SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_104485480.1 NCBI__GCF_002936955.1:WP_104485480.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 2 papers)
25% identity, 53% coverage: 68:218/283 of query aligns to 88:236/296 of P68183

query
sites
P68183

S

S

L

V

T

K

I

V

A

A

F

G

F

I

A

S

A

A

S

I

T

G

A

I

V

V

V

A

L

L

G

S

T

T

V

T

A

C

G

A

F

Y

V

A

L

F

T

A

R

R

M

M

G

-

R

R

F

F

R

P

G

G

E

K

S

A

G

T

F

L

A

L

F

K

L

G

I

M

T

L

A

I

P

F

L

Q

V

M

M

F

P

P

E

A

V

V

I

L

T

S

G

L

L

V

S

A

L

L

L

Y

L

A

L

L

F

F

V

D

A

R

M

L

G

G

D

E

W

Y

L

I

G

P

W

F

P

I

Q

G

Q

L

R

N

G

T

M

H

G

G

T

G

I

V

W

I

I

F

A

A

H

Y

V

L

T

G

F

G

C

I

T

A

A

L

Y

H

V

V

A

W

V

T

V

I

V

-

S

K

S

G

R

Y

L

F

R

E

E

T

L

I

D

D

R

S

S

S

V

L

E

E

E
|
E

A

A

A
|
A

M

A

D

L

L

D

G
|
G

A

A

R

T

P

P

L

W

K

Q

V

A

F

F

F

R

I

L

I

V

T

L

L

L

P
|
P

I

L

I

S

A

V

P

P

A

I

I

L

V

A

A

V

G

V

W

F

L

I

L

L

A

S

F

F

T

I

L

A

S

A

L

I

D

T

D

E

L

V

V

P

I

V

A

A

S

S

F

L

V

L

E190 (= E172) mutation E->A,C,K,L: Reduction of transport rate.
A192 (= A174) mutation A->D,S,L: Loss of transport and MalK dissociation from the membrane.
G196 (= G178) mutation to A: No effect.; mutation to P: Loss of transport and MalK dissociation from the membrane.
P209 (= P191) mutation to A: No effect.

Query Sequence

>WP_104485480.1 NCBI__GCF_002936955.1:WP_104485480.1
MNQIPISRSRLRPVILLLGFGFLYLPMLLLIIYSFNSSRLVTVWAGWSTRWYGELWQDQM
MMQAVGLSLTIAFFAASTAVVLGTVAGFVLTRMGRFRGESGFAFLITAPLVMPEVITGLS
LLLLFVAMGDWLGWPQQRGMGTIWIAHVTFCTAYVAVVVSSRLRELDRSVEEAAMDLGAR
PLKVFFIITLPIIAPAIVAGWLLAFTLSLDDLVIASFVSGPNATTLPMVVFSSVRLGVSP
KINALATVIILIVSLVTFIGWWLMARAEKRRAQEAAAGRSSGT

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory