SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_099019356.1 NCBI__GCF_002591915.1:WP_099019356.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 11 hits to proteins with known functional sites (download)

1itwA Crystal structure of the monomeric isocitrate dehydrogenase in complex with isocitrate and mn (see paper)
64% identity, 99% coverage: 6:734/740 of query aligns to 5:733/740 of 1itwA

query
sites
1itwA

I

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Y

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T

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M

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P

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E

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D

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E

E

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I

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D

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R

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G

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S

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H

Y

F

Y

Y

L

L

T

A

K

L

Y

Y

W

W

A

A

K

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A

A

L

L

S

A

A

A

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Q

D

T

E

E

D

D

A

K

A

E

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F

F

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Q

G

V

I

F

A

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A

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T

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D

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N

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G

E

E

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I

A

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A

A

A

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Q

G

G

S

K

P

P

V

V

D

D

I

I

G

A

G

G

Y

Y

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Y

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H

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P

N

N

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T

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D

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A

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T

F

F

N

N

binding manganese (ii) ion: D349 (= D350), D547 (= D548)

P16100 Isocitrate dehydrogenase [NADP]; IDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Azotobacter vinelandii (see 2 papers)
64% identity, 99% coverage: 1:734/740 of query aligns to 1:734/741 of P16100

query
sites
P16100

M
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M

T

S

K

T

Q

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T

K

I

I

I

I

Y

Y

T

T

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D

D

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E

A

A

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P

A

A

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L

A

A

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T

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Y

S

S

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L

L

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P

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K

K

A

F

F

A

T

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G

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D

G

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I

E

A

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V

E

E

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T

K

R

D

D

I

I

S

S

L

L

A

A

S

G

R

R

I

L

L

I

A

A

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T

F

F

P

P

E

E

R

Y

L

L

K

T

A

D

G

T

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Q

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K

C

I

E

S

D

D

A

D

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L

G

A

Q

E

L

L

G

G

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K

L

L

A

A

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T

T

P

P

E

D

A

A

N

N

I

I

I

I

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K

L

L

P

P

N

N

I

I

S

S

A

A

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S

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P

Q

Q

L

L

N

K

A

A

A

A

I

I

K

K

E

E

L

L

Q

Q

A

Q

A

Q

G

G

Y

Y

D

K

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L

P

P

D

D

C

Y

P

P

E

E

D

E

P

P

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K

T

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E

D

E

T

E

E

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K

A

D

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M

K

A

A

K

R

Y

Y

A

D

N

K

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I

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G

G

S

S

A

A

V

V

N

N

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P

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V

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L

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R

E

E

G

G

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S

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D

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A

A

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A

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S

H

H

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A

A

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H

M

M

D

D

A

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N

G

D

D

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F

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Y

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E

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M

M

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A

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A

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E

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D

A

A

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K

A

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M

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M

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K

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D

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P

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M

M

F

F

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Y

F

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D

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A

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K

H

H

A

A

A

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F

L

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K

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I

I

G

G

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F

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D

V

V

N

N

N

N

G

G

I

I

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G

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D

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L

Y

Y

N

A

K

R

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T

L

L

P

P

A

E

A

A

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K

Q

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A

K

E

E

I

I

K

E

A

A

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D

I

I

A

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A

A

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A

A

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M

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D

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P

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D

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M

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M

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W

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L

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G

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I

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S

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G

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V

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D

Y

Y

L

L

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T

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D

L

L

F

F

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P

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E

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A

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K

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M

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S

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P

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L

L

M

A

S

G

G

G

G

G

G

L

L

F

F

E

E

T

T

G

G

A

A

G

G

G

G

S

S

A

A

P

P

K

K

H

H

V

V

Q

Q

Q

Q

F

F

V

L

T

E

E

E

G

G

H

Y

L

L

R

R

W

W

D

D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

L

L

A

A

V

A

S

S

L

L

E

E

D

H

I

L

A

G

E

N

K

A

T

Y

N

K

N

N

Q

P

Q

K

A

A

K

L

V

V

L

L

A

A

A

S

A

T

L

L

D

D

D

Q

A

A

N

T

E

G

R

K

Y

I

L

L

S

D

F

N

N

N

K

K

S

S

P

P

S

A

R

R

K

K

V

V

N

G

E

E

L

I

D

D

N

N

R

R

G

G

S

S

Q

H

Y

F

Y

Y

L

L

T

A

K

L

Y

Y

W

W

A

A

K

Q

A

A

L

L

S

A

A

A

Q

Q

D

T

E

E

D

D

A

K

A

E

L

L

K

Q

A

A

T

Q

F

F

T

T

Q

G

V

I

F

A

E

K

A

A

L

L

K

T

N

D

N

N

E

E

A

T

Q

K

I

I

L

V

Q

G

E

E

L

L

I

A

D

A

A

A

Q

Q

G

G

S

K

P

P

V

V

D

D

I

I

G

A

G

G

Y

Y

F

Y

Q

H

P

P

N

N

D

T

A

D

L

L

A

T

K

S

A

K

A

A

M

I

R

R

P

P

S

S

S

A

T

T

F

F

N

N

M1 (= M1) modified: Initiator methionine, Removed
D350 (= D350) binding Mn(2+)
D548 (= D548) binding Mn(2+)

1j1wA Crystal structure of the monomeric isocitrate dehydrogenase in complex with NADP+ (see paper)
64% identity, 99% coverage: 6:734/740 of query aligns to 4:732/738 of 1j1wA

query
sites
1j1wA

I

I

I

I

Y

Y

T

T

I

L

T

T

D

D

E

E

A

A

P

P

A

A

L

L

A

A

T

T

Y

Y

S

S

F

L

L

L

P

P

I

I

V

I

Q

K

K

A

F

F

A

T

G

G

Q

S

A

S

D

G

V

I

E

A

V

V

E

E

T

T

K

R

D

D

I

I

S

S

L

L

A

A

S

G

R

R

I

L

L

I

A

A

Q

T

F

F

P

P

E

E

R

Y

L

L

K

T

A

D

G

T

Q

Q

K

K

C

I

E

S

D

D

A

D

L

L

G

A

Q

E

L

L

G

G

V

K

L

L

A

A

K

T

T

T

P

P

E

D

A

A

N

N

I

I

I

I

K

K

L

L

P
|
P

N
|
N

I

I

S
|
S

A

A

S

S

V

V

P

P

Q

Q

L

L

N

K

A

A

A

A

I

I

K

K

E

E

L

L

Q

Q

A

Q

A

Q

G

G

Y

Y

D

K

L

L

P

P

D

D

C

Y

P

P

E

E

D

E

P

P

E

K

T

T

E

D

E

T

E

E

K

K

A

D

I

V

M

K

A

A

K

R

Y

Y

A

D

N

K

V

I

L

K

G

G

S

S

A

A

V

V

N
|
N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R

R

R

R

V

A

A

P

A

L

A

S

V

V

K

K

A

N

Y

Y

A

A

R

R

K

K

N

H

P

P

H

H

R

K

L

M

G

G

A

A

I

W

T

S

K

A

N

D

S

S

K

K

T

S

H

H

V

V

A

A

H

H

M

M

D

D

A

N

N

G

D

D

F

F

Y

Y

G

G

S

S

E

E

Q

K

S

A

Y

A

V

L

M

I

P

G

A

A

A

P

D

G

E

S

V

V

R

K

I

I

E

E

H

L

V

I

G

A

T

K

D

D

G

G

Q

S

V

S

T

T

V

V

M

L

K

K

S

A

A

K

V

T

A

S

L

V

Q

Q

A

A

G

G

E

E

V

I

I

I

D

D

S

S

S

S

C

V

M

M

S

S

V

K

R

N

A

A

L

L

R

R

Q

N

F

F

F

I

A

A

K

A

E

E

I

I

K

E

D

D

A

A

K

K

S

K

S

Q

G

G

V

V

L

L

L

L

S

S

L

V

H

H

L

L

K

K

A

A

T

T

M

M

M

M

K

K

V

V

S

S

D

D

P

P

I

I

M

M

F

F

G

G

H

Q

S

I

V

V

E

S

V

E

Y

F

Y

Y

A

K

E

D

V

A

F

L

K

T

K

K

H

H

A

A

A

E

T

V

F

L

E

K

K

Q

I

I

G

G

V

F

E

D

V

V

N

N

N

N

G

G

I

I

G

G

S

D

V

L

Y

Y

N

A

K

R

I

I

T

K

E

T

L

L

P

P

A

E

A

A

K

K

Q

Q

A

K

E

E

I

I

K

E

A

A

D

D

I

I

A

Q

A

A

C

V

Y

Y

A

A

N

Q

Q

R

P

P

A

Q

L

L

A

A

M

M

V

V

D

N

S

S

D

D

K

K

G

G

I

I

T

T

N

N

L

L

H

H

V

V

P

P

N

S

D

D

V

V

I

I

I

V

D

D

A

A

S

S

M

M

P

P

A

A

A

M

I

I

K

R

S

D

S

S

A

G

K

K

M

M

W

W

N

G

A

P

E

D

G

G

K

K

L

L

Q

H

D

D

T

T

K

K

A

A

M

V

I

I

P

P

D

D

R

R

S

C

Y

Y

A

A

G

G

I

V

Y

Y

Q

Q

E

V

I

V

I

I

A

E

Y

D

C

C

K

K

E

Q

H

H

G

G

A

A

F

F

D

D

V

P

V

T

T

T

M

M

G

G

N

S

V

V

C

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

K

A

A

E

E

E

E

Y

Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

Q

M

I

A

P

S

A

D

D

G

G

M

V

M

V

R

R

V

V

V

T

N

D

S

E

S

S

G

G

E

K

I

L

L

L

M

L

Q

E

H

Q

E

S

V

V

E

E

Q

A

G

G

D

D

I

I

W

W

R

R

A

M

C

C

Q

Q

T

A

K

K

D

D

L

A

P

P

I

I

R

Q

D

D

W

W

V

V

K

K

L

L

A

A

V

V

T

N

R

R

A

A

K

R

N

A

T

T

G

N

S

T

A

P

A

A

V

V

F

F

W

W

L

L

D

D

E

P

N

A

R

R

A

A

H

H

D

D

R

A

N

Q

L

V

I

I

E

A

K

K

V

V

E

E

L

R

Y

Y

L

L

Q

K

D

D

H

Y

D

D

T

T

T

S

G

G

L

L

E

D

I

I

K

R

I

I

M

L

N

S

P

P

K

V

A

E

A

A

M

T

R

R

Y

F

T

S

C

L

E

A

R

R

V

I

T

R

A

E

G

G

L

K

D

D

T

T

I

I

S

S

V

V

T

T

G

G

N

N

V

V

L

L

R

R

D

D

Y

Y

L

L

T

T

D

D

L

L

F

F

P

P

I

I

L

M

E

E

L

L

G

G

T
|
T

S

S

A
|
A

K

K

M

M

L

L

S

S

I

I

V

V

P

P

L

L

L

M

A

S

G

G

G

G

G

G

L

L

F

F

E

E

T

T

G

G

A

A

G
|
G

G
|
G

S
|
S

A

A

P

P

K

K

H
|
H

V

V

Q

Q

Q

Q

F

F

V

L

T

E

E

E

G

G

H

Y

L

L

R
|
R

W
|
W

D
|
D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

L

L

A

A

V

A

S

S

L

L

E

E

D

H

I

L

A

G

E

N

K

A

T

Y

N

K

N

N

Q

P

Q

K

A

A

K

L

V

V

L

L

A

A

A

S

A

T

L

L

D

D

D

Q

A

A

N

T

E

G

R

K

Y

I

L

L

S

D

F

N

N

N

K

K

S

S

P

P

S

A

R
|
R

K

K

V

V

N

G

E

E

L

I

D

D

N

N

R

R

G

G

S

S

Q

H

Y

F

Y

Y

L

L

T

A

K

L

Y

Y

W

W

A

A

K

Q

A

A

L

L

S

A

A

A

Q

Q

D

T

E

E

D

D

A

K

A

E

L

L

K

Q

A

A

T

Q

F

F

T

T

Q

G

V

I

F

A

E

K

A

A

L

L

K

T

N

D

N

N

E

E

A

T

Q

K

I

I

L

V

Q

G

E

E

L

L

I

A

D

A

A

A

Q

Q

G

G

S

K

P

P

V

V

D

D

I

I

G

A

G

G

Y

Y

F

Y

Q

H

P

P

N

N

D

T

A

D

L

L

A

T

K

S

A

K

A

A

M

M

R

R

P

P

S

S

S

A

T

T

F

F

N

N

binding nadp nicotinamide-adenine-dinucleotide phosphate: P82 (= P84), N83 (= N85), S85 (= S87), N133 (= N135), T559 (= T561), A561 (= A563), G581 (= G583), G582 (= G584), S583 (= S585), H587 (= H589), R598 (= R600), W599 (= W601), D600 (= D602), R647 (= R649)

6g3uA Structure of pseudomonas aeruginosa isocitrate dehydrogenase, idh (see paper)
64% identity, 99% coverage: 6:740/740 of query aligns to 3:736/737 of 6g3uA

query
sites
6g3uA

I

I

I

T

Y

Y

T

T

I

F

T

T

D

D

E

E

A

A

P

P

A

A

L

L

A

A

T

T

Y

Y

S

S

F

L

L

L

P

P

I

I

V

V

Q

K

K

A

F

F

A

A

G

A

Q

S

A

A

D

G

V

I

E

D

V

V

E

E

T

T

K

S

D

D

I

I

S

S

L

L

A

A

S

G

R

R

I

I

L

L

A

A

Q

N

F

F

P

A

E

D

R

R

L

L

K

E

A

A

G

D

Q

Q

K

R

C

I

E

E

D

D

A

D

L

L

G

A

Q

R

L

L

G

A

V

V

L

L

A

A

K

T

T

S

P

P

E

D

A

A

N

N

I

I

I

I

K

K

L

L

P
|
P

N
|
N

I

I

S
|
S

A

A

S

S

V

V

P

P

Q

Q

L

L

N

K

A

G

A

A

I

I

K

A

E

E

L

L

Q

Q

A

G

A

L

G

G

Y

Y

D

K

L

V

P

P

D

D

C

F

P

P

E

E

D

D

P

P

E

Q

T

T

E

D

E

E

E

E

K

K

A

E

I

V

M

R

A

A

K

R

Y

Y

A

A

N

K

V

I

L

L

G

G

S
|
S

A

A

V

V

N
|
N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R
|
R

R

R

V

A

A

P

A

A

A

A

V

V

K

K

A

A

Y

Y

A

A

R

R

K

K

N

H

P

P

H

H

R

S

L

M

G

G

A

K

I

W

T

S

K

M

N

A

S

S

K

R

T

S

H

H

V

A

A

D

H

Y

M

M

D

R

A

G

N

G

D

D

F

F

Y

F

G

S

S

S

E

E

Q

Q

S

S

Y

I

V

T

M

M

P

A

A

K

A

A

D

G

E

D

V

V

R

R

I

I

E

E

H

F

V

V

G

G

T

K

D

D

G

G

Q

K

V

V

T

E

V

V

M

-

K

K

S

K

A

Q

V

L

A

S

L

L

Q

Q

A

E

G

G

E

E

V

V

I

L

D

D

S

S

S

M

C

F

M

M

S

S

V

C

R

G

A

K

L

L

R

R

Q

D

F

F

F

F

A

E

K

K

E

T

I

L

K

Q

D

D

A

C

K

K

S

E

S

T

G

G

V

V

L

M

L

W

S

S

L

L

H

H

L

V

K
|
K

A

A

T

T

M

M

M

M

K

K

V

I

S

S

D

H

P

P

I

I

M

V

F

F

G

G

H

H

S

A

V

V

E

S

V

V

Y

Y

Y

Y

A

K

E

D

V

V

F

F

K

D

K

K

H

W

A

G

A

Q

T

L

F

F

E

E

K

E

I

L

G

G

V

V

E

N

V

P

N

N

N

N

G

G

I

I

G

S

S

S

V

V

Y

Y

N

D

K

K

I

I

T

K

E

S

L

L

P

P

A

A

A

S

K

Q

Q

Q

A

E

E

E

I

I

K

L

A

H

D

D

I

I

A

H

A

E

C

V

Y

Y

A

S

N

H

Q

R

P

P

A

E

L

M

A

A

M

M

V

V

D

D

S

S

D

V

K

K

G

G

I

I

T

T

N

N

L

L

H

H

V

I

P

P

N

S

D

D

V

V

I
|
I

I

V

D

D

A
|
A

S

S

M

M

P

P

A

A

A

M

I

I

K

R

S

N

S

S

A

G

K

Q

M

M

W

W

N

G

A

K

E

D

G

G

K

K

L

Q

Q

K

D

D

T

T

K

K

A

A

M

V

I

M

P

P

D

E

R

S

S

T

Y

Y

A

A

G

R

I

I

Y

Y

Q

Q

E

E

I

M

I

I

A

N

Y

F

C

C

K

K

E

T

H

N

G

G

A

A

F

F

D

D

V

P

V

T

T

T

M

M

G

G

N

S

V

V

C

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

K

A

A

E

E

E

E

Y
|
Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

E

M

M

A

T

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G

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G

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S

S

A

T

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N

N

Q

A

I

A

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D

S

S

I

L

binding 2-oxoglutaric acid: S84 (= S87), S129 (= S132), R142 (= R145), K251 (= K255), Y416 (= Y420), R543 (= R547), D544 (= D548)
binding nadp nicotinamide-adenine-dinucleotide phosphate: P81 (= P84), N82 (= N85), S84 (= S87), N132 (= N135), I344 (= I348), A347 (= A351), T557 (= T561), A559 (= A563), G579 (= G583), G580 (= G584), S581 (= S585), A582 (= A586), P583 (= P587), H585 (= H589), R596 (= R600), W597 (= W601), D598 (= D602), R645 (= R649)

5z16B A novel dimeric isocitrate dehydrogenase from acinetobacter baumannii
60% identity, 99% coverage: 5:740/740 of query aligns to 2:738/739 of 5z16B

query
sites
5z16B

T

T

I

I

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Y

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D

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N

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binding magnesium ion: D347 (= D350), D546 (= D548), D550 (= D552)

5kvuA Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from mycobacterium tuberculosis
58% identity, 99% coverage: 5:740/740 of query aligns to 3:738/738 of 5kvuA

query
sites
5kvuA

T

T

I

I

I

I

Y

Y

T

T

I

L

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D

D

E

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A

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|
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|
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|
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N

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binding nadp nicotinamide-adenine-dinucleotide phosphate: P82 (= P84), N83 (= N85), S85 (= S87), N132 (= N135), I345 (= I348), A348 (= A351), T559 (= T561), A561 (= A563), G582 (= G584), S583 (= S585), A584 (= A586), H587 (= H589), R598 (= R600), W599 (= W601), D600 (= D602), R647 (= R649)

4zdaA Crystal structure of isocitrate dehydrogenase in complex with isocitrate and mn from m. Smegmatis
59% identity, 99% coverage: 5:737/740 of query aligns to 2:735/735 of 4zdaA

query
sites
4zdaA

T

T

I

I

I

I

Y

Y

T

T

I

L

T

T

D

D

E

E

A

A

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