SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_101589014.1 NCBI__GCF_900169175.1:WP_101589014.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4ywuA Structural insight into the substrate inhibition mechanism of NADP+- dependent succinic semialdehyde dehydrogenase from streptococcus pyogenes (see paper)
43% identity, 99% coverage: 5:457/457 of query aligns to 2:454/455 of 4ywuA

query
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4ywuA

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active site: N131 (= N134), K154 (= K157), E228 (= E231), C262 (= C265), E359 (= E362), E436 (= E439)
binding 4-oxobutanoic acid: N131 (= N134), Q136 (= Q139), R139 (= R142), E228 (= E231), V261 (≠ S264), C262 (= C265), F425 (= F428)

4ohtA Crystal structure of succinic semialdehyde dehydrogenase from streptococcus pyogenes in complex with NADP+ as the cofactor (see paper)
43% identity, 99% coverage: 5:457/457 of query aligns to 2:454/455 of 4ohtA

query
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4ohtA

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active site: N131 (= N134), K154 (= K157), E228 (= E231), C262 (= C265), E359 (= E362), E436 (= E439)
binding nadp nicotinamide-adenine-dinucleotide phosphate: V127 (= V130), E128 (≠ M131), P129 (= P132), W130 (= W133), K154 (= K157), H155 (= H158), A156 (= A159), S157 (≠ P160), Y187 (≠ T190), S207 (= S210), I214 (≠ V217)

4itbA Structure of bacterial enzyme in complex with cofactor and substrate (see paper)
44% identity, 98% coverage: 7:454/457 of query aligns to 4:450/453 of 4itbA

query
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4itbA

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A

I

I

H

A

L

L

A

A

N

N

D

D

S

I

S

P

F

F

G

G

L

L

G

G

G

A

S

S

V

A

M

W

S

T

A

N

D

D

P

P

A

A

R

E

A

Q

R

Q

R

R

V

F

A

I

D

Q

R

E

I

L

D

D

S

A

A

G

M

A

V

V

W

F

I

I

N

N

A

G

A

M

T

V

W

K

T
x
S

E

D

P

P

D

R

L

L

P

P

F

F

G

G

T

T

K

K

R

R

S

S

G

G

I

Y

G

G

R

R

E
|
E

L

L

G

G

A

L

E

A

G

G

I

I

L

R

E

T

F

F

V

V

N

N

K

A

K

K

L

T

I

V

active site: N130 (= N134), K153 (= K157), E227 (= E231), C261 (= C265), E358 (= E362), E435 (= E439)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: V126 (= V130), M127 (= M131), P128 (= P132), W129 (= W133), N130 (= N134), K153 (= K157), A155 (= A159), S156 (≠ P160), A186 (≠ T190), V189 (≠ I193), G205 (= G209), S206 (= S210), A209 (= A213), S212 (≠ A216), L228 (= L232), C261 (= C265), E358 (= E362), F360 (= F364)
binding 4-oxobutanoic acid: E227 (= E231), C261 (= C265), S418 (≠ T422)

3vz3A Structural insights into substrate and cofactor selection by sp2771 (see paper)
44% identity, 98% coverage: 7:454/457 of query aligns to 4:450/453 of 3vz3A

query
sites
3vz3A

T

T

T

I

G

N

P

P

A

T

N

T

G

G

E

E

M

I

L

C

K

Q

E

R

F

F

P

K

A

A

A

L

A

T

D

P

H

A

E

E

I

I

A

D

D

A

A

K

I

L

A

A

A

K

S

A

H

Q

A

E

A

A

F

F

Q

Q

T

A

W

Y

R

R

T

R

T

T

P

S

V

F

E

S

K

Q

R

R

T

R

E

Q

P

W

I

L

R

E

R

N

A

A

D

A

L

I

M

L

E

E

E

R

R

D

I

T

D

S

E

K

L

F

S

A

R

E

L

I

L

M

T

T

L

T

E

E

M

M

G

G

K

K

L

T

T

H

A

Q

E

S

A

A

R

I

A

A

E

E

V

A

E

E

L

K

C

S

A

A

K

L

I

V

L

C

R

R

Y

Y

A

A

D

E

E

H

G

G

P

E

G

Q

H

F

L

L

A

A

D

N

E

E

R

Y

R

-

T

T

P

E

D

T

S

Q

G

A

G

T

T

E

G

S

V

Y

V

V

K

C

K

Y

E

Q

P

P

K

L

G

G

P

I

L

L

I

L

G

A

V
|
V

M
|
M

P

P

W
|
W

N
|
N

F
|
F

P

P

Y

F

Y
x
W

Q
|
Q

V

V

V

F

R
|
R

L

F

A

A

P

P

N

A

L

L

I

M

A

A

G

G

N

N

T

V

I

A

L

V

L

L

K
|
K

H

H

A
|
A

P
x
S

N

N

C

V

P

P

Q

Q

S

C

A

A

V

L

A

A

F

V

A

E

A

A

L

I

M

L

S

E

D

A

A

A

G

G

L

F

P

P

D

E

D

G

C

V

Y

F

I

Q

N

T

L

L

F

L

A

I

D

G

T
x
A

D

S

Q

Q

I
x
V

Q

E

T

Q

I

V

I

I

A

K

D

D

E

P

R

R

V

V

A

K

G

A

A

A

S

T

L

L

T
|
T

G
|
G

S
|
S

E

E

A

P

A
|
A

G

G

S

A

A

S

V

L

A

A

A

S

G

L

A

A

G

G

E

Q

N

E

L

I

T

K

K

P

V

T

I

L

L

L

E
|
E

L
|
L

G
|
G

G

G

S

S

D

D

P

P

F

F

I

V

V

V

L

F

D

P

S

S

D

A

D

D

L

L

D

D

E

E

T

A

V

V

S

E

T

V

A

G

V

T

A

V

G

A

R

R

M

T

A

M

N

N

A

N

G

G

Q

Q

S
|
S

C
x
A

I
|
I

A

A

S

A

K

K

R

R

L

F

I

I

V

L

V

H

E

E

D

A

H

I

Y

A

E

A

E

E

F

F

V

L

E

E

K

K

F

L

T

H

T

L

A

K

M

F

A

A

G

S

F

L

T

K

P

I

G

G

D

D

P

P

A

M

D

A

P

P

D

E

T

T

T

D

L

I

A

G

P

P

L

L

S

A

S

T

E

E

Q

G

A

I

A

L

A

Q

D

D

L

I

M

S

E

R

Q

Q

V

V

H

D

D

Q

A

A

V

V

E

A

Q

A

G

G

A

A

T

K

V

I

Q

L

I

L

G

G

G

R

R

P

V

L

D

D

R

R

P

A

G

G

A

Y

Y

F

V

Y

Q

P

P

P

T

T

V

I

L

L

T

T

G

E

V

I

I

P

P

P

S

G

M

A

R

K

A

I

Y

L

S

Q

E

E

E
|
E

L

L

F
|
F

G

A

P

P

V

V

A

A

V

M

I

V

Y

F

R

T

V

V

A

K

D

D

E

L

E

D

E

Q

A

A

I

I

H

A

L

L

A

A

N

N

D

D

S

I

S

P

F

F

G

G

L

L

G

G

G

A

S

S

V

A

M

W

S

T

A

N

D

D

P

P

A

A

R

E

A

Q

R

Q

R

R

V

F

A

I

D

Q

R

E

I

L

D

D

S

A

A

G

M

A

V

V

W

F

I

I

N

N

A

G

A

M

T

V

W

K

T
x
S

E

D

P

P

D

R

L

L

P

P

F

F

G

G

T

T

K

K

R

R

S

S

G

G

I

Y

G

G

R

R

E
|
E

L

L

G

G

A

L

E

A

G

G

I

I

L

R

E

T

F

F

V

V

N

N

K

A

K

K

L

T

I

V

active site: N130 (= N134), K153 (= K157), E227 (= E231), A261 (≠ C265), E358 (= E362), E435 (= E439)
binding nadp nicotinamide-adenine-dinucleotide phosphate: V126 (= V130), M127 (= M131), W129 (= W133), N130 (= N134), Q135 (= Q139), R138 (= R142), K153 (= K157), A155 (= A159), S156 (≠ P160), A186 (≠ T190), V189 (≠ I193), T204 (= T208), G205 (= G209), S206 (= S210), A209 (= A213), E227 (= E231), L228 (= L232), G229 (= G233), A261 (≠ C265), F360 (= F364)
binding 4-oxobutanoic acid: F131 (= F135), W134 (≠ Y138), S260 (= S264), A261 (≠ C265), I262 (= I266), S418 (≠ T422)

3efvA Crystal structure of a putative succinate-semialdehyde dehydrogenase from salmonella typhimurium lt2 with bound NAD (see paper)
39% identity, 99% coverage: 2:454/457 of query aligns to 3:454/459 of 3efvA

query
sites
3efvA

A

A

S

T

T

Q

F

A

T

L

T

S

T

V

G

N

P

P

A

A

N

T

G

G

E

Q

M

T

L

L

K

A

E

A

F

M

P

P

A

W

A

A

A

N

D

A

H

Q

E

E

I

I

A

E

D

H

A

A

I

L

A

S

A

L

S

A

H

A

A

S

A

G

F

F

Q

K

T

K

W

W

R

K

T

M

T

T

P

S

V

V

E

A

K

Q

R

R

T

A

E

Q

P

T

I

L

R

R

R

D

A

I

A

G

D

Q

L

A

M

L

E

R

E

A

R

H

I

A

D

E

E

E

L

M

S

A

R

Q

L

C

L

I

T

T

L

R

E

E

M

M

G

G

K

K

L

P

T

I

A

K

E

Q

A

A

R

R

A

A

E

E

V

V

E

T

L

K

C

S

A

A

K

A

I

L

L

C

R

D

Y

W

Y

Y

A

A

D

E

E

H

G

G

P

P

G

A

H

M

L

L

A

N

D

P

E

E

R

P

R

-

T

T

P

L

D

V

S

E

G

N

G

Q

T

Q

G

A

V

V

V

I

K

E

K

Y

E

R

P

P

K

L

G

G

P

V

L

I

I

L

G

A

V
x
I

M
|
M

P
|
P

W
|
W

N
|
N

F

F

P

P

Y

L

Y

W

Q
|
Q

V

V

V

L

R
|
R

L

G

A

A

A

V

P

P

N

I

L

L

I

L

A

A

G

G

N

N

T

S

I

Y

L

L

K
|
K

H

H

A
|
A

P

P

N

N

C

V

P

T

Q

G

S

C

A

A

V

Q

A

M

F

I

A

A

A

R

L

I

M

L

S

A

D

E

A

A

G

G

L

T

P

P

D

A

D

G

C

V

Y

Y

I

G

N

W

L

V

F

N

A

A

D

N

T
x
N

D

E

Q

G

I
x
V

Q

S

T

Q

I

M

I

I

A

N

D

D

E

P

R

R

V

I

A

A

G

A

A

V

S

T

L

V

T
|
T

G
|
G

S
|
S

E

V

A

R

A
|
A

G

G

S

A

A

A

V

I

A

G

A

A

G

Q

A

A

G

G

E

A

N

A

L

L

T

K

K

K

V

C

I

V

L

L

E
|
E

L
|
L

G
|
G

G

G

S

S

D

D

P

P

F

F

I

I

V

V

L

L

D

N

S

D

D

A

D

D

L

L

D

E

E

L

T

A

V

V

S

K

T

A

A

A

V

V

A

A

G

G

R

R

M

Y

A

Q

N

N

A

T

G

G

Q

Q

S

V

C
|
C

I

A

A

A

S

A

K

K

R

R

L

F

I

I

V

V

V

E

E

E

D

G

H

I

Y

A

E

Q

E

A

F

F

V

T

E

D

K

R

F

F

T

V

T

A

A

A

M

A

A

A

G

A

F

L

T

K

P

M

G

G

D

D

P

P

A

L

D

V

P

E

D

E

T

N

T

D

L

L

A

G

P

P

L

M

S

A

S

R

E

F

Q

D

A

L

A

R

A

D

D

E

L

L

M

H

E

Q

Q

Q

V

V

H

Q

D

A

A

S

V

V

E

A

Q

E

G

G

A

A

T

R

V

L

Q

L

I

L

G

G

G

E

R

K

V

I

D

A

R

G

P

E

G

G

A

N

Y

Y

V

Y

Q

A

P

A

T

T

V

V

L

L

T

A

G

D

V

V

I

T

P

P

S

D

M

M

R

T

A

A

Y

F

S

R

E

Q

E
|
E

L

L

F
|
F

G

G

P

P

V

V

A

A

V

A

I

I

Y

T

R

V

V

A

A

K

D

D

E

A

E

H

A

A

I

L

H

A

L

L

A

A

N

N

D

D

S

S

S

E

F

F

G

G

L

L

G

S

G

A

S

T

V

I

M

F

S

T

A

A

D

D

P

D

A

T

R

L

A

A

R

A

R

E

V

M

A

A

D

A

R

R

I

L

D

E

S

C

A

G

M

G

V

V

W

F

I

I

N

N

A

G

A

Y

T

S

W

A

T

S

E

D

P

A

D

R

L

V

P

A

F
|
F

G

G

T

V

K

K

R

K

S

S

G

G

I

F

G

G

R

R

E
|
E

L

L

G

S

A

H

E

F

G

G

I

L

L

H

E

E

F

F

V

C

N

N

K

V

K

Q

L

T

I

V

active site: N134 (= N134), E231 (= E231), C265 (= C265), E439 (= E439)
binding nicotinamide-adenine-dinucleotide: I130 (≠ V130), M131 (= M131), P132 (= P132), W133 (= W133), N134 (= N134), Q139 (= Q139), R142 (= R142), K157 (= K157), A159 (= A159), N190 (≠ T190), V193 (≠ I193), T208 (= T208), G209 (= G209), S210 (= S210), A213 (= A213), E231 (= E231), L232 (= L232), G233 (= G233), C265 (= C265), E362 (= E362), F364 (= F364), F428 (= F428)

3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
37% identity, 98% coverage: 7:454/457 of query aligns to 29:477/481 of 3jz4A

query
sites
3jz4A

T

V

T

T

G

N

P

P

A

A

N

N

G

G

E

D

M

K

L

L

K

G

E

S

F

V

P

P

A

K

A

M

A

G

D

A

H

D

E

E

I

T

A

R

D

A

A

A

I

I

A

D

A

A

S

A

H

N

A

R

A

A

F

L

Q

P

T

A

W

W

R

R

T

A

T

L

P

T

V

A

E

K

K

E

R

R

T

A

E

T

P

I

I

L

R

R

R

N

A

W

A

F

D

N

L

L

M

M

E

M

E

E

R

H

I

Q

D

D

E

D

L

L

S

A

R

R

L

L

L

M

T

T

L

L

E

E

M

Q

G

G

K

K

L

P

T

L

A

A

E

E

A

A

R

K

A

G

E

E

V

I

E

S

L

Y

C

A

A

A

K

S

I

F

L

I

R

E

Y

W

Y

F

A

A

D

E

E

E

G

G

-

K

-

R

-

I

-

Y

-

G

-

D

-

T

-

I

P

P

G

G

H

H

L

Q

A

A

D

D

E

K

R

R

R

L

T

-

P

-

D

-

S

-

G

-

T

-

G

-

V

I

V

V

K

I

K

K

E

Q

P

P

K

I

G

G

P

V

L

T

I

A

G

A

V

I

M

T

P
|
P

W
|
W

N
|
N

F

F

P

P

Y

A

Q

M

V

I

V

T

R

R

L

K

A

A

A

G

P

P

N

A

L

L

I

A

A

A

G

G

N

C

T

T

I

M

L

V

L

L

K
|
K

H

P

A
|
A

P
x
S

N

Q

C

T

P

P

Q

F

S

S

A

A

V

L

A

A

F

L

A

A

A

E

L

L

M

A

S

I

D

R

A

A

G

G

L

V

P

P

D

A

D

G

C

V

Y

F

I

N

N

V

L

V

F

T

A

G

D

S

T
x
A

D

G

Q

A

I

V

-
x
G

Q

N

T

E

I

L

I

T

A

S

D

N

E

P

R

L

V

V

A

R

G

K

A

L

S

S

L

F

T

T

G
|
G

S
|
S

E

T

A

E

A
x
I

G

G

S

R

A

Q

V

L

A

M

A

E

G

Q

A

C

G

A

E

K

N

D

L

I

T

K

K

K

V

V

I

S

L

L

E
|
E

L

L

G

G

S

N

D

A

P

P

F

F

I

I

V

V

L

F

D

D

S

D

D

A

D

D

L

L

D

D

E

K

T

A

V

V

S

E

T

G

A

A

V

L

A

A

G

S

R

K

M

F

A

R

N

N

A

A

G

G

Q

Q

S

T

C
|
C

I

V

A

C

S

A

K

N

R

R

L

L

I

Y

V

V

V

Q

E

D

D

G

H

V

Y

Y

E

D

E

R

F

F

V

A

E

E

K

K

F

L

T

Q

A

A

M

M

A

S

G

K

F

L

T

H

P

I

G

G

D

D

P

G

A

L

D

D

P

N

D

G

T

V

T

T

L

I

A

G

P

P

L

L

S

I

S

D

E

E

Q

K

A

A

A

V

A

A

D
x
K

L

V

M

E

E

E

Q

H

V

I

H

A

D

D

A

A

V

L

E

E

Q

K

G

G

A

A

T

R

V

V

Q

V

I

C

G

G

G

K

R

A

V

H

D

E

R

R

P

G

G

G

A

N

Y

F

V

F

Q

Q

P

P

T

T

V

I

L

L

T

V

G

D

V

V

I

P

P

A

S

N

M

A

R

K

A

V

Y

S

S

K

E

E

E
|
E

L

T

F
|
F

G

G

P

P

V

L

A

A

V

P

I

L

Y

F

R

R

V

F

A

K

D

D

E

E

E

A

E

D

A

V

I

I

H

A

L

Q

A

A

N

N

D

D

S

T

S

E

F

F

G

G

L

L

G

A

S

Y

V

F

M

Y

S

A

A

R

D

D

P

L

A

S

R

R

A

V

R

F

R

R

V

V

A

G

D

E

R

A

I

L

D

E

S

Y

A

G

M

I

V

V

W

G

I

I

N

N

A

T

A

G

T

I

W

I

T

S

E

N

P

E

D

V

L

A

P

P

F

F

G

G

T

I

K

K

R

A

S

S

G

G

I

L

G

G

R

R

E
|
E

L

G

G

S

A

K

E

Y

G

G

I

I

L

E

E

D

F

Y

V

L

N

E

K

I

K

K

L

Y

I

M

active site: N156 (= N134), K179 (= K157), E254 (= E231), C288 (= C265), E385 (= E362), E462 (= E439)
binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (= P132), W155 (= W133), K179 (= K157), A181 (= A159), S182 (≠ P160), A212 (≠ T190), G216 (vs. gap), G232 (= G209), S233 (= S210), I236 (≠ A213), C288 (= C265), K338 (≠ D315), E385 (= E362), F387 (= F364)

P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
37% identity, 98% coverage: 7:454/457 of query aligns to 30:478/482 of P25526

query
sites
P25526

T

V

T

T

G

N

P

P

A

A

N

N

G

G

E

D

M

K

L

L

K

G

E

S

F

V

P

P

A

K

A

M

A

G

D

A

H

D

E

E

I

T

A

R

D

A

A

A

I

I

A

D

A

A

S

A

H

N

A

R

A

A

F

L

Q

P

T

A

W

W

R

R

T

A

T

L

P

T

V

A

E

K

K

E

R

R

T

A

E

T

P

I

I

L

R

R

R

N

A

W

A

F

D

N

L

L

M

M

E

M

E

E

R

H

I

Q

D

D

E

D

L

L

S

A

R

R

L

L

L

M

T

T

L

L

E

E

M

Q

G

G

K

K

L

P

T

L

A

A

E

E

A

A

R

K

A

G

E

E

V

I

E

S

L

Y

C

A

A

A

K

S

I

F

L

I

R

E

Y

W

Y

F

A

A

D

E

E

E

G

G

-

K

-

R

-

I

-

Y

-

G

-

D

-

T

-

I

P

P

G

G

H

H

L

Q

A

A

D

D

E

K

R

R

R

L

T

-

P

-

D

-

S

-

G

-

T

-

G

-

V

I

V

V

K

I

K

K

E

Q

P

P

K

I

G

G

P

V

L

T

I

A

G

A

V

I

M

T

P

P

W
|
W

N
|
N

F

F

P

P

Y

A

Q

M

V

I

V

T

R

R

L

K

A

A

A

G

P

P

N

A

L

L

I

A

A

A

G

G

N

C

T

T

I

M

L

V

L

L

K
|
K

H
x
P

A
|
A

P
x
S

N

Q

C

T

P

P

Q

F

S

S

A

A

V

L

A

A

F

L

A

A

A

E

L

L

M

A

S

I

D

R

A

A

G

G

L

V

P

P

D

A

D

G

C

V

Y

F

I

N

N

V

L

V

F

T

A

G

D

S

T

A

D

G

Q

A

I

V

-

G

Q

N

T

E

I

L

I

T

A

S

D

N

E

P

R

L

V

V

A

R

G

K

A

L

S

S

L

F

T

T

G
|
G

S
|
S

E

T

A

E

A

I

G

G

S

R

A

Q

V

L

A

M

A

E

G

Q

A

C

G

A

E

K

N

D

L

I

T

K

K

K

V

V

I

S

L

L

E

E

L
|
L

G

G

S

N

D

A

P

P

F

F

I

I

V

V

L

F

D

D

S

D

D

A

D

D

L

L

D

D

E

K

T

A

V

V

S

E

T

G

A

A

V

L

A

A

G

S

R

K

M

F

A

R

N

N

A

A

G

G

Q

Q

S

T

C

C

I

V

A

C

S

A

K

N

R

R

L

L

I

Y

V

V

V

Q

E

D

D

G

H

V

Y

Y

E

D

E

R

F

F

V

A

E

E

K

K

F

L

T

Q

A

A

M

V

A

S

G

K

F

L

T

H

P

I

G

G

D

D

P

G

A

L

D

D

P

N

D

G

T

V

T

T

L

I

A

G

P

P

L

L

S

I

S

D

E

E

Q

K

A

A

A

V

A

A

D

K

L

V

M

E

E

E

Q

H

V

I

H

A

D

D

A

A

V

L

E

E

Q

K

G

G

A

A

T

R

V

V

Q

V

I

C

G

G

G

K

R

A

V

H

D

E

R

R

P

G

G

G

A

N

Y

F

V

F

Q

Q

P

P

T

T

V

I

L

L

T

V

G

D

V

V

I

P

P

A

S

N

M

A

R

K

A

V

Y

S

S

K

E

E

E
|
E

L

T

F

F

G

G

P

P

V

L

A

A

V

P

I

L

Y

F

R

R

V

F

A

K

D

D

E

E

E

A

E

D

A

V

I

I

H

A

L

Q

A

A

N

N

D

D

S

T

S

E

F

F

G

G

L

L

G

A

S

Y

V

F

M

Y

S

A

A

R

D

D

P

L

A

S

R

R

A

V

R

F

R

R

V

V

A

G

D

E

R

A

I

L

D

E

S

Y

A

G

M

I

V

V

W

G

I

I

N

N

A

T

A

G

T

I

W

I

T

S

E

N

P

E

D

V

L

A

P

P

F

F

G

G

T

I

K

K

R

A

S

S

G

G

I

L

G

G

R

R

E

E

L

G

G

S

A

K

E

Y

G

G

I

I

L

E

E

D

F

Y

V

L

N

E

K

I

K

K

L

Y

I

M

WN 156:157 (= WN 133:134) binding NADP(+)
KPAS 180:183 (≠ KHAP 157:160) binding NADP(+)
GS 233:234 (= GS 209:210) binding NADP(+)
L256 (= L232) binding NADP(+)
E386 (= E362) binding NADP(+)

8of1A Structure of aldh5f1 from moss physcomitrium patens in complex with NAD+ in the contracted conformation
35% identity, 99% coverage: 4:454/457 of query aligns to 44:495/505 of 8of1A

query
sites
8of1A

T

T

F

L

T

P

T

V

T

N

G

N

P

P

A

A

N

T

G

G

E

E

M

I

L

L

K

T

E

S

F

V

P

P

A

F

A

M

A

G

D

K

H

R

E

E

I

A

A

E

D

K

A

A

I

I

A

A

S

A

H

S

A

Q

A

A

F

F

Q

T

T

S

W

W

R

S

T

K

T

R

P

T

V

A

E

N

K

D

R

R

T

S

E

K

P

I

I

L

R

R

R

Q

A

W

A

F

D

N

L

L

M

L

E

I

E

K

R

N

I

K

D

D

E

D

L

L

S

G

R

K

L

L

L

I

T

V

L

L

E

E

M

Q

G

G

K

K

L

P

T

L

A

A

E

E

A

A

R

V

A

G

E

E

V

I

E

V

L

Y

C

G

A

A

K

A

I

F

L

V

R

E

Y

Y

A

A

D

E

E

E

G

A

P

K

G

R

H

V

L

Y

A

G

D

D

E

I

R

I

R

P

T

S

P

P

D

F

S

P

G

E

G

K

T

R

G

M

V

L

V

V

K

M

K

K

E

Q

P

P

K

V

G

G

P

V

L

V

I

A

G

A

V
x
I

M
x
A

P
|
P

W
|
W

N

N

F

F

P

P

Y

L

Y

A

Q

M

V

I

V

T

R

R

L

K

A

V

A

A

P

P

N

A

L

L

I

A

A

A

G

G

N

C

T

T

I

V

L

V

L

I

K
|
K

H

P

A

S

P

E

N

L

C

T

P

P

Q

L

S

T

A

A

V

L

A

A

F

A

A

A

A

E

L

L

M

A

S

L

D

Q

A

A

G

G

L

I

P

P

D

P

D

G

C

V

Y

V

I

N

N

V

L

V

F

M

A

G

D

D

T
x
A

D

K

Q

G

I

I

Q

G

T

D

I

A

I

M

A

L

D

D

E

S

-

T

R

E

V

V

A

R

G

K

A

I

S

T

L
x
F

T

T

G
|
G

S
|
S

E

T

A

G

A
x
V

G

G

S

K

A
x
M

V

L

A

L

A

A

G

G

A

A

G

G

E

K

N

T

L

V

T

K

K

K

V

V

I

S

L

L

E

E

L
|
L

G

G

S

N

D

A

P

P

F

C

I

I

V

V

L

F

D

D

S

D

D

A

D

N

L

L

D

D

E

V

T

A

V

V

S

K

T

G

A

V

V

L

A

A

G

G

R

K

M

Y

A

R

N

N

A

S

G

G

Q

Q

S

T

C
|
C

I

V

A

C

S

I

K

N

R

K

L

I

I

F

V

V

V

Q

E

D

D

G

H

I

Y

Y

E

D

E

K

F

F

V

A

E

E

K

A

F

F

T

A

T

K

A

A

M

V

A

S

G

G

F

L

T

R

P

A

G

G

D

N

P

G

A

L

D

E

P

P

D

G

T

I

T

T

L

Q

A

G

P

P

L

L

S

I

S

N

E

E

Q

T

A

A

A

L

A

E

D
x
K

L

V

M

E

E

R

Q

H

V

V

H

Q

D

D

A

A

V

V

E

S

Q

K

G

G

A

A

T

K

V

V

Q

L

I

V

G

G

G

K

R

R

V

H

D

S

R

L

P

G

G

R

A

T

Y

F

V

Y

Q

E

P

P

T

T

V

I

L

L

T

G

G

N

V

A

I

S

P

D

S

E

M

M

R

L

A

I

Y

F

S

R

E

E

E
|
E

L

V

F
|
F

G

G

P

P

V

V

A

A

V

P

I

L

Y

V

R

R

V

F

A

N

D

T

E

D

E

E

A

A

I

I

H

K

L

L

A

A

N

N

D

N

S

S

S

E

F

F

G

G

L

L

G

A

S

Y

V

A

M

F

S

T

A

E

D

N

P

I

A

T

R

R

A

G

R

W

R

R

V

V

A

A

D

E

R

S

I

L

D

E

S

F

A

G

M

M

V

V

W

G

I

L

N

N

A

E

A

G

T

L

W

I

T

S

E

T

P

E

D

V

L

A

P

P

F

F

G

G

T

M

K

K

R

Q

S

S

G

G

I

L

G

G

R

R

E

E

L

G

G

S

A

K

E

Y

G

G

I

L

L

D

E

E

F

Y

V

L

N

E

K

M

K

K

L

Y

I

V

binding nicotinamide-adenine-dinucleotide: I170 (≠ V130), A171 (≠ M131), P172 (= P132), W173 (= W133), K197 (= K157), A230 (≠ T190), F248 (≠ L207), G250 (= G209), S251 (= S210), V254 (≠ A213), M257 (≠ A216), L273 (= L232), C306 (= C265), K356 (≠ D315), E403 (= E362), F405 (= F364)

8c54A Cryo-em structure of nadh bound sla dehydrogenase rlgabd from rhizobium leguminosarum bv. Trifolii srd1565 (see paper)
35% identity, 98% coverage: 3:448/457 of query aligns to 25:474/482 of 8c54A

query
sites
8c54A

S

K

T

S

F

I

T

A

T

V

T

T

G

D

P

P

A

F

N

D

G

G

E

A

M

L

L

I

K

A

E

N

F

V

P

P

A

D

A

L

A

G

D

Q

H

A

E

V

I

V

A

A

D

Q

A

A

I

I

A

D

A

A

S

A

H

A

A

E

A

A

F

Q

Q

K

T

L

W

W

R

E

T

R

P

T

V

A

E

K

K

E

R

R

T

A

E

Q

P

V

I

L

R

K

R

R

A

W

A

Y

D

D

L

L

M

I

E

V

E

E

R

N

I

A

D

D

E

D

L

L

S

A

R

L

L

I

L

L

T

T

L

T

E

E

M

Q

G

G

K

K

L

P

T

L

A

A

E

E

A

A

R

R

A

G

E

E

V

V

E

V

L

S

C

N

A

A

K

A

I

Y

L

L

R

E

Y

W

Y

F

A

A

D

E

E

E

G

A

P

K

G

R

H

I

L

D

A

G

D

D

E

I

R

I

R

P

T

G

P

P

D

N

S

A

G

G

G

Q

T

R

G

I

V

M

V

V

K

L

K

K

E

Q

P

P

K

V

G

G

P

V

L

C

I

A

G

A

V
x
I

M
x
T

P
|
P

W

W

N

N

F

F

P

P

Y

N

Y

G

Q

M

V

I

V

T

R

R

L

K

A

A

A

G

P

P

N

A

L

L

I

A

A

A

G

G

N

C

T

S

I

M

L

I

L

L

K
|
K

H

P

A

A

P

S

N

Q

C

T

P

P

Q

L

S

S

A

A

V

L

A

A

F

L

A

A

A

V

L

L

M

A

S

E

D

R

A

A

G

G

L

V

P

P

D

K

D

G

C

V

Y

F

I

S

N

V

L

V

F

T

A

G

D

E

T
x
A

D
x
K

Q

P

I

I

Q

G

T

L

-

E

I

F

I

C

A

H

D

N

E

P

R

R

V

I

A

A

G

K

A

I

S

T

L
x
F

T
|
T

G
|
G

S
|
S

E

T

A

G

A
x
V

G

G

S

R

A
x
W

V

L

A

M

A

K

G

E

A

A

G

A

E

G

N

G

L

I

T

K

K

R

V

L

I

S

L

L

E

E

L

L

G
|
G

G

G

S

N

D

A

P

P

F

F

I

I

V

V

L

F

D

D

S

D

D

A

D

D

L

L

D

D

E

A

T

A

V

V

S

E

T

G

A

A

V

M

A

I

G

S

R

K

M

F

A

R

N

N

A

A

G

G

Q

Q

S

T

C

C

I

V

A

C

S

A

K

N

R

R

L

I

I

Y

V

V

V

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H

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Y

A

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A

F

F

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D

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A

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T

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A

G

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P

L

L

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I

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D

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E

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K

A

A

A

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A

A

D

K

L

M

M

E

E

E

Q

H

V

I

H

A

D

D

A

A

V

M

E

A

Q

N

G

G

A

G

T

T

V

V

Q

L

I

T

G

G

G

K

R

R

V

S

D

V

R

L

P

G

G

G

A

T

Y

F

V

F

Q

E

P

P

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T

V

V

L

V

T

T

G

G

V

V

I

T

P

Q

S

T

M

M

R

K

A

V

Y

A

S

K

E

E

L

T

F

F

G

A

P

P

V

L

A

A

V

P

I

I

Y

I

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S

V

F

A

K

D

H

E

E

E

N

E

D

A

V

I

I

H

A

L

M

A

A

N

N

D

D

S

S

S

E

F

F

G

G

L

L

G

A

G

S

S

Y

V

F

M

Y

S

A

A

K

D

D

P

M

A

A

R

R

A

I

R

W

R

R

V

V

A

A

D

E

R

A

I

L

D

E

S

A

A

G

M

M

V

V

W

G

I

V

N

N

A

T

A

G

T

M

W

I

T

A

E

N

P

E

D

M

L

A

P

P

F

F

G

G

T

I

K

K

R

Q

S

S

G

G

I

T

G

G

R

R

E

E

-

G

-

S

-

K

L

Y

G

G

A

I

E

E

G

G

I

F

L

L

E

E

F

L

binding 1,4-dihydronicotinamide adenine dinucleotide: I152 (≠ V130), T153 (≠ M131), P154 (= P132), K179 (= K157), A212 (≠ T190), K213 (≠ D191), F230 (≠ L207), T231 (= T208), G232 (= G209), S233 (= S210), V236 (≠ A213), W239 (≠ A216), G256 (= G233)

O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
32% identity, 98% coverage: 10:455/457 of query aligns to 45:494/503 of O14293

query
sites
O14293

P

P

A

S

N

T

G

E

E

K

M

L

L

I

K

C

E

E

F

V

P

A

A

D

A

A

A

D

D

E

H

E

E

D

I

V

A

D

D

I

A

A

I

V

A

K

A

V

S

A

H

R

A

A

F

F

Q

Q

T

T

-

D

-

A

-

P

W

W

R

R

T

K

T

F

P

S

V

S

E

A

K

Q

R

R

T

G

E

R

P

C

I

L

R

S

R

R

A

L

A

A

D

D

L

C

M

I

E

E

E

Q

R

N

I

L

D

E

E

Y

L

L

S

A

R

S

L

I

L

E

T

T

L

L

E

D

M

N

G

G

K

K

L

S

T

I

A

T

E

L

A

A

R

R

A

G

E

D

V

V

E

Q

L

A

C

A

A

A

K

D

I

C

L

F

R

R

Y

Y

-

G

-

W

A

A

D

D

E

K

G

D

P

Y

G

G

H

Q

L

T

A

I

D

E

E

-

R

-

T

-

P

T

D

D

S

I

G

K

G

R

T

F

G

A

V

Y

V

T

K

R

K

H

E

E

P

P

K

I

G

G

P

V

L

C

I

G

G

Q

V

I

M

I

P

P

W

W

N

N

F

F

P

P

Y

F

Y

L

Q

M

V

C

V

A

R

W

L

K

A

I

A

A

P

P

N

A

L

V

I

A

A

C

G

G

N

N

T

T

I

I

L

I

L

L

K

K

H

T

A

A

P

E

N

L

C

T

P

P

Q

L

S

S

A

A

V

L

A

C

F

L

A

T

A

K

L

F

M

V

S

P

D

E

A

C

G

G

L

F

P

P

D

P

D

G

C

V

Y

I

I

N

N

V

L

L

F

S

A

G

D

D

T

G

D

R

Q

R

I

C

Q

G

T

N

I

A

I

I

A

S

D

S

E

H

R

M

-

D

V

I

A

D

G

K

A

V

S

A

L

F

T

T

G

G

S
|
S

E

T

A

G

A

V

G

G

S

R

A

M

V

V

A

M

-

R

A

A

G

A

A

A

G

S

E

S

N

N

L

L

T

K

K

K

V

V

I

T

L

L

E

E

L

L

G

G

S

K

D

S

P

P

F

N

I

I

V

V

L

F

D

N

S

D

D

A

D

D

L

L

D

D

E

S

T

A

V

A

S

V

T

W

A

T

V

N

A

Y

G

G

R

I

M

F

A

Y

N

N

A

S

G

G

Q

Q

S

V

C

C

I

C

A

A

S

G

K

S

R

R

L

V

I

Y

V

V

V

Q

E

E

D

D

H

V

Y

Y

E

D

E

E

F

F

V

I

E

K

K

R

F

M

T

V

T

A

A

K

M

A

A

K

G

T

F

L

T

K

P

V

G

G

D

D

P

P

A

F

D

A

P

E

D

D

T

T

T

F

L

Q

A

G

P

A

L

Q

S

V

S

S

E

K

Q

Q

A

Q

A

Y

A

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D

R

L

I

M

V

E

S

Q

Y

V

I

H

E

D

S

A

G

V

I

E

A

Q

H

G

G

A

A

T

K

V

L

Q

E

I

I

G

G

G

K

R

R

V

H

D

G

R

N

P

L

G

G

A

Y

Y

F

V

V

Q

E

P

P

T

T

V

I

L

L

T

S

G

N

V

V

I

T

P

E

S

D

M

M

R

A

A

V