SitesBLAST

P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12) (see paper)
31% identity, 86% coverage: 5:225/258 of query aligns to 11:228/257 of P0AAH0

query
sites
P0AAH0

L

I

K

Q

A

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R

G

N

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L

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F

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Y

Y

Y

G

G

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G

G48 (= G42) mutation to I: Loss of phosphate transport.
K49 (= K43) mutation to Q: Loss of phosphate transport.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

3c4jA Abc protein artp in complex with atp-gamma-s
31% identity, 84% coverage: 4:219/258 of query aligns to 3:208/242 of 3c4jA

query
sites
3c4jA

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M

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S
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binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45)

3c41J Abc protein artp in complex with amp-pnp/mg2+
31% identity, 84% coverage: 4:219/258 of query aligns to 3:208/242 of 3c41J

query
sites
3c41J

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M

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D

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binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45)
binding magnesium ion: S43 (= S44), D163 (= D174)

2olkA Abc protein artp in complex with adp-beta-s
31% identity, 84% coverage: 4:219/258 of query aligns to 3:208/242 of 2olkA

query
sites
2olkA

I

M

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Y
x
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D

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binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45)

2oljA Abc protein artp in complex with adp/mg2+
31% identity, 84% coverage: 4:219/258 of query aligns to 3:208/242 of 2oljA

query
sites
2oljA

I

M

L

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K

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K

K

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Y
x
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K

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S
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A

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K

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H

H

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G

H

F

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E

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G

D

D

R

R

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V

binding adenosine-5'-diphosphate: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 84% coverage: 4:221/258 of query aligns to 4:222/253 of 1g9xB

query
sites
1g9xB

I

I

L

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K

R

A

T

R

E

G

N

L

I

V

V

K

K

R

Y

Y
x
F

G

G

K

E

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x
F

T

K

A

A

L

L

N

D

N

G

C

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D

S

F

I

D

S

L

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Y

C

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K

G

G

E

D

I

V

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A

L

V

I

I

I

G

G

D

P

N

N

G
|
G

A
x
S

G
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G

K
|
K

S
|
S

S
x
T

L

L

I

I

K

N

A

V

L

I

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T

G

G

A

F

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K

K

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A

D

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K

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K

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E

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A

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F

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A

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K

A

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T

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A

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E

N

N

M

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F

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L

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K

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G

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E

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S

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P

-

L

-

N

-

S

-

L

I

F

M

Y

G

K

K

K

W

W

F

I

R

P

A

K

L

-

D

-

R

E

A

E

E

E

M

M

E

V

R

E

R

K

A

A

R

F

E

K

K

I

L

L

T

E

E

F

L

L

G

K

L

L

M

S

T

H

I

L

Q

Y

N

D

I

-

G

-

Q

R

A

K

V

A

E

G

T

E

L

L

S

S

G

G

Q

Q

R

M

Q

K

G

L

V

V

A

E

V

I

A

G

R

R

A

A

A

L

A

M

F

T

G

N

S

P

K

K

V

M

V

I

I

V

M

M

D

D

E
|
E

P

P

T

I

A

A

A

G

L

V

G

A

V

P

K

G

E

L

S

A

R

H

R

D

V

I

L

F

E

N

L

H

I

V

L

L

D

E

V

L

K

K

R

A

R

K

G

G

L

I

P

T

I

F

V

L

L

I

I

I

S

E

H

H

N

R

M

L

P

D

H

I

V

V

F

L

E

N

V

Y

A

I

D

D

R

H

I

L

H

Y

V

V

binding adenosine-5'-diphosphate: F14 (≠ Y14), F17 (≠ V17), G40 (= G40), S41 (≠ A41), G42 (= G42), K43 (= K43), S44 (= S44), T45 (≠ S45)
binding magnesium ion: S44 (= S44), E176 (= E175)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
27% identity, 84% coverage: 4:221/258 of query aligns to 4:222/254 of 1g6hA

query
sites
1g6hA

I

I

L

L

K

R

A

T

R

E

G

N

L

I

V

V

K

K

R

Y

Y
x
F

G

G

K

E

V
x
F

T

K

A

A

L

L

N

D

N

G

C

V

D

S

F

I

D

S

L

V

Y

N

P

K

G

G

E

D

I

V

L

T

A

L

V

I

I

I

G

G

D

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

I

I

K

N

A

V

L

I

S

T

G

G

A

F

V

L

K

K

V

A

D

D

E

E

G

G

T

R

I

V

E

Y

L

F

D

E

G

N

R

K

P

D

M

I

S

T

F

N

V

K

S

E

P

P

L

A

D

E

A

L

R

Y

E

H

A

Y

G

G

I

I

E

V

T

R

V

T

Y

F

Q

Q

N

T

L

P

A

Q

L

P

S

L

P

K

A

E

L

M

S

T

I

V

A

L

D

E

N

N

M

L

F

L

L

I

G

G

R

E

E

I

I

C

R

-

K

-

P

P

G

G

-

E

-

S

-

P

-

L

-

N

-

S

-

L

I

F

M

Y

G

K

K

K

W

W

F

I

R

P

A

K

L

-

D

-

R

E

A

E

E

E

M

M

E

V

R

E

R

K

A

A

R

F

E

K

K

I

L

L

T

E

E

F

L

L

G

K

L

L

M

S

T

H

I

L

Q

Y

N

D

I

-

G

-

Q

R

A

K

V

A

E

G

T

E

L

L

S

S

G

G

Q

Q

R

M

Q

K

G

L

V

V

A

E

V

I

A

G

R

R

A

A

A

L

A

M

F

T

G

N

S

P

K

K

V

M

V

I

I

V

M

M

D

D

E

E

P

P

T

I

A

A

A

G

L

V

G

A

V

P

K

G

E

L

S

A

R

H

R

D

V

I

L

F

E

N

L

H

I

V

L

L

D

E

V

L

K

K

R

A

R

K

G

G

L

I

P

T

I

F

V

L

L

I

I

I

S

E

H

H

N

R

M

L

P

D

H

I

V

V

F

L

E

N

V

Y

A

I

D

D

R

H

I

L

H

Y

V

V

binding adenosine-5'-diphosphate: F14 (≠ Y14), F17 (≠ V17), N39 (= N39), G40 (= G40), G42 (= G42), K43 (= K43), S44 (= S44), T45 (≠ S45)

Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
29% identity, 84% coverage: 19:235/258 of query aligns to 19:223/276 of Q5M243

query
sites
Q5M243

A

T

L

L

N

N

N

D

C

V

D

S

F

F

D

H

L

V

Y

K

P

H

G

G

E

E

I

W

L

L

A

S

V

I

I

V

G

G

D

H

N

N

G

G

A

S

G

G

K

K

S

S

S

T

L

T

I

A

K

R

A

L

L

I

S

G

G

G

A

L

V

L

K

V

V

A

D

D

E

S

G

G

T

Q

I

I

E

I

L

V

D

D

G

G

R

Q

P

E

M

L

S

T

F

E

V

E

S

T

P

V

L

W

D

D

A

I

R

R

E

D

A

K

G

-

I

I

E

G

T

M

V

V

Y

F

Q

Q

N

N

L

-

A

-

L

-

S

-

P

-

A

-

L

-

S

-

I

-

A

P

D

D

N

N

M
x
Q

F

F

L

V

G

G

R

A

E

T

I

V

R

E

K

D

P

D

G

V

I

A

M

F

G

G

K

L

W

E

F

N

R

K

A

G

L

L

D

P

R

Y

A

K

E

E

M

M

E

V

R

S

R

R

A

V

R

Q

E

E

K

A

L

L

T

S

E

F

L

V

G

G

L

M

M

M

T

D

I

F

Q

K

N

D

I

R

G

E

Q

P

A

A

V

-

E

-

T

R

L

L

S

S

G

G

Q

Q

R

K

Q

Q

G

R

V

V

A

A

V

I

A

A

R

G

A

I

A

A

F

M

G

R

S

P

K

S

V

I

V

L

I

I

M

L

D

D

E
|
E

P

A

T

T

A

S

A

M

L

L

G

D

V

P

K

E

E

G

S

R

R

Q

R

E

V

L

L

I

E

Q

L

Y

I

I

L

E

D

D

V

I

K

R

R

Q

-

Y

G

G

L

M

P

T

I

V

V

L

L

S

I

I

S

T

H

H

N

D

M

L

P

D

H

E

V

V

F

-

E

A

V

M

A

S

D

N

R

R

I

V

H

L

V

V

H

L

R

K

L

Q

G

G

R

K

R

V

L

E

C

S

V

I

I

S

D

S

P

P

R

R

R

E

Q90 (≠ M100) mutation to A: No effect on ATPase, 10-fold decrease in riboflavin uptake; when associated with A-97 in EcfA2.
E163 (= E175) mutation to Q: 10-fold decrease in ATPase and riboflavin uptake; when associated with Q-171 in EcfA2.

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
30% identity, 86% coverage: 4:226/258 of query aligns to 3:216/230 of 6z4wA

query
sites
6z4wA

I

I

L

I

K

E

A

M

R

R

G

D

L

V

V

V

K

K

R

K

Y
|
Y

G

D

K

N

-

G

V
x
T

T

T

A
|
A

L

L

N

R

N

G

C

V

D

S

F

V

D

S

L

V

Y

Q

P

P

G

G

E

E

I

F

L

A

A

Y

V

I

I

V

G

G

D

P

N

S

G
|
G

A

A

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

I

K

R

A

S

L

L

S

Y

G

R

A

E

V

V

K

K

V

I

D

D

E

K

G

G

T

S

I

L

E

S

L

V

D

A

G

G

R

F

P

N

M

L

S

V

F

K

V

I

S

K

-

K

-

D

-

V

P

P

L

L

D

L

A

R

R

R

E

S

A

V

G

G

I

V

E

-

T

-

V

V

Y

F

Q

Q

N

D

L

Y

A

K

L

L

S

L

P

P

A

K

L

K

S

T

I

V

A

Y

D

E

N

N

M

I

F

A

L

Y

G

A

R

M

E

E

I

V

R

-

K

-

P

-

G

-

I

-

M

I

G

G

K

E

W

-

F

-

R

-

A

-

L

-

D

N

R

R

A

R

E

N

M

I

E

K

R

R

A

V

R

M

E

E

K

V

L

L

T

D

E

L

L

V

G

G

L

L

M

K

T

-

I

-

Q

H

N

K

I

V

G

R

Q

S

A

F

V

P

E

N

T

E

L

L

S

S

G

G

Q

E

R

Q

Q

Q

G

R

V

I

A

A

V

I

A

A

R

R

A

A

A

I

A

V

F

N

G

N

S

P

K

K

V

V

V

L

I

I

M

A

D

D

E

E

P

P

T

T

A

G

A

N

L

L

G

D

V

P

K

D

E

N

S

S

R

W

R

E

V

I

L

M

E

N

L

L

I

L

L

E

D

R

V

I

K

N

R

L

R

Q

G

G

L

T

P

T

I

I

V

L

L

M

I

A

S

T

H

H

N

N

M

S

P

Q

H

I

V

V

F

N

E

T

V

L

A

R

D

H

R

R

I

V

H

I

V

A

H

I

R

E

L

N

G

G

R

R

binding adenosine-5'-diphosphate: Y13 (= Y14), T17 (≠ V17), A19 (= A19), G40 (= G40), G42 (= G42), K43 (= K43), S44 (= S44), T45 (≠ S45)

A0A0H2ZM82 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
30% identity, 86% coverage: 4:226/258 of query aligns to 3:216/230 of A0A0H2ZM82

query
sites
A0A0H2ZM82

I

I

L

I

K

E

A

M

R

R

G

D

L

V

V

V

K

K

R

K

Y

Y

G

D

K

N

-

G

V

T

T

T

A

A

L

L

N

R

N

G

C

V

D

S

F

V

D

S

L

V

Y

Q

P

P

G

G

E

E

I

F

L

A

A

Y

V

I

I

V

G

G

D

P

N

S

G

G

A

A

G

G

K
|
K

S

S

S

T

L

F

I

I

K

R

A

S

L

L

S

Y

G

R

A

E

V

V

K

K

V

I

D

D

E

K

G

G

T

S

I

L

E

S

L

V

D

A

G

G

R

F

P

N

M

L

S

V

F

K

V

I

S

K

-

K

-

D

-

V

P

P

L

L

D

L

A

R

R

R

E

S

A

V

G

G

I

V

E

-

T

-

V

V

Y

F

Q

Q

N

D

L

Y

A

K

L

L

S

L

P

P

A

K

L

K

S

T

I

V

A

Y

D

E

N

N

M

I

F

A

L

Y

G

A

R

M

E

E

I

V

R

-

K

-

P

-

G

-

I

-

M

I

G

G

K

E

W

-

F

-

R

-

A

-

L

-

D

N

R

R

A

R

E

N

M

I

E

K

R

R

A

V

R

M

E

E

K

V

L

L

T

D

E

L

L

V

G

G

L

L

M

K

T

-

I

-

Q

H

N

K

I

V

G

R

Q

S

A

F

V

P

E

N

T

E

L

L

S

S

G

G

Q

E

R

Q

Q

Q

G

R

V

I

A

A

V

I

A

A

R

R

A

A

A

I

A

V

F

N

G

N

S

P

K

K

V

V

V

L

I

I

M

A

D
|
D

E
|
E

P

P

T

T

A

G

A

N

L

L

G

D

V

P

K

D

E

N

S

S

R

W

R

E

V

I

L

M

E

N

L

L

I

L

L

E

D

R

V

I

K

N

R

L

R

Q

G

G

L

T

P

T

I

I

V

L

L

M

I

A

S

T

H

H

N

N

M

S

P

Q

H

I

V

V

F

N

E

T

V

L

A

R

D

H

R

R

I

V

H

I

V

A

H

I

R

E

L

N

G

G

R

R

K43 (= K43) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
D164 (= D174) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
E165 (= E175) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
30% identity, 84% coverage: 4:219/258 of query aligns to 3:209/229 of 6z67B

query
sites
6z67B

I

I

L

I

K

E

A

M

R

R

G

D

L

V

V

V

K

K

R

K

Y
|
Y

G

D

K

N

-
x
G

V

T

T

T

A
|
A

L

L

N

R

N

G

C

V

D

S

F

V

D

S

L

V

Y

Q

P

P

G

G

E

E

I

F

L

A

A

Y

V

I

I

V

G

G

D

P

N
x
S

G
|
G

A

A

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

I

K

R

A

S

L

L

S

Y

G

R

A

E

V

V

K

K

V

I

D

D

E

K

G

G

T

S

I

L

E

S

L

V

D

A

G

G

R

F

P

N

M

L

S

V

F

K

V

I

S

K

-

K

-

D

-

V

P

P

L

L

D

L

A

R

R

R

E

S

A

V

G

G

I

V

E

-

T

-

V

V

Y

F

Q

Q

N

D

L

Y

A

K

L

L

S

L

P

P

A

K

L

K

S

T

I

V

A

Y

D

E

N

N

M

I

F

A

L

Y

G

A

R

M

E

E

I

V

R

-

K

-

P

-

G

-

I

-

M

I

G

G

K

E

W

-

F

-

R

-

A

-

L

-

D

N

R

R

A

R

E

N

M

I

E

K

R

R

A

V

R

M

E

E

K

V

L

L

T

D

E

L

L

V

G

G

L

L

M

K

T

-

I

-

Q

H

N

K

I

V

G

R

Q

S

A

F

V

P

E

N

T

E

L

L

S

S

G

G

Q

E

R

Q

Q

Q

G

R

V

I

A

A

V

I

A

A

R

R

A

A

A

I

A

V

F

N

G

N

S

P

K

K

V

V

V

L

I

I

M

A

D

D

E

E

P

P

T

T

A

G

A

N

L

L

G

D

V

P

K

D

E

N

S

S

R

W

R

E

V

I

L

M

E

N

L

L

I

L

L

E

D

R

V

I

K

N

R

L

R

Q

G

G

L

T

P

T

I

I

V

L

L

M

I

A

S

T

H

H

N

N

M

S

P

Q

H

I

V

V

F

N

E

T

V

L

A

R

D

H

R

R

I

V

binding phosphoaminophosphonic acid-adenylate ester: Y13 (= Y14), G16 (vs. gap), A19 (= A19), S39 (≠ N39), G40 (= G40), G42 (= G42), K43 (= K43), S44 (= S44), T45 (≠ S45)

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
28% identity, 88% coverage: 1:226/258 of query aligns to 14:225/378 of P69874

query
sites
P69874

M

L

E

S

P

P

I

L

L

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Q

A

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A

G

G

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C

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F

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C

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D

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N

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x
F

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x
C

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x
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L

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P

-

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-

A

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-

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x
V

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R

C26 (≠ R13) mutation to A: Lower ATPase activity and transport efficiency.
F27 (≠ Y14) mutation to L: Lower ATPase activity and transport efficiency.
F45 (≠ I32) mutation to L: Lower ATPase activity and transport efficiency.
C54 (≠ A41) mutation to T: Loss of ATPase activity and transport.
L60 (≠ I47) mutation to F: Lower ATPase activity and transport efficiency.
L76 (= L63) mutation to P: Lower ATPase activity and transport efficiency.
V135 (≠ L135) mutation to M: Loss of ATPase activity and transport.
D172 (= D174) mutation to N: Loss of ATPase activity and transport.

Sites not aligning to the query:

276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

2d62A Crystal structure of multiple sugar binding transport atp- binding protein
29% identity, 86% coverage: 5:225/258 of query aligns to 7:219/375 of 2d62A

query
sites
2d62A

L

V

K

K

A

L

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N

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I

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W

K

K

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T

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M

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M

L

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E

A

L

E

I

L

L

K

D

K

V

L

K

Q

R

R

R

Q

-

L

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G

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L

Y

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M

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P

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F

M

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M

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G

D

D

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M

R

N

L

K

G

G

binding pyrophosphate 2-: G42 (= G40), C43 (≠ A41), G44 (= G42), K45 (= K43), T46 (≠ S44), T47 (≠ S45)

O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 35 papers)
30% identity, 86% coverage: 8:230/258 of query aligns to 902:1112/2261 of O95477

query
sites
O95477

R

Q

G

N

L

L

V

V

K

K

R

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Y

Y

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R

-

D

G

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M

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x
D

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C

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D

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R

E

-

A

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M

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Q

N

N

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M

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x
S

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A

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A

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F

A

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S

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M

L

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D

E

E

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A

A

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x
P

K

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E

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S

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G

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L

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M
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M

P

D

H

E

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A

F

D

E

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G

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D

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C

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V

D917 (≠ N21) to Y: in a colorectal cancer sample; somatic mutation
T929 (≠ L33) to I: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane
N935 (= N39) to S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs28937313
K939 (= K43) mutation to M: Inhibits ATPase activity; when associated with M-1952. Decreases translocase activity; when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-1952.
S1042 (≠ A159) modified: Phosphoserine; by PKA
P1065 (≠ V182) natural variant: P -> S
M1091 (= M209) to T: in FHA1; loss of localization to plasma membrane; decreased cholesterol efflux; decreased phospholipid efflux
C1110 (≠ L228) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1111.
C1111 (= C229) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1110.

Sites not aligning to the query:

3 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation; when associated with S-23, S-1110 and S-1111.
23 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation; when associated with S-3, S-1110 and S-1111.
74 I→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.; I→K: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-371.
75 modified: Disulfide link with 309
85 P → L: in FHA1; Alabama; dbSNP:rs145183203
98 modified: carbohydrate, N-linked (GlcNAc...) asparagine
100 S→C: Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
210 E → D: in a colorectal cancer sample; somatic mutation
219 R → K: in dbSNP:rs2230806
230 R → C: in dbSNP:rs9282541
244 modified: carbohydrate, N-linked (GlcNAc...) asparagine
248 P → A: in dbSNP:rs142625938
255 A → T: in TGD; deficient cellular cholesterol efflux; dbSNP:rs758100110
304 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-308.
308 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-304.
309 modified: Disulfide link with 75
364 S → C: in dbSNP:rs775035559
371 I→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane. 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-74 or C-375.; I→E: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-74.
375 L→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.
399 V → A: in dbSNP:rs9282543
401 K → Q: in dbSNP:rs138487227
496 R → W: in dbSNP:rs147675550
568 K→A: 60-65% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane.
573 Y→F: No effect on phospholipid and cholesterol efflux and on localization to cell membrane.
581 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-584 and K-585.
583 F→K: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-590.
584 E→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-585.
585 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-584.
590 W → S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs137854496; W→E: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-583.
593 F→L: Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
638 R → Q: in dbSNP:rs374190304
771 V → M: in dbSNP:rs2066718
774 T → P: in dbSNP:rs35819696; natural variant: T -> S
776 K → N: in dbSNP:rs138880920
815 E → G: in dbSNP:rs145582736
825 V → I: in dbSNP:rs2066715
883 I → M: in dbSNP:rs2066714
1172 E → D: in dbSNP:rs33918808
1181 S → F: in dbSNP:rs76881554
1216 G → V: in dbSNP:rs562403512
1341 R → T: in dbSNP:rs147743782
1376 S → G: in dbSNP:rs145689805
1379 L → F: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1407 A → T: in a colorectal cancer sample; somatic mutation; dbSNP:rs189206655
1463 modified: Disulfide link with 1477
1477 modified: Disulfide link with 1463; C → R: in TGD; loss of interaction with APOE; unable to generate APOE-containing high density lipoproteins; moderately decreased protein abundance; moderately decreased ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs137854494
1512 T→M: Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity.
1555 I → T: in dbSNP:rs1997618
1587 K → R: in dbSNP:rs2230808
1611 N → D: in FHA1; deficient cellular cholesterol efflux
1615 R → Q: in dbSNP:rs1251839800
1648 L → P: in dbSNP:rs1883024
1670 A → T: in dbSNP:rs1203589782
1680 R → Q: in dbSNP:rs150125857
1704 V → D: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1731 S → C: in dbSNP:rs760507032
1897 R → W: in FHA1; uncertain significance; dbSNP:rs760768125
1925 R → Q: in Scott syndrome; shows impaired trafficking of the mutant protein to the plasma membrane; dbSNP:rs142688906
1952 K→M: Inhibits ATPase activity; when associated with M-939. Decreases translocase activity; when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-939.
2054 modified: Phosphoserine; by PKA
2081 R → W: in TGD; highly decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane; dbSNP:rs137854501
2109 A → T: in a colorectal cancer sample; somatic mutation
2150 P → L: in FHA1; moderately decreased protein abundance; does not affect ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs369098049
2163 natural variant: F -> S
2168 L → P: in dbSNP:rs2853577
2243 D → E: in dbSNP:rs34879708
2244 V → I: in dbSNP:rs144588452

Query Sequence

>WP_097030541.1 NCBI__GCF_900207575.1:WP_097030541.1
MEPILKARGLVKRYGKVTALNNCDFDLYPGEILAVIGDNGAGKSSLIKALSGAVKVDEGT
IELDGRPMSFVSPLDAREAGIETVYQNLALSPALSIADNMFLGREIRKPGIMGKWFRALD
RAEMERRAREKLTELGLMTIQNIGQAVETLSGGQRQGVAVARAAAFGSKVVIMDEPTAAL
GVKESRRVLELILDVKRRGLPIVLISHNMPHVFEVADRIHVHRLGRRLCVIDPRRHSMSD
AVALMTGAMAPEKLNEFA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory