

D

F

F

D

D

G

A

M

L

R

I

E

Q

K

A

K

Q

S

T

S

G

F

L

G

G

T

T

G

A

G

A

V

V

I

I

V

V

M

M

D

D

K

R

S

S

T

T

D

D

V

I

I

V

K

K

A

A

I

I

A

A

R

R

L

L

A

I

A

E

F

F

F

Y

K

K

H

H

E

E

S
|
S

C
|
C

G
|
G

Q

Q

C
|
C

T

T

P

P

C
|
C

R

R

E

E

G

G

T

V

G

D

W

W

M

M

W

N

R

K

V

V

M

M

E

A

R

R

M

F

V

V

K

R

G

G

N

D

A

A

Q

R

K

P

R

A

E

E

I

I

D

D

M

S

L

L

L

W

D

E

V

I

T

S

K

K

Q

Q

I

I

E

E

G

G

H

H

T

T

I

I

C
|
C

A

A

L
|
L

G

G

D

D

A

G

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

R

R

P

P

E

E

I

L

E

E

K

E

R

R

I

M

D

Q

D

Q

Y

F

T

A

R

Q

N

Q

binding flavin mononucleotide: G58 (= G56), K67 (= K65), N85 (= N83), D87 (= D85), E88 (= E86), G89 (≠ S87), C175 (= C172), G176 (= G173), A212 (≠ N209), N213 (= N210)
binding iron/sulfur cluster: S347 (= S344), C348 (= C345), G349 (= G346), C351 (= C348), C354 (= C351), C394 (= C391), L396 (= L393)
binding : R121 (≠ H119), Y132 (≠ M130), Q139 (= Q137), R143 (≠ D141), Y146 (= Y144), E147 (≠ D145), F165 (= F162), R168 (≠ H165)

7v2cA Active state complex i from q10 dataset (see paper)
66% identity, 96% coverage: 2:420/435 of query aligns to 10:429/433 of 7v2cA

query
sites
7v2cA

L

L

A

K

D

D

K

E

D

D

R

R

I

I

F

F

T

T

N

N

I

L

Y

Y

G

G

F

R

K

H

D

D

Q

W

S

R

L

L

K

K

G

G

A

A

M

Q

S

S

R

R

G

G

H

D

W

W

D

Y

N

K

T

T

K

K

G

E

F

I

V

L

E

L

K

K

G

G

R

P

D

D

W

W

I

I

I

L

N

G

E

E

M

V

K

K

A

T

S

S

N

G

L

L

R

R

G
|
G

R

R

G

G

G

G

A

A

G

G

F

F

P

P

T

T

G

G

L

L

K
|
K

W

W

S

S

F

F

M

M

P

N

K

K

E

P

V

S

T

D

D

G

R

R

P

P

H

K

Y

Y

L

L

V

V

V

V

N
|
N

A

A

D

D

E

E

S

G

E

E

P

P

G

G

T

T

C

C

K

K

D

D

R

R

E

E

I

I

L

I

R

R

H

H

D

D

P

P

H

H

T

K

L

L

I

V

E

E

G

G

C

C

V

L

I

V

A

G

G

G

C

R

A

A

M

M

S

G

A

A

H

R

T

A

A

A

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M

Y

R

N

E

E

R

A

E

S

A

N

L

L

Q

Q

A

V

A

A

I

I

D

R

E

E

C

A

Y

Y

D

E

A

A

G

G

L

L

L

I

G

G

K

K

N

N

N

A

-

C

K

G

C

S

G

G

W

Y

D

D

M

F

D

D

I

V

F

F

L

V

H

V

H

R

G

G

A

A

G

G

A

A

Y
|
Y

I

I

C

C

G
|
G

E
|
E

E

E

T

T

A

A

L

L

L

I

E

E

S

S

L

I

E

E

G

G

K

K

K

Q

G

G

Q

K

P
|
P

R

R

L

L

K

K

P

P

P

P

F

F

P

P

A

A

N

D

M

V

G

G

L

V

Y

F

G

G

C

C

P

P

T

T

T

T

V

V

N

A

N
|
N

V

V

E

E

S

T

I

V

A

A

V

V

A

S

P

P

T

T

I

I

L

C

R

R

R

R

G

G

G

G

A

A

W

W

F

F

S

A

S

S

I

F

G

G

R

R

P

E

N

R

N

N

V

S

G

G

T

T

K

K

L

L

F

F

Q

N

I

I

S

S

G

G

H

H

V

V

N

N

T

H

P

P

C

C

T

T

V

V

E

E

E

E

S

E

L

M

G

S

I

V

T

P

F

L

R

K

E

E

L

L

I

I

E

E

K

K

H

H

G

A

G

G

G

G

I

V

R

I

G

G

G

G

W

W

D

D

N

N

L

L

L

L

G

A

V

V

I

I

P

P

G

G

G

G

A

S

S

S

C

T

P

P

I

L

I

I

K

P

G

K

E

S

D

V

M

C

M

E

D

T

A

V

I

L

M

M

D

D

F

F

D

D

G

A

M

L

R

V

E

Q

K

A

K

Q

S

T

S

G

F

L

G

G

T

T

G

A

G

A

V

V

I

I

V

V

M

M

D

D

K

R

S

S

T

T

D

D

V

I

I

V

K

K

A

A

I

I

A

A

R

R

L

L

A

I

A

E

F

F

F

Y

K

K

H

H

E

E

S

S

C
|
C

G
|
G

Q
|
Q

C
|
C

T

T

P

P

C
|
C

R

R

E

E

G

G

T

V

G

D

W

W

M

M

W

N

R

K

V

V

M

M

E

A

R

R

M

F

V

V

K

K

G

G

N

D

A

A

Q

R

K

P

R

A

E

E

I

I

D

D

M

S

L

L

L

W

D

E

V

I

T

S

K

K

Q

Q

I

I

E

E

G

G

H

H

T
|
T

I

I

C
|
C

A
|
A

L
|
L

G

G

D

D

A

G

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

R

R

P

P

E

E

I

L

E

E

K

E

R

R

I

M

D

Q

D

Q

Y

F

T

A

binding flavin mononucleotide: G62 (= G54), K73 (= K65), N91 (= N83), Y179 (= Y170), G182 (= G173), E183 (= E174), N219 (= N210), A401 (= A392), L402 (= L393)
binding iron/sulfur cluster: P198 (= P189), C354 (= C345), G355 (= G346), Q356 (= Q347), C357 (= C348), C360 (= C351), T398 (= T389), C400 (= C391), L402 (= L393)

6zk91 Peripheral domain of open complex i during turnover (see paper)
65% identity, 97% coverage: 2:422/435 of query aligns to 7:428/430 of 6zk91

query
sites
6zk91

L

L

A

K

D

D

K

E

D

D

R

R

I

I

F

F

T

T

N

N

I

L

Y

Y

G

G

F

R

K

H

D

D

Q

W

S

R

L

L

K

K

G

G

A

A

M

Q

S

S

R

R

G

G

H

D

W

W

D

Y

N

K

T

T

K

K

G

E

F

I

V

L

E

L

K

K

G

G

R

P

D

D

W

W

I

I

I

L

N

G

E

E

M

V

K

K

A

T

S

S

N

G

L

L

R

R

G
|
G

R

R

G
|
G

G
|
G

A
|
A

G

G

F
|
F

P

P

T

T

G

G

L

L

K
|
K

W

W

S

S

F

F

M

M

P

N

K

K

E

P

V

S

T

D

D

G

R

R

P

P

H

K

Y

Y

L

L

V

V

V

V

N
|
N

A

A

D
|
D

E
|
E

S

G

E
|
E

P

P

G

G

T

T

C

C

K

K

D

D

R

R

E

E

I

I

L

I

R

R

H

H

D

D

P

P

H

H

T

K

L

L

I

V

E

E

G

G

C

C

V

L

I

V

A

G

G

G

C

R

A

A

M

M

S

G

A

A

H

R

T

A

A

A

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M

Y

R

N

E

E

R

A

E

S

A

N

L

L

Q

Q

A

V

A

A

I

I

D

R

E

E

C

A

Y

Y

D

E

A

A

G

G

L

L

L

I

G

G

K

K

N

N

N

A

-

C

K

G

C

S

G

G

W

Y

D

D

M

F

D

D

I

V

F

F

L

V

H

V

H

R

G

G

A

A

G

G

A

A

Y
|
Y

I
|
I

C

C

G
|
G

E
|
E

E
|
E

T

T

A

A

L

L

L

I

E

E

S

S

L

I

E

E

G

G

K

K

K

Q

G

G

Q

K

P
|
P

R

R

L

L

K

K

P

P

P

P

F
|
F

P

P

A

A

N

D

M

V

G

G

L

V

Y

F

G

G

C

C

P

P

T

T

T

T

V

V

N
x
A

N
|
N

V

V

E

E

S

T

I

V

A

A

V

V

A

S

P

P

T

T

I

I

L

C

R

R

R

R

G

G

G

G

A

A

W

W

F

F

S

A

S

S

I

F

G

G

R

R

P

E

N

R

N

N

V

S

G

G

T

T

K

K

L

L

F

F

Q

N

I

I

S

S

G

G

H

H

V

V

N

N

T

N

P

P

C

C

T

T

V

V

E

E

E

E

S

E

L

M

G

S

I

V

T

P

F

L

R

K

E

E

L

L

I

I

E

E

K

K

H

H

G

A

G

G

G

G

I

V

R

T

G

G

G

G

W

W

D

D

N

N

L

L

L

L

G

A

V

V

I

I

P

P

G

G

G

G

A

S

S

S

C

T

P

P

I

L

I

I

K

P

G

K

E

S

D

V

M

C

M

E

D

T

A

V

I

L

M

M

D

D

F

F

D

D

G

A

M

L

R

I

E

Q

K

A

K

Q

S

T

S

G

F

L

G

G

T
|
T

G

A

G

A

V

V

I

I

V

V

M

M

D

D

K

R

S

S

T

T

D

D

V

I

I

V

K

K

A

A

I

I

A

A

R

R

L

L

A

I

A

E

F

F

F

Y

K

K

H

H

E

E

S

S

C
|
C

G
|
G

Q
|
Q

C
|
C

T

T

P

P

C
|
C

R

R

E

E

G

G

T

V

G

D

W

W

M

M

W

N

R

K

V

V

M

M

E

A

R

R

M

F

V

V

K

R

G

G

N

D

A

A

Q

R

K

P

R

A

E

E

I

I

D

D

M

S

L

L

L

W

D

E

V

I

T

S

K

K

Q

Q

I

I

E

E

G

G

H

H

T
|
T

I

I

C
|
C

A
|
A

L
|
L

G

G

D

D

A

G

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

R

R

P

P

E

E

I

L

E

E

K

E

R

R

I

M

D

Q

D

R

Y

F

T

A

R

Q

N

Q

binding flavin mononucleotide: G59 (= G54), G61 (= G56), K70 (= K65), N88 (= N83), D90 (= D85), E91 (= E86), G179 (= G173), E180 (= E174), A215 (≠ N209), N216 (= N210), A398 (= A392), L399 (= L393)
binding 1,4-dihydronicotinamide adenine dinucleotide: G61 (= G56), G62 (= G57), A63 (= A58), F65 (= F60), K70 (= K65), E93 (= E88), Y176 (= Y170), E181 (= E175), F201 (= F195), T323 (= T317)
binding iron/sulfur cluster: I177 (= I171), P195 (= P189), C351 (= C345), G352 (= G346), Q353 (= Q347), C354 (= C348), C357 (= C351), T395 (= T389), C397 (= C391), L399 (= L393)

5lnk1 Entire ovine respiratory complex i (see paper)
65% identity, 97% coverage: 2:422/435 of query aligns to 9:430/432 of 5lnk1

query
sites
5lnk1

L

L

A

K

D

D

K

E

D

D

R

R

I

I

F

F

T

T

N

N

I

L

Y

Y

G

G

F

R

K

H

D

D

Q

W

S

R

L

L

K

K

G

G

A

A

M

Q

S

S

R

R

G

G

H

D

W

W

D

Y

N

K

T

T

K

K

G

E

F

I

V

L

E

L

K

K

G

G

R

P

D

D

W

W

I

I

I

L

N

G

E

E

M

V

K

K

A

T

S

S

N

G

L

L

R

R

G
|
G

R
|
R

G

G

G

G

A

A

G

G

F

F

P

P

T

T

G

G

L

L

K
|
K

W

W

S

S

F

F

M

M

P

N

K

K

E

P

V

S

T

D

D

G

R

R

P

P

H

K

Y

Y

L

L

V

V

V

V

N
|
N

A

A

D
|
D

E
|
E

S
x
G

E

E

P
|
P

G
|
G

T

T

C

C

K

K

D

D

R

R

E

E

I

I

L

I

R

R

H

H

D

D

P

P

H

H

T

K

L

L

I

V

E

E

G

G

C

C

V

L

I

V

A

G

G

G

C

R

A

A

M

M

S

G

A

A

H

R

T

A

A

A

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M

Y

R

N

E

E

R

A

E

S

A

N

L

L

Q

Q

A

V

A

A

I

I

D

R

E

E

C

A

Y

Y

D

E

A

A

G

G

L

L

L

I

G

G

K

K

N

N

N

A

-

C

K

G

C

S

G

G

W

Y

D

D

M

F

D

D

I

V

F

F

L

V

H

V

H

R

G

G

A

A

G

G

A

A

Y
|
Y

I

I

C

C

G
|
G

E
|
E

E

E

T

T

A

A

L

L

L

I

E

E

S

S

L

I

E

E

G

G

K

K

K

Q

G

G

Q

K

P
|
P

R

R

L

L

K

K

P

P

P

P

F

F

P

P

A

A

N

D

M

V

G

G

L

V

Y

F

G

G

C

C

P

P

T

T

T

T

V
|
V

N
x
A

N
|
N

V

V

E

E

S
x
T

I

V

A

A

V

V

A

S

P

P

T

T

I

I

L

C

R

R

R

R

G

G

G

G

A

A

W

W

F

F

S

A

S

S

I

F

G

G

R

R

P

E

N

R

N

N

V

S

G

G

T

T

K

K

L

L

F

F

Q

N

I

I

S

S

G

G

H

H

V

V

N

N

T

N

P

P

C

C

T

T

V

V

E

E

E

E

S

E

L

M

G

S

I

V

T

P

F

L

R

K

E

E

L

L

I

I

E

E

K

K

H

H

G

A

G

G

G

G

I

V

R

T

G

G

G

G

W

W

D

D

N

N

L

L

L

L

G

A

V

V

I

I

P

P

G

G

G

G

A

S

S

S

C

T

P

P

I

L

I

I

K

P

G

K

E

S

D

V

M

C

M

E

D

T

A

V

I

L

M

M

D

D

F

F

D

D

G

A

M

L

R

I

E

Q

K

A

K

Q

S

T

S

G

F

L

G

G

T

T

G

A

G

A

V

V

I

I

V

V

M

M

D

D

K

R

S

S

T

T

D

D

V

I

I

V

K

K

A

A

I

I

A

A

R

R

L

L

A

I

A

E

F

F

F

Y

K

K

H

H

E

E

S
|
S

C
|
C

G

G

Q
|
Q

C
|
C

T

T

P

P

C
|
C

R

R

E

E

G

G

T

V

G

D

W

W

M

M

W

N

R

K

V

V

M

M

E

A

R

R

M

F

V

V

K

R

G

G

N

D

A

A

Q

R

K

P

R

A

E

E

I

I

D

D

M

S

L

L

L

W

D

E

V

I

T

S

K

K

Q

Q

I

I

E

E

G

G

H

H

T
|
T

I
|
I

C
|
C

A

A

L
|
L

G

G

D

D

A

G

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

R

R

P

P

E

E

I

L

E

E

K

E

R

R

I

M

D

Q

D

R

Y

F

T

A

R

Q

N

Q

binding fe2/s2 (inorganic) cluster: P96 (= P89), G97 (= G90)
binding flavin mononucleotide: G61 (= G54), R62 (= R55), K72 (= K65), N90 (= N83), D92 (= D85), E93 (= E86), G94 (≠ S87), Y178 (= Y170), G181 (= G173), E182 (= E174), V216 (= V208), A217 (≠ N209), N218 (= N210), T221 (≠ S213), L401 (= L393)
binding iron/sulfur cluster: P197 (= P189), S352 (= S344), C353 (= C345), Q355 (= Q347), C356 (= C348), C359 (= C351), T397 (= T389), I398 (= I390), C399 (= C391)

P25708 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Bos taurus (Bovine) (see paper)
66% identity, 95% coverage: 2:416/435 of query aligns to 35:450/464 of P25708

query
sites
P25708

L

L

A

K

D

D

K

E

D

D

R

R

I

I

F

F

T

T

N

N

I

L

Y

Y

G

G

F

R

K

H

D

D

Q

W

S

R

L

L

K

K

G

G

A

A

M

Q

S

S

R

R

G

G

H

D

W

W

D

Y

N

K

T

T

K

K

G

E

F

I

V

L

E

L

K

K

G

G

R

P

D

D

W

W

I

I

I

L

N

G

E

E

M

V

K

K

A

T

S

S

N

G

L

L

R

R

G

G

R

R

G

G

G

G

A

A

G

G

F

F

P

P

T

T

G

G

L

L

K

K

W

W

S

S

F

F

M

M

P

N

K

K

E

P

V

S

T

D

D

G

R

R

P

P

H

K

Y

Y

L

L

V

V

V

V

N

N

A

A

D

D

E

E

S

G

E

E

P

P

G

G

T

T

C

C

K

K

D

D

R

R

E

E

I

I

L

I

R

R

H

H

D

D

P

P

H

H

T

K

L

L

I

V

E

E

G

G

C

C

V

L

I

V

A

G

G

G

C

R

A

A

M

M

S

G

A

A

H

R

T

A

A

A

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M

Y

R

N

E

E

R

A

E

S

A

N

L

L

Q

Q

A

V

A

A

I

I

D

R

E

E

C

A

Y

Y

D

E

A

A

G

G

L

L

L

I

G

G

K

K

N

N

N

A

-

C

K

G

C

S

G

G

W

Y

D

D

M

F

D

D

I

V

F

F

L

V

H

V

H

R

G

G

A

A

G

G

A

A

Y

Y

I

I

C

C

G

G

E

E

E

E

T

T

A

A

L

L

L

I

E

E

S

S

L

I

E

E

G

G

K

K

K

Q

G

G

Q

K

P

P

R

R

L

L

K

K

P

P

P

P

F

F

P

P

A

A

N

D

M

V

G

G

L

V

Y

F

G

G

C

C

P

P

T

T

T

T

V

V

N

A

N

N

V

V

E

E

S

T

I

V

A

A

V

V

A

S

P

P

T

T

I

I

L

C

R

R

R

R

G

G

G

G

A

A

W

W

F

F

S

A

S

S

I

F

G

G

R

R

P

E

N

R

N

N

V

S

G

G

T

T

K

K

L

L

F

F

Q

N

I

I

S

S

G

G

H

H

V

V

N

N

T

N

P

P

C

C

T

T

V

V

E

E

E

E

S

E

L

M

G

S

I

V

T

P

F

L

R

K

E

E

L

L

I

I

E

E

K

K

H

H

G

A

G

G

G

G

I

V

R

T

G

G

G

G

W

W

D

D

N

N

L

L

L

L

G

A

V

V

I

I

P

P

G

G

G

G

A

S

S

S

C

T

P

P

I

L

I

I

K

P

G

K

E

S

D

V

M

C

M

E

D

T

A

V

I

L

M

M

D

D

F

F

D

D

G

A

M

L

R

I

E

Q

K

A

K

Q

S

T

S

G

F

L

G

G

T

T

G

A

G

A

V

V

I

I

V

V

M

M

D

D

K

R

S

S

T

T

D

D

V

I

I

V

K

K

A

A

I

I

A

A

R

R

L

L

A

I

A

E

F

F

F

Y

K

K

H

H

E

E

S

S

C
|
C

G

G

Q

Q

C
|
C

T

T

P

P

C
|
C

R

R

E

E

G

G

T

V

G

D

W

W

M

M

W

N

R

K

V

V

M

M

E

A

R

R

M

F

V

V

K

R

G

G

N

D

A

A

Q

R

K

P

R

A

E

E

I

I

D

D

M

S

L

L

L

W

D

E

V

I

T

S

K

K

Q

Q

I

I

E

E

G

G

H

H

T

T

I

I

C
|
C

A

A

L

L

G

G

D

D

A

G

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

R

R

P

P

E

E

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L

E

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E

R

R

I

M

C379 (= C345) binding [4Fe-4S] cluster
C382 (= C348) binding [4Fe-4S] cluster
C385 (= C351) binding [4Fe-4S] cluster
C425 (= C391) binding [4Fe-4S] cluster

Q91YT0 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Mus musculus (Mouse) (see 2 papers)
65% identity, 97% coverage: 2:422/435 of query aligns to 35:456/464 of Q91YT0

query
sites
Q91YT0

L

L

A

K

D

D

K

E

D

D

R

R

I

I

F

F

T

T

N

N

I

L

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Y

G

G

F

R

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H

D

D

Q

W

S

R

L

L

K

K

G

G

A

A

M

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S

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R

R

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H

D

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D

Y

N

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K

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E

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L

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K

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G

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P

D

D

W

W

I

I

I

L

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M

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K

A

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S

N

G

L

L

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R

G

G

R

R

G

G

G

G

A

A

G

G

F

F

P

P

T

T

G

G

L

L

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K

W

W

S

S

F

F

M

M

P

N

K

K

E

P

V

S

T

D

D

G

R

R

P

P

H

K

Y

Y

L

L

V

V

V

V

N

N

A

A

D

D

E

E

S

G

E

E

P

P

G

G

T

T

C

C

K

K

D

D

R

R

E

E

I

I

L

M

R

R

H

H

D

D

P

P

H

H

T

K

L

L

I

V

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E

G

G

C

C

V

L

I

V

A

G

G

G

C

R

A

A

M

M

S

G

A

A

H

R

T

A

A

A

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M

Y

R

N

E

E

R

A

E

S

A

N

L

L

Q

Q

A

V

A

A

I

I

D

R

E

E

C

A

Y

Y

D

E

A

A

G

G

L

L

L

I

G

G

K

K

N

N

N

-

K

A

C

C

G

G

-

S

-

D

W

Y

D

D

M

F

D

D

I

V

F

F

L

V

H

V

H

R

G

G

A

A

G

G

A

A

Y

Y

I

I

C

C

G

G

E

E

E

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T

T

A

A

L

L

L

I

E

E

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S

L

I

E

E

G

G

K

K

K

Q

G

G

Q

K

P

P

R

R

L

L

K

K

P

P

P

P

F

F

P

P

A

A

N

D

M

V

G

G

L

V

Y

F

G

G

C

C

P

P

T

T

T

T

V

V

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A

N

N

V

V

E

E

S

T

I

V

A

A

V

V

A

S

P

P

T

T

I

I

L

C

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R

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G

G

G

A

T

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W

F

F

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A

S

G

I

F

G

G

R

R

P

E

N

R

N

N

V

S

G

G

T

T

K

K

L

L

F

F

Q

N

I

I

S

S

G

G

H

H

V

V

N

N

T

H

P

P

C

C

T

T

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V

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E

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E

L

M

G

S

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T

P

F

L

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K

E

E

L

L

I

I

E

E

K

K

H

H

G

A

G

G

G

G

I

V

R

T

G

G

G

G

W

W

D

D

N

N

L

L

L

L

G

A

V

V

I

I

P

P

G

G

G

G

A

S

S

S

C

T

P

P

I

L

I

I

K

P

G

K

E

S

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V

M

C

M

E

D

T

A

V

I

L

M

M

D

D

F

F

D

D

G

A

M

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E

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A

K

Q

S

T

S

G

F

L

G

G

T

T

G

A

G

A

V

V

I

I

V

V

M

M

D

D

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S

T

T

D

D

V

I

I

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K

A

A

I

I

A

A

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R

L

L

A

I

A

E

F

F

F

Y

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K

H

H

E

E

S

S

C
|
C

G

G

Q

Q

C
|
C

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P

P

C
|
C

R

R

E

E

G

G

T

V

G

D

W

W

M

M

W

N

R

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V

V

M

M

E

A

R

R

M

F

V

V

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G

G

N

D

A

A

Q

R

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P

R

A

E

E

I

I

D

D

M

S

L

L

L

W

D

E

V

I

T

S

K

K

Q

Q

I

I

E

E

G

G

H

H

T

T

I

I

C
|
C

A

A

L

L

G

G

D

D

A

G

A

A

A

A

W

W

P

P

I

V

Q

Q

G

G

L

L

I

I

R

R

N

H

F

F

R

R

P

P

E

E

I

L

E

E

K

D

R

R

I

M

D

Q

D

R

Y

F

T

A

R

Q

N

Q

C379 (= C345) binding [4Fe-4S] cluster
C382 (= C348) binding [4Fe-4S] cluster
C385 (= C351) binding [4Fe-4S] cluster
C425 (= C391) binding [4Fe-4S] cluster

Sites not aligning to the query:

1:20 modified: transit peptide, Mitochondrion

P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Homo sapiens (Human) (see paper)
65% identity, 96% coverage: 2:419/435 of query aligns to 35:453/464 of P49821

query
sites
P49821

L

L

A

K

D

D

K

E

D

D

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R

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I

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F

T

T

N

N

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L

Y

Y

G

G

F

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K

H

D

D

Q

W

S

R

L

L

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K

G

G

A

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M

L

S

S

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R

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G

H

D

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W

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Y

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T

K

K

G

E

F

I

V

L

E

L

K

K

G

G

R

P

D

D

W

W

I

I

I

L

N

G

E

E

M

I

K

K

A

T

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S

N

G

L

L

R

R

G

G

R

R

G

G

G

G

A

A

G

G

F

F

P

P

T

T

G

G

L

L

K

K

W

W

S

S

F

F

M

M

P

N

K

K

E

P

V

S

T

D

D

G

R

R

P

P

H

K

Y

Y

L

L

V

V

V

V

N

N

A

A

D

D

E

E

S

G

E

E

P

P

G

G

T

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C

C

K

K

D

D

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R

E

E

I

I

L

L

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R

H

H

D

D

P

P

H

H

T

K

L

L

I

L

E

E

G

G

C

C

V

L

I

V

A

G

G

G

C

R

A

A

M

M

S

G

A

A

H

R

T

A

A

A

Y

Y

I

I

Y

Y

L

I

R

R

G

G

E

E

F

F

M

Y

R

N

E

E

R

A

E

S

A

N

L

L

Q

Q

A

V

A

A

I

I

D

R

E

E

C

A

Y

Y

D

E

A

A

G

G

L

L

L

I

G

G

K

K

N

N

N

A

-

C

K

G

C

S

G

G

W

Y

D

D

M

F

D

D

I

V

F

F

L

V

H

V

H

R

G

G

A

A

G

G

A

A

Y

Y

I

I

C

C