SitesBLAST

Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
31% identity, 81% coverage: 12:217/255 of query aligns to 2:225/234 of Q7WTT9

query
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Q7WTT9

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C12 (= C22) binding [4Fe-4S] cluster
C15 (= C25) binding [4Fe-4S] cluster
C18 (= C28) binding [4Fe-4S] cluster
C22 (= C32) binding [4Fe-4S] cluster
C57 (= C90) binding [4Fe-4S] cluster
C60 (= C93) binding [4Fe-4S] cluster
C65 (= C98) binding [4Fe-4S] cluster
C69 (= C102) binding [4Fe-4S] cluster
C89 (= C123) binding [4Fe-4S] cluster
C92 (= C126) binding [4Fe-4S] cluster
C95 (= C129) binding [4Fe-4S] cluster
C99 (= C133) binding [4Fe-4S] cluster
C164 (= C150) binding [4Fe-4S] cluster
C167 (= C153) binding [4Fe-4S] cluster
C179 (= C171) binding [4Fe-4S] cluster
C183 (= C175) binding [4Fe-4S] cluster

P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
35% identity, 70% coverage: 10:187/255 of query aligns to 2:157/205 of P18776

query
sites
P18776

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C102 (= C126) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
27% identity, 89% coverage: 11:236/255 of query aligns to 6:280/329 of 5ch7B

query
sites
5ch7B

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binding fe3-s4 cluster: C145 (= C102), I150 (≠ S107), C166 (= C123), K167 (≠ I124), G168 (= G125), A169 (≠ C126), Q170 (≠ G127), A171 (≠ L128), C172 (= C129), A190 (≠ M147)
binding iron/sulfur cluster: C17 (= C22), I18 (≠ V23), G19 (= G24), C20 (= C25), Q21 (≠ H26), C23 (= C28), C27 (= C32), W31 (= W35), R43 (vs. gap), V45 (vs. gap), P130 (= P87), C133 (= C90), N134 (≠ L91), C136 (= C93), P139 (≠ A96), C141 (= C98), C176 (= C133), C193 (= C150), G195 (≠ L152), C196 (= C153), C208 (= C171), C212 (= C175), V213 (≠ P176), G214 (≠ V177)

2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
27% identity, 87% coverage: 11:232/255 of query aligns to 2:273/337 of 2ivfB

query
sites
2ivfB

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binding fe3-s4 cluster: C148 (= C102), T150 (= T104), I153 (≠ S107), C169 (= C123), K170 (≠ I124), G171 (= G125), H172 (≠ C126), R173 (≠ G127), H174 (≠ L128), C175 (= C129), S193 (≠ M147)
binding protoporphyrin ix containing fe: T150 (= T104), K170 (≠ I124), H172 (≠ C126)
binding iron/sulfur cluster: C13 (= C22), L14 (≠ V23), G15 (= G24), C16 (= C25), Q17 (≠ H26), C19 (= C28), C23 (= C32), W27 (vs. gap), W38 (= W35), N39 (= N36), V41 (vs. gap), M135 (≠ S89), C136 (= C90), N137 (≠ L91), H138 (= H92), C139 (= C93), P142 (≠ A96), C144 (= C98), V162 (= V116), C179 (= C133), A183 (= A137), I184 (≠ R138), K195 (= K149), C196 (= C150), I197 (≠ T151), L198 (= L152), C199 (= C153), N209 (≠ P169), C211 (= C171), C215 (= C175), V219 (≠ A179), R220 (= R180)

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
30% identity, 67% coverage: 12:183/255 of query aligns to 29:187/294 of P0AAJ3

query
sites
P0AAJ3

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S

D

E

K

N

C
|
C

I

I

G

G

C
|
C

G

G

L

Y

C
|
C

A

I

W

A

A

G

C
|
C

S

P

Y

F

G

N

A

I

R

P

E

R

M

L

D

N

L

K

A

E

A

D

G

N

V

R

M

V

K

Y

K

K

C
|
C

T

T

L

L

C
|
C

V

V

D

D

R

R

I

V

Y

-

N

-

E

-

T

S

L

V

K

G

Q

Q

E

E

D

-

R

-

V

-

P

P

S

A

C
|
C

V

V

R

K

T

T

C
|
C

P

P

V

T

N

G

A

A

R

I

H

H

Y

F

G

G

C39 (= C22) binding [4Fe-4S] cluster
C42 (= C25) binding [4Fe-4S] cluster
C45 (= C28) binding [4Fe-4S] cluster
C49 (= C32) binding [4Fe-4S] cluster
C100 (= C90) binding [4Fe-4S] cluster
C103 (= C93) binding [4Fe-4S] cluster
C108 (= C98) binding [4Fe-4S] cluster
C112 (= C102) binding [4Fe-4S] cluster
C133 (= C123) binding [4Fe-4S] cluster
C136 (= C126) binding [4Fe-4S] cluster
C139 (= C129) binding [4Fe-4S] cluster
C143 (= C133) binding [4Fe-4S] cluster
C160 (= C150) binding [4Fe-4S] cluster
C163 (= C153) binding [4Fe-4S] cluster
C175 (= C171) binding [4Fe-4S] cluster
C179 (= C175) binding [4Fe-4S] cluster

1kqfB Formate dehydrogenase n from e. Coli (see paper)
31% identity, 66% coverage: 16:183/255 of query aligns to 32:186/289 of 1kqfB

query
sites
1kqfB

V

L

I

I

D

D

L

V

D

S

I

T

C
|
C

V
x
I

G
|
G

C
|
C

H
x
K

A

A

C
|
C

V

Q

I

V

S

A

C
|
C

K

S

E

E

W

W

N
|
N

-

D

-

I

-

R

-

D

-

E

-

V

-

G

-

H

-

C

T

V

G

G

G

V

Y

Y

G

D

N

N

A

-

L

-

S

-

D

-

Q

-

H

-

P

P

Y

A

G

D

E

L

Q

S

V

A

S

K

G

S

T

W

F
x
T

L

V

N
x
M

R

R

I

F

H

S

T

E

Y

T

E

E

V

-

P

-

E

-

G

-

L

-

V

-

I

-

G

-

E

Q

A

N

G

G

E

K

A

L

R

E

I

W

V

L

H

I

F

R

P

K

K

D

S

G

C
|
C

L
x
M

H
|
H

C
|
C

E

E

D

D

A
x
P

P

G

C
|
C

V

L

T

K

V

A

C
|
C

P
|
P

T

S

G

A

A

G

S

A

Y
x
I

K

I

R

Q

A

Y

D

A

D

N

G

G

I

I

V
|
V

L

D

V

F

D

Q

E

S

D

E

K

N

C
|
C

I
|
I

G
|
G

C
|
C

G
|
G

L
x
Y

C
|
C

A

I

W

A

A

G

C
|
C

S

P

Y

F

G

N

A
x
I

R
x
P

E

R

M

L

D

N

L

K

A

E

A

D

G

N

V

R

M
x
V

K

Y

K
|
K

C
|
C

T

T

L
|
L

C
|
C

V

V

D

D

R

R

I

V

Y

-

N

-

E

-

T

S

L

V

K

G

Q

Q

E

E

D

-

R

-

V

-

P
|
P

S

A

C
|
C

V

V

R

K

T

T

C
|
C

P
|
P

V

T

N

G

A

A

R
x
I

H

H

Y

F

G

G

binding protoporphyrin ix containing fe: Y137 (≠ L128)
binding iron/sulfur cluster: C38 (= C22), I39 (≠ V23), G40 (= G24), C41 (= C25), K42 (≠ H26), C44 (= C28), C48 (= C32), N52 (= N36), T77 (≠ F58), M79 (≠ N60), C99 (= C90), M100 (≠ L91), H101 (= H92), C102 (= C93), P105 (≠ A96), C107 (= C98), C111 (= C102), P112 (= P103), I117 (≠ Y108), V125 (= V116), C132 (= C123), I133 (= I124), G134 (= G125), C135 (= C126), G136 (= G127), Y137 (≠ L128), C138 (= C129), C142 (= C133), I146 (≠ A137), P147 (≠ R138), V156 (≠ M147), K158 (= K149), C159 (= C150), L161 (= L152), C162 (= C153), P172 (= P169), C174 (= C171), C178 (= C175), P179 (= P176), I183 (≠ R180)

Sites not aligning to the query:

6f0kB Alternative complex iii (see paper)
28% identity, 83% coverage: 11:222/255 of query aligns to 722:957/961 of 6f0kB

query
sites
6f0kB

K

N

R

Q

L

W

G

A

L

M

V

V

I

I

D

D

L

L

D

N

I

A

C
|
C

V
x
T

G
|
G

C
|
C

H
x
N

A
|
A

C
|
C

V

I

I

V

S

A

C
|
C

K

D

E

S

W

E

N

N

T

N

G

-

Y

-

G

-

N

I

A

P

L

M

S

V

D

G

Q

K

H

N

P

E

Y

V

G

G

E

R

Q

G

V

R

S

E

G

M

T

H

F
x
W

L

L

N

-

R

R

I
|
I

H

D

T

R

Y

Y

E

F

V

V

V

S

P

D

E

E

G

A

G

-

L

-

V

-

I

-

G

-

E

H

A

A

G

D

E

D

A

P

R

Q

I

I

V

V

H

V

F

Q

P

P

K

V

S

P

C
|
C

L
x
M

H
|
H

C
|
C

E

E

D

N

A

A

P
|
P

C
|
C

V

E

T

S

V

V

C
|
C

P

P

T
x
V

G

A

A

A

S

T

Y

V

K

H

R

-

A

S

D

P

D

D

G

G

I

L

V
x
N

L

E

V
x
M

D

V

E

Y

D
x
N

K
x
R

C
|
C

I
|
I

G
|
G

C

T

G

R

L

Y

C
|
C

A

S

W

N

A

N

C
|
C

S

P

Y

Y

G

K

A

V

R

R

E

R

M

F

D

N

L

W

-

F

-

N

-

W

-

V

-

K

-

T

-

L

-

P

-

I

-

Q

-

V

-

Q

-

M

-

A

-

Q

-

N

-

P

-

D

-

V

-

T

-

V

-

R

A

F

A

R

G

G

V

V

M
|
M

K

E

K

K

C
|
C

T

T

L
x
Y

C
|
C

V

V

D

Q

R

R

I

I

Y

R

-

E

-

A

-

Q

-
x
R

-

Q

-

A

-
x
N

-

I

-

E

N

K

E

R

T

P

L

L

K

R

Q

D

E

G

D

E

R

V

V

K

P

T

S
x
A

C
|
C

V

Q

R

Q

T

A

C
|
C

P

P

V

A

N

E

A

A

R

I

H

T

Y

F

G

G

D

D

L

L

G

N

D

D

P

P

M

N

S

N

D

A

V

V

S

V

I

K

M

Q

V

R

A

Q

E

N

R

A

G

R

F

Y

D

E

L

M

M

L

P

A

E

A

Q

L

G

N

T

V

L

K

P

P

T

R

N

T

K

S

Y

Y

L

L

P

A

-

R

-

I

-

T

-

N

P

P

R

N

P

P

R

R

binding fe3-s4 cluster: C803 (= C102), V805 (≠ T104), M818 (≠ V118), C823 (= C123), I824 (= I124), G825 (= G125), C829 (= C129), M869 (= M147)
binding heme c: N821 (≠ D121), R822 (≠ K122), R884 (vs. gap), N887 (vs. gap)
binding iron/sulfur cluster: C733 (= C22), T734 (≠ V23), G735 (= G24), C736 (= C25), N737 (≠ H26), A738 (= A27), C739 (= C28), C743 (= C32), W765 (≠ F58), I768 (= I62), C791 (= C90), M792 (≠ L91), H793 (= H92), C794 (= C93), P798 (= P97), C799 (= C98), N816 (≠ V116), C833 (= C133), C872 (= C150), Y874 (≠ L152), C875 (= C153), A901 (≠ S170), C902 (= C171), C906 (= C175)

Sites not aligning to the query:

binding heme c: 719

8k9fB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 2.9 angstrom (see paper)
27% identity, 80% coverage: 14:217/255 of query aligns to 711:939/951 of 8k9fB

query
sites
8k9fB

G

G

L

M

V

T

I

I

D

N

L

L

D

N

I

A

C
|
C

V

I

G
|
G

C
|
C

H
x
N

A

A

C
|
C

V

V

I

V

S

A

C
|
C

K

Q

-

A

E

E

W
x
N

N

N

T

I

G

A

G

V

Y

V

G

G

N

-

A

-

L

-

S

K

D

D

Q

Q

H

V

P

S

Y

R

G

G

E

R

Q

E

V

M

S

H

G
x
W

T
x
I

F

R

L

I

N

D

R

R

I

Y

H

F

T

A

Y

G

E

E

V

-

P

-

E

-

G

-

L

-

V

-

I

-

G

-

E

D

A

L

G

D

E

N

A

P

R

S

I

I

V

Y

H

M

F

M

P
|
P

K

V

S

N

C
|
C

L
x
M

H
x
Q

C
|
C

E

E

D

K

A

A

P

P

C
|
C

V

E

T

V

V

V

C
|
C

P
|
P

T

V

G

A

A

A

S

T

Y

V

K

H

R

D

A

Y

D

-

D

E

G

G

I

L

V
x
N

L

N

V
x
M

D

V

E

Y

D
x
N

K
x
R

C
|
C

I

V

G
|
G

C
x
T

G
x
K

L
x
Y

C
|
C

A

S

W

N

A

N

C
|
C

S

P

Y
|
Y

G

K

A
x
V

R

R

E

R

M

F

D

N

L

F

A

L

A

Q

-

Y

-

S

-

D

-

T

-

E

-

T

-

F

-

K

-

L

-

A

-

F

-

N

-

P

-

D

-

V

-

T

-

V

-

R

-

I

-

R

G

G

V

V

M

M

K

E

K

K

C
|
C

T

T

L
x
Y

C
|
C

V

V

D

Q

R

R

I

I

Y

S

N

G

E

A

T
x
R

L

I

K

A

-

A

-
x
K

-

R

-

A

-

V

-

Q

-

A

-

G

Q

Q

E

S

D

S

R

Y

V

V

P

I

S

S

-

D

-

G

-

A

-

I

-

Q

-
x
T

-

A

C
|
C

V

E

R

Q

T

A

C
|
C

P
|
P

V
x
T

N

G

A

A

R

I

H

V

Y

F

G

G

D

D

L

I

G

N

D

D

P

S

M

N

S

S

D

R

V

V

S

A

I

K

M

W

V

K

A

A

E

E

R

G

G

H

G

N

F

Y

D

G

L

L

M

L

P

G

E

F

Q

L

G

N

T

T

L

V

P

P

T

R

N

T

K

T

Y

Y

L

L

binding fe3-s4 cluster: C787 (= C102), P788 (= P103), M802 (≠ V118), C807 (= C123), G809 (= G125), T810 (≠ C126), K811 (≠ G127), Y812 (≠ L128), C813 (= C129)
binding heme c: N805 (≠ D121), R806 (≠ K122), R867 (≠ T161), K871 (vs. gap)
binding iron/sulfur cluster: C719 (= C22), G721 (= G24), C722 (= C25), N723 (≠ H26), C725 (= C28), C729 (= C32), N733 (≠ W35), W751 (≠ G56), I752 (≠ T57), P772 (= P87), C775 (= C90), M776 (≠ L91), Q777 (≠ H92), C778 (= C93), C783 (= C98), N800 (≠ V116), C817 (= C133), Y819 (= Y135), V821 (≠ A137), C856 (= C150), Y858 (≠ L152), C859 (= C153), T891 (vs. gap), C893 (= C171), C897 (= C175), P898 (= P176), T899 (≠ V177)

Sites not aligning to the query:

8k9eB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 3.3 angstrom (see paper)
27% identity, 80% coverage: 14:217/255 of query aligns to 711:939/951 of 8k9eB

query
sites
8k9eB

G

G

L

M

V

T

I

I

D

N

L

L

D

N

I

A

C
|
C

V
x
I

G
|
G

C
|
C

H
x
N

A

A

C
|
C

V

V

I

V

S

A

C
|
C

K

Q

-

A

E

E

W
x
N

N

N

T

I

G

A

G

V

Y

V

G

G

N

-

A

-

L

-

S

K

D

D

Q

Q

H

V

P

S

Y

R

G

G

E

R

Q

E

V

M

S

H

G

W

T

I

F

R

L
x
I

N

D

R

R

I

Y

H

F

T

A

Y

G

E

E

V

-

P

-

E

-

G

-

L

-

V

-

I

-

G

-

E

D

A

L

G

D

E

N

A

P

R

S

I

I

V

Y

H

M

F

M

P

P

K

V

S

N

C
|
C

L
x
M

H

Q

C
|
C

E

E

D

K

A

A

P
|
P

C
|
C

V

E

T

V

V

V

C
|
C

P

P

T

V

G

A

A

A

S

T

Y

V

K

H

R

D

A

Y

D

-

D

E

G

G

I

L

V
x
N

L

N

V
x
M

D

V

E

Y

D
x
N

K

R

C
|
C

I
x
V

G
|
G

C
x
T

G
x
K

L
x
Y

C
|
C

A

S

W

N

A

N

C
|
C

S

P

Y
|
Y

G

K

A
x
V

R
|
R

E

R

M

F

D

N

L

F

A

L

A

Q

-

Y

-

S

-

D

-

T

-

E

-

T

-

F

-

K

-

L

-

A

-

F

-

N

-

P

-

D

-

V

-

T

-

V

-

R

-

I

-

R

G

G

V

V

M
|
M

K

E

K

K

C
|
C

T

T

L
x
Y

C
|
C

V

V

D

Q

R

R

I

I

Y

S

N

G

E

A

T
x
R

L

I

K

A

-

A

-
x
K

-

R

-

A

-

V

-

Q

-

A

-

G

Q

Q

E

S

D

S

R

Y

V

V

P

I

S

S

-

D

-

G

-

A

-

I

-

Q

-
x
T

-

A

C
|
C

V

E

R

Q

T

A

C
|
C

P

P

V
x
T

N

G

A

A

R

I

H

V

Y

F

G

G

D

D

L

I

G

N

D

D

P

S

M

N

S

S

D

R

V

V

S

A

I

K

M

W

V

K

A

A

E

E

R

G

G

H

G

N

F

Y

D

G

L

L

M

L

P

G

E

F

Q

L

G

N

T

T

L

V

P

P

T

R

N

T

K

T

Y

Y

L

L

binding fe3-s4 cluster: C787 (= C102), M802 (≠ V118), C807 (= C123), V808 (≠ I124), G809 (= G125), T810 (≠ C126), K811 (≠ G127), Y812 (≠ L128), C813 (= C129), M853 (= M147)
binding heme c: N805 (≠ D121), R867 (≠ T161), K871 (vs. gap)
binding iron/sulfur cluster: C719 (= C22), I720 (≠ V23), G721 (= G24), C722 (= C25), N723 (≠ H26), C725 (= C28), C729 (= C32), N733 (≠ W35), I754 (≠ L59), C775 (= C90), M776 (≠ L91), C778 (= C93), P782 (= P97), C783 (= C98), N800 (≠ V116), C817 (= C133), Y819 (= Y135), V821 (≠ A137), R822 (= R138), C856 (= C150), Y858 (≠ L152), C859 (= C153), T891 (vs. gap), C893 (= C171), C897 (= C175), T899 (≠ V177)

Sites not aligning to the query:

binding heme c: 3

3egwB The crystal structure of the narghi mutant narh - c16a
37% identity, 40% coverage: 83:185/255 of query aligns to 177:273/509 of 3egwB

query
sites
3egwB

I

M

V

M

H

Y

F

L

P
|
P

K

R

S

L

C
|
C

L
x
E

H
|
H

C
|
C

E

L

D

N

A
x
P

P

A

C
|
C

V

V

T

A

V

T

C
|
C

P

P

T
x
S

G

G

A

A

S
x
I

Y

Y

K

K

R

R

A

E

D

E

D

D

G

G

I

I

V

V

L

L

V

I

D

D

E

Q

D

D

K

K

C
|
C

I
x
R

G
|
G

C
x
W

G
x
R

L

M

C
|
C

A

I

W

T

A

G

C
|
C

S

P

Y

Y

G

K

A

K

R
x
I

E

Y

M

F

D

N

L

W

A

K

A

S

G

G

V

K

M
x
S

K

E

K
|
K

C
|
C

T

I

L
x
F

C
|
C

V

Y

D

P

R

R

I

I

Y

-

N

-

E

-

T

-

L

-

K

-

Q

E

E

A

D

G

R

Q

V

P

P
x
T

S

V

C
|
C

V

S

R

E

T

T

C
|
C

P

V

V
x
G

N

R

A

I

R
|
R

H

Y

Y

L

G

G

D

V

L

L

binding fe3-s4 cluster: P181 (= P87), C196 (= C102), S198 (≠ T104), I201 (≠ S107), C217 (= C123), R218 (≠ I124), G219 (= G125), W220 (≠ C126), R221 (≠ G127), C223 (= C129), S241 (≠ M147), C263 (= C175), G265 (≠ V177), R268 (= R180)
binding protoporphyrin ix containing fe: W220 (≠ C126), R221 (≠ G127)
binding iron/sulfur cluster: C184 (= C90), E185 (≠ L91), H186 (= H92), C187 (= C93), P190 (≠ A96), C192 (= C98), C227 (= C133), I232 (≠ R138), K243 (= K149), C244 (= C150), F246 (≠ L152), C247 (= C153), T257 (≠ P169), C259 (= C171)

Sites not aligning to the query:

binding fe3-s4 cluster: 17, 18, 19, 20, 22
binding protoporphyrin ix containing fe: 88, 89
binding iron/sulfur cluster: 26, 30, 41, 42

P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
37% identity, 40% coverage: 83:185/255 of query aligns to 177:273/512 of P11349

query
sites
P11349

I

M

V

M

H

Y

F

L

P

P

K

R

S

L

C
|
C

L

E

H

H

C
|
C

E

L

D

N

A

P

P

A

C
|
C

V

V

T

A

V

T

C
|
C

P

P

T

S

G

G

A

A

S

I

Y

Y

K

K

R

R

A

E

D

E

D

D

G

G

I

I

V

V

L

L

V

I

D

D

E

Q

D

D

K

K

C
|
C

I

R

G

G

C

W

G

R

L

M

C
|
C

A

I

W

T

A

G

C
|
C

S

P

Y

Y

G

K

A

K

R

I

E

Y

M

F

D

N

L

W

A

K

A

S

G

G

V

K

M

S

K

E

K

K

C
|
C

T

I

L

F

C
|
C

V

Y

D

P

R

R

I

I

Y

-

N

-

E

-

T

-

L

-

K

-

Q

E

E

A

D

G

R

Q

V

P

P

T

S

V

C
|
C

V

S

R

E

T

T

C
|
C

P

V

V

G

N

R

A

I

R

R

H

Y

Y

L

G

G

D

V

L

L

C184 (= C90) binding [4Fe-4S] cluster
C187 (= C93) binding [4Fe-4S] cluster
C192 (= C98) binding [4Fe-4S] cluster
C196 (= C102) binding [3Fe-4S] cluster
C217 (= C123) binding [3Fe-4S] cluster
C223 (= C129) binding [3Fe-4S] cluster
C227 (= C133) binding [4Fe-4S] cluster
C244 (= C150) binding [4Fe-4S] cluster
C247 (= C153) binding [4Fe-4S] cluster
C259 (= C171) binding [4Fe-4S] cluster
C263 (= C175) binding [4Fe-4S] cluster

Sites not aligning to the query:

16 binding [4Fe-4S] cluster
19 binding [4Fe-4S] cluster
22 binding [4Fe-4S] cluster
26 binding [4Fe-4S] cluster

6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
27% identity, 81% coverage: 12:217/255 of query aligns to 682:917/929 of 6lodB

query
sites
6lodB

R

K

L

W

G

G

L

M

V

S

I

I

D

D

L

L

D

N

I

V

C
|
C

V
x
N

G
x
S

C
|
C

H
x
N

A
|
A

C
|
C

V

V

I

V

S

A

C
|
C

K

Q

-

S

E

E

W
x
N

N

N

T

I

G

P

G

V

Y

V

G

G

N

-

A

-

L

-

S

K

D

D

Q

E

H

V

P

W

Y

L

G

G

E

R

Q

E

V

M

S

H

G
x
W

T

I

F

-

L

-

N

-

R

R

I
|
I

H

D

T

Q

Y

Y

E

Y

V

V

V

-

P

-

E

-

G

-

L

-

V

-

I

-

G

G

E

D

A

E

G

H

E

T

A

P

R

N

I

V

V

Y

H

N

F

M

P

V

K

M

S
x
L

C
|
C

L
x
Q

H
x
Q

C
|
C

E

E

D

H

A

A

P
|
P

C
|
C

V

E

T

I

V
|
V

C
|
C

P
|
P

T

V

G

A

A

A

S

T

Y

V

K

H

R

D

A

A

D

-

D

E

G

G

I

L

V
x
N

L

N

V

M

D

V

E

Y

D
x
N

K
x
R

C
|
C

I
x
V

G
|
G

C
x
T

G

K

L

Y

C
|
C

A

S

W

N

A

N

C
|
C

S

P

Y
|
Y

G

K

A
x
V

R
|
R

E

R

M

F

D

N

L

F

-

L

-

Q

-

Y

-

Q

-

D

-

V

-

P

-

Y

-

R

-

S

-

P

-

I

-

D

-

A

-

S

-

T

-

E

-

N

-

D

-

S

-

I

-

P

-

V

-

L

-

K

-

M

-

R

-

N

-

P

-

D

-

V

-

T

-

V

-

R

A

A

A

R

G

G

V

V

M
|
M

K

E

K
|
K

C
|
C

T

T

L
x
F

C
|
C

V

V

D

Q

R

R

I

I

Y

-

N

N

E

E

T

A

L
x
R

K
x
I

Q

Q

-

A

-
x
R

-

T

E

E

D

N

R

R

-

R

-

I

-

A

-

D

-

G

-

E

-

I

V

M

P
x
T

S

A

C
|
C

V

Q

R

Q

T

V

C
|
C

P

P

V

T

N

Q

A

A

R
x
I

H

V

Y

F

G

G

D

D

L

L

G

N

D

D

P

P

M

Q

S

A

D

R

V

V

S

V

I

D

M

L

V

K

A

E

E

Q

R

P

G

L

G

K

F

Y

D

T

L

S

M

L

P

D

E

K

Q

L

G

N

T

T

L

K

P

P

T

R

N

V

K

S

Y

Y

L

L

binding fe3-s4 cluster: V758 (= V101), C759 (= C102), P760 (= P103), C779 (= C123), V780 (≠ I124), G781 (= G125), T782 (≠ C126), C785 (= C129), M838 (= M147)
binding heme c: N777 (≠ D121), R778 (≠ K122), R852 (≠ L162), I853 (≠ K163), R856 (vs. gap)
binding iron/sulfur cluster: C692 (= C22), N693 (≠ V23), S694 (≠ G24), C695 (= C25), N696 (≠ H26), A697 (= A27), C698 (= C28), C702 (= C32), N706 (≠ W35), W724 (≠ G56), I727 (= I62), L746 (≠ S89), C747 (= C90), Q748 (≠ L91), Q749 (≠ H92), C750 (= C93), P754 (= P97), C755 (= C98), N772 (≠ V116), C789 (= C133), Y791 (= Y135), V793 (≠ A137), R794 (= R138), K840 (= K149), C841 (= C150), F843 (≠ L152), C844 (= C153), T869 (≠ P169), C871 (= C171), C875 (= C175), I880 (≠ R180)

7b04A of Nitrite oxidoreductase (Nxr) from the anammox bacterium Kuenenia stuttgartiensis.
32% identity, 56% coverage: 83:225/255 of query aligns to 167:315/409 of 7b04A

query
sites
7b04A

I

F

V

F

H

Y

F

L

P
x
Q

K

R

S
x
I

C
|
C

L
x
N

H
|
H

C
|
C

E

T

D

Y

A
x
P

P

G

C
|
C

V

L

T

A

V

A

C
|
C

P

P

T
x
R

G

K

A

A

S
x
I

Y

Y

K

K

R

R

A

K

D

E

D

D

G

G

I

I

V

V

L

L

V

I

D

D

E

Q

D

K

K

R

C
|
C

I
x
R

G
|
G

C
x
Y

G
x
R

L
x
K

C
|
C

A

V

W

E

A

Q

C
|
C

S

P

Y

Y

G

K

A

K

R
x
P

E

M

M

Y

D

R

L

G

A

L

A

T

G

R

V

V

M
x
S

K

E

K
|
K

C
|
C

T

I

L
x
A

C
|
C

V

Y

D

P

R

R

I

I

Y

E

N

G

E

R

T

D

L

S

K

L

Q

T

E

D

D

G

R

R

-

P

-

M

V

E

P
x
T

S
x
R

C
|
C

V

M

R

S

T

A

C
|
C

P
x
V

V

G

N

Q

A
x
I

R
|
R

H

L

Y

Q

G

G

D

F

L

L

G

D

D

D

-

N

P

P

M

K

S

N

D

P

V

I

S

T

I

W

M

L

V

I

A

R

-

H

E

Q

R

K

G

I

G

A

F

L

D

P

L

L

M

Y

P

P

E

Q

Q

F

G

G

T

T

L

E

P

P

T

N

N

I

K

Y

Y

Y

L

I

P

P

R

R

-

W

-

A

P

P

R

R

T

A

S

Y

L

L

binding fe3-s4 cluster: C186 (= C102), I191 (≠ S107), C207 (= C123), R208 (≠ I124), G209 (= G125), Y210 (≠ C126), R211 (≠ G127), K212 (≠ L128), C213 (= C129), S231 (≠ M147)
binding protoporphyrin ix containing fe: R188 (≠ T104), R208 (≠ I124), Y210 (≠ C126)
binding iron/sulfur cluster: Q171 (≠ P87), I173 (≠ S89), C174 (= C90), N175 (≠ L91), H176 (= H92), C177 (= C93), P180 (≠ A96), C182 (= C98), C217 (= C133), P222 (≠ R138), K233 (= K149), C234 (= C150), A236 (≠ L152), C237 (= C153), T255 (≠ P169), R256 (≠ S170), C257 (= C171), C261 (= C175), V262 (≠ P176), I265 (≠ A179), R266 (= R180)

Sites not aligning to the query:

binding iron/sulfur cluster: 34, 35, 36, 37, 38, 40, 44, 48, 59, 60, 62

7z0sB Structure of the escherichia coli formate hydrogenlyase complex (anaerobic preparation, without formate dehydrogenase h) (see paper)
26% identity, 67% coverage: 15:184/255 of query aligns to 5:168/170 of 7z0sB

query
sites
7z0sB

L

V

V

I

I

A

D

D

L

S

D

T

I

L

C
|
C

V
x
I

G
|
G

C
|
C

H
|
H

A
x
T

C
|
C

V

E

I

A

S

A

C
|
C

K

S

E

E

W

-

N

-

T

-

G

-

Y

-

G

-

N

-

A

-

L

-

S

-

D

-

Q

-

H

-

P

-

Y

-

G

-

E

-

Q

-

V

-

S

-

G

-

T

-

F

-

L

T

N
x
H

R

R

I

Q

H

H

T

G

Y

L

E

Q

V

S

V

M

P

P

E
x
R

G
x
L

G

R

L

V

V

M

I

L

G

N

E

E

A

K

G

E

E

S

A

A

R

-

I

-

V

-

H

-

F

-

P
|
P

K

Q

S
x
L

C
|
C

L
x
H

H
|
H

C
|
C

E

E

D

D

A

A

P

P

C
|
C

V

A

T

V

V

V

C
|
C

P
|
P

T

V

G

N

A

A

S
x
I

Y

T

K

R

R

V

A

-

D

-

D

D

G

G

I

A

V
|
V

L

Q

V
x
L

D

N

E

E

D

S

K

L

C
|
C

I
x
V

G

S

C
|
C

G
x
K

L

L

C
|
C

A

G

W

I

A

A

C
|
C

S

P

Y

F

G

G

A

A

-
x
I

-

E

-

F

-

S

-

G

-

S

R

R

E

P

M

L

D

D

L

I

A

P

A

A

-

N

-

A

-

N

-

T

-

P

-

K

-

A

-

P

-

A

-

P

-

A

-

P

-

A

-

R

-

V

-

S

-

T

-

L

-

D

-

W

-

V

-

P

-

G

-

I

-

R

G

A

V

I

M
x
A

K

V

K
|
K

C
|
C

T
x
D

L
|
L

C
|
C

V

-

D

-

R

-

I

-

Y

-

N

-

E

-

T

-

L

-

K

S

Q

F

E

D

D

E

R

Q

V

G

P
|
P

S

A

C
|
C

V

V

R

R

T

M

C
|
C

P
|
P

V
x
T

N

K

A

A

R
x
L

H

H

Y

L

G

V

D

D

binding iron/sulfur cluster: C12 (= C22), I13 (≠ V23), G14 (= G24), C15 (= C25), H16 (= H26), T17 (≠ A27), C18 (= C28), C22 (= C32), H26 (≠ N60), R36 (≠ E70), L37 (≠ G71), P48 (= P87), L50 (≠ S89), C51 (= C90), H52 (≠ L91), H53 (= H92), C54 (= C93), C59 (= C98), C63 (= C102), P64 (= P103), I68 (≠ S107), V75 (= V116), L77 (≠ V118), C82 (= C123), V83 (≠ I124), C85 (= C126), K86 (≠ G127), C88 (= C129), C92 (= C133), I97 (vs. gap), A140 (≠ M147), K142 (= K149), C143 (= C150), D144 (≠ T151), L145 (= L152), C146 (= C153), P153 (= P169), C155 (= C171), C159 (= C175), P160 (= P176), T161 (≠ V177), L164 (≠ R180)

1h0hB Tungsten containing formate dehydrogenase from desulfovibrio gigas (see paper)
27% identity, 73% coverage: 14:198/255 of query aligns to 3:179/214 of 1h0hB

query
sites
1h0hB

G

G

L
x
F

V

F

I

V

D

D

L

T

D

T

I

R

C
|
C

V
x
T

G
x
A

C
|
C

H
x
R

A

G

C
|
C

V

Q

I

V

S

A

C
|
C

K

K

E

Q

W

W

N

-

T

-

G

-

Y
x
H

G

G

N

N

A

P

L

A

S

T

D

P

Q

T

H

E

P

N

Y

T

G

G

E

F

Q

H

V

Q

S

N

G

P

T

P

F

D

L

F

N

N

R

-

I

F

H

H

T

T

Y

Y

E
x
K

V

L

V

V

P

R

E

M

G

H

G

E

L

Q

V

E

I

I

G

D

E

-

A

-

G

G

E

R

A

I

R

D

I

W

V

L

H

F

F

F

P

P

K

D

S
x
Q

C
|
C

L
x
R

H

H

C
|
C

E

I

D

A

A

P

P
|
P

C
|
C

V

-

T

-

V

-

C

-

P

-

T

-

G

K

A

A

S

T

Y

A

K

D

R

M

A

E

D

D

D

E

G

S

I

A

V

I

L

I

V

-

D

-

E

H

D

D

K

D

C

A

I

T

G

G

C

C

G
x
V

L

L

C

F

A

T

-

P

-

K

-

T

-

K

-

D

-

L

-

E

-

D

-

Y

-

E

-

S

-

V

-

I

W

S

A

A

C
|
C

S

P

Y

Y

G

D

A

V

R
x
P

E

R

M

K

D

V

L

A

A

E

A

S

G

N

V

Q

M

M

K

A

K
|
K

C
|
C

T
x
D

L
x
M

C
|
C

V

I

D

D

R

R

I

I

Y

T

N

N

E

G

T

L

L

R

K

-

Q

-

E

-

D

-

R

-

V

-

P

P

S

A

C
|
C

V

V

R

T

T

S

C
|
C

P
|
P

V

T

N

G

A
|
A

R

M

H

N

Y

F

G

G

D

D

L

L

G

S

D

E

P

M

M

E

S

A

D

M

V

A

S

S

I

A

M

R

V

L

A

A

E

E

binding iron/sulfur cluster: F4 (≠ L15), C11 (= C22), T12 (≠ V23), A13 (≠ G24), C14 (= C25), R15 (≠ H26), C17 (= C28), C21 (= C32), H25 (≠ Y40), K50 (≠ E66), Q71 (≠ S89), C72 (= C90), R73 (≠ L91), C75 (= C93), P79 (= P97), C80 (= C98), V101 (≠ G127), C120 (= C133), P125 (≠ R138), K136 (= K149), C137 (= C150), D138 (≠ T151), M139 (≠ L152), C140 (= C153), C152 (= C171), C156 (= C175), P157 (= P176), A160 (= A179)

Q8GC87 Formate dehydrogenase subunit beta; FDH subunit beta; Formate dehydrogenase small subunit from Megalodesulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759) (Desulfovibrio gigas) (see paper)
27% identity, 73% coverage: 14:198/255 of query aligns to 4:180/215 of Q8GC87

query
sites
Q8GC87

G

G

L

F

V

F

I

V

D

D

L

T

D

T

I

R

C
|
C

V

T

G

A

C
|
C

H

R

A

G

C
|
C

V

Q

I

V

S

A

C
|
C

K

K

E

Q

W

W

N

-

T

-

G

-

Y

H

G

G

N

N

A

P

L

A

S

T

D

P

Q

T

H

E

P

N

Y

T

G

G

E

F

Q

H

V

Q

S

N

G

P

T

P

F

D

L

F

N

N

R

-

I

F

H

H

T

T

Y

Y

E

K

V

L

V

V

P

R

E

M

G

H

G

E

L

Q

V

E

I

I

G

D

E

-

A

-

G

G

E

R

A

I

R

D

I

W

V

L

H

F

F

F

P

P

K

D

S

Q

C
|
C

L

R

H

H

C
|
C

E

I

D

A

A

P

P

P

C
|
C

V

-

T

-

V

-

C

-

P

-

T

-

G

K

A

A

S

T

Y

A

K

D

R

M

A

E

D

D

D

E

G

S

I

A

V

I

L

I

V

-

D

-

E

H

D

D

K

D

C

A

I

T

G

G

C

C

G

V

L

L

C

F

A

T

-

P

-

K

-

T

-

K

-

D

-

L

-

E

-

D

-

Y

-

E

-

S

-

V

-

I

W

S

A

A

C
|
C

S

P

Y

Y

G

D

A

V

R

P

E

R

M

K

D

V

L

A

A

E

A

S

G

N

V

Q

M

M

K

A

K

K

C
|
C

T

D

L

M

C
|
C

V

I

D

D

R

R

I

I

Y

T

N

N

E

G

T

L

L

R

K

-

Q

-

E

-

D

-

R

-

V

-

P

P

S

A

C
|
C

V

V

R

T

T

S

C
|
C

P

P

V

T

N

G

A

A

R

M

H

N

Y

F

G

G

D

D

L

L

G

S

D

E

P

M

M

E

S

A

D

M

V

A

S

S

I

A

M

R

V

L

A

A

E

E

C12 (= C22) binding [4Fe-4S] cluster
C15 (= C25) binding [4Fe-4S] cluster
C18 (= C28) binding [4Fe-4S] cluster
C22 (= C32) binding [4Fe-4S] cluster
C73 (= C90) binding [4Fe-4S] cluster
C76 (= C93) binding [4Fe-4S] cluster
C81 (= C98) binding [4Fe-4S] cluster
C121 (= C133) binding [4Fe-4S] cluster
C138 (= C150) binding [4Fe-4S] cluster
C141 (= C153) binding [4Fe-4S] cluster
C153 (= C171) binding [4Fe-4S] cluster
C157 (= C175) binding [4Fe-4S] cluster

7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
34% identity, 62% coverage: 22:179/255 of query aligns to 14:158/183 of 7qv7B

query
sites
7qv7B

C
|
C

V

I

G
|
G

C
|
C

H
x
K

A
|
A

C
|
C

V

E

I

V

S

A

C
|
C

K

-

E

-

W

-

N

-

T

-

G

-

Y

-

G

-

N

F

A

A

L

V

S
x
H

D

N

Q

R

H

N

P

N

Y

H

G

V

E

G

Q

A

V

T

S

V

G

G

T

T

F

V

L

-

N

-

R

-

I

-

H

-

T

S

Y

I

E

P

V

V

V

I

P

P

E
x
R

G

L

G

H

L

L

V

I

I

K

G

T

E

E

A

H

G

G

E

T

A

-

R

-

I

-

V

-

H

-

F

M

P

P

K

I

S

Q

C
|
C

L
x
R

H
|
H

C
|
C

E

E

D

D

A
|
A

P

P

C
|
C

V

A

T

N

V

V

C
|
C

P

T

T

V

G

G

A
|
A

S

-

Y
x
I

K

K

R

R

A

E

D

G

D

N

G

A

I

I

V

V

L

-

V

V

D

D

E

E

D

K

K

L

C
|
C

I
|
I

G

G

C
|
C

G

K

L

S

C
|
C

A

L

W

L

A

A

C
|
C

S

P

Y

F

G

G

A

A

R
x
I

E

E

M

L

D

L

L

P

A

Q

A

Y

G

E

V

D

M

G

K

R

K

E

C

-

T

-

L

-

C

-

V

V

D

F

R

Q

I

I

Y

-

N

N

E

L

T

K

L

L

K

V

Q

Q

E

E

D

P

R

R

V

I

-

I

-

A

-

Y

-

K

-
x
C

-

D

-
x
L

-
x
C

-

N

-

D

-

L

-

G

-

E

P
|
P

S

A

C
|
C

V

V

R

K

T

A

C
|
C

P
|
P

V

E

N

N

A

A

binding iron/sulfur cluster: C14 (= C22), G16 (= G24), C17 (= C25), K18 (≠ H26), A19 (= A27), C20 (= C28), C24 (= C32), H28 (≠ S45), R48 (≠ E70), C63 (= C90), R64 (≠ L91), H65 (= H92), C66 (= C93), A69 (= A96), C71 (= C98), C75 (= C102), A79 (= A106), I80 (≠ Y108), C94 (= C123), I95 (= I124), C97 (= C126), C100 (= C129), C104 (= C133), I109 (≠ R138), C139 (vs. gap), L141 (vs. gap), C142 (vs. gap), P148 (= P169), C150 (= C171), C154 (= C175), P155 (= P176)

Sites not aligning to the query:

binding iron/sulfur cluster: 159

Query Sequence

>WP_106717160.1 NCBI__GCF_003010935.1:WP_106717160.1
MTSLPHNRTTKRLGLVIDLDICVGCHACVISCKEWNTGGYGNALSDQHPYGEQVSGTFLN
RIHTYEVVPEGGLVIGEAGEARIVHFPKSCLHCEDAPCVTVCPTGASYKRADDGIVLVDE
DKCIGCGLCAWACSYGAREMDLAAGVMKKCTLCVDRIYNETLKQEDRVPSCVRTCPVNAR
HYGDLGDPMSDVSIMVAERGGFDLMPEQGTLPTNKYLPPRPRTSLSDNAPIVPLAENTEG
ARGFFAWLDKTLDRI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory