SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_101442772.1 NCBI__GCF_002846395.1:WP_101442772.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
44% identity, 100% coverage: 1:231/231 of query aligns to 1:232/648 of P75831

query
sites
P75831

M

M

S

T

T

P

I

L

L

L

E

E

I

L

N

K

N

D

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Y

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Y

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K
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T

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T

L

L

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N

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H

N

K47 (= K47) mutation to L: Lack of activity.
D169 (= D167) mutation to N: Lack of activity.

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
43% identity, 96% coverage: 4:225/231 of query aligns to 1:228/232 of 1f3oA

query
sites
1f3oA

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M

L

I

E

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L

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N

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Y
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x
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A

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E

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K

binding adenosine-5'-diphosphate: Y11 (= Y14), G41 (= G44), G43 (= G46), K44 (= K47), S45 (≠ T48), T46 (= T49)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
45% identity, 95% coverage: 4:223/231 of query aligns to 5:226/233 of P75957

query
sites
P75957

I

L

L

L

E

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C

N

D

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N

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A

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R

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N

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G

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N

F

F

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L

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L

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A

A

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L

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E

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N

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A

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L

L

E

-

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A

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G

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A

D

E

G42 (= G41) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
45% identity, 95% coverage: 4:223/231 of query aligns to 2:223/226 of 7mdyC

query
sites
7mdyC

I

L

L

L

E

Q

I

C

N

D

N

N

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E

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G

G

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D

D

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D

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A

D

E

binding adp orthovanadate: Y12 (= Y14), G42 (= G44), S43 (= S45), G44 (= G46), K45 (= K47), S46 (≠ T48), T47 (= T49), Q91 (= Q93), H138 (= H138), E142 (≠ Q142), S144 (= S144), G145 (= G145), G146 (= G146), E168 (= E168), N172 (= N172), H201 (= H201)
binding magnesium ion: S46 (≠ T48), Q91 (= Q93)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
45% identity, 95% coverage: 4:222/231 of query aligns to 2:222/222 of 7arlD

query
sites
7arlD

I

L

L

L

E

Q

I

C

N

D

N

N

L

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K

C

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T

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A

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G

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G
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T
x
S

T

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L

L

L

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G

H

L

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C

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A

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G

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L

D

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D

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A

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A

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N

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A

A

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A

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P

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L

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K

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A

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D

D

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G

G

N

N

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L

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D

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A

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K

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A

binding adenosine-5'-diphosphate: G42 (= G44), G44 (= G46), K45 (= K47), S46 (≠ T48)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
43% identity, 96% coverage: 4:225/231 of query aligns to 1:228/230 of 1l2tA

query
sites
1l2tA

I

M

L

I

E

K

I

L

N

K

N

N

L

V

K

T

K

K

T

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Y
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Y

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M

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G

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K

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G

S
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G
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K
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K

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x
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G

G

F

F

I

V

F

F

Q

Q

N

Q

F

F

Q

N

L

L

I

I

P

P

T

L

L

L

T

T

A

A

L

L

E

E

N

N

V

V

M

E

V

L

P

P

L

L

E

I

L

F

R

K

G

Y

E

R

R

G

N

A

V

M

Q

S

G

G

Q

E

-

E

-

R

-

R

-

K

-

R

A

A

M

L

E

E

L

C

L

L

A

K

R

M

V

A

G

E

L

L

A

E

E

E

R

R

H
x
F

-

A

D

N

H

H

Y

K

P

P

T

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

A

N

N

R

N

P

P

T

P

I

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

E

S

E

K

T

T

G

G

E

E

K

K

V

I

E

M

K

Q

L

L

L

L

F

K

E

K

L

L

N

N

R

E

E

E

A

D

G

G

T

K

T

T

L

V

V

V

L

V

V

V

T

T

H
|
H

D

D

L

I

E

N

L

V

A

A

E

R

K

F

T

G

Q

E

R

R

I

I

I

I

R

Y

I

L

K

K

G

D

G

G

H

E

V

V

V

E

S

R

D

E

T

E

K

K

binding adenosine-5'-triphosphate: Y11 (= Y14), S40 (= S43), G41 (= G44), S42 (= S45), G43 (= G46), K44 (= K47), S45 (≠ T48), T46 (= T49), F138 (≠ H136), Q145 (= Q142), S147 (= S144), G149 (= G146), Q150 (≠ E147), H204 (= H201)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
45% identity, 95% coverage: 4:223/231 of query aligns to 4:225/229 of 7v8iD

query
sites
7v8iD

I

L

L

L

E

Q

I

C

N

D

N

N

L

L

K

C

K

K

T

R

Y

Y

N

Q

S

E

G

G

D

S

R

V

H

Q

L

T

T

D

V
|
V

L

L

E

H

G

N

I

V

N

S

I

F

T

S

L

V

Q

G

A

E

G

G

D

E

T

M

C

M

A

A

I

I

V

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

L

G

H

L

L

C

L

A

G

G

G

L

L

D

D

R

T

A

P

S

T

S

S

G

G

S

D

V

V

V

I

L

F

N

N

G

G

V

Q

Q

P

L

M

D

S

N

K

L

L

S

S

E

S

D

A

A

A

R

K

A

A

Q

E

V

L

R

R

N

N

Q

Q

Y

K

V

L

G

G

F

F

I

I

F

Y

Q
|
Q

N

F

F

H

Q

H

L

L

I

L

P

P

T

D

L

F

T

T

A

A

L

L

E

E

N

N

V

V

M

A

V

M

P

P

L

L

E

-

L

L

R

I

G

G

E

K

R

K

N

K

-

P

-

A

-

E

V

I

Q

N

G

S

Q

R

A

A

M

L

E

E

L

M

L

L

A

K

R

A

V

V

G

G

L

L

A

D

E

H

R
|
R

H

A

D

N

H
|
H

Y

R

P

P

T

S

Q
x
E

L

L

S
|
S

G

G

G
|
G

E
|
E

Q

R

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

V

N

N

R

N

P

P

T

R

I

L

L

V

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

E

A

E

R

T

N

G

A

E

D

K

S

V

I

E

F

K

Q

L

L

L

L

F

G

E

E

L

L

N

N

R

R

E

L

A

Q

G

G

T

T

T

A

L

F

V

L

L

V

V

V

T

T

H
|
H

D

D

L

L

E

Q

L

L

A

A

E

K

K

R

T

M

Q

S

R

R

I

Q

I

L

R

E

I

M

K

R

G

D

G

G

H

R

V

L

V

T

S

A

D

E

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V23), S43 (= S43), G44 (= G44), G46 (= G46), K47 (= K47), S48 (≠ T48), T49 (= T49), Q93 (= Q93), R137 (= R135), H140 (= H138), E144 (≠ Q142), S146 (= S144), G148 (= G146), E149 (= E147), H203 (= H201)
binding magnesium ion: S48 (≠ T48), Q93 (= Q93)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
44% identity, 96% coverage: 4:224/231 of query aligns to 3:224/226 of 5xu1B

query
sites
5xu1B

I

L

L

I

E

S

I

L

N

K

N

N

L

I

K

F

K

R

T

S

Y

Y

N

R

S

N

G

G

D

D

R

Q

H

E

L

L

T

Q

V

V

L

L

E

K

G

N

I

I

N

N

I

L

T

E

L

V

Q

N

A

E

G

G

D

E

T

F

C

V

A

A

I

I

V

M

G

G

P

P

S

S

G

G

S

S

G
|
G

K
|
K

T
x
S

T

T

L

L

L

M

G

N

L

T

C

I

A

G

G

M

L

L

D

D

R

T

A

P

S

T

S

S

G

G

S

E

V

Y

V

Y

L

L

N

E

G

G

V

Q

Q

E

L

V

D

A

N

G

L

L

S

G

E

E

D

K

A

Q

R

L

A

A

Q

K

V

V

R

R

N

N

Q

Q

Y

Q

V

I

G

G

F

F

I

V

F

F

Q

Q

N

Q

F

F

Q

F

L

L

I

L

P

S

T

K

L

L

T

N

A

A

L

L

E

Q

N

N

V

V

M

E

V

L

P

P

L

L

E

I

L

Y

R

A

G

G

E

V

R

S

N

S

V

S

Q

K

G

R

Q

R

-

K

-

L

A

A

M

E

E

E

L

Y

L

L

A

D

R

K

V

V

G

E

L

L

A

T

E

E

R

R

H

S

D

H

H

H

Y

L

P

P

T

S

Q

E

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

V

N

N

R

N

P

P

T

S

I

I

L

I

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

E

T

E

K

T

T

G

G

E

N

K

Q

V

I

E

M

K

Q

L

L

L

L

F

V

E

D

L

L

N

N

R

K

E

E

A

-

G

G

T

K

T

T

L

I

V

I

L

M

V

V

T

T

H

H

D

E

L

P

E

E

L

I

A

A

E

A

K

Y

T

A

Q

K

R

R

I

Q

I

I

R

V

I

I

K

R

G

D

G

G

H

V

V

I

V

S

S

S

D

D

T

S

binding magnesium ion: G45 (= G46), K46 (= K47), S47 (≠ T48)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
44% identity, 95% coverage: 4:223/231 of query aligns to 4:224/650 of 5ws4A

query
sites
5ws4A

I

L

L

L

E

E

I

V

N

S

N

N

L

L

K

V

K

R

T

E

Y

F

N

P

S

A

G

G

D

E

R

S

H

T

L

I

T

Q

V

I

L

L

E

K

G

G

I

I

N

D

I

L

T

T

L

I

Q

Y

A

E

G

G

D

E

T

L

C

V

A

A

I

I

V

V

G

G

P

Q

S
|
S

G
|
G

S

S

G

G

K

K

T
x
S

T

T

L

L

L

M

G

N

L

I

C

L

A

G

G

C

L

L

D

D

R

R

A

P

S

T

S

S

G

G

S

S

V

Y

V

K

L

V

N

N

G

G

V

Q

Q

E

L

T

D

G

N

K

L

L

S

E

E

P

D

D

A

Q

R

L

A

A

Q

Q

V

L

R

R

N

R

Q

E

Y

Y

V

F

G

G

F

F

I

I

F

F

Q

Q

N

R

F

Y

Q

H

L

L

I

L

P

G

T

D

L

L

T

S

A

A

L

E

E

G

N

N

V

V

M

E

V

V

P

P

L

A

E

V

L

Y

R

A

G

G

-

V

-

T

E

P

R

A

N

D

V

R

Q

K

G

Q

Q

R

A

A

M

T

E

A

L

L

L

L

A

T

R

E

V

L

G

G

L

L

A

G

E

T

R

K

H

T

D

Q

H

N

Y

R

P

P

T

S

Q

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

V

V

S

S

L

I

A

A

R

R

A

A

F

L

S

M

N

N

R

G

P

G

T

D

I

V

L

I

F

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

E

S

E

H

T

S

G

G

E

V

K

E

V

V

E

M

K

R

L

I

L

L

F

R

E

E

L

L

N

N

R

-

E

A

A

A

G

G

T

H

T

T

L

I

V

I

L

L

V

V

T

T

H

H

D

D

L

M

E

Q

L

V

A

A

E

K

K

N

T

A

Q

T

R

R

I

I

I

I

R

E

I

I

K

S

G

D

G

G

H

E

V

I

V

I

S

S

D

D

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S43), G44 (= G44), S48 (≠ T48)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
43% identity, 96% coverage: 2:223/231 of query aligns to 1:219/223 of 2pclA

query
sites
2pclA

S

A

T

E

I

I

L

L

E

R

I

A

N

E

N

N

L

I

K

K

K

K

T

V

Y

I

N

-

S

-

G

-

D

-

R

R

H

G

L

Y

T

E

V

I

L

L

E

K

G

G

I

I

N

S

I

L

T

S

L

V

Q

K

A

K

G

G

D

E

T

F

C

V

A

S

I

I

V

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

T

S

T

T

L

L

L

L

G

Y

L

I

C

L

A

G

G

L

L

L

D

D

R

A

A

P

S

T

S

E

G

G

S

K

V

V

V

F

L

L

N

E

G

G

V

K

Q

E

L

V

D

D

N

Y

L

T

S

N

E

E

D

K

A

E

R

L

A

S

Q

L

V

L

R

R

N

N

Q

R

Y

K

V

L

G

G

F

F

I

V

F

F

Q

Q

N

F

F

H

Q

Y

L

L

I

I

P

P

T

E

L

L

T

T

A

A

L

L

E

E

N

N

V

V

M

I

V

V

P

P

L

M

E

L

L

K

R

M

G

G

-

K

-

P

E

K

R

K

N

E

V

A

Q

K

G

E

Q

R

A

G

M

E

E

Y

L

L

L

L

A

S

R

E

V

L

G

G

L

L

A

G

E

D

R

K

H

L

D

S

H

R

Y

K

P

P

T

Y

Q

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

A

N

N

R

E

P

P

T

I

I

L

L

L

F

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

N

N

L

L

D

D

E

S

E

A

T

N

G

T

E

K

K

R

V

V

E

M

K

D

L

I

L

F

F

L

E

K

L

I

N

N

R

-

E

E

A

G

G

G

T

T

T

S

L

I

V

V

L

M

V

V

T
|
T

H

H

D

E

L

R

E

E

L

L

A

A

E

E

K

L

T

T

Q

H

R

R

I

T

I

L

R

E

I

M

K

K

G

D

G

G

H

K

V

V

V

V

S

G

D

E

binding magnesium ion: E165 (= E168), P166 (= P169), T167 (= T170), T196 (= T200)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
42% identity, 96% coverage: 4:225/231 of query aligns to 3:225/592 of 5lj7A

query
sites
5lj7A

I

I

L

I

E

E

I

I

N

K

N

Q

L

L

K

N

K

R

T

Y

Y

F

N

G

S

E

G

G

D

E

R

N

H

R

L

V

T

H

V
|
V

L

L

E

K

G

D

I

I

N

S

I

L

T

S

L

I

Q

E

A

R

G

G

D

D

T

F

C

V

A

A

I

I

V

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

M

G

N

L

I

C

I

A

G

G

C

L

L

D

D

R

T

A

A

S

T

S

G

G

G

S

S

V

S

V

K

L

I

N

D

G

G

V

K

Q

E

L

T

D

I

N

E

L

L

S

T

E

N

D

D

A

Q

R

L

A

S

Q

D

V

L

R

R

N

S

Q

Q

Y

K

V

F

G

G

F

F

I

I

F

F

Q
|
Q

N

R

F

Y

Q

N

L

L

I

L

P

S

T

S

L

L

T

T

A

A

L

A

E

E

N

N

V

V

M

A

V

L

P

P

L

A

E

I

L

Y

R

A

G

G

E

M

R

P

N

Q

V

S

Q

Q

-

R

-

L

G

E

Q

R

A

A

M

K

E

Q

L

L

L

L

A

E

R

K

V

L

G

G

L

L

A

G

E

D

R
x
K

H

W

D

Q

H

N

Y

K

P

P

T

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

S

S

L

I

A

A

R

R

A

A

F

L

S

M

N

N

R

G

P

G

T

E

I

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

E

S

E

H

T

S

G

G

E

E

K

N

V

V

E

M

K

E

L

I

L

L

F

R

E

Q

L

L

N

H

R

E

E

E

A

-

G

G

T

H

T

T

L

I

V

I

L

M

V

V

T

T

H

H

D

D

L

K

E

H

L

I

A

A

E

A

K

S

T

A

Q

N

R

R

I

I

I

I

R

E

I

I

K

K

G

D

G

G

H

E

V

I

V

I

S

S

D

D

T

T

K

Q

binding adenosine-5'-triphosphate: V22 (= V23), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (≠ T48), T48 (= T49), Q92 (= Q93), K136 (≠ R135), Q143 (= Q142), S145 (= S144), G147 (= G146), Q148 (≠ E147)
binding magnesium ion: S47 (≠ T48), Q92 (= Q93)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
42% identity, 96% coverage: 4:225/231 of query aligns to 3:225/615 of 5lilA

query
sites
5lilA

I

I

L

I

E

E

I

I

N

K

N

Q

L

L

K

N

K

R

T

Y

Y
x
F

N

G

S

E

G

G

D

E

R

N

H

R

L

V

T

H

V
|
V

L

L

E

K

G

D

I

I

N

S

I

L

T

S

L

I

Q

E

A

R

G

G

D

D

T

F

C

V

A

A

I

I

V

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

M

G

N

L

I

C

I

A

G

G

C

L

L

D

D

R

T

A

A

S

T

S

G

G

G

S

S

V

S

V

K

L

I

N

D

G

G

V

K

Q

E

L

T

D

I

N

E

L

L

S

T

E

N

D

D

A

Q

R

L

A

S

Q

D

V

L

R

R

N

S

Q

Q

Y

K

V

F

G

G

F

F

I

I

F

F

Q
|
Q

N

R

F

Y

Q

N

L

L

I

L

P

S

T

S

L

L

T

T

A

A

L

A

E

E

N

N

V

V

M

A

V

L

P

P

L

A

E

I

L

Y

R

A

G

G

E

M

R

P

N

Q

V

S

Q

Q

-

R

-

L

G

E

Q

R

A

A

M

K

E

Q

L

L

L

L

A

E

R

K

V

L

G

G

L

L

A

G

E

D

R
x
K

H

W

D

Q

H

N

Y

K

P

P

T

N

Q
|
Q

L

L

S
|
S

G

G

G
|
G

E
x
Q

Q

Q

Q

Q

R

R

V

V

S

S

L

I

A

A

R

R

A

A

F

L

S

M

N

N

R

G

P

G

T

E

I

I

L

I

F

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

E

S

E

H

T

S

G

G

E

E

K

N

V

V

E

M

K

E

L

I

L

L

F

R

E

Q

L

L

N

H

R

E

E

E

A

-

G

G

T

H

T

T

L

I

V

I

L

M

V

V

T

T

H

H

D

D

L

K

E

H

L

I

A

A

E

A

K

S

T

A

Q

N

R

R

I

I

I

I

R

E

I

I

K

K

G

D

G

G

H

E

V

I

V

I

S

S

D

D

T

T

K

Q

binding adenosine-5'-triphosphate: F13 (≠ Y14), V22 (= V23), S42 (= S43), G43 (= G44), G45 (= G46), K46 (= K47), S47 (≠ T48), T48 (= T49), Q92 (= Q93), K136 (≠ R135), Q143 (= Q142), S145 (= S144), G147 (= G146), Q148 (≠ E147)
binding magnesium ion: S47 (≠ T48), Q92 (= Q93)

8g4cB Bceabs atpgs high res tm (see paper)
38% identity, 95% coverage: 4:222/231 of query aligns to 3:223/248 of 8g4cB

query
sites
8g4cB

I

I

L

L

E

E

I

A

N

N

N

K

L

I

K

R

K

K

T

S

Y
|
Y

N

G

S

N

G

K

D

L

R

N

H

K

L

Q

T

E

V

V

L

L

E

K

G

G

I

I

N

D

I

I

T

H

L

I

Q

E

A

K

G

G

D

E

T

F

C

V

A

S

I

I

V

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

T
|
T

T

T

L

L

L

L

G

N

L

V

C

L

A

S

G

S

L

I

D

D

R

Q

A

V

S

S

S

H

G

G

S

T

V

I

V

H

L

I

N

N

G

G

V

N

Q

D

L

M

D

T

N

A

L

M

S

K

E

E

D

K

A

Q

R

L

A

A

Q

E

V

F

R

R

N

K

Q

Q

Y

H

V

L

G

G

F

F

I

I

F

F

Q

Q

N

D

F

Y

Q

N

L

L

I

L

P

D

T

T

L

L

T

T

A

V

L

K

E

E

N

N

V

I

M

L

V

L

P

P

L

L

E

S

L

I

R

T

-

K

-

L

G

S

E

K

R

K

N

E

V

A

Q

N

G

R

Q

K

A

F

M

E

E

E

L

V

L

A

A

K

R

E

V

L

G

G

L

I

A

Y

E

E

R

L

H

R

D

D

H

K

Y

Y

P

P

T

N

Q

E

L

I

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

T

S

S

L

A

A

G

R

R

A

A

F

F

S

I

N

H

R

D

P

P

T

S

I

I

L

I

F

F

A

A

D
|
D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

E

S

E

K

T

S

G

A

E

S

K

D

V

L

E

L

K

N

L

K

L

L

F

S

E

Q

L

L

N

N

R

Q

E

K

A

R

G

N

T

A

T

T

L

I

V

I

L

M

V

V

T

T

H

H

D

D

L

P

E

V

L

A

A

A

E

S

K

Y

T

C

Q

G

R

R

I

V

I

I

R

F

I

I

K

K

G

D

G

G

H

Q

V

M

V

Y

S

T

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y14), S42 (= S43), S44 (= S45), T47 (= T48), D168 (= D167)

7tchB Bceab e169q variant atp-bound conformation (see paper)
38% identity, 95% coverage: 4:222/231 of query aligns to 2:222/245 of 7tchB

query
sites
7tchB

I

I

L

L

E

E

I

A

N

N

N

K

L

I

K

R

K

K

T

S

Y
|
Y

N

G

S

N

G

K

D

L

R

N

H

K

L
x
Q

T

E

V
|
V

L

L

E

K

G

G

I

I

N

D

I

I

T

H

L

I

Q

E

A

K

G

G

D

E

T

F

C

V

A

S

I

I

V

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

T
|
T

T

T

L

L

L

L

G

N

L

V

C

L

A

S

G

S

L

I

D

D

R

Q

A

V

S

S

S

H

G

G

S

T

V

I

V

H

L

I

N

N

G

G

V

N

Q

D

L

M

D

T

N

A

L

M

S

K

E

E

D

K

A

Q

R

L

A

A

Q

E

V

F

R

R

N

K

Q

Q

Y

H

V

L

G

G

F

F

I

I

F

F

Q

Q

N

D

F

Y

Q

N

L

L

I

L

P

D

T

T

L

L

T

T

A

V

L

K

E

E

N

N

V

I

M

L

V

L

P

P

L

L

E

S

L

I

R

T

-

K

-

L

G

S

E

K

R

K

N

E

V

A

Q

N

G

R

Q

K

A

F

M

E

E

E

L

V

L

A

A

K

R

E

V

L

G

G

L

I

A

Y

E

E

R

L

H

R

D

D

H

K

Y

Y

P

P

T

N

Q
x
E

L

I

S

S

G
|
G

G
|
G

E

Q

Q

K

Q

Q

R

R

V

T

S

S

L

A

A

G

R

R

A

A

F

F

S

I

N

H

R

D

P

P

T

S

I

I

L

I

F

F

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

E

S

E

K

T

S

G

A

E

S

K

D

V

L

E

L

K

N

L

K

L

L

F

S

E

Q

L

L

N

N

R

Q

E

K

A

R

G

N

T

A

T

T

L

I

V

I

L

M

V

V

T

T

H

H

D

D

L

P

E

V

L

A

A

A

E

S

K

Y

T

C

Q

G

R

R

I

V

I

I

R

F

I

I

K

K

G

D

G

G

H

Q

V

M

V

Y

S

T

binding adenosine-5'-triphosphate: Y12 (= Y14), Q19 (≠ L21), V21 (= V23), S41 (= S43), G42 (= G44), S43 (= S45), K45 (= K47), T46 (= T48), E142 (≠ Q142), G145 (= G145), G146 (= G146)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
37% identity, 89% coverage: 4:208/231 of query aligns to 1:206/343 of P30750

query
sites
P30750

I

M

L

I

E

K

I

L

N

S

N

N

L

I

K

T

K

K

T

V

Y

F

N

H

S

Q

G

G

D

T

R

R

H

T

L

I

T

Q

V

A

L

L

E

N

G

N

I

V

N

S

I

L

T

H

L

V

Q

P

A

A

G

G

D

Q

T

I

C

Y

A

G

I

V

V

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

G

R

L

C

C

V

A

N

G

L

L

L

D

E

R

R

A

P

S

T

S

E

G

G

S

S

V

V

V

L

L

V

N

D

G

G

V

Q

Q

E

L

L

D

T

N

T

L

L

S

S

E

E

D

S

A

E

R

L

A

T

Q

K

V

A

R

R

N

R

Q

Q

Y

-

V

I

G

G

F

M

I

I

F

F

Q

Q

N

H

F

F

Q

N

L

L

I

L

P

S

T

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

M

A

V

L

P

P

L

L

E

E

L

L

R

D

G

N

-

T

-

P

E

K

R

D

N

E

V

V

Q

K

G

R

Q

R

A

V

M

T

E

E

L

L

L

L

A

S

R

L

V

V

G

G

L

L

A

G

E

D

R

K

H

H

D

D

H

S

Y

Y

P

P

T

S

Q

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

A

N

S

R

N

P

P

T

K

I

V

L

L

F

L

A

C

D

D

E
|
E

P

A

T

T

G

S

N

A

L

L

D

D

E

P

E

A

T

T

G

T

E

R

K

S

V

I

E

L

K

E

L

L

L

L

F

K

E

D

L

I

N

N

R

R

E

R

A

L

G

G

T

L

T

T

L

I

V

L

L

L

V

I

T

T

H

H

D

E

L

M

E

D

L

V

A

V

E

K

K

R

40:46 (vs. 43:49, 71% identical) binding ATP
E166 (= E168) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
37% identity, 89% coverage: 4:208/231 of query aligns to 2:207/344 of 6cvlD

query
sites
6cvlD

I

M

L

I

E

K

I

L

N

S

N

N

L

I

K

T

K

K

T

V

Y
x
F

N

H

S
x
Q

G

G

D

T

R

R

H

T

L
x
I

T

Q

V

A

L

L

E

N

G

N

I

V

N

S

I

L

T

H

L

V

Q

P

A

A

G

G

D

Q

T

I

C

Y

A

G

I

V

V

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

G

R

L

C

C

V

A

N

G

L

L

L

D

E

R

R

A

P

S

T

S

E

G

G

S

S

V

V

V

L

L

V

N

D

G

G

V

Q

Q

E

L

L

D

T

N

T

L

L

S

S

E

E

D

S

A

E

R

L

A

T

Q

K

V

A

R

R

N

R

Q

Q

Y

-

V

I

G

G

F

M

I

I

F

F

Q

Q

N

H

F

F

Q

N

L

L

I

L

P

S

T

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

M

A

V

L

P

P

L

L

E

E

L

L

R

D

G

N

-

T

-

P

E

K

R

D

N

E

V

V

Q

K

G

R

Q

R

A

V

M

T

E

E

L

L

L

L

A

S

R

L

V

V

G

G

L

L

A

G

E

D

R

K

H

H

D

D

H

S

Y

Y

P

P

T

S

Q
x
N

L

L

S
|
S

G

G

G

G

E
x
Q

Q

K

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

A

N

S

R

N

P

P

T

K

I

V

L

L

F

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

E

P

E

A

T

T

G

T

E

R

K

S

V

I

E

L

K

E

L

L

L

L

F

K

E

D

L

I

N

N

R

R

E

R

A

L

G

G

T

L

T

T

L

I

V

L

L

L

V

I

T

T

H
|
H

D

E

L

M

E

D

L

V

A

V

E

K

K

R

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y14), Q14 (≠ S16), I19 (≠ L21), S41 (= S43), G42 (= G44), A43 (≠ S45), G44 (= G46), K45 (= K47), S46 (≠ T48), T47 (= T49), N141 (≠ Q142), S143 (= S144), Q146 (≠ E147), H200 (= H201)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
37% identity, 89% coverage: 4:208/231 of query aligns to 2:207/344 of 3tuzC

query
sites
3tuzC

I

M

L

I

E

K

I

L

N

S

N

N

L

I

K

T

K

K

T

V

Y
x
F

N

H

S
x
Q

G

G

D

T

R

R

H

T

L

I

T

Q

V

A

L

L

E

N

G

N

I

V

N

S

I

L

T

H

L

V

Q

P

A

A

G

G

D

Q

T

I

C

Y

A

G

I

V

V

I

G

G

P

A

S

S

G
|
G

S

A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

G

R

L

C

C

V

A

N

G

L

L

L

D

E

R

R

A

P

S

T

S

E

G

G

S

S

V

V

V

L

L

V

N

D

G

G

V

Q

Q

E

L

L

D

T

N

T

L

L

S

S

E

E

D

S

A

E

R

L

A

T

Q

K

V

A

R

R

N

R

Q

Q

Y

-

V

I

G

G

F

M

I

I

F

F

Q

Q

N

H

F

F

Q

N

L

L

I

L

P

S

T

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

M

A

V

L

P

P

L

L

E

E

L

L

R

D

G

N

-

T

-

P

E

K

R

D

N

E

V

V

Q

K

G

R

Q

R

A

V

M

T

E

E

L

L

L

L

A

S

R

L

V

V

G

G

L

L

A

G

E

D

R

K

H

H

D

D

H

S

Y

Y

P

P

T

S

Q

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

A

N

S

R

N

P

P

T

K

I

V

L

L

F

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

E

P

E

A

T

T

G

T

E

R

K

S

V

I

E

L

K

E

L

L

L

L

F

K

E

D

L

I

N

N

R

R

E

R

A

L

G

G

T

L

T

T

L

I

V

L

L

L

V

I

T

T

H

H

D

E

L

M

E

D

L

V

A

V

E

K

K

R

binding adenosine-5'-diphosphate: F12 (≠ Y14), Q14 (≠ S16), G42 (= G44), G44 (= G46), K45 (= K47), S46 (≠ T48), T47 (= T49)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
37% identity, 89% coverage: 4:208/231 of query aligns to 2:207/344 of 3tuiC

query
sites
3tuiC

I

M

L

I

E

K

I

L

N

S

N

N

L

I

K

T

K

K

T

V

Y
x
F

N

H

S

Q

G

G

D

T

R

R

H

T

L

I

T

Q

V

A

L

L

E

N

G

N

I

V

N

S

I

L

T

H

L

V

Q

P

A

A

G

G

D

Q

T

I

C

Y

A

G

I

V

V

I

G

G

P

A

S

S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

G

R

L

C

C

V

A

N

G

L

L

L

D

E

R

R

A

P

S

T

S

E

G

G

S

S

V

V

V

L

L

V

N

D

G

G

V

Q

Q

E

L

L

D

T

N

T

L

L

S

S

E

E

D

S

A

E

R

L

A

T

Q

K

V

A

R

R

N

R

Q

Q

Y

-

V

I

G

G

F

M

I

I

F

F

Q

Q

N

H

F

F

Q

N

L

L

I

L

P

S

T

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

M

A

V

L

P

P

L

L

E

E

L

L

R

D

G

N

-

T

-

P

E

K

R

D

N

E

V

V

Q

K

G

R

Q

R

A

V

M

T

E

E

L

L

L

L

A

S

R

L

V

V

G

G

L

L

A

G

E

D

R

K

H

H

D

D

H

S

Y

Y

P

P

T

S

Q

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

V

V

S

A

L

I

A

A

R

R

A

A

F

L

S

A

N

S

R

N

P

P

T

K

I

V

L

L

F

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

L

L

D

D

E

P

E

A

T

T

G

T

E

R

K

S

V

I

E

L

K

E

L

L

L

L

F

K

E

D

L

I

N

N

R

R

E

R

A

L

G

G

T

L

T

T

L

I

V

L

L

L

V

I

T

T

H

H

D

E

L

M

E

D

L

V

A

V

E

K

K

R

binding adenosine-5'-diphosphate: F12 (≠ Y14), G42 (= G44), A43 (≠ S45), G44 (= G46), K45 (= K47), S46 (≠ T48), T47 (= T49)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
37% identity, 98% coverage: 3:228/231 of query aligns to 2:225/230 of 6z4wA

query
sites
6z4wA

T

S

I

I

L

I

E

E

I

M

N

R

N

D

L

V

K

V

K

K

T

K

Y
|
Y

N

D

S

N

G

G

D
x
T

R

-

H

-

L

-

T

T

V
x
A

L

L

E

R

G

G

I

V

N

S

I

V

T

S

L

V

Q

Q

A

P

G

G

D

E

T

F

C

A

A

Y

I

I

V

V

G

G

P

P

S

S

G
|
G

S

A

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

I

G

R

L

S

C

L

A

Y

G

R

L

E

D

V

R

K

A

I

S

D

S

K

G

G

S

S

V

L

V

S

L

V

N

A

G

G

V

F

Q

N

L

L

D

V

N

K

L

I

S

K

E

K

D

K

A

D

R

V

A

P

Q

L

V

L

R

R

N

R

Q

S

Y

-

V

V

G

G

F

V

I

V

F

F

Q

Q

N

D

F

Y

Q

K

L

L

I

L

P

P

T

K

L

K

T

T

A

V

L

Y

E

E

N

N

V

I

M

A

V

Y

P

A

L

M

E

E

L

V

R

I

G

G

E

E

-

N

-

R

R

R

N

N

V

I

Q

K

G

R

Q

R

A

V

M

M

E

E

L

V

L

L

A

D

R

L

V

V

G

G

L

L

A

K

E

H

R

K

H

V

D

R

H

S

Y

F

P

P

T

N

Q

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

I

S

A

L

I

A

A

R

R

A

A

F

I

S

V

N

N

R

N

P

P

T

K

I

V

L

L

F

I

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

E

P

E

D

T

N

G

S

E

W

K

E

V

I

E

M

K

N

L

L

L

L

F

E

E

R

L

I

N

N

R

L

E

Q

A

-

G

G

T

T

T

T

L

I

V

L

L

M

V

A

T

T

H

H

D

N

L

S

E

Q

L

I

A

V

E

N

K

T

T

L

Q

R

-

H

R

R

I

V

I

I

R

A

I

I

K

E

G

N

G

G

H

R

V

V

V

V

S

R

D

D

T

E

K

S

T

K

A

G

E

E

binding adenosine-5'-diphosphate: Y13 (= Y14), T17 (≠ D18), A19 (≠ V23), G40 (= G44), G42 (= G46), K43 (= K47), S44 (≠ T48), T45 (= T49)

A0A0H2ZM82 Cell division ATP-binding protein FtsE from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
37% identity, 98% coverage: 3:228/231 of query aligns to 2:225/230 of A0A0H2ZM82

query
sites
A0A0H2ZM82

T

S

I

I

L

I

E

E

I

M

N

R

N

D

L

V

K

V

K

K

T

K

Y

Y

N

D

S

N

G

G

D

T

R

-

H

-

L

-

T

T

V

A

L

L

E

R

G

G

I

V

N

S

I

V

T

S

L

V

Q

Q

A

P

G

G

D

E

T

F

C

A

A

Y

I

I

V

V

G

G

P

P

S

S

G

G

S

A

G

G

K
|
K

T

S

T

T

L

F

L

I

G

R

L

S

C

L

A

Y

G

R

L

E

D

V

R

K

A

I

S

D

S

K

G

G

S

S

V

L

V

S

L

V

N

A

G

G

V

F

Q

N

L

L

D

V

N

K

L

I

S

K

E

K

D

K

A

D

R

V

A

P

Q

L

V

L

R

R

N

R

Q

S

Y

-

V

V

G

G

F

V

I

V

F

F

Q

Q

N

D

F

Y

Q

K

L

L

I

L

P

P

T

K

L

K

T

T

A

V

L

Y

E

E

N

N

V

I

M

A

V

Y

P

A

L

M

E

E

L

V

R

I

G

G

E

E

-

N

-

R

R

R

N

N

V

I

Q

K

G

R

Q

R

A

V

M

M

E

E

L

V

L

L

A

D

R

L

V

V

G

G

L

L

A

K

E

H

R

K

H

V

D

R

H

S

Y

F

P

P

T

N

Q

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

V

I

S

A

L

I

A

A

R

R

A

A

F

I

S

V

N

N

R

N

P

P

T

K

I

V

L

L

F

I

A

A

D
|
D

E
|
E

P

P

T

T

G

G

N

N

L

L

D

D

E

P

E

D

T

N

G

S

E

W

K

E

V

I

E

M

K

N

L

L

L

L

F

E

E

R

L

I

N

N

R

L

E

Q

A

-

G

G

T

T

T

T

L

I

V

L

L

M

V

A

T

T

H

H

D

N

L

S

E

Q

L

I

A

V

E

N

K

T

T

L

Q

R

-

H

R

R

I

V

I

I

R

A

I

I

K

E

G

N

G

G

H

R

V

V

V

V

S

R

D

D

T

E

K

S

T

K

A

G

E

E

K43 (= K47) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
D164 (= D167) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.
E165 (= E168) mutation to A: Growth cessation and formation of spherical cells with aberrant division planes.

Query Sequence

>WP_101442772.1 NCBI__GCF_002846395.1:WP_101442772.1
MSTILEINNLKKTYNSGDRHLTVLEGINITLQAGDTCAIVGPSGSGKTTLLGLCAGLDRA
SSGSVVLNGVQLDNLSEDARAQVRNQYVGFIFQNFQLIPTLTALENVMVPLELRGERNVQ
GQAMELLARVGLAERHDHYPTQLSGGEQQRVSLARAFSNRPTILFADEPTGNLDEETGEK
VEKLLFELNREAGTTLVLVTHDLELAEKTQRIIRIKGGHVVSDTKTAESVH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory