SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_094509170.1 NCBI__GCF_002252445.1:WP_094509170.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4yweA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
60% identity, 98% coverage: 13:486/486 of query aligns to 2:476/476 of 4yweA

query
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4yweA

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active site: N147 (= N158), K170 (= K181), E245 (= E256), C279 (= C290), E378 (= E388), E456 (= E466)
binding calcium ion: V21 (≠ E32), D88 (= D99), D174 (= D185)
binding magnesium ion: G449 (= G459), G452 (= G462)

4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
44% identity, 97% coverage: 9:481/486 of query aligns to 8:484/494 of 4pz2B

query
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4pz2B

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active site: N159 (= N158), K182 (= K181), E258 (= E256), C292 (= C290), E392 (= E388), D469 (≠ E466)
binding nicotinamide-adenine-dinucleotide: I155 (= I154), I156 (= I155), P157 (= P156), W158 (= W157), N159 (= N158), M164 (≠ I163), K182 (= K181), A184 (= A183), E185 (= E184), G215 (= G214), G219 (= G218), F233 (= F232), T234 (= T233), G235 (= G234), S236 (= S235), V239 (≠ T238), E258 (= E256), L259 (= L257), C292 (= C290), E392 (= E388), F394 (= F390)

4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
44% identity, 97% coverage: 12:481/486 of query aligns to 6:476/486 of 4pxlA

query
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4pxlA

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R

V

I

L

Y

V

V

Q

Q

K

E

G

G

I

I

Y

Y

D

D

E

E

V

F

K

V

R

K

R

K

M

A

I

A

A

E

I

L

Y

A

K

S

G

K

L

S

T

V

V

V

G

G

-

D

P

P

A

F

I

N

D

P

S

S

L

V

S

S

L

Q

G

G

P

P

V

Q

V

V

S

D

K

K

K

D

Q
|
Q

H

Y

Q

E

I
x
K

V

V

Q

L

G

R

F

Y

I

I

D

D

R

I

G

G

R

K

A

R

E

E

L

G

T

A

M

T

A

L

A

V

Q

T

G

G

N

G

L

-

H

-

P

-

E

-

A

K

P

P

A

C

G

G

-

D

-

K

G

G

N

Y

Y

Y

V

I

L

E

P

P

T

T

L

I

F

F

S

T

E

D

V

V

S

K

P

D

D

D

H

M

T

T

L

I

A

A

Q

Q

Q

D

E
|
E

I

I

F
|
F

G

G

P

P

V

V

Q

M

V

A

L

L

I

M

P

K

F

F

E

K

D

T

E

V

E

E

E

E

A

V

L

I

K

Q

I

K

A

A

N

N

G

N

T

T

D

R

Y

Y

G

G

L

L

V

A

T

A

G

G

I

I

W

V

T

T

R

K

D

N

G

I

A

D

R

V

Q

A

L

N

R

T

M

V

A

S

R

R

K

S

I

I

S

R

S

A

G

G

Q

A

V

I

F

W

I

I

N

N

N

C

Y

Y

G

F

A

A

G

F

G

D

G

P

I

-

E

D

L

A

P

P

F

F

G

G

G

G

V

Y

G

K

K

M

S

S

G

G

H

F

G

G

R

K

E
x
D

K

M

G

G

F

M

E

D

A

A

L

L

N

D

G

K

F

Y

T

L

H

Q

I

T

K

K

T

T

V

V

active site: N154 (= N158), K177 (= K181), E253 (= E256), C287 (= C290), E384 (= E388), D461 (≠ E466)
binding nicotinamide-adenine-dinucleotide: I150 (= I154), V151 (≠ I155), P152 (= P156), W153 (= W157), K177 (= K181), E180 (= E184), G210 (= G214), G214 (= G218), A215 (= A219), F228 (= F232), G230 (= G234), S231 (= S235), V234 (≠ T238), E253 (= E256), G255 (= G258), C287 (= C290), Q334 (= Q336), K337 (≠ I339), E384 (= E388), F386 (= F390)

5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 97% coverage: 13:484/486 of query aligns to 18:489/491 of 5gtlA

query
sites
5gtlA

K

K

V

M

F

F

L

I

N

N

G

G

Q

E

W

F

I

V

T

S

P

A

T

I

G

G

G

G

K

K

T

T

I

F

P

E

V

T

E

Y

N

N

P

P

S

A

T

T

G

E

D

D

V

V

I

L

G

A

Q

V

I

V

G

C

R

E

G

A

T

Q

E

E

A

E

E

D

I

I

D

D

T

A

A

A

V

V

V

K

A

A

A

A

R

R

A

S

A

A

L

F

-

E

N

S

G

G

E

P

W

W

G

A

R

E

L

M

T

T

A

T

T

A

Q

E

R

R

G

A

R

H

I

L

L

I

M

Y

K

K

M

L

S

A

E

D

L

L

V

I

L

E

E

E

R

H

A

R

E

E

E

E

L

L

A

A

M

Q

I

L

E

E

T

A

L

L

D

D

V

N

G

G

K

K

P

P

L

Y

N

Q

Q

V

S

A

R

L

N

D

D

D

A

D

I

I

-

S

A

A

L

T

A

V

R

E

Y

N

L

Y

E

R

F

Y

Y

Y

A

A

G

G

A

W

A

T

D

T

K

K

L

I

M

I

G

G

T

Q

T

T

I

I

P

P

Y

I

Q

S

E

K

G

D

F

Y

T

L

V

N

Y

Y

T

T

L

R

R

H

E

E

A

P

H

V

G

G

V

V

C

V

G

G

I

Q

I
|
I

I

I

P
|
P

W

W

N
|
N

Y

F

P

P

I

L

Q

V

I

M

L

S

G

S

R

W

G

K

V

M

G

G

A

A

A

A

L

L

A

A

A

T

G

G

N

C

T

T

V

I

V

V

V

L

K
|
K

P

P

A
|
A

E
|
E

D
x
Q

A

T

S

P

L

L

S

S

S

L

L

L

A

Y

V

A

A

A

A

K

I

L

A

F

A

K

E

E

A

A

G

G

V

F

P

P

A

N

G

G

V

V

I

V

N

N

V

F

V

V

T

P

G

G

Y

F

G
|
G

H

P

D

E

V

A

G
|
G

A

A

H

A

L

I

S

V

S

N

H

H

P

H

G

D

I

I

N

D

H

K

I

V

S

A

F

F

T

T

G
|
G

S
|
S

V

T

A

V

T
|
T

G

G

V

K

R

Y

I

I

Q

M

E

R

A

Q

A

S

A

A

K

E

N

M

V

I

V

K

P

H

V

V

T

T

L

L

E
|
E

L
|
L

G

G

G

G

K

K

S

S

P

P

H

N

I

I

V

I

F

L

D

E

D

D

V

A

D

D

L

L

E

E

K

E

A

A

M

I

P

N

I

G

L

A

V

F

G

Q

A

G

C

I

M

M

Q

Y

N

N

A

H

G

G

Q

Q

T

N

C
|
C

S

S

A

A

A

G

S

S

R

R

V

V

L

F

V

V

Q

H

K

R

G

K

I

H

Y

Y

D

E

E

T

V

V

K

V

R

D

R

A

M

L

I

V

A

K

I

M

Y

A

K

N

G

N

L

V

T

K

V

L

G

G

P

A

A

G

I

M

D

E

S

K

-

E

L

T

S

E

L

M

G

G

P

P

V

L

V

V

S

S

K

K

K

K

Q

Q

H

Q

Q

E

I

R

V

V

Q

L

G

N

F

Y

I

I

D

E

R

Q

G

G

R

K

A

K

E

E

-

G

L

A

T

T

M

V

A

A

A

A

Q

G

G

G

N

E

L

-

H

-

P

-

E

R

A

A

P

L

A

E

G

K

G

G

N

Y

Y

F

V

V

L

K

P

P

T

T

L

V

F

F

S

T

E

D

V

V

S

T

P

D

D

D

H

M

T

T

L

I

A

V

Q

K

Q

E

E
|
E

I

I

F
|
F

G

G

P

P

V

V

Q

V

V

V

L

V

I

L

P

P

F

F

E

D

D

S

E

T

E

E

E

E

A

V

L

I

K

E

I

R

A

A

N

N

G

N

T

S

D

S

Y

Y

G

G

L

L

V

A

T

A

G

G

I

V

W

W

T

T

R

Q

D

N

G

I

A

K

R

T

Q

G

L

H

R

Q

M

V

A

A

R

N

K

K

I

L

S

K

S

A

G

G

Q

T

V

V

F

W

I

I

N

N

N

D

Y

Y

G

N

A

L

G

E

G

N

G

A

I

A

E

-

L

A

P

P

F

F

G

G

G

G

V

Y

G

K

K

Q

S

S

G

G

H

I

G

G

R

R

E
|
E

K

L

G

G

F

S

E

Y

A

A

L

L

N

D

G

N

F

Y

T

T

H

E

I

V

K

K

T

S

V

V

T

W

I

V

S

N

active site: N165 (= N158), K188 (= K181), E263 (= E256), C297 (= C290), E394 (= E388), E471 (= E466)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I154), P163 (= P156), K188 (= K181), A190 (= A183), E191 (= E184), Q192 (≠ D185), G221 (= G214), G225 (= G218), G241 (= G234), S242 (= S235), T245 (= T238), L264 (= L257), C297 (= C290), E394 (= E388), F396 (= F390)

5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 97% coverage: 13:484/486 of query aligns to 18:489/491 of 5gtkA

query
sites
5gtkA

K

K

V

M

F

F

L

I

N

N

G

G

Q

E

W

F

I

V

T

S

P

A

T

I

G

G

G

G

K

K

T

T

I

F

P

E

V

T

E

Y

N

N

P

P

S

A

T

T

G

E

D

D

V

V

I

L

G

A

Q

V

I

V

G

C

R

E

G

A

T

Q

E

E

A

E

E

D

I

I

D

D

T

A

A

A

V

V

V

K

A

A

A

A

R

R

A

S

A

A

L

F

-

E

N

S

G

G

E

P

W

W

G

A

R

E

L

M

T

T

A

T

T

A

Q

E

R

R

G

A

R

H

I

L

L

I

M

Y

K

K

M

L

S

A

E

D

L

L

V

I

L

E

E

E

R

H

A

R

E

E

E

E

L

L

A

A

M

Q

I

L

E

E

T

A

L

L

D

D

V

N

G

G

K

K

P

P

L

Y

N

Q

Q

V

S

A

R

L

N

D

D

D

A

D

I

I

-

S

A

A

L

T

A

V

R

E

Y

N

L

Y

E

R

F

Y

Y

Y

A

A

G

G

A

W

A

T

D

T

K

K

L

I

M

I

G

G

T

Q

T

T

I

I

P

P

Y

I

Q

S

E

K

G

D

F

Y

T

L

V

N

Y

Y

T

T

L

R

R

H

E

E

A

P

H

V

G

G

V

V

C

V

G

G

I

Q

I
|
I

I
|
I

P
|
P

W
|
W

N
|
N

Y

F

P

P

I

L

Q

V

I

M

L

S

G

S

R

W

G

K

V

M

G

G

A

A

A

A

L

L

A

A

A

T

G

G

N

C

T

T

V

I

V

V

V

L

K
|
K

P

P

A

A

E
|
E

D

Q

A

T

S

P

L

L

S

S

S

L

L

L

A

Y

V

A

A

A

A

K

I

L

A

F

A

K

E

E

A

A

G

G

V

F

P

P

A

N

G

G

V

V

I

V

N

N

V

F

V

V

T

P

G

G

Y

F

G
|
G

H

P

D

E

V

A

G
|
G

A
|
A

H

A

L

I

S

V

S

N

H

H

P

H

G

D

I

I

N

D

H

K

I

V

S

A

F
|
F

T

T

G
|
G

S
|
S

V

T

A

V

T
|
T

G

G

V

K

R
x
Y

I

I

Q

M

E

R

A

Q

A

S

A

A

K

E

N

M

V

I

V

K

P

H

V

V

T

T

L

L

E
|
E

L
|
L

G

G

G

G

K

K

S

S

P

P

H

N

I

I

V

I

F

L

D

E

D

D

V

A

D

D

L

L

E

E

K

E

A

A

M

I

P

N

I

G

L

A

V

F

G

Q

A

G

C

I

M

M

Q

Y

N

N

A

H

G

G

Q

Q

T

N

C
|
C

S

S

A

A

A

G

S

S

R

R

V

V

L

F

V

V

Q

H

K

R

G

K

I

H

Y

Y

D

E

E

T

V

V

K

V

R

D

R

A

M

L

I

V

A

K

I

M

Y

A

K

N

G

N

L

V

T

K

V

L

G

G

P

A

A

G

I

M

D

E

S

K

-

E

L

T

S

E

L

M

G

G

P

P

V

L

V

V

S

S

K

K

K

K

Q
|
Q

H

Q

Q

E

I
x
R

V

V

Q

L

G

N

F

Y

I

I

D

E

R

Q

G

G

R

K

A

K

E

E

-

G

L

A

T

T

M

V

A

A

A

A

Q

G

G

G

N

E

L

-

H

-

P

-

E

R

A

A

P

L

A

E

G

K

G

G

N

Y

Y

F

V

V

L

K

P

P

T

T

L

V

F

F

S

T

E

D

V

V

S

T

P

D

D

D

H

M

T

T

L

I

A

V

Q

K

Q

E

E
|
E

I

I

F
|
F

G

G

P

P

V

V

Q

V

V

V

L

V

I

L

P

P

F

F

E

D

D

S

E

T

E

E

E

E

A

V

L

I

K

E

I

R

A

A

N

N

G

N

T

S

D

S

Y

Y

G

G

L

L

V

A

T

A

G

G

I

V

W

W

T

T

R

Q

D

N

G

I

A

K

R

T

Q

G

L

H

R

Q

M

V

A

A

R

N

K

K

I

L

S

K

S

A

G

G

Q

T

V

V

F

W

I

I

N

N

N

D

Y

Y

G

N

A

L

G

E

G

N

G

A

I

A

E

-

L

A

P

P

F

F

G

G

G

G

V

Y

G

K

K

Q

S

S

G

G

H

I

G

G

R

R

E
|
E

K

L

G

G

F

S

E

Y

A

A

L

L

N

D

G

N

F

Y

T

T

H

E

I

V

K

K

T

S

V

V

T

W

I

V

S

N

active site: N165 (= N158), K188 (= K181), E263 (= E256), C297 (= C290), E394 (= E388), E471 (= E466)
binding nicotinamide-adenine-dinucleotide: I161 (= I154), I162 (= I155), P163 (= P156), W164 (= W157), K188 (= K181), E191 (= E184), G221 (= G214), G225 (= G218), A226 (= A219), F239 (= F232), G241 (= G234), S242 (= S235), T245 (= T238), Y248 (≠ R241), L264 (= L257), C297 (= C290), Q344 (= Q336), R347 (≠ I339), E394 (= E388), F396 (= F390)

6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor (see paper)
41% identity, 98% coverage: 9:484/486 of query aligns to 3:477/478 of 6tgwA

query
sites
6tgwA

I

V

D

K

T

F

T

T

K

K

V

I

F

F

L

I

N

N

G

N

Q

E

W

W

I

H

T

E

P

S

T

K

G

S

G

G

K

K

T

K

I

F

P

A

V

T

E

C

N

N

P

P

S

S

T

T

G

R

D

E

V

Q

I

I

G

C

Q

E

I

V

G

E

R

E

G

G

T

D

E

K

A

P

E

D

I

V

D

D

T

K

A

A

V

V

V

E

A

A

A

A

R

Q

A

V

A

A

L

F

N

Q

-

R

-

G

G

S

E

P

W

W

G

R

R

R

L

L

T

D

A

A

T

L

Q

S

R

R

G

G

R

R

I

L

L

L

M

H

K

Q

M

L

S

A

E

D

L

L

V

V

L

E

E

R

R

D

A

R

E

A

E

T

L

L

A

A

M

A

I

L

E

E

T

T

L

M

D

D

V

T

G

G

K

K

P

P

-

F

L

L

N

H

Q

A

S

F

R

F

N
x
I

D

D

A

L

I

E

A
x
G

L

C

A

I

R

R

Y

T

L

L

E

R

F

Y

Y

F

A

A

G

G

A

W

A

A

D

D

K

K

L

I

M

Q

G

G

T

K

T

T

I

I

P

P

Y

T

Q

D

E

D

G

N

F

V

T

V

V

C

Y

F

T

T

L

R

R

H

E

E

A

P

H

I

G

G

V

V

C

C

G

G

I

A

I
|
I

I
x
T

P
|
P

W
|
W

N
|
N

Y
x
F

P

P

I

L

Q

L

I

M

L

L

G

V

R

W

G

K

V

L

G

A

A

P

A

A

L

L

A

C

A

C

G

G

N

N

T

T

V

M

V

V

V

L

K
|
K

P

P

A

A

E

E

D

Q

A

T

S

P

L

L

S

T

S

A

L

L

A

Y

V

L

A

G

A

S

I

L

A

I

A

K

E

E

A

A

G

G

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F

P

P

A

P

G

G

V

V

I

V

N

N

V

I

V

V

T

P

G

G

Y

F

G
|
G

H

P

D

T

V

V

G
|
G

A

A

H

A

L

I

S

S

S

S

H

H

P

P

G

Q

I

I

N

N

H

K

I

I

S

A

F
|
F

T

T

G
|
G

S
|
S

V

T

A

E

T
x
V

G

G

V

K

R

L

I

V

Q

K

E

E

A

A

A

A

A

S

K

R

-

S

N

N

V

L

V

K

P

R

V

V

T

T

L

L

E
|
E

L

L

G

G

G

G

K

K

S

N

P

P

H

C

I

I

V

V

F

C

D

A

D

D

V

A

D

D

L

L

E

D

K

L

A

A

M

V

P

E

I

C

L

A

V

H

G
x
Q

A

G

C

V

M

F

Q
x
F

N

N

A

Q

G

G

Q

Q

T

C

C
|
C

S

T

A

A

A

A

S

S

R

R

V

V

L

F

V

V

Q

E

K

E

G

Q

I

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Y

Y

D

S

E

E

V

F

K

V

R

R

R

R

M

S

I

V

A

E

I

Y

Y

A

K

K

G

K

L

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V

V

G

G

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D

A

P

I

F

D

D

-

V

S

K

L

T

S

E

L

Q

G

G

P

P

V

Q

V

I

S

D

K

Q

K

K

Q

Q

H

F

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D

I

K

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I

Q

L

G

E

F

L

I

I

D

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R

S

G

G

R

K

A

K

E

E

L

-

T

-

M

-

A

-

A

-

Q

G

G

A

N

K

L

L

H

E

P

C

E

G

A

G

P

S

A

A

G

M

G

G

N

L

Y

F

V

I

L

K

P

P

T

T

L

V

F

F

S

S

E

E

V

V

S

T

P

D

D

N

H

M

T

R

L

I

A

A

Q

K

Q

E

E

E

I

I

F

F

G

G

P

P

V

V

Q

Q

V

P

L

I

I

L

P

K

F

F

E

K

D

S

E

I

E

E

E

E

A

V

L

I

K

K

I

R

A

A

N

N

G

S

T

T

D

D

Y

Y

G

G

L

L

V

T

T

A

G

A

I

V

W

F

T

T

R

K

D

N

G

L

A

D

R

K

Q

A

L

L

R

K

M

L

A

A

R

S

K

A

I

L

S

E

S

S

G

G

Q

T

V

V

F

W

I

I

N

N

N

C

Y

Y

G

N

A

A

G
x
L

G

Y

G
x
A

I

-

E

Q

L

A

P

P

F

F

G

G

G

G

V

F

G

K

K

M

S

S

G

G

H

N

G

G

R

R

E
|
E

K

L

G

G

F

E

E

Y

A

A

L

L

N

A

G

E

F

Y

T

T

H

E

I

V

K

K

T

T

V

V

T

T

I

I

S

K

active site: N155 (= N158), E254 (= E256), C288 (= C290), E459 (= E466)
binding methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate: I106 (≠ N109), G110 (≠ A113), F156 (≠ Y159), Q278 (≠ G280), F282 (≠ Q284), L442 (≠ G448), A444 (≠ G450)
binding nicotinamide-adenine-dinucleotide: I151 (= I154), T152 (≠ I155), P153 (= P156), W154 (= W157), K178 (= K181), G211 (= G214), G215 (= G218), F229 (= F232), G231 (= G234), S232 (= S235), V235 (≠ T238)

7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
41% identity, 98% coverage: 9:486/486 of query aligns to 10:489/489 of 7qk9A

query
sites
7qk9A

I

V

D

K

T

F

T

T

K

K

V

I

F

F

L

I

N

N

G

N

Q

E

W

W

I

H

T

E

P

S

T

K

G

S

G

G

K

K

T

K

I

F

P

A

V

T

E

C

N

N

P

P

S

S

T

T

G

R

D

E

V

Q

I

I

G

C

Q

E

I

V

G

E

R

E

G

G

T

D

E

K

A

P

E

D

I

V

D

D

T

K

A

A

V

V

V

E

A

A

A

A

R

Q

A

V

A

A

L

F

N

Q

-

R

-

G

G

S

E

P

W

W

G

R

R

R

L

L

T

D

A

A

T

L

Q

S

R

R

G

G

R

R

I

L

L

L

M

H

K

Q

M

L

S

A

E

D

L

L

V

V

L

E

E

R

R

D

A

R

E

A

E

T

L

L

A

A

M

A

I

L

E

E

T

T

L

M

D

D

V

T

G

G

K

K

P

P

-

F

L

L

N

H

Q

A

S

F

R

F

N

I

D

D

A

L

I

E

A

G

L

C

A

I

R

R

Y

T

L

L

E

R

F

Y

Y

F

A

A

G

G

A

W

A

A

D

D

K

K

L

I

M

Q

G

G

T

K

T

T

I

I

P

P

Y

T

Q

D

E

D

G

N

F

V

T

V

V

C

Y

F

T

T

L

R

R

H

E

E

A

P

H

I

G

G

V

V

C

C

G

G

I

A

I
|
I

I
x
T

P
|
P

W
|
W

N

N

Y

F

P

P

I

L

Q

L

I

M

L

L

G

V

R

W

G

K

V

L

G

A

A

P

A

A

L

L

A

C

A

C

G

G

N

N

T

T

V

M

V

V

V

L

K
|
K

P

P

A

A

E
|
E

D

Q

A

T

S

P

L

L

S

T

S

A

L

L

A

Y

V

L

A

G

A

S

I

L

A

I

A

K

E

E

A

A

G

G

V

F

P

P

A

P

G

G

V

V

I

V

N

N

V

I

V

V

T

P

G

G

Y

F

G
|
G

H

P

D

T

V

V

G
|
G

A

A

H

A

L

I

S

S

S

S

H

H

P

P

G

Q

I

I

N

N

H

K

I

I

S

A

F
|
F

T

T

G

G

S
|
S

V

T

A

E

T
x
V

G

G

V

K

R

L

I

V

Q

K

E

E

A

A

A

A

A

S

K

R

-

S

N

N

V

L

V

K

P

R

V

V

T

T

L

L

E

E

L

L

G

G

G

G

K

K

S

N

P

P

H

C

I

I

V

V

F

C

D

A

D

D

V

A

D

D

L

L

E

D

K

L

A

A

M

V

P

E

I

C

L

A

V

H

G

Q

A

G

C

V

M

F

Q

F

N

N

A

Q

G

G

Q

Q

T

C

C

C

S

T

A

A

A

A

S

S

R

R

V

V

L

F

V

V

Q

E

K

E

G

Q

I

V

Y

Y

D

S

E

E

V

F

K

V

R

R

R

R

M

S

I

V

A

E

I

Y

Y

A

K

K

G

K

L

R

T

P

V

V

G

G

P

D

A

P

I

F

D

D

-

V

S

K

L

T

S

E

L

Q

G

G

P

P

V

Q

V

I

S

D

K

Q

K

K

Q

Q

H

F

Q

D

I

K

V

I

Q

L

G

E

F

L

I

I

D

E

R

S

G

G

R

K

A

K

E

E

L

G

T

A

M

K

A

L

A

E

Q

C

G

G

N

G

L

S

H

A

P

M

E

E

A

-

P

-

A

D

G

K

G

G

N

L

Y

F

V

I

L

K

P

P

T

T

L

V

F

F

S

S

E

E

V

V

S

T

P

D

D

N

H

M

T

R

L

I

A

A

Q

K

Q

E

E

E

I

I

F

F

G

G

P

P

V

V

Q

Q

V

P

L

I

I

L

P

K

F

F

E

K

D

S

E

I

E

E

E

E

A

V

L

I

K

K

I

R

A

A

N

N

G

S

T

T

D

D

Y

Y

G

G

L

L

V

T

T

A

G

A

I

V

W

F

T

T

R

K

D

N

G

L

A

D

R

K

Q

A

L

L

R

K

M

L

A

A

R

S

K

A

I

L

S

E

S

S

G

G

Q

T

V

V

F

W

I

I

N

N

N

C

Y

Y

G

N

A

A

G

L

G

Y

G

A

I

-

E

Q

L

A

P

P

F

F

G

G

G

G

V

F

G

K

K

M

S

S

G

G

H

N

G

G

R

R

E

E

K

L

G

G

F

E

E

Y

A

A

L

L

N

A

G

E

F

Y

T

T

H

E

I

V

K

K

T

T

V

V

T

T

I

I

S

K

H

L

G

G

binding adenosine-5'-triphosphate: I158 (= I154), T159 (≠ I155), P160 (= P156), W161 (= W157), K185 (= K181), E188 (= E184), G218 (= G214), G222 (= G218), F236 (= F232), S239 (= S235), V242 (≠ T238)

4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
41% identity, 97% coverage: 12:484/486 of query aligns to 4:478/489 of 4o6rA

query
sites
4o6rA

T

T

K

Q

V

L

F

F

L

I

N

D

G

G

Q

R

W

F

I

V

T

D

P

A

T

V

G

D

G

R

K

G

T

T

I

I

P

D

V

V

E

L

N

N

P

P

S

H

T

D

G

G

D

S

V

V

I

I

G

T

Q

K

I

I

G

A

R

A

G

A

T

T

E

A

A

A

E

D

I

V

D

D

T

L

A

A

V

V

V

D

A

A

A

A

R

T

A

R

A

A

L

F

N

P

G

A

E

-

W

W

G

S

R

A

L

M

T

P

A

A

T

A

Q

E

R

R

G

G

R

R

I

L

L

L

M

L

K

R

M

L

S

A

E

D

L

A

V

I

L

E

E

A

R

N

A

T

E

E

E

A

L

L

A

A

M

Q

I

L

E

E

T

S

L

L

D

D

V

T

G

G

K

H

P

P

L

I

N

R

Q

D

S

S

R

R

N

A

-

L

D

D

A

V

I

P

A

R

L

T

A

A

R

A

Y

C

L

F

E

R

F

Y

Y

F

A

G

G

G

A

M

A

A

D

D

K

K

L

L

M

Q

G

G

T

S

T

V

I

I

P

P

Y

V

Q

D

E

T

G

G

F

F

T

L

V

N

Y

Y

T

V

L

Q

R

R

E

A

A

P

H

I

G

G

V

V

C

V

G

G

I

Q

I
|
I

I
x
V

P

P

W

W

N
|
N

Y

F

P

P

I

L

Q

M

I

F

L

T

G

S

R

W

G

K

V

M

G

G

A

P

A

A

L

L

A

A

A

A

G

G

N

N

T

T

V

V

V

V

V

L

K
|
K

P

P

A

S

E

E

D

I

A

T

S

P

L

L

S

S

S

T

L

L

A

R

V

I

A

V

A

E

I

L

A

M

A

A

E

E

A

V

G

G

V

F

P

P

A

A

G

G

V

V

I

V

N

N

V

I

V

V

T

P

G

G

Y

Y

G
|
G

H

H

D

T

V

A

G
|
G

A
x
Q

H

R

L

L

S

A

S

E

H

H

P

P

G

G

I

V

N

G

H

K

I

I

S

A

F
|
F

T

T

G
|
G

S
|
S

V

T

A

A

T
|
T

G

G

V

R

R
|
R

I

I

Q

V

E

E

A

A

A

S

A

Q

K

G

N

N

V

L

V

K

P

R

V

V

T

Q

L

L

E
|
E

L

L

G

G

G

G

K

K

S

G

P

A

H

N

I

I

V

V

F

F

D

D

D

D

V

A

D

N

L

L

E

D

K

A

A

A

M

I

P

N

I

G

L

A

V

A

G

W

A

A

C

I

M

F

Q

H

N

N

A

Q

G

G

Q

Q

T

A

C
|
C

S

I

A

A

A

G

S

S

R

R

V

L

L

V

V

L

Q

H

K

E

G

R

I

I

Y

A

D

D

E

A

V

F

K

L

R

E

R

R

M

F

I

V

A

A

I

L

Y

A

K

S

G

S

L

I

T

R

V

I

G

G

P

N

A

P

I

L

D

D

-

P

S

N

L

T

S

E

L

M

G

G

P

P

V

L

V

T

S

S

K

K

K

Q

Q

H

H

L

Q

D

I

R

V

V

Q

L

G

S

F

Y

I

V

D

D

R

V

G

A

R

R

A

E

E

Q

L

G

T

G

M

R

A

V

A

L

Q

T

G

G

N

G

L

S

H

A

P

P

E

Q

A

D

P

P

-

A

-

L

A

A

G

N

G

G

N

Y

Y

Y

V

V

L

R

P

P

T

T

L

I

F

V

S

E

E

A

V

K

S

H

P

A

D

T

H

D

T

R

L

V

A

A

Q

Q

Q

E

E
|
E

I

V

F

F

G

G

P

P

V

F

Q

V

V

T

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active site: N150 (= N158), K173 (= K181), E248 (= E256), C282 (= C290), E383 (= E388), E460 (= E466)
binding adenosine monophosphate: I146 (= I154), V147 (≠ I155), K173 (= K181), G206 (= G214), G210 (= G218), Q211 (≠ A219), F224 (= F232), G226 (= G234), S227 (= S235), T230 (= T238), R233 (= R241)

P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
41% identity, 98% coverage: 9:486/486 of query aligns to 29:508/512 of P47895

query
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P47895

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R89 (≠ G67) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
K204 (= K181) binding NAD(+)
E207 (= E184) binding NAD(+)
GSTEVG 257:262 (≠ GSVATG 234:239) binding NAD(+)
Q361 (= Q336) binding NAD(+)
E411 (= E388) binding NAD(+)
A493 (= A471) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylalanine

7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
41% identity, 98% coverage: 9:484/486 of query aligns to 11:488/489 of 7a6qB

query
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