SitesBLAST

26 C→A: Lower ATPase activity and transport efficiency.
27 F→L: Lower ATPase activity and transport efficiency.
276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

8y5iA Cryo-em structure of e.Coli spermidine transporter potd-potabc in translocation intermidiate state (see paper)
39% identity, 87% coverage: 21:207/214 of query aligns to 23:211/358 of 8y5iA

query
sites
8y5iA

F

L

T

T

L

I

P

N

D

N

D

G

A

E

W

F

C

L

I

T

I

L

S

L

G

G

P

P

S

S

G
|
G

S

C

G

G

K
|
K

T
|
T

L
x
T

F

V

L

L

E

R

T

L

I

I

A

A

G

G

F

L

Y

E

Q

T

P

V

C

D

S

S

G

G

K

R

I

I

I

M

Q

L

N

D

G

N

M

E

D

D

I

I

T

T

Y

H

F

V

S

P

P

A

E

E

K

N

R

R

G

Y

I

V

G

N

I

T

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L

L

F

F

P

P

H

H

M

M

T

T

V

V

A

F

K

E

N

N

I

V

G

A

Y

F

G

G

L

L

A

R

I

M

R

Q

R

K

-

T

-

P

H

A

S

A

D

E

I

I

H

T

N

P

I

R

V

V

L

M

D

E

I

A

S

L

R

R

K

M

L

V

G

Q

I

L

D

E

S

T

L

F

L

A

D

Q

R
|
R

N

K

P

P

L

H

T
x
Q

L

L

S
|
S

G

G

E

Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

V

V

V

V

N

K

K

P

P

K

R

L

L

D

D

E

Q

P

S

A

L

S

S

A

A

L

L

D

D

L

Y

Q

K

A

L

K

R

K

K

E

Q

L

M

W

Q

D

N

D

E

I

L

R

K

D

A

L

L

F

Q

E

R

Q

K

G

L

G

G

L

I

T

T

I

F

I

V

H

F

V

V

T

T

H

H

D

D

I

Q

S

E

E

E

S

A

N

L

N

T

L

M

G

S

T

D

H

R

K

I

I

V

L

V

L

M

M

R

N

D

G

G

K

R

I

I

binding adenosine-5'-triphosphate: G38 (= G36), K41 (= K39), T42 (= T40), T43 (≠ L41), R128 (= R124), Q132 (≠ T128), S134 (= S130)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12, 15

P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
41% identity, 90% coverage: 20:211/214 of query aligns to 24:216/393 of P9WQI3

query
sites
P9WQI3

S

N

F

L

T

T

L

I

P

A

D

D

D

G

A

E

W

F

C

L

I

I

I

L

S

V

G

G

P

P

S

S

G

G

S

C

G

G

K

K

T

T

L

T

F

T

L

L

E

N

T

M

I

I

A

A

G

G

F

L

Y

E

Q

D

P

I

C

S

S

S

G

G

K

E

I

L

I

R

Q

I

N

A

G

G

M

E

D

R

I

V

T

N

Y

E

F

K

S

A

P

P

E

K

K

D

R

R

G

D

I

I

G

A

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

M

T

T

V

V

A

R

K

Q

N

N

I

I

G

A

Y

F

-

P

-

L

G

T

L

L

A

A

I

K

R

M

R

R

H

K

S

A

D

D

I

I

H

A

N

Q

I

K

V

V

L

S

D

E

I

T

S

A

R

K

K

I

L

L

G

D

I

L

D

T

S

N

L

L

D

D

R

R

N

K

P

P

L

S

T

Q

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

M

A

G

R

R

A

A

L

I

V

V

V

R

K

H

P

P

K

K

L

A

L

F

L

L

L

M

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

K

A

L

K

R

K

V

E

Q

L

M

W

R

D

G

D

E

I

I

R

A

D

Q

L

L

F

Q

E

R

Q

R

G

L

G

G

L

T

T

T

I

T

I

V

H

Y

V

V

T

T

H
|
H

D

D

I

Q

S

T

E

E

S

A

N

M

N

T

L

L

G

G

T

-

H

D

K

R

I

V

L

V

M

M

N

Y

G

G

K

G

I

I

V

A

K

Q

T

Q

I

I

H193 (= H187) mutation to A: Decreased hydrolysis of ATP. No change in KM, but 2-fold reduction in Vmax compared to wild-type.

1g291 Malk (see paper)
38% identity, 90% coverage: 20:211/214 of query aligns to 23:221/372 of 1g291

query
sites
1g291

S

S

F

L

T

E

L

V

P

K

D

D

D

G

A

E

W

F

C

M

I

I

I

L

S

L

G

G

P

P

S
|
S

G
|
G

S
x
C

G
|
G

K
|
K

T
|
T

L
x
T

F

T

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

E

P

P

C

S

S

R

G

G

-

Q

-

I

-

Y

-

I

-

G

-

D

K

K

I

L

I

V

Q

A

N
x
D

G

P

M
x
E

D
x
K

I

G

T

I

Y

F

F

V

S

P

P

P

E
x
K

K
x
D

R

R

G

D

I

I

G

A

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

M

T

T

V

V

A

Y

K

D

N

N

I

I

G

A

Y

F

G

P

L

L

A

K

I

L

R

R

R

K

-

V

-

P

H

R

S

Q

D

E

I

I

H

D

N

Q

I

R

V

V

L

R

D

E

I

V

S

A

R

E

K

L

L

L

G

G

I

L

D

T

S

E

L

L

D

N

R

R

N

K

P

P

L

R

T

E

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

L

A

G

R

R

A

A

L

I

V

V

V

R

K

K

P

P

K

Q

L

V

L

F

L

L

L

M

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

K

A

L

K

R

K

V

E

R

L

M

W

R

D

A

D

E

I

L

R

K

D

K

L

L

F

Q

E

R

Q

Q

G

L

G

G

L

V

T

T

I

T

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

M

G

G

T

-

H

D

K

R

I

I

L

A

L

V

M

M

N

N

G

R

K

G

I

V

V

L

K

Q

T

Q

I

V

binding magnesium ion: D69 (≠ N60), E71 (≠ M62), K72 (≠ D63), K79 (≠ E70), D80 (≠ K71)
binding pyrophosphate 2-: S38 (= S35), G39 (= G36), C40 (≠ S37), G41 (= G38), K42 (= K39), T43 (= T40), T44 (≠ L41)

Sites not aligning to the query:

binding magnesium ion: 292, 293, 359

2d62A Crystal structure of multiple sugar binding transport atp-binding protein
38% identity, 86% coverage: 20:204/214 of query aligns to 26:217/375 of 2d62A

query
sites
2d62A

S

S

F

L

T

E

L

I

P

K

D

D

D

G

A

E

W

F

C

L

I

V

I

L

S

L

G

G

P

P

S

S

G
|
G

S
x
C

G
|
G

K
|
K

T
|
T

L
x
T

F

T

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

E

P

P

C

T

S

R

G

G

K

Q

I

I

-

Y

-

I

-

E

-

D

-

N

-

L

I

V

Q

A

N

D

G

P

M

E

D

K

I

G

T

V

Y

F

F

V

S

P

P

P

E

K

K

E

R

R

G

D

I

V

G

A

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

M

T

T

V

V

A

Y

K

D

N

N

I

I

G

A

Y

F

G

P

L

L

A

K

I

L

R

R

R

K

-

V

-

P

H

K

S

Q

D

E

I

I

H

D

N

K

I

R

V

V

L

R

D

E

I

V

S

A

R

E

K

M

L

L

G

G

I

L

D

T

S

E

L

L

D

N

R

R

N

K

P

P

L

R

T

E

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

L

A

G

R

R

A

A

L

I

V

I

V

R

K

R

P

P

K

K

L

V

L

F

L

L

L

M

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

K

A

L

K

R

K

V

E

K

L

M

W

R

D

A

D

E

I

L

R

K

D

K

L

L

F

Q

E

R

Q

Q

G

L

G

G

L

V

T

T

I

T

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

M

G

G

T

-

H

D

K

R

I

I

L

A

L

V

M

M

N

N

binding pyrophosphate 2-: G42 (= G36), C43 (≠ S37), G44 (= G38), K45 (= K39), T46 (= T40), T47 (≠ L41)

8hplC Lpqy-sugabc in state 1 (see paper)
38% identity, 88% coverage: 20:207/214 of query aligns to 21:210/384 of 8hplC

query
sites
8hplC

S

S

F

M

T

T

L

I

P

A

D

D

D

G

A

E

W

F

C

I

I

I

I

L

S

V

G

G

P

P

S

S

G
|
G

S
x
C

G
|
G

K
|
K

T
x
S

L
x
T

F

T

L

L

E

N

T

M

I

I

A

A

G

G

F

L

Y

E

Q

E

P

I

C

T

S

S

G

G

K

E

I

L

I

R

Q

I

N

G

G

G

M

E

D

R

I

V

T

N

Y

E

F

K

S

A

P

P

E

K

K

D

R

R

G

D

I

I

G

A

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

M

T

T

V

V

A

R

K

Q

N

N

I

I

G

A

Y

F

G

P

L

L

A

T

I

L

R

A

R

K

-

V

-

P

H

K

S

A

D

E

I

I

H

A

N

A

I

K

V

V

L

E

D

E

I

T

S

A

R

K

K

I

L

L

G

D

I

L

D

S

S

E

L

L

D

D

R

R

N

K

P

P

L

G

T

Q

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

M

A

G

R

R

A

A

L

I

V

V

V

R

K

S

P

P

K

K

L

A

L

F

L

L

L

M

D

D

E

Q

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

K

A

L

K

R

K

V

E

Q

L

M

W

R

D

A

D

E

I

I

R

S

D

R

L

L

F

Q

E

D

Q

R

G

L

G

G

L

T

T

T

I

T

I

V

H

Y

V

V

T

T

H

H

D

D

I

Q

S

T

E

E

S

A

N

M

N

T

L

L

G

G

T

D

H

R

K

V

I

V

L

V

L

M

M

L

N

A

G

G

K

E

I

V

binding adenosine-5'-triphosphate: G37 (= G36), C38 (≠ S37), G39 (= G38), K40 (= K39), S41 (≠ T40), T42 (≠ L41)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12

8hprC Lpqy-sugabc in state 4 (see paper)
38% identity, 88% coverage: 20:207/214 of query aligns to 23:212/363 of 8hprC

query
sites
8hprC

S

S

F

M

T

T

L

I

P

A

D

D

D

G

A

E

W

F

C

I

I

I

I

L

S

V

G

G

P

P

S
|
S

G
|
G

S

C

G
|
G

K
|
K

T
x
S

L

T

F

T

L

L

E

N

T

M

I

I

A

A

G

G

F

L

Y

E

Q

E

P

I

C

T

S

S

G

G

K

E

I

L

I

R

Q

I

N

G

G

G

M

E

D

R

I

V

T

N

Y

E

F

K

S

A

P

P

E

K

K

D

R

R

G

D

I

I

G

A

I

M

V

V

F

F

Q
|
Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

M

T

T

V

V

A

R

K

Q

N

N

I

I

G

A

Y

F

G

P

L

L

A

T

I

L

R

A

R

K

-

V

-

P

H

K

S

A

D

E

I

I

H

A

N

A

I

K

V

V

L

E

D

E

I

T

S

A

R

K

K

I

L

L

G

D

I

L

D

S

S

E

L

L

D

D

R

R

N

K

P

P

L

G

T
x
Q

L

L

S

S

G
|
G

E
x
Q

K

R

Q

Q

R

R

V

V

A

A

I

M

A

G

R

R

A

A

L

I

V

V

V

R

K

S

P

P

K

K

L

A

L

F

L

L

L

M

D

D

E

Q

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

K

A

L

K

R

K

V

E

Q

L

M

W

R

D

A

D

E

I

I

R

S

D

R

L

L

F

Q

E

D

Q

R

G

L

G

G

L

T

T

T

I

T

I

V

H

Y

V

V

T

T

H
|
H

D

D

I

Q

S

T

E

E

S

A

N

M

N

T

L

L

G

G

T

D

H

R

K

V

I

V

L

V

L

M

M

L

N

A

G

G

K

E

I

V

binding adenosine-5'-triphosphate: S38 (= S35), G39 (= G36), G41 (= G38), K42 (= K39), S43 (≠ T40), Q82 (= Q79), Q133 (≠ T128), G136 (= G131), G137 (= G132), Q138 (≠ E133), H192 (= H187)
binding magnesium ion: S43 (≠ T40), Q82 (= Q79)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12

8hprD Lpqy-sugabc in state 4 (see paper)
38% identity, 88% coverage: 20:207/214 of query aligns to 23:212/362 of 8hprD

query
sites
8hprD

S

S

F

M

T

T

L

I

P

A

D

D

D

G

A

E

W

F

C

I

I

I

I

L

S

V

G

G

P

P

S
|
S

G

G

S
x
C

G
|
G

K
|
K

T
x
S

L
x
T

F

T

L

L

E

N

T

M

I

I

A

A

G

G

F

L

Y

E

Q

E

P

I

C

T

S

S

G

G

K

E

I

L

I

R

Q

I

N

G

G

G

M

E

D

R

I

V

T

N

Y

E

F

K

S

A

P

P

E

K

K

D

R

R

G

D

I

I

G

A

I

M

V

V

F

F

Q
|
Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

M

T

T

V

V

A

R

K

Q

N

N

I

I

G

A

Y

F

G

P

L

L

A

T

I

L

R

A

R

K

-

V

-

P

H

K

S

A

D

E

I

I

H

A

N

A

I

K

V

V

L

E

D

E

I

T

S

A

R

K

K

I

L

L

G

D

I

L

D

S

S

E

L

L

D

D

R
|
R

N

K

P

P

L

G

T
x
Q

L

L

S
|
S

G
|
G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

M

A

G

R

R

A

A

L

I

V

V

V

R

K

S

P

P

K

K

L

A

L

F

L

L

L

M

D

D

E
x
Q

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

K

A

L

K

R

K

V

E

Q

L

M

W

R

D

A

D

E

I

I

R

S

D

R

L

L

F

Q

E

D

Q

R

G

L

G

G

L

T

T

T

I

T

I

V

H

Y

V

V

T

T

H
|
H

D

D

I

Q

S

T

E

E

S

A

N

M

N

T

L

L

G

G

T

D

H

R

K

V

I

V

L

V

L

M

M

L

N

A

G

G

K

E

I

V

binding adenosine-5'-triphosphate: S38 (= S35), C40 (≠ S37), G41 (= G38), K42 (= K39), S43 (≠ T40), T44 (≠ L41), Q82 (= Q79), R129 (= R124), Q133 (≠ T128), S135 (= S130), G136 (= G131), G137 (= G132), Q159 (≠ E154), H192 (= H187)
binding magnesium ion: S43 (≠ T40), Q82 (= Q79)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12

1vciA Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
37% identity, 97% coverage: 2:209/214 of query aligns to 7:209/353 of 1vciA

query
sites
1vciA

I

V

A

K

I

L

S

E

N

N

L

L

V

T

V

K

H

R

A
x
F

G

G

Q

N

F
|
F

E

T

L

A

V

V

I

N

D

K

-

L

S

N

F

L

T

T

L

I

P

K

D

D

D

G

A

E

W

F

C

L

I

V

I

L

S

L

G

G

P

P

S
|
S

G
|
G

S

C

G
|
G

K
|
K

T
|
T

L
x
T

F

T

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

E

P

P

C

T

S

E

G

G

K

R

I

I

I

Y

Q

F

N

G

G

D

M

R

D

D

I

V

T

T

Y

Y

F

L

S

P

P

P

E

K

K

D

R

R

G

N

I

I

G

S

I

M

V

V

F

F

Q

Q

D

-

Y

-

S

-

L

-

F

-

P

-

H

H

M

M

T

T

V

V

A

Y

K

E

N

N

I

I

G

A

Y

F

G

P

L

L

A

K

I

K

R

F

R

P

H

K

S

D

D

E

I

I

H

D

N

K

I

R

V

V

L

R

D

W

I

A

S

A

R

E

K

L

L

L

G

Q

I

I

D

E

S

E

L

L

D

N

R

R

N

Y

P

P

L

A

T

Q

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

V

A

A

R

R

A

A

L

I

V

V

K

E

P

P

K

D

L

V

L

L

L

M

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

K

A

L

K

R

K

V

E

A

L

M

W

R

D

A

D

E

I

I

R

K

D

K

L

L

F

Q

E

Q

Q

K

G

L

G

K

L

V

T

T

I

T

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

M

G

G

T

D

H

R

K

I

I

A

L

V

L

M

M

N

N

R

G

G

K

Q

I

L

V

L

K

Q

binding adenosine-5'-triphosphate: F16 (≠ A11), F19 (= F14), S41 (= S35), G42 (= G36), G44 (= G38), K45 (= K39), T46 (= T40), T47 (≠ L41)

2awnB Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
36% identity, 97% coverage: 6:212/214 of query aligns to 22:216/374 of 2awnB

query
sites
2awnB

N

N

L

L

V

D

V

I

H

H

A

E

G

G

Q

E

F

F

E

-

L

-

V

-

I

-

D

-

S

-

F

-

T

-

L

-

P

-

D

-

A

-

W

-

C

V

I

V

I

F

S

V

G

G

P

P

S
|
S

G
|
G

S

C

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

K

D

R

I

M

T

N

Y

D

F

T

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R

K

H

K

S

E

D

V

I

I

H

N

N

Q

I

R

V

V

L

N

D

Q

I

V

S

A

R

E

K

V

L

L

G

Q

I

L

D

A

S

H

L

L

D

D

R

R

N

K

P

P

L

K

T

A

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

S

L

V

L

F

L

L

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

binding adenosine-5'-diphosphate: S37 (= S35), G38 (= G36), G40 (= G38), K41 (= K39), S42 (≠ T40), T43 (≠ L41)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 17

P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
37% identity, 88% coverage: 25:212/214 of query aligns to 28:217/369 of P19566

query
sites
P19566

D

D

D

G

A

E

W

F

C

V

I

V

I

F

S

V

G

G

P

P

S

S

G

G

S

C

G

G

K

K

T

S

L

T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

T

D

R

I

M

T

N

Y

D

F

I

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L
|
L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R

K

H

K

S

E

D

V

I

M

H

N

N

Q

I

R

V

V

L

N

D

Q

I

V

S

A

R

E

K

V

L

L

G

Q

I

L

D

A

S

H

L

L

D

E

R

R

N

K

P

P

L

K

T

A

L

L

S

S

G

G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

R

L

V

L

F

L

L

D

D

E

E

P
|
P

A

L

S

S

A

N

L

L

D
|
D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

L86 (= L83) mutation to F: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
P160 (= P155) mutation to L: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
D165 (= D160) mutation to N: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.

Sites not aligning to the query:

306 E→K: Loss of transport. No effect on ATP-binding and ATP hydrolysis. Retains repressor activity.

P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 5 papers)
36% identity, 97% coverage: 6:212/214 of query aligns to 23:217/371 of P68187

query
sites
P68187

N

N

L

L

V

D

V

I

H

H

A

E

G

G

Q

E

F

F

E

-

L

-

V

-

I

-

D

-

S

-

F

-

T

-

L

-

P

-

D

-

A

-

W

-

C

V

I

V

I

F

S

V

G

G

P

P

S

S

G

G

S

C

G

G

K

K

T

S

L

T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

K

D

R

I

M

T

N

Y

D

F

T

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S
x
A

L

L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R
x
K

H

K

S

E

D

V

I

I

H

N

N

Q

I

R

V
|
V

L

N

D

Q

I
x
V

S

A

R
x
E

K

V

L

L

G

Q

I

L

D
x
A

S

H

L

L

D

D

R

R

N

K

P

P

L

K

T

A

L

L

S

S

G

G

G
|
G

E

Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

S

L

V

L

F

L

L

D
|
D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

A85 (≠ S82) mutation to M: Suppressor of EAA loop mutations in MalFG.
K106 (≠ R101) mutation to C: Suppressor of EAA loop mutations in MalFG.
V114 (= V109) mutation to C: Suppressor of EAA loop mutations in MalFG.
V117 (≠ I112) mutation to M: Suppressor of EAA loop mutations in MalFG.
E119 (≠ R114) mutation to K: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
A124 (≠ D119) mutation to T: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
G137 (= G132) mutation to A: Loss of maltose transport. Has greater ability to decrease mal gene expression than wild-type MalK.
D158 (= D153) mutation to N: Loss of maltose transport but retains ability to repress mal genes.

Sites not aligning to the query:

228 R→C: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
241 F→I: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
267 W→G: Normal maltose transport but constitutive mal gene expression.
278 G→P: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
282 S→L: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
284 G→S: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
302 G→D: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
308 E→Q: Maltose transport is affected but retains ability to interact with MalT.
322 S→F: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
340 G→A: Maltose transport is affected but retains ability to interact with MalT.
346 G→S: Normal maltose transport but constitutive mal gene expression.
355 F→Y: Maltose transport is affected but retains ability to interact with MalT.

1q12A Crystal structure of the atp-bound e. Coli malk (see paper)
36% identity, 97% coverage: 6:212/214 of query aligns to 20:214/367 of 1q12A

query
sites
1q12A

N

N

L

L

V

D

V

I

H

H

A

E

G

G

Q

E

F

F

E

-

L

-

V

-

I

-

D

-

S

-

F

-

T

-

L

-

P

-

D

-

A

-

W

-

C

V

I

V

I

F

S

V

G

G

P

P

S
|
S

G
|
G

S
x
C

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

K

D

R

I

M

T

N

Y

D

F

T

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q

Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R

K

H

K

S

E

D

V

I

I

H

N

N

Q

I

R

V

V

L

N

D

Q

I

V

S

A

R

E

K

V

L

L

G

Q

I

L

D

A

S

H

L

L

D

D

R
|
R

N

K

P

P

L

K

T
x
A

L

L

S
|
S

G

G

G
|
G

E
x
Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

S

L

V

L

F

L

L

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

binding adenosine-5'-triphosphate: S35 (= S35), G36 (= G36), C37 (≠ S37), G38 (= G38), K39 (= K39), S40 (≠ T40), T41 (≠ L41), R126 (= R124), A130 (≠ T128), S132 (= S130), G134 (= G132), Q135 (≠ E133)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 10

3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state (see paper)
36% identity, 97% coverage: 6:212/214 of query aligns to 22:216/371 of 3puyA

query
sites
3puyA

N

N

L

L

V

D

V

I

H

H

A

E

G

G

Q

E

F

F

E

-

L

-

V

-

I

-

D

-

S

-

F

-

T

-

L

-

P

-

D

-

A

-

W

-

C

V

I

V

I

F

S

V

G

G

P

P

S
|
S

G
|
G

S
x
C

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

K

D

R

I

M

T

N

Y

D

F

T

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q
|
Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R

K

H

K

S

E

D

V

I

I

H

N

N

Q

I

R

V

V

L

N

D

Q

I

V

S

A

R

E

K

V

L

L

G

Q

I

L

D

A

S

H

L

L

D

D

R
|
R

N

K

P

P

L

K

T
x
A

L

L

S
|
S

G

G

G
|
G

E
x
Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

S

L

V

L

F

L

L

D

D

E
|
E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H
|
H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

binding phosphoaminophosphonic acid-adenylate ester: S37 (= S35), G38 (= G36), C39 (≠ S37), G40 (= G38), K41 (= K39), S42 (≠ T40), T43 (≠ L41), Q81 (= Q79), R128 (= R124), A132 (≠ T128), S134 (= S130), G136 (= G132), Q137 (≠ E133), E158 (= E154), H191 (= H187)
binding magnesium ion: S42 (≠ T40), Q81 (= Q79)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 12

3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3 (see paper)
36% identity, 97% coverage: 6:212/214 of query aligns to 22:216/371 of 3puxA

query
sites
3puxA

N

N

L

L

V

D

V

I

H

H

A

E

G

G

Q

E

F

F

E

-

L

-

V

-

I

-

D

-

S

-

F

-

T

-

L

-

P

-

D

-

A

-

W

-

C

V

I

V

I

F

S

V

G

G

P

P

S
|
S

G
|
G

S
x
C

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

K

D

R

I

M

T

N

Y

D

F

T

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q
|
Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R

K

H

K

S

E

D

V

I

I

H

N

N

Q

I

R

V

V

L

N

D

Q

I

V

S

A

R

E

K

V

L

L

G

Q

I

L

D

A

S

H

L

L

D

D

R
|
R

N

K

P

P

L

K

T

A

L

L

S
|
S

G

G

G
|
G

E
x
Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

S

L

V

L

F

L

L

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H
|
H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

binding adenosine-5'-diphosphate: G38 (= G36), C39 (≠ S37), G40 (= G38), K41 (= K39), S42 (≠ T40), T43 (≠ L41), R128 (= R124), S134 (= S130), Q137 (≠ E133)
binding beryllium trifluoride ion: S37 (= S35), G38 (= G36), K41 (= K39), Q81 (= Q79), S134 (= S130), G136 (= G132), H191 (= H187)
binding magnesium ion: S42 (≠ T40), Q81 (= Q79)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4 (see paper)
36% identity, 97% coverage: 6:212/214 of query aligns to 22:216/371 of 3puwA

query
sites
3puwA

N

N

L

L

V

D

V

I

H

H

A

E

G

G

Q

E

F

F

E

-

L

-

V

-

I

-

D

-

S

-

F

-

T

-

L

-

P

-

D

-

A

-

W

-

C

V

I

V

I

F

S

V

G

G

P

P

S
|
S

G
|
G

S
x
C

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

K

D

R

I

M

T

N

Y

D

F

T

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q
|
Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R

K

H

K

S

E

D

V

I

I

H

N

N

Q

I

R

V

V

L

N

D

Q

I

V

S

A

R

E

K

V

L

L

G

Q

I

L

D

A

S

H

L

L

D

D

R
|
R

N

K

P

P

L

K

T
x
A

L

L

S
|
S

G
|
G

E
x
Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

S

L

V

L

F

L

L

D

D

E
|
E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H
|
H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

binding adenosine-5'-diphosphate: G38 (= G36), C39 (≠ S37), G40 (= G38), K41 (= K39), S42 (≠ T40), T43 (≠ L41), R128 (= R124), A132 (≠ T128), S134 (= S130), Q137 (≠ E133)
binding tetrafluoroaluminate ion: S37 (= S35), G38 (= G36), K41 (= K39), Q81 (= Q79), S134 (= S130), G135 (= G131), G136 (= G132), E158 (= E154), H191 (= H187)
binding magnesium ion: S42 (≠ T40), Q81 (= Q79)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 17

3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4 (see paper)
36% identity, 97% coverage: 6:212/214 of query aligns to 22:216/371 of 3puvA

query
sites
3puvA

N

N

L

L

V

D

V

I

H

H

A

E

G

G

Q

E

F

F

E

-

L

-

V

-

I

-

D

-

S

-

F

-

T

-

L

-

P

-

D

-

A

-

W

-

C

V

I

V

I

F

S

V

G

G

P

P

S

S

G
|
G

S
x
C

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

L

E

R

T

M

I

I

A

A

G

G

F

L

Y

E

Q

T

P

I

C

T

S

S

G

G

K

D

I

L

I

F

Q

I

N

G

G

E

M

K

D

R

I

M

T

N

Y

D

F

T

S

P

P

P

E

A

K

E

R

R

G

G

I

V

G

G

I

M

V

V

F

F

Q
|
Q

D

S

Y

Y

S

A

L

L

F

Y

P

P

H

H

M

L

T

S

V

V

A

A

K

E

N

N

I

M

G

S

Y

F

G

G

L

L

A

K

I

L

R

A

-

G

-

A

R

K

H

K

S

E

D

V

I

I

H

N

N

Q

I

R

V

V

L

N

D

Q

I

V

S

A

R

E

K

V

L

L

G

Q

I

L

D

A

S

H

L

L

D

D

R
|
R

N

K

P

P

L

K

T
x
A

L

L

S
|
S

G

G

E
x
Q

K

R

Q

Q

R

R

V

V

A

A

I

I

A

G

R

R

A

T

L

L

V

V

V

A

K

E

P

P

K

S

L

V

L

F

L

L

D

D

E

E

P

P

A

L

S

S

A

N

L

L

D

D

L

A

Q

A

A

L

K

R

K

V

E

Q

L

M

W

R

D

I

D

E

I

I

R

S

D

R

L

L

F

H

E

K

Q

R

G

L

G

G

L

R

T

T

I

M

I

I

H

Y

V

V

T

T

H

H

D

D

I

Q

S

V

E

E

S

A

N

M

N

T

L

L

G

A

T

D

H

K

K

I

I

V

L

V

L

L

M

D

N

A

G

G

K

R

I

V

V

A

K

Q

T

V

I

G

K

K

binding adenosine-5'-diphosphate: G38 (= G36), C39 (≠ S37), G40 (= G38), K41 (= K39), S42 (≠ T40), T43 (≠ L41), R128 (= R124), A132 (≠ T128), S134 (= S130), Q137 (≠ E133)
binding magnesium ion: S42 (≠ T40), Q81 (= Q79)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 17

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
36% identity, 87% coverage: 29:214/214 of query aligns to 31:221/241 of 4u00A

query
sites
4u00A

C

L

I

V

I

I

S

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

I

E

R

T

T

I

I

A

N

G

R

F

L

Y

E

Q

D

P

F

C

Q

S

E

G

G

K

E

I

V

Q

V

N

D

G

G

M

L

D

S

I

V

T

K

-

D

-

R

Y

A

F

L

S

R

P

E

E

I

K

R

R

R

G

E

I

V

G

G

I

M

V

V

F

F

Q

Q

D

Q

Y

F

S

N

L

L

F

F

P

P

H

H

M

M

T

T

V

V

A

L

K

E

N

N

I

V

G

T

Y

L

G

A

-

P

L

M

A

R

I

V

R

R

-

W

-

P

H

R

S

E

D

K

I

A

H

E

N

K

I

K

V

A

L

L

D

E

I

L

S

L

R

E

K

R

L

V

G

G

I

I

D

L

S

D

L

Q

L

A

D

R

R

K

N

Y

P

P

L

A

T

Q

L

L

S

S

G

G

E

Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

A

V

M

K

E

P

P

K

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

A

T

S

S

A

A

L

L

D

D

L

P

Q

E

A

M

K

V

K

G

E

E

L

V

W

L

D

D

D

V

I

M

R

R

D

D

L

L

F

-

E

A

Q

Q

G

G

L

M

T

T

I

M

I

V

H

V

V

V

T

T

H

H

D

E

I

M

S

G

E

F

S

A

N

R

N

E

L

V

G

A

T

D

H

R

K

V

I

V

L

F

L

M

M

D

N

G

G

G

K

Q

I

I

V

V

K

E

T

E

I

G

K

R

H

P

E

E

binding adenosine-5'-diphosphate: S37 (= S35), G38 (= G36), S39 (= S37), G40 (= G38), K41 (= K39), S42 (≠ T40), T43 (≠ L41)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 17

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
33% identity, 98% coverage: 1:209/214 of query aligns to 1:216/240 of 4ymuJ

query
sites
4ymuJ

M

M

I

I

A

F

I

V

S

N

N

D

L

V

V

Y

V

K

H

N

A
x
F

G

G

Q

S

F

L

E

E

L

-

V
|
V

I

L

D

K

S

G

F

V

T

T

L

L

P

K

D

V

D

N

A

K

W

G

-

E

-

V

C

V

I

V

I

I

S

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

L
x
T

F

L

L

L

E

R

T

C

I

I

A

N

G

L

F

L

Y

E

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G

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I

V

I

F

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N

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G

G

M

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I

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Y

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-

G

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K

-

V

-

N

F

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A

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|
E

P

P

A

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S

S

A

A

L

L

D

D

L

P

Q

E

A

M

K

V

K

K

E

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W

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N

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N

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|
H

D

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S

A

N

R

N

E

L

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G

G

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D

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V

I

I

L

F

L

M

M

D

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D

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K

E

binding adenosine-5'-triphosphate: F11 (≠ A11), V16 (= V17), S36 (= S35), G37 (= G36), S38 (= S37), G39 (= G38), K40 (= K39), S41 (≠ T40), T42 (≠ L41), E162 (= E154), H194 (= H187)
binding magnesium ion: S41 (≠ T40), E162 (= E154)

Query Sequence

>WP_109967750.1 NCBI__GCF_003173355.1:WP_109967750.1
MIAISNLVVHAGQFELVIDSFTLPDDAWCIISGPSGSGKTLFLETIAGFYQPCSGKIIQN
GMDITYFSPEKRGIGIVFQDYSLFPHMTVAKNIGYGLAIRRHSDIHNIVLDISRKLGIDS
LLDRNPLTLSGGEKQRVAIARALVVKPKLLLLDEPASALDLQAKKELWDDIRDLFEQGGL
TIIHVTHDISESNNLGTHKILLMNGKIVKTIKHE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory