SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_106713128.1 NCBI__GCF_003010955.1:WP_106713128.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
40% identity, 96% coverage: 14:506/516 of query aligns to 4:496/501 of P04983

query
sites
P04983

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K43 (= K53) mutation to R: Loss of transport.

8k1pB Mycobacterial efflux pump, adp+vanadate bound state
33% identity, 42% coverage: 15:231/516 of query aligns to 4:210/213 of 8k1pB

query
sites
8k1pB

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binding adenosine-5'-diphosphate: F13 (= F24), N38 (= N49), G39 (= G50), A40 (= A51), G41 (= G52), K42 (= K53), S43 (= S54), T44 (= T55)
binding adenosine-5'-triphosphate: T129 (≠ R150), S131 (= S152)

8k1oB Mycobacterial efflux pump, amppnp bound state
33% identity, 42% coverage: 15:231/516 of query aligns to 6:212/215 of 8k1oB

query
sites
8k1oB

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binding phosphoaminophosphonic acid-adenylate ester: N40 (= N49), G43 (= G52), K44 (= K53), S45 (= S54), T46 (= T55), T131 (≠ R150), S133 (= S152)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 42% coverage: 20:237/516 of query aligns to 7:223/240 of 4ymuJ

query
sites
4ymuJ

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binding adenosine-5'-triphosphate: F11 (= F24), V16 (= V29), S36 (≠ N49), G37 (= G50), S38 (≠ A51), G39 (= G52), K40 (= K53), S41 (= S54), T42 (= T55), E162 (= E176), H194 (= H208)
binding magnesium ion: S41 (= S54), E162 (= E176)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 45% coverage: 11:240/516 of query aligns to 1:241/253 of 1g9xB

query
sites
1g9xB

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H

R

Y

G

G

L

I

V

V

L

R

V

T

H

F

Q

Q

E

T

I

P

L

Q

L

P

A

L

P

K

D

E

L

M

T

T

V

V

A

L

Q

E

N

N

I

L

F

L

M

I

G

G

R

E

-

I

-

N

-

P

-

G

-

E

-

S

-

P

-

L

-

N

-

S

E

L

L

F

K

Y

R

K

G

K

L

W

M

I

V

P

N

K

D

E

R

E

E

E

M

M

N

V

R

E

Q

K

S

A

A

F

E

K

A

I

V

L

H

E

S

F

L

L

G

K

A

L

D

S

I

H

D

L

P

Y

T

D

T

R

Q

K

I

A

S

G

R

E

L

L

S

S

I

G

A

G

R

Q

R

M

Q

K

L

L

V

V

Q

E

I

I

A

G

R

R

A

A

L

L

Q

M

V

T

P

N

H

P

R

K

V

M

V

I

I

V

F

M

D

D

E
|
E

P

P

T

I

A

A

S

G

L

V

T

A

P

P

F

G

E

L

T

A

E

H

A

D

L

I

L

F

K

N

V

H

I

V

R

L

D

E

L

L

R

K

D

A

K

K

G

G

V

I

A

T

V

F

L

L

Y

I

I

I

S

E

H

H

R

R

L

L

P

D

E

I

V

V

G

L

A

N

I

Y

A

I

D

D

R

H

I

L

T

Y

V

V

L

M

R

F

D

N

G

G

K

Q

L

I

I

I

A

A

T

E

-

G

R

R

N

G

A

E

S

E

E

E

L

I

Q

K

P

N

V

V

binding adenosine-5'-diphosphate: F14 (= F24), F17 (≠ V27), G40 (= G50), S41 (≠ A51), G42 (= G52), K43 (= K53), S44 (= S54), T45 (= T55)
binding magnesium ion: S44 (= S54), E176 (= E176)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 45% coverage: 11:240/516 of query aligns to 1:241/254 of 1g6hA

query
sites
1g6hA

T

T

M

M

P

E

V

I

L

L

E

R

A

T

R

E

G

N

I

I

A

V

K

K

A

Y

F
|
F

G

G

P

E

V
x
F

E

K

V

A

L

L

T

D

D

G

I

V

S

S

L

I

T

S

V

V

M

N

P

K

G

G

E

D

V

V

H

T

A

L

I

I

G

G

E

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

N

L

V

M

I

S

T

G

G

H

F

L

L

Q

K

P

A

T

D

R

E

G

G

T

R

V

V

A

Y

I

F

D

E

G

N

E

K

P

D

V

I

H

T

F

N

A

K

G

E

P

P

V

A

D

E

A

L

E

Y

H

H

R

Y

G

G

L

I

V

V

L

R

V

T

H

F

Q

Q

E

T

I

P

L

Q

L

P

A

L

P

K

D

E

L

M

T

T

V

V

A

L

Q

E

N

N

I

L

F

L

M

I

G

G

R

E

-

I

-

C

-

P

-

G

-

E

-

S

-

P

-

L

-

N

-

S

E

L

L

F

K

Y

R

K

G

K

L

W

M

I

V

P

N

K

D

E

R

E

E

E

M

M

N

V

R

E

Q

K

S

A

A

F

E

K

A

I

V

L

H

E

S

F

L

L

G

K

A

L

D

S

I

H

D

L

P

Y

T

D

T

R

Q

K

I

A

S

G

R

E

L

L

S

S

I

G

A

G

R

Q

R

M

Q

K

L

L

V

V

Q

E

I

I

A

G

R

R

A

A

L

L

Q

M

V

T

P

N

H

P

R

K

V

M

V

I

I

V

F

M

D

D

E

E

P

P

T

I

A

A

S

G

L

V

T

A

P

P

F

G

E

L

T

A

E

H

A

D

L

I

L

F

K

N

V

H

I

V

R

L

D

E

L

L

R

K

D

A

K

K

G

G

V

I

A

T

V

F

L

L

Y

I

I

I

S

E

H

H

R

R

L

L

P

D

E

I

V

V

G

L

A

N

I

Y

A

I

D

D

R

H

I

L

T

Y

V

V

L

M

R

F

D

N

G

G

K

Q

L

I

I

I

A

A

T

E

-

G

R

R

N

G

A

E

S

E

E

E

L

I

Q

K

P

N

V

V

binding adenosine-5'-diphosphate: F14 (= F24), F17 (≠ V27), N39 (= N49), G40 (= G50), G42 (= G52), K43 (= K53), S44 (= S54), T45 (= T55)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
32% identity, 45% coverage: 13:242/516 of query aligns to 3:233/648 of P75831

query
sites
P75831

P

P

V

L

L

L

E

E

A

L

R

K

G

D

I

I

A

R

K

R

A

S

F

Y

G

P

P

A

-

G

-

D

-

E

-

Q

V

V

E

E

V

V

L

L

T

K

D

G

I

I

S

S

L

L

T

D

V

I

M

Y

P

A

G

G

E

E

V

M

H

V

A

A

I

I

I

V

G

G

E

A

N

S

G

G

A

S

G

G

K
|
K

S

S

T

T

L

L

M

M

K

N

L

I

M

L

S

G

G

C

H

L

L

D

Q

K

P

A

T

T

R

S

G

G

T

T

V

Y

A

R

I

V

D

A

G

G

E

Q

P

D

V

V

H

-

F

-

A

-

G

A

P

T

V

L

D

D

A

A

-

D

-

A

-

L

-

A

-

Q

-

L

-

R

E

E

H

H

R

F

G

G

L

F

V

I

L

F

V

-

H

-

Q

Q

E

R

I

Y

L

H

L

L

A

L

P

S

D

H

L

L

T

T

V

A

A

E

Q

Q

N

N

I

V

-

E

-

V

-

P

-

A

-

V

F

Y

M

A

G

G

R

L

E

E

L

R

K

K

R

Q

G

R

L

L

M

L

V

-

N

-

D

-

R

-

E

-

M

-

N

-

R

-

Q

R

S

A

A

Q

E

E

A

L

V

L

H

Q

S

R

L

L

G

G

A

L

D

E

I

D

D

R

P

T

T

E

T

Y

Q

Y

I

P

S

A

R

Q

L

L

S

S

I

G

A

G

R

Q

Q

Q

L

R

V

V

Q

S

I

I

A

A

R

R

A

A

L

L

Q

M

V

N

P

G

H

G

R

Q

V

V

V

I

I

L

F

A

D
|
D

E

E

P

P

T

T

A

G

S

A

L

L

T

D

P

S

F

H

E

S

T

G

E

E

A

E

L

V

L

M

K

A

V

I

I

L

R

H

D

Q

L

L

R

R

D

D

K

R

G

G

V

H

A

T

V

V

L

I

Y

I

I

V

S

T

H

H

R

D

L

-

P

P

E

Q

V

V

G

A

A

A

I

Q

A

A

D

E

R

R

I

V

T

I

V

E

L

I

R

R

D

D

G

G

K

E

L

I

I

V

A

-

T

-

R

R

N

N

A

P

S

P

E

A

L

I

Q

E

P

K

V

V

D

N

M

V

K47 (= K53) mutation to L: Lack of activity.
D169 (= D175) mutation to N: Lack of activity.

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
30% identity, 44% coverage: 13:237/516 of query aligns to 1:223/241 of 4u00A

query
sites
4u00A

P

P

V

I

L

I

E

R

A

I

R

R

G

N

I

L

A

H

K

K

A

W

F
|
F

G

G

P

P

V

L

E

H

V
|
V

L

L

T

K

D

G

I

I

S

H

L

L

T

E

V

V

M

A

P

P

G

G

E

E

V

K

H

L

A

V

I

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

L

T

M

I

S

N

G

R

H

L

L

E

Q

D

P

F

T

Q

R

E

G

G

T

E

V

V

A

V

I

V

D

D

G

G

E

L

P

S

V

V

H

K

F

D

A

D

G

R

P

A

V

L

D

R

A

E

E

I

H

R

R

R

G

E

L

V

V

G

L

M

V

V

H

F

Q

Q

E

Q

I

F

L

N

L

L

A

F

P

P

D

H

L

M

T

T

V

V

A

L

Q

E

N

N

I

V

F

T

M

L

G

A

R

P

E

M

L

R

K

V

R

R

G

R

L

W

M

P

V

R

N

E

D

K

R

A

E

E

M

-

N

-

R

K

Q

K

S

A

A

L

E

E

A

L

V

L

H

E

S

R

L

V

G

G

A

I

D

L

I

D

D

Q

P

A

T

R

T

K

Q

Y

I

P

S

A

R

Q

L

L

S

S

I

G

A

G

R

Q

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

A

V

M

P

E

H

P

R

K

V

I

V

M

I

L

F

F

D

D

E

E

P

P

T

T

A

S

S

A

L

L

T

D

P

P

F

E

E

M

T

V

E

G

A

E

L

V

L

L

K

D

V

V

I

M

R

R

D

D

L

L

R

A

D

Q

K

G

G

G

V

M

A

T

V

M

L

V

Y

V

I

V

S

T

H

H

R

E

L

M

P

G

E

F

V

A

G

R

A

E

I

V

A

A

D

D

R

R

I

V

T

V

V

F

L

M

R

D

D

G

G

G

K

Q

L

I

I

V

A

E

T

E

R

G

N

R

A

P

S

E

E

E

L

I

binding adenosine-5'-diphosphate: F12 (= F24), V17 (= V29), S37 (≠ N49), G38 (= G50), S39 (≠ A51), G40 (= G52), K41 (= K53), S42 (= S54), T43 (= T55)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
34% identity, 40% coverage: 27:230/516 of query aligns to 22:225/233 of P75957

query
sites
P75957

V

T

E

D

V

V

L

L

T

H

D

N

I

V

S

S

L

F

T

S

V

V

M

G

P

E

G

G

E

E

V

M

H

M

A

A

I

I

I

V

G
|
G

E

S

N

S

G

G

A

S

G

G

K

K

S

S

T

T

L

L

M

L

K

H

L

L

M

L

S

G

G

G

H

L

L

D

Q

T

P

P

T

T

R

S

G

G

T

D

V

V

A

I

I

F

D

N

G

G

E

Q

P

P

V

M

-

S

H

K

F

L

A

S

G

S

P

A

V

A

D

K

A

A

E

E

H

L

R

R

G

N

-

Q

-

K

L

L

V

G

L

F

V

I

H

Y

Q

Q

E

F

I

H

L

H

L

L

A

L

P

P

D

D

L

F

T

T

V

A

A

L

Q

E

N

N

I

V

F

A

M

M

G

-

R

-

E

-

L

-

K

-

R

-

G

P

L

L

M

L

V

I

N

G

D

K

R

K

-

K

-

P

-

A

E

E

M

I

N

N

R

S

Q

R

S

A

A

L

E

E

A

M

V

L

H

K

S

A

L

V

G

G

A

L

D

D

I

H

D

R

P

A

T

N

T

H

Q

R

I

P

S

S

R

E

L

L

S

S

I

G

A

G

R

E

R

R

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

V

V

N

P

N

H

P

R

R

V

L

V

V

I

L

F

A

D

D

E

E

P

P

T

T

A

G

S

N

L

L

T

D

P

A

F

R

E

N

T

A

E

D

A

S

L

I

L

F

K

Q

V

L

I

L

R

G

D

E

L

L

-

N

R

R

D

L

K

Q

G

G

V

T

A

A

V

F

L

L

Y

V

I

V

S

T

H

H

R

D

L

L

P

-

E

Q

V

L

G

A

A

K

I

R

A

M

D

S

R

R

I

Q

T

L

V

E

L

M

R

R

D

D

G

G

K

R

L

L

I

T

A

A

G42 (= G47) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
34% identity, 40% coverage: 27:230/516 of query aligns to 19:222/226 of 7mdyC

query
sites
7mdyC

V

T

E

D

V

V

L

L

T

H

D

N

I

V

S

S

L

F

T

S

V

V

M

G

P

E

G

G

E

E

V

M

H

M

A

A

I

I

I

V

G

G

E

S

N

S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

K

H

L

L

M

L

S

G

G

G

H

L

L

D

Q

T

P

P

T

T

R

S

G

G

T

D

V

V

A

I

I

F

D

N

G

G

E

Q

P

P

V

M

-

S

H

K

F

L

A

S

G

S

P

A

V

A

D

K

A

A

E

E

H

L

R

R

G

N

-

Q

-

K

L

L

V

G

L

F

V

I

H

Y

Q
|
Q

E

F

I

H

L

H

L

L

A

L

P

P

D

D

L

F

T

T

V

A

A

L

Q

E

N

N

I

V

F

A

M

M

G

-

R

-

E

-

L

-

K

-

R

-

G

P

L

L

M

L

V

I

N

G

D

K

R

K

-

K

-

P

-

A

E

E

M

I

N

N

R

S

Q

R

S

A

A

L

E

E

A

M

V

L

H

K

S

A

L

V

G

G

A

L

D

D

I

H

D

R

P

A

T

N

T
x
H

Q

R

I

P

S

S

R
x
E

L

L

S
|
S

I
x
G

A
x
G

R

E

R

R

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

V

V

N

P

N

H

P

R

R

V

L

V

V

I

L

F

A

D

D

E
|
E

P

P

T

T

A

G

S
x
N

L

L

T

D

P

A

F

R

E

N

T

A

E

D

A

S

L

I

L

F

K

Q

V

L

I

L

R

G

D

E

L

L

-

N

R

R

D

L

K

Q

G

G

V

T

A

A

V

F

L

L

Y

V

I

V

S

T

H
|
H

R

D

L

L

P

-

E

Q

V

L

G

A

A

K

I

R

A

M

D

S

R

R

I

Q

T

L

V

E

L

M

R

R

D

D

G

G

K

R

L

L

I

T

A

A

binding adp orthovanadate: G42 (= G50), S43 (≠ A51), G44 (= G52), K45 (= K53), S46 (= S54), T47 (= T55), Q91 (= Q96), H138 (≠ T146), E142 (≠ R150), S144 (= S152), G145 (≠ I153), G146 (≠ A154), E168 (= E176), N172 (≠ S180), H201 (= H208)
binding magnesium ion: S46 (= S54), Q91 (= Q96)

Sites not aligning to the query:

binding adp orthovanadate: 12

7arlD Lolcde in complex with lipoprotein and adp (see paper)
33% identity, 40% coverage: 27:230/516 of query aligns to 19:222/222 of 7arlD

query
sites
7arlD

V

T

E

D

V

V

L

L

T

H

D

N

I

V

S

S

L

F

T

S

V

V

M

G

P

E

G

G

E

E

V

M

H

M

A

A

I

I

I

V

G

G

E

S

N

S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T

T

L

L

M

L

K

H

L

L

M

L

S

G

G

G

H

L

L

D

Q

T

P

P

T

T

R

S

G

G

T

D

V

V

A

I

I

F

D

N

G

G

E

Q

P

P

-

M

-

S

-

K

V

L

H

S

F

S

A

A

G

A

P

K

V

A

D

E

A

L

E

R

H

N

R

Q

G

K

L

L

V

G

L

F

V

I

H

Y

Q

Q

E

F

I

H

L

H

L

L

A

L

P

P

D

D

L

F

T

T

V

A

A

L

Q

E

N

N

I

V

F

A

M

M

G

-

R

-

E

-

L

-

K

-

R

-

G

P

L

L

M

L

V

I

N

G

D

K

R

K

-

K

-

P

-

A

E

E

M

I

N

N

R

S

Q

R

S

A

A

L

E

E

A

M

V

L

H

K

S

A

L

V

G

G

A

L

D

D

I

H

D

R

P

A

T

N

T

H

Q

R

I

P

S

S

R

E

L

L

S

S

I

G

A

G

R

E

R

R

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

V

V

N

P

N

H

P

R

R

V

L

V

V

I

L

F

A

D

D

E

E

P

P

T

T

A

G

S

N

L

L

T

D

P

A

F

R

E

N

T

A

E

D

A

S

L

I

L

F

K

Q

V

L

I

L

R

G

D

E

L

L

-

N

R

R

D

L

K

Q

G

G

V

T

A

A

V

F

L

L

Y

V

I

V

S

T

H

H

R

D

L

L

P

-

E

Q

V

L

G

A

A

K

I

R

A

M

D

S

R

R

I

Q

T

L

V

E

L

M

R

R

D

D

G

G

K

R

L

L

I

T

A

A

binding adenosine-5'-diphosphate: G42 (= G50), G44 (= G52), K45 (= K53), S46 (= S54)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
32% identity, 40% coverage: 27:230/516 of query aligns to 21:224/229 of 7v8iD

query
sites
7v8iD

V

T

E

D

V
|
V

L

L

T

H

D

N

I

V

S

S

L

F

T

S

V

V

M

G

P

E

G

G

E

E

V

M

H

M

A

A

I

I

I

V

G

G

E

S

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

K

H

L

L

M

L

S

G

G

G

H

L

L

D

Q

T

P

P

T

T

R

S

G

G

T

D

V

V

A

I

I

F

D

N

G

G

E

Q

P

P

-

M

-

S

-

K

V

L

H

S

F

S

A

A

G

A

P

K

V

A

D

E

A

L

E

R

H

N

R

Q

G

K

L

L

V

G

L

F

V

I

H

Y

Q
|
Q

E

F

I

H

L

H

L

L

A

L

P

P

D

D

L

F

T

T

V

A

A

L

Q

E

N

N

I

V

F

A

M

M

G

-

R

-

E

-

L

-

K

-

R

-

G

P

L

L

M

L

V

I

N

G

D

K

R

K

-

K

-

P

-

A

E

E

M

I

N

N

R

S

Q

R

S

A

A

L

E

E

A

M

V

L

H

K

S

A

L

V

G

G

A

L

D

D

I

H

D
x
R

P

A

T

N

T
x
H

Q

R

I

P

S

S

R
x
E

L

L

S
|
S

I

G

A
x
G

R
x
E

R

R

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

V

V

N

P

N

H

P

R

R

V

L

V

V

I

L

F

A

D

D

E

Q

P

P

T

T

A

G

S

N

L

L

T

D

P

A

F

R

E

N

T

A

E

D

A

S

L

I

L

F

K

Q

V

L

I

L

R

G

D

E

L

L

-

N

R

R

D

L

K

Q

G

G

V

T

A

A

V

F

L

L

Y

V

I

V

S

T

H
|
H

R

D

L

L

P

-

E

Q

V

L

G

A

A

K

I

R

A

M

D

S

R

R

I

Q

T

L

V

E

L

M

R

R

D

D

G

G

K

R

L

L

I

T

A

A

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V29), S43 (≠ N49), G44 (= G50), G46 (= G52), K47 (= K53), S48 (= S54), T49 (= T55), Q93 (= Q96), R137 (≠ D143), H140 (≠ T146), E144 (≠ R150), S146 (= S152), G148 (≠ A154), E149 (≠ R155), H203 (= H208)
binding magnesium ion: S48 (= S54), Q93 (= Q96)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 41% coverage: 27:237/516 of query aligns to 18:228/343 of P30750

query
sites
P30750

V

I

E

Q

V

A

L

L

T

N

D

N

I

V

S

S

L

L

T

H

V

V

M

P

P

A

G

G

E

Q

V

I

H

Y

A

G

I

V

I

I

G

G

E

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

L

C

M

V

S

N

G

L

H

L

L

E

Q

R

P

P

T

T

R

E

G

G

T

S

V

V

A

L

I

V

D

D

G

G

E

Q

P

E

V

L

H

T

F

T

-

L

-

S

A

E

G

S

P

E

V

L

D

T

A

K

E

A

H

R

R

R

G

Q

L

I

V

G

L

M

V

I

H

F

Q

Q

E

H

I

F

L

N

L

L

A

L

P

S

D

S

L

R

T

T

V

V

A

F

Q

G

N

N

I

V

F

A

M

L

G

P

R

L

E

E

L

L

K

D

R

N

G

-

L

-

M

-

V

T

N

P

D

K

R

D

E

E

M

V

N

K

R

R

Q

R

S

V

A

T

E

E

A

L

V

L

H

S

S

L

L

V

G

G

A

L

D

G

I

D

D

K

P

H

T

D

T

S

Q

Y

I

P

S

S

R

N

L

L

S

S

I

G

A

G

R

Q

R

K

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

A

V

S

P

N

H

P

R

K

V

V

V

L

I

L

F

C

D

D

E
|
E

P

A

T

T

A

S

S

A

L

L

T

D

P

P

F

A

E

T

T

T

E

R

A

S

L

I

L

L

K

E

V

L

I

L

R

K

D

D

L

I

-

N

R

R

D

R

K

L

G

G

V

L

A

T

V

I

L

L

Y

L

I

I

S

T

H

H

R

E

L

M

P

D

E

V

V

V

G

K

A

R

I

I

A

C

D

D

R

C

I

V

T

A

V

V

L

I

R

S

D

N

G

G

K

E

L

L

I

I

A

E

T

Q

R

D

N

T

A

V

S

S

E

E

L

V

40:46 (vs. 49:55, 86% identical) binding ATP
E166 (= E176) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

5x40A Structure of a cbio dimer bound with amppcp (see paper)
33% identity, 47% coverage: 13:257/516 of query aligns to 3:260/280 of 5x40A

query
sites
5x40A

P

P

V

I

L

L

E

A

A

A

R

E

G

A

I

L

A

T

K

Y

A

A

F
|
F

-

P

G

G

P

G

V
|
V

E

K

V
x
A

L

L

T

D

D

D

I

L

S

S

L

L

T

A

V

V

M

P

P

K

G

G

E

E

V

S

H

L

A

A

I

I

I

L

G

G

E

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

K

L

L

H

M

L

S

N

G

G

H

T

L

L

Q

R

P

P

T

Q

R

S

G

G

T

R

V

V

A

L

I

L

D

G

G

G

E

T

P

A

V

T

-

G

H

H

F

S

A

R

G

K

P

D

V

L

D

T

A

G

E

W

H

R

R

R

G

R

L

V

V

G

L

L

V

V

H

L

Q
|
Q

E

D

I

A

-

D

-

Q

L

L

L

F

A

A

P

T

D

-

L

-

T

T

V

V

A

F

Q

E

N

D

I

V

F

S

M

F

G

G

R

-

E

P

L

L

K

N

R

L

G

G

L

L

M

S

V

E

N

A

D

E

R

A

E

R

M

A

N

R

R

V

Q

E

S

E

A

A

E

L

A

A

V

A

H

L

S

S

L

I

G

S

A

D

D

L

I

R

D

D

P

R

T

P

T

T

Q
x
H

I
x
M

S

-

R

-

L
|
L

S
|
S

I

G

A
x
G

R
x
Q

R

K

Q

R

L

R

V

V

Q

A

I

I

A

A

R

G

A

A

L

V

Q

A

V

M

P

R

H

P

R

E

V

V

V

L

I

L

F

L

D

D

E
x
Q

P

P

T

T

A

A

S

G

L

L

T

D

P

L

F

A

E

G

T

T

E

E

A

Q

L

L

K

T

V

L

I

L

R

R

D

G

L

L

R

R

D

A

K

A

G

G

V

M

A

T

V

L

L

V

Y

F

I

S

S

T

H
|
H

R

D

L

V

P

E

E

L

V

A

G

A

A

A

I

L

A

A

D

D

R

R

I

V

T

A

V

L

L

F

R

R

D

T

G

G

K

R

L

V

I

L

A

A

T

E

R

G

N

A

A

A

S

E

-

A

-

V

-

L

-

S

-

D

-

R

-

A

-

T

-

L

-

A

-

K

-

V

E

A

L

L

Q

R

P

P

-

P

-

L

-

V

V

I

D

D

M

L

A

A

R

-

L

-

M

L

V

L

G

A

R

R

D

D

M

H

S

G

K

L

L

L

Y

A

P

P

E

E

binding phosphomethylphosphonic acid adenylate ester: F14 (= F24), V18 (= V27), A20 (≠ V29), N40 (= N49), G41 (= G50), G43 (= G52), K44 (= K53), S45 (= S54), T46 (= T55), Q88 (= Q96), H139 (≠ Q147), M140 (≠ I148), L141 (= L151), S142 (= S152), G144 (≠ A154), Q145 (≠ R155), Q166 (≠ E176), H198 (= H208)
binding magnesium ion: S45 (= S54), Q88 (= Q96)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
30% identity, 41% coverage: 27:237/516 of query aligns to 19:229/344 of 6cvlD

query
sites
6cvlD

V
x
I

E

Q

V

A

L

L

T

N

D

N

I

V

S

S

L

L

T

H

V

V

M

P

P

A

G

G

E

Q

V

I

H

Y

A

G

I

V

I

I

G

G

E

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

L

C

M

V

S

N

G

L

H

L

L

E

Q

R

P

P

T

T

R

E

G

G

T

S

V

V

A

L

I

V

D

D

G

G

E

Q

P

E

V

L

H

T

F

T

-

L

-

S

A

E

G

S

P

E

V

L

D

T

A

K

E

A

H

R

R

R

G

Q

L

I

V

G

L

M

V

I

H

F

Q

Q

E

H

I

F

L

N

L

L

A

L

P

S

D

S

L

R

T

T

V

V

A

F

Q

G

N

N

I

V

F

A

M

L

G

P

R

L

E

E

L

L

K

D

R

N

G

-

L

-

M

-

V

T

N

P

D

K

R

D

E

E

M

V

N

K

R

R

Q

R

S

V

A

T

E

E

A

L

V

L

H

S

S

L

L

V

G

G

A

L

D

G

I

D

D

K

P

H

T

D

T

S

Q

Y

I

P

S

S

R
x
N

L

L

S
|
S

I

G

A

G

R
x
Q

R

K

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

A

V

S

P

N

H

P

R

K

V

V

V

L

I

L

F

C

D

D

E

Q

P

A

T

T

A

S

S

A

L

L

T

D

P

P

F

A

E

T

T

T

E

R

A

S

L

I

L

L

K

E

V

L

I

L

R

K

D

D

L

I

-

N

R

R

D

R

K

L

G

G

V

L

A

T

V

I

L

L

Y

L

I

I

S

T

H
|
H

R

E

L

M

P

D

E

V

V

V

G

K

A

R

I

I

A

C

D

D

R

C

I

V

T

A

V

V

L

I

R

S

D

N

G

G

K

E

L

L

I

I

A

E

T

Q

R

D

N

T

A

V

S

S

E

E

L

V

binding phosphothiophosphoric acid-adenylate ester: I19 (≠ V27), S41 (≠ N49), G42 (= G50), A43 (= A51), G44 (= G52), K45 (= K53), S46 (= S54), T47 (= T55), N141 (≠ R150), S143 (= S152), Q146 (≠ R155), H200 (= H208)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 12, 14

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
30% identity, 41% coverage: 27:237/516 of query aligns to 19:229/344 of 3tuzC

query
sites
3tuzC

V

I

E

Q

V

A

L

L

T

N

D

N

I

V

S

S

L

L

T

H

V

V

M

P

P

A

G

G

E

Q

V

I

H

Y

A

G

I

V

I

I

G

G

E

A

N

S

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

L

C

M

V

S

N

G

L

H

L

L

E

Q

R

P

P

T

T

R

E

G

G

T

S

V

V

A

L

I

V

D

D

G

G

E

Q

P

E

V

L

H

T

F

T

-

L

-

S

A

E

G

S

P

E

V

L

D

T

A

K

E

A

H

R

R

R

G

Q

L

I

V

G

L

M

V

I

H

F

Q

Q

E

H

I

F

L

N

L

L

A

L

P

S

D

S

L

R

T

T

V

V

A

F

Q

G

N

N

I

V

F

A

M

L

G

P

R

L

E

E

L

L

K

D

R

N

G

-

L

-

M

-

V

T

N

P

D

K

R

D

E

E

M

V

N

K

R

R

Q

R

S

V

A

T

E

E

A

L

V

L

H

S

S

L

L

V

G

G

A

L

D

G

I

D

D

K

P

H

T

D

T

S

Q

Y

I

P

S

S

R

N

L

L

S

S

I

G

A

G

R

Q

R

K

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

A

V

S

P

N

H

P

R

K

V

V

V

L

I

L

F

C

D

D

E

Q

P

A

T

T

A

S

S

A

L

L

T

D

P

P

F

A

E

T

T

T

E

R

A

S

L

I

L

L

K

E

V

L

I

L

R

K

D

D

L

I

-

N

R

R

D

R

K

L

G

G

V

L

A

T

V

I

L

L

Y

L

I

I

S

T

H

H

R

E

L

M

P

D

E

V

V

V

G

K

A

R

I

I

A

C

D

D

R

C

I

V

T

A

V

V

L

I

R

S

D

N

G

G

K

E

L

L

I

I

A

E

T

Q

R

D

N

T

A

V

S

S

E

E

L

V

binding adenosine-5'-diphosphate: G42 (= G50), G44 (= G52), K45 (= K53), S46 (= S54), T47 (= T55)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 14
binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
30% identity, 41% coverage: 27:237/516 of query aligns to 19:229/344 of 3tuiC

query
sites
3tuiC

V

I

E

Q

V

A

L

L

T

N

D

N

I

V

S

S

L

L

T

H

V

V

M

P

P

A

G

G

E

Q

V

I

H

Y

A

G

I

V

I

I

G

G

E

A

N

S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

L

C

M

V

S

N

G

L

H

L

L

E

Q

R

P

P

T

T

R

E

G

G

T

S

V

V

A

L

I

V

D

D

G

G

E

Q

P

E

V

L

H

T

F

T

-

L

-

S

A

E

G

S

P

E

V

L

D

T

A

K

E

A

H

R

R

R

G

Q

L

I

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G

L

M

V

I

H

F

Q

Q

E

H

I

F

L

N

L

L

A

L

P

S

D

S

L

R

T

T

V

V

A

F

Q

G

N

N

I

V

F

A

M

L

G

P

R

L

E

E

L

L

K

D

R

N

G

-

L

-

M

-

V

T

N

P

D

K

R

D

E

E

M

V

N

K

R

R

Q

R

S

V

A

T

E

E

A

L

V

L

H

S

S

L

L

V

G

G

A

L

D

G

I

D

D

K

P

H

T

D

T

S

Q

Y

I

P

S

S

R

N

L

L

S

S

I

G

A

G

R

Q

R

K

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

A

V

S

P

N

H

P

R

K

V

V

V

L

I

L

F

C

D

D

E

Q

P

A

T

T

A

S

S

A

L

L

T

D

P

P

F

A

E

T

T

T

E

R

A

S

L

I

L

L

K

E

V

L

I

L

R

K

D

D

L

I

-

N

R

R

D

R

K

L

G

G

V

L

A

T

V

I

L

L

Y

L

I

I

S

T

H

H

R

E

L

M

P

D

E

V

V

V

G

K

A

R

I

I

A

C

D

D

R

C

I

V

T

A

V

V

L

I

R

S

D

N

G

G

K

E

L

L

I

I

A

E

T

Q

R

D

N

T

A

V

S

S

E

E

L

V

binding adenosine-5'-diphosphate: G42 (= G50), A43 (= A51), G44 (= G52), K45 (= K53), S46 (= S54), T47 (= T55)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

8wm7D Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
30% identity, 41% coverage: 15:226/516 of query aligns to 5:214/257 of 8wm7D

query
sites
8wm7D

L

L

E

V

A

V

R

E

G

G

I

V

A

S

K

K

A

I

F
x
Y

-

P

-

T

-

P

-

E

G

G

P

P

V
x
Y

E

T

V
|
V

L

L

T

D

D

G

I

I

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D

L

L

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K

V

V

M

R

P

E

G

G

E

E

V

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H

V

A

C

I

L

I

I

G

G

E

H

N
x
S

G
|
G

A
x
C

G
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G

K
|
K

S
|
S

T
|
T

L

L

M

L

K

N

L

M

M

I

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S

G

G

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F

L

N

Q

T

P

P

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E

G

G

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V

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V

A

L

I

L

D

Q

G

D

E

K

P

P

V

I

H

T

F

E

A

P

G

G

P

P

V

-

D

-

A

-

E

-

H

-

R

-

G

D

L

R

V

M

L

M

V

V

H

F

Q

Q

E

N

I

Y

L

C

L

L

A

L

P

P

D

W

L

L

T

N

V

V

A

F

Q

E

N

N

I

V

F

Y

M

L

G

A

R

V

E

D

L

-

K

-

R

-

G

A

L

V

M

F

V

P

N

N

D

K

R

P

E

Q

M

A

N

E

R

K

Q

R

S

A

A

I

-

V

-

R

E

E

A

H

V

L

H

A

S

M

L

V

G

G

A

L

D

T

I

E

D

A

P

A

T

E

T

K

Q

K

I

P

S

S

R

Q

L

I

S

S

I

G

A

G

R

M

R

K

Q

Q

L

R

V

V

Q

A

I

I

A

A

R

R

A

A

L

L

Q

S

V

I

P

R

H

P

R

Q

V

V

V

L

I

I

F

L

D

D

E

E

P

P

T

F

A

G

S

A

L

L

T

D

P

A

F

I

E

T

T

K

E

E

A

E

L

L

L

Q

-

E

K

E

V

L

I

L

R

Q

D

I

L

W

R

S

D

D

K

H

G

Q

V

V

A

T

V

V

L

L

Y

M

I

I

S

T

H

H

R

D

L

I

P

D

E

E

V

A

G

L

A

F

I

L

A

A

D

D

R

R

I

V

T

V

V

M

L

M

R

T

D

N

G

G

binding adenosine-5'-diphosphate: Y14 (≠ F24), Y21 (≠ V27), V23 (= V29), S43 (≠ N49), G44 (= G50), C45 (≠ A51), G46 (= G52), K47 (= K53), S48 (= S54), T49 (= T55)

2d62A Crystal structure of multiple sugar binding transport atp-binding protein
30% identity, 43% coverage: 19:241/516 of query aligns to 11:236/375 of 2d62A

query
sites
2d62A

G

N

I

I

A

W

K

K

A

R

F

F

G

G

P

D

V

V

E

T

V

A

L

V

T

K

D

D

I

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S

L

L

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E

V

I

M

K

P

D

G

G

E

E

V

F

H

L

A

V

I

L

G

G

E

P

N

S

G
|
G

A
x
C

G
|
G

K
|
K

S
x
T

T
|
T

L

T

M

L

K

R

L

M

M

I

S

A

G

G

H

L

L

E

Q

E

P

P

T

T

R

R

G

G

T

Q

V

I

A

Y

I

I

D

E

G

D

E

N

P

L

V

V

H

-

F

-

A

A

G

D

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P

-

E

-

K

-

G

-

V

-

F

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A

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H

E

R

R

G

D

L

V

V

A

L

M

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V

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Q

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I

Y

L

A

L

L

A

Y

P

P

D

H

L

M

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T

V

V

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Y

Q

D

N

N

I

I

F

A

M

F

G

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R

L

E

K

L

L

K

R

R

K

G

-

L

-

M

-

V

V

N

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I

N

D

R

K

Q

R

S

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A

R

E

E

A

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V

A

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E

S

M

L

L

G

G

A

L

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T

I

E

D

L

P

L

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N

T

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Q

K

I

P

S

R

R

E

L

L

S

S

I

G

A

G

R

Q

R

R

Q

Q

L

R

V

V

Q

A

I

L

A

G

R

R

A

A

L

I

Q

I

V

R

P

R

H

P

R

K

V

V

V

F

I

L

F

M

D

D

E

E

P

P

T

L

A

S

S

N

L

L

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A

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-

L

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E

K

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E

R

A

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