SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_109968169.1 NCBI__GCF_003173355.1:WP_109968169.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 11 hits to proteins with known functional sites (download)

P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
21% identity, 70% coverage: 4:302/425 of query aligns to 77:377/534 of P53322

query
sites
P53322

S

S

Q

H

E

P

S

M

E

E

K

K

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A

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M

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L

Y

Y

I

F

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L

A

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F

N

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N

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L

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Y

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A

A

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-

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L

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K

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D

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Y

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K

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E

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L

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I

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A

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A

A

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Y

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L

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A

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M

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Y

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D

D

K283 (≠ S211) modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

8u3gA Structure of naag-bound sialin
24% identity, 88% coverage: 16:390/425 of query aligns to 4:386/427 of 8u3gA

query
sites
8u3gA

R

R

L

Y

H

N

I

L

I

A

P

I

F

L

A

A

L

F

L

G

Y
x
F

I

F

V

I

A

V

F
x
Y

L

A

D

L

R

R

V

V

N

N

L

L

G

S

Y

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A

A

A

L

I

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V

D

M

M

N

V

P

D

D

S

L

T

G

G

I

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S

K

-

Y

-

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-

W

-

D

A

A

E

E

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G

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I

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G

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F

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Y

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G

Y

Y

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E

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I

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P

S

G

N

G

I

Y

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A

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K

V

I

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G

A

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R

-

I

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W

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I

-

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G

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I

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M

L

I

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S

G

W

F

G

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A

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L

F

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A

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E

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|
F

P

P

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M

G

Y

I

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A

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Q

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L

A

F

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Y

H

F

F

A

S

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Y

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N

V

W

G

T

M

F

Y

Y

A

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T

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P

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S

E

F

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D

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L

F

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M

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N

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M

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S

V

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x
H

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A

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S

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Y

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-

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x
L

A

G

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I

I

T

N

N

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F

M

V

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G

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V

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A

G

K

Y

S

L

L

binding aspartic acid: F15 (≠ Y27), Y19 (≠ F31), F118 (= F124)
binding glutamic acid: S350 (= S358), H353 (≠ T361), L365 (≠ V369)

8u3hA Structure of fmoc-leu-oh bound sialin
24% identity, 88% coverage: 16:390/425 of query aligns to 4:384/425 of 8u3hA

query
sites
8u3hA

R

R

L

Y

H

N

I

L

I

A

P

I

F

L

A

A

L

F

L

G

Y

F

I

F

V

I

A

V

F
x
Y

L

A

D

L

R

R

V

V

N

N

L

L

G

S

Y

V

A

A

A

L

I

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V

D

M

M

-

V

-

D

N

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P

K

D

K

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Y

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D

A

A

E

E

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T

F

Q

G

G

F

W

I

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G

G

I

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F

F

I

Y

G

G

Y

Y

L

I

I

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F

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E

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I

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P

S

G

N

G

I

Y

I

V

M

A

Q

S

K

K

V

I

G

G

A

-

R

-

I

-

W

-

I

-

G

G

R

K

I

M

M

L

I

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G

W

F

G

G

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I

V

L

-

G

-

T

A

A

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L

M

T

G

L

F

F

V

T

Q

P

S

I

P

A

E

A

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D

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L

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V

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G

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P

L

L

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I

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R

F

A

L

L

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E

G

G

I

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A

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E

E

A

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F

F

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G

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E

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N

T

I

V

I

I

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A

L

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P

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L

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M

G

Y

I

I

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C

D

Y

T

Y

V

M

N

N

W

-

G

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S

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-

A

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-

W

W

R

T

W

Y

L

V

F

F

I

Y

I

F

E

F

G

G

I

T

P

I

A

G

I

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L

F

F

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G

F

V

L

L

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W

L

I

F

W

I

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V

K

S

N

D

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P

P

A

Q

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K

A

H

G

K

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Y

Q

E

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K

Q

E

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Y

L

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L

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N

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Q

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K

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G

V

D

P

I

I

L

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T

K

D

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T

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V

L

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W

L

A

F

I

S

V

G

V

T

A

Y
x
H

F

F

A

S

V
x
Y

T

N

V

W

G

T

M

F

Y
|
Y

A

T

I

L

F

T

F

L

L

L

P

P

T

T

L

Y

S

M

S

K

S

E

F

I

L

L

H

R

D

-

L

F

D

N

M

V

R

Q

V

E

I

N

G

G

L

F

I

L

L

S

M

S

I

L

P

P

Y

Y

I

L

V

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T

S

L

W

I

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C

C

M
|
M

F

I

L

L

V

S

S

G

S

Q

H

A

S

A

D

D

-

N

L

L

R

R

G

A

E

K

R

W

L

N

Y

F

H

S

I

T

I

L

-

C

-

V

-

R

I

I

L

F

F

S

F

L

I

I

A

G

G

M

A

I

G

G

L

P

T

A

L

V

D

F

Q

L

L

V

A

A

E

A

D

G

P

F

I

I

L

G

S

C

L

D

L

Y

G

S

I

L

T

A

I

V

A

A

L

F

S

L

G

T

I

I

L

S

S

T

I

T

I

L

G

G

P

G

F

F

W

C

S
|
S

Y

S

V

G

L

F

S

S

V

I

F

N

T

H

P

L

D

D

E

I

Q

A

P

P

-

S

-

Y

-

A

-

G

V

I

G

L

V

L

A

G

V

I

I

T

N

N

S

T

I

F

G

A

N

T

L

I

G

P

G

G

F

M

V

V

G

G

P

P

V

V

I

I

T

A

G

K

Y

S

L

L

binding leucine: M279 (= M294), S344 (= S354)
binding Fluorenylmethyloxycarbonyl chloride: Y19 (≠ F31), H235 (≠ Y249), Y238 (≠ V252), Y243 (= Y257)

P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see paper)
21% identity, 91% coverage: 3:390/425 of query aligns to 7:395/430 of P0AA76

query
sites
P0AA76

V

A

S

A

Q

K

E

P

S

G

E

R

K

R

R

R

I

Y

I

L

S

T

L

L

I

V

R

M

L

I

H

F

I

I

I

T

P

-

F

-

A

-

L

-

Y

V

I

V

V

I

A

C

F
x
Y

L

V

D
|
D

R
|
R

V

A

N

N

L

L

G

A

Y

V

A

A

A

S

I

A

V

H

M

I

N

Q

P

E

D

E

L

F

G

G

I

I

S

T

A

K

E

A

L

E

F

M

G

G

F

Y

I

V

S

F

G

S

I

A

F

F

F

A

I

W

G

L

Y
|
Y

L

T

I

L

F

C

E

Q

V

I

P

P

S

G

N

G

I

W

I

F

M

L

Q

D

K

R

V

V

G

G

A

S

R

R

I

V

W

T

I

Y

G

F

R

I

I

A

M

I

I

F

S

G

W

W

G

S

L

V

V

A

A

T

V

L

L

F

M

Q

G

G

F

F

V

A

Q

T

S

G

P

L

E

M

H

S

L

L

I

I

I

G

L

L

R

R

F

A

L

I

L

T

G

G

I

I

A

F

E
|
E

A

A

G

P

F

A

F

F

P

P

G

T

M

N

I

N

W

R

Y

M

L

V

G

T

T

S

W

W

F

F

P

P

H

E

R

H

Y

E

L

R

A

A

R

S

S

A

I

V

A

G

L

F

F

Y

S

T

T

S

A

G

I

Q

V

F

I

V

S

G

N

L

I

A

I

F

G

L

A

T

P

P

L

L

S

L

M

I

Y

W

I

I

L

Q

D

E

T

M

V

L

N

-

W

-

G

-

S

-

V

-

A

-

S

S

W

W

R

H

W

W

L

V

F

F

I

I

I

V

E

T

G

G

I

G

P

I

A

G

I

I

L

I

F

W

G

S

V

L

L

I

S

-

L

W

F

F

I

K

L

V

K

Y

N

Q

R

P

P

P

A

R

D

L

A

T

G

K

W

G

L

I

D

S

S

K

D

A

Q

E

K

L

Q

D

W

Y

L

I

V

R

S

D

-

G

E

G

L

L

E

V

S

D

G

G

T

D

I

A

R

P

M

V

K

K

S

K

H

E

R

A

L

R

G

Q

D

P

I

L

L

T

T

A

D

K

T

D

R

W

V

K

L

L

L

V

F

F

S

H

G

R

T

K

Y

L

F

I

A

G

V

V

T

Y

V

L

G

G

M

Q

Y

F

A

A

I

V

I

A

-

S

-

T

-

L

-

W

F

F

L

L

P

T

T

W

L

F

S

P

S

N

S

Y

F

L

L

T

H

Q

D

E

L

K

D

G

M

I

R

T

V

A

I

L

-

K

-

A

G

G

L

F

I

M

L

T

M

T

I

V

P

P

Y

F

I

L

V

A

T

A

L

F

I

V

C

G

M

V

F

L

L

L

V

S

S

G

S

W

H

V

S

A

D

D

L

L

R

L

G

V

E

R

R

K

L

G

Y

F

H

S

-

L

-

G

-

F

-

A

-

R

-

K

-

T

-

P

-

I

-

C

-

G

I

L

I

I

L

S

F

T

F

C

I

I

A

M

G

G

A

A

G

N

L

Y

T

T

L

N

D

D

Q

P

L

M

A

M

E

-

D

-

P

-

I

I

L

M

S

C

L

L

L

M

G

A

I

L

T

A

I

F

A

F

L

G

S

N

G

G

I

F

L

A

S

S

I

I

I

T

G

-

P

-

F

-

W
|
W

S

S

Y

L

V

V

L

S

S

S

V

L

F

A

T

P

P

M

D

R

E

L

Q

I

P

G

V

L

G

T

V

G

A

G

V

V

I

F

N

N

S

F

I

A

G

G

N

G

L

L

G

G

F

I

V

T

G

V

P

P

V

L

I

V

T

V

G

G

Y

Y

L

L

Y29 (≠ F31) binding D-galactonate
D31 (= D33) mutation to N: Loss of galactonate transport activity.
R32 (= R34) binding D-galactonate
Y64 (= Y66) binding D-galactonate
E118 (= E120) mutation to Q: Loss of galactonate transport activity.
W358 (= W353) binding D-galactonate

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form (see paper)
21% identity, 91% coverage: 5:390/425 of query aligns to 1:360/393 of 6e9oA

query
sites
6e9oA

Q

K

E

P

S

G

E

R

K

R

R

R

I

Y

I

L

S

T

L

L

I

V

R

M

L

I

H

F

I

I

I

T

P

-

F

-

A

-

L

-

Y

V

I

V

V

I

A

C

F
x
Y

L

V

D

D

R

R

V

A

N

N

L

L

G

A

Y

V

A

A

A

S

I

A

V

H

M

I

N

Q

P

E

D

E

L

F

G

G

I

I

S

T

A

K

E

A

L

E

F

M

G

G

F

Y

I

V

S

F

G

S

I

A

F

F

F

A

I

W

G

L

Y

Y

L

T

I

L

F

C

E

Q

V

I

P

P

S

G

N

G

I

W

I

F

M

L

Q

D

K

R

V

V

G

G

A

S

R

R

I

V

W

T

I

Y

G

F

R

I

I

A

M

I

I

F

S

G

W

W

G

S

L

V

V

A

A

T

V

L

L

F

M

Q

G

G

F

F

V

A

Q

T

S

G

P

L

E

M

H

S

L

L

I

I

I

G

L

L

R

R

F

A

L

I

L

T

G

G

I

I

A

F

E

Q

A

A

G

P

F

A

F
|
F

P

P

G

T

M

N

I

N

W

R

Y

M

L

V

G

T

T

S

W

W

F

F

P

P

H

E

R

H

Y

E

L

R

A

A

R

S

S

A

I

V

A

G

L

F

F

Y

S

T

T

S

A

G

I
x
Q

V

F

I

V

S

G

N

L

I

A

I

F

G

L

A

T

P

P

L

L

S

L

M

I

Y

W

I

I

L

Q

D

E

T

M

V

L

N

-

W

-

G

-

S

-

V

-

A

-

S

S

W

W

R

H

W

W

L

V

F

F

I

I

I

V

E

T

G

G

I

G

P

I

A

G

I

I

L

I

F

W

G

S

V

L

L

I

S

-

L

-

F

-

I

-

L

-

K

-

N

-

R

-

P

-

A

-

D

-

A

-

G

-

W

W

L

F

D

K

S

V

D

Y

Q

Q

K

P

Q

P

W

R

L

L

V

T

S

K

E

G

L

I

E

S

S

K

G

A

T

E

I

L

R

D

M

Y

K

I

S

R

H

D

R

G

L

G

G

G

D

L

I

V

L

L

T

T

D

A

T

K

R

D

-

W

V

K

L

L

L

V

F

F

S

H

G

R

T

K

Y

L

F

I

A

G

V

V

T

Y

V

L

G

G

M
x
Q

Y

F

A

A

I

V

-

A

-

S

-

T

I

L

F

W

F

F

L

F

P

L

T

T

L

L

S

K

S

A

S

G

F

F

L

M

H

T

D

T

L

-

D

-

M

-

R

-

V

-

I

-

G

-

L

-

I

-

L

-

M

-

I

V

P

P

Y

F

I

L

V

A

T

A

L

F

I

V

C

G

M

V

F

L

L

L

V

S

S

G

S

W

H

V

S

A

D

D

L

L

R

L

G

V

E

R

R

K

L

G

Y

F

H

S

I

L

-

G

-

F

-

A

-

R

-

K

-

T

-

P

I

I

L

C

F

G

F

L

I

L

A

I

G

S

A

T

G

C

L

I

T

M

L

G

D

A

Q

N

L

Y

A

T

E

N

D

D

P

P

-

M

I

I

L

M

S

C

L

L

L

M

G

A

I

L

T

A

I

F

A

F

L

G

S

N

G

G

I

F

L

A

S
|
S

I

I

I

T

G

-

P

-

F

-

W

W

S

S

Y

L

V

V

L

S

S

S

V

L

F

A

T

P

P

M

D

R

E

L

Q

I

P

G

V

L

G

T

V

G

A

G

V

V

I

F

N
|
N

S

F

I

A

G

G

N

G

L

L

G

G

F

I

V

T

G

V

P

P

V

L

I

V

T

V

G

G

Y

Y

L

L

binding D-galactonic acid: Y21 (≠ F31), F114 (= F124), Q141 (≠ I151), Q228 (≠ M256), S320 (= S347), N343 (= N373)

Q9C0U9 Uncharacterized transporter PB1C11.03 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
25% identity, 65% coverage: 25:301/425 of query aligns to 102:393/570 of Q9C0U9

query
sites
Q9C0U9

L

L

Y

L

I

M

V

L

A

G

F

F

L

L

D

D

-

M

-

L

-

F

-

I

-

G

R

K

V

A

N

T

L

L

G

S

Y

Y

A

S

A

T

I

I

V

L

-

G

M

L

N

F

P

D

D

D

L

V

G

H

I

I

S

T

A

S

E

N

L

Q

F

Y

G

N

F

N

I

L

S

N

G

T

I

L

F

F

F

Y

I

V

G

G

Y

Y

L

I

I

V

F

G

E

Q

V

F

P

P

S

G

N

H

I

Y

I

I

M

M

Q

Q

K

T

V

F

G

P

A

L

R

G

I

K

W

F

I

V

G

G

R

L

I

V

M

T

I

F

S

S

W

W

G

S

L

V

V

I

A

V

V

F

L

L

M

H

G

C

F

C

V

A

Q

Y

S

N

P

Y

E

G

H

G

L

L

I

I

I

A

L

L

R

R

F

F

L

F

L

L

G

G

I

F

A

T

E

E

A

S

G

C

F

L

P

P

G

A

M

M

I

E

W

A

Y

T

L

M

G

G

T

M

W

F

F

F

P

T

H

H

R

Q

Y

E

L

Q

A

A

R

F

S

L

I

Q

A

P

L

V

F

F

S

W

T

I

A

S

I

-

V

C

I

L

S

S

N

C

I

G

I

I

G

P

A

A

P

G

L

F

S

I

M

A

Y

Y

I

G

L

L

D

E

T

F

V

V

N

T

W

-

G

K

S

S

V

I

A

A

S

P

W

W

R

K

W

L

L

F

F

M

I

I

E

T

G

G

I

G

P

I

A

T

I

F

L

F

F

L

G

S

V

I

L

F

S

L

L

F

F

F

I

Y

L

Y

K

P

N

D

R

N

P

P

A

S

D

K

A

A

G

R

W

F

L

L

D

T

S

D

D

E

Q

E

K

K

Q

L

W

Y

L

T

V

I

S

D

E

R

L

V

E

R

S

K

G

S

T

T

I

R

R

G

-

G

-

I

-

E

-

N

-

K

-

I

M

F

K

K

S

K

H

H

R

Q

L

F

G

I

D

E

I

A

L

L

T

K

D

D

T

P

R

I

V

T

L

W

L

L

F

F

S

-

G

-

T

T

Y

F

F

A

A

A

V

F

T

T

V

L

G

M

M

L

Y

S

A

N

I

N

I

L

F

A

F

Y

L

Q

P

Q

T

N

L

L

-

I

-

F

S

T

S

S

S

L

F

N

L

V

H

S

D

D

L

L

D

N

M

S

R

T

V

L

I

V

G

G

L

V

I

A

L

L

-

A

-

G

-

Y

-

N

M

T

I

V

P

S

Y

A

I

I

V

I

T

A

L

T

I

F

C

A

M

M

F

Y

L

L

V

I

S

P

S

N

H

Q

S

S

Sites not aligning to the query:

14 modified: Phosphoserine

6e9nA E. Coli d-galactonate:proton symporter in the inward open form (see paper)
22% identity, 90% coverage: 8:390/425 of query aligns to 1:376/409 of 6e9nA

query
sites
6e9nA

E

R

K

R

R

R

I

Y

I

L

S

T

L

L

I

V

R

M

L

I

H

F

I

I

I

T

P

-

F

-

A

-

L

-

Y

V

I

V

V

I

A

C

F

Y

L

V

D

D

R

R

V

A

N

N

L

L

G

A

Y

V

A

A

A

S

I

A

V

H

M

I

N

Q

P

E

D

E

L

F

G

G

I

I

S

T

A

K

E

A

L

E

F

M

G

G

F

Y

I

V

S

F

G

S

I

A

F

F

F

A

I

W

G

L

Y

Y

L

T

I

L

F

C

E

Q

V

I

P

P

S

G

N

G

I

W

I

F

M

L

Q

D

K

R

V

V

G

G

A

S

R

R

I

V

W

T

I

Y

G

F

R

I

I

A

M

I

I

F

S

G

W

W

G

S

L

V

V

A

A

T

V

L

L

F

M

Q

G

G

F

F

V

A

Q

T

S

G

P

L

E

M

H

S

L

L

I

I

I

G

L

L

R

R

F

A

L

I

L

T

G

G

I

I

A

F

E

E

A

A

G

P

F

A

F
|
F

P

P

G

T

M

N

I

N

W

R

Y

M

L

V

G

T

T

S

W

W

F

F

P

P

H

E

R

H

Y

E

L

R

A

A

R

S

S

A

I

V

A

G

L

F

F

Y

S

T

T

S

A

G

I

Q

V

F

I

V

S

G

N

L

I

A

I

F

G

L

A

T

P

P

L

L

S

L

M

I

Y

W

I

I

L

Q

D

E

T

M

V

L

N

-

W

-

G

-

S

-

V

-

A

-

S

S

W

W

R

H

W

W

L

V

F

F

I

I

I

V

E

T

G

G

I

G

P

I

A

G

I

I

L

I

F

W

G

S

V

L

L

I

S

W

L

F

F

K

I

V

L

Y

K

Q

N

P

R

P

P

R

A

L

D

T

A

K

G

G

W

-

L

-

D

-

S

-

D

-

Q

-

K

-

Q

-

W

-

L

-

V

I

S

S

E

K

L

A

E

E

S

L

G

D

T

Y

I

I

R

R

M

D

K

G

S

G

H

G

R

L

L

V

-

D

G

G

D

D

-

A

-

P

I

L

L

T

T

A

D

K

T

D

R

W

V

K

L

L

L

V

F

F

S

H

G

R

T

K

Y

L

F

I

A

G

V

V

T

Y

V

L

G

G

M

Q

Y

F

A

A

I

V

I

A

-

S

-

T

-

L

-

W

F

F

L

L

P

T

T

W

L

F

S

P

S

N

S

Y

F

L

L

T

H

Q

D

E

L

K

D

G

M

I

R

T

V

A

I

L

-

K

-

A

G

G

L

F

I

M

L

T

M

T

I

V

P

P

Y

F

I

L

V

A

T

A

L

F

I

V

C

G

M

V

F

L

L

L

V

S

S

G

S

W

H

V

S

A

D

D

L

L

R

L

G

V

E

R

R

K

L

G

Y

F

H

S

-

L

-

G

-

F

-

A

-

R

-

K

-

T

-

P

-

I

-

C

-

G

I

L

I

I

L

S

F

T

F

C

I

I

A

M

G

G

A

A

G

N

L

Y

T

T

L

N

D

D

Q

P

L

M

A

M

E

-

D

-

P

-

I

I

L

M

S

C

L

L

L

M

G

A

I

L

T

A

I

F

A

F

L

G

S

N

G

G

I

F

L

A

S

S

I

I

I

T

G

-

P

-

F

-

W

W

S

S

Y

L

V

V

L

S

S

S

V

L

F

A

T

P

P

M

D

R

E

L

Q

I

P

G

V

L

G

T

V

G

A

G

V

V

I

F

N
|
N

S

F

I

A

G

G

N

G

L

L

G

G

F

I

V

T

G

V

P

P

V

L

I

V

T

V

G

G

Y

Y

L

L

binding D-gluconic acid: F111 (= F124), N359 (= N373)

Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 8 papers)
24% identity, 80% coverage: 51:390/425 of query aligns to 104:447/495 of Q9NRA2

query
sites
Q9NRA2

S

D

A

A

E

E

L

T

F

Q

G

G

F

W

I

I

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G

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F

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Y

G

G

Y

Y

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I

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P

S

G

N

G

I

Y

I

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A

Q

S

K

K

V

I

G

G

A

-

R

-

I

-

W

-

I

-

G

G

R
x
K

I

M

M

L

I

L

S

G

W

F

G

G

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-

L

-

G

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A

A

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A

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x
H

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A

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P

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P

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x
L

I
x
L

A

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T

A

A

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I

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Q

I

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P

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L

S

S

M

G

Y

I

I

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C

D

Y

T

Y

V

M

N

N

W

-

G

-

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-

A

-

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-

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x
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x
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S

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|
L

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x
N

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P

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M

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-

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-

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x
G

G

M

A

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Q

L

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A

A

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C

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A

A

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S

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I

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S

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T

I

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P

G

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C

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G

L

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S

S

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I

F

N

T

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P

L

D

D

E

I

Q

A

P

P

-

S

-

Y

-

A

-

G

V

I

G

L

V

L

A

G

V

I

I

T

N

N

S

T

I

F

G

A

N

T

L

I

G

P

G

G

F

M

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V

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G

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P

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V

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A

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K

Y

S

L

L

K136 (≠ R88) to E: in SD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transporter activity, but retains appreciable H(+)-coupled sialic acid transporter activity; dbSNP:rs80338795
H183 (≠ I128) to R: in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity; dbSNP:rs119491109
LL 198:199 (≠ SI 143:144) mutation to AA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
IL 266:267 (≠ LV 217:218) mutation to LA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
SSLRN 268:272 (≠ SELES 219:223) natural variant: Missing (in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity)
G328 (= G280) to E: in ISSD; some patients may manifest a milder phenotype consistent with Salla disease; markedly decreases H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs386833996
P334 (= P286) to R: in ISSD; does not affect intracellular localization, targeted to lysosomes; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs119491110
G371 (≠ A318) to V: in ISSD; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs777862172

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane.; LL→GG: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R → C: in SD; frequent variant in Finland; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transport activity, but retains appreciable H(+)-coupled sialic acid and nitrate transporter activity; dbSNP:rs80338794

Q8BN82 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Mus musculus (Mouse) (see paper)
24% identity, 80% coverage: 52:390/425 of query aligns to 105:447/495 of Q8BN82

query
sites
Q8BN82

A

A

E

E

L

T

F

Q

G

G

F

W

I

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S

L

G

G

I

S

F

F

I

Y

G

G

Y

Y

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Q

V

I

P

P

S

G

N

G

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I

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A

Q

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K

R

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V

-

G

-

K

-

L

G

G

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G

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L

A

A

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A

L

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M

L

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-

P

-

E

-

H

-

L

L

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L

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R

F

A

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L

L

E

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G

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L

A

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E

A

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A

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M

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x
H

W

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N

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A

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I

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F

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A

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P

L

D

D

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A

P

P

-

S

-

Y

-

A

-

G

V

I

G

L

V

L

A

G

V

I

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N

N

S

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L

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L

H183 (≠ I128) mutation to R: Abolishes sialic acid transporter activity. Does not affect L-aspartate and L-glutamate transporter activity.

Sites not aligning to the query:

39 R→C: Completely abolishes L-aspartate and L-glutamate transporter activity. Retains appreciable H(+)-coupled sialic acid transporter activity.

Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
23% identity, 80% coverage: 51:390/425 of query aligns to 104:447/495 of Q5Q0U0

query
sites
Q5Q0U0

S

D

A

A

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E

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x
K

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G

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G

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-

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L

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R

F

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x
E

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G

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E

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x
G

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P

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x
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S

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x
S

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L

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x
K

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x
N

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|
P

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-

Y

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x
G

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A

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A

A

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I

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N

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D

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A

P

P

-

S

-

Y

-

A

-

G

V

I

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V

L

A

G

V

I

I

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N

N

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K

Y

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L

L

K136 (≠ R83) mutation to E: Markedly decreases H(+)-coupled sialic acid transporter activity.
R168 (= R113) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
E171 (≠ L116) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-175.
G172 (= G117) mutation to C: Decreases protein levels and alters subcellular localization.
E175 (= E120) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-171.
G176 (≠ A121) mutation to C: Decreases protein levels and alters subcellular localization.
F179 (= F124) mutation to C: Decreases the affinity and transport rate for D-glucuronate. Does not affect H(+)-coupled sialic acid transporter activity.
P180 (= P125) mutation to C: Decreases protein levels and alters subcellular localization.
H183 (≠ I128) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.
W186 (≠ L131) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
SSLKN 268:272 (≠ SELES 219:223) mutation Missing: Abolishes H(+)-coupled sialic acid transporter activity.
P334 (= P286) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.
G371 (≠ A318) mutation to V: Remains in the endoplasmic reticulum.

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R→C: Markedly decreases H(+)-coupled sialic acid transporter activity.

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans (see paper)
21% identity, 67% coverage: 7:289/425 of query aligns to 6:319/493 of Q03567

query
sites
Q03567

S

T

E

K

K

P

R

R

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A

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A

M

L

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C

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V

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Y

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D

M

R

R

V

T

N

N

L

M

G

S

Y

F

A

A

A

V

I

V

V

C

M

M

-

V

-

N

-

E

-

N

N

K

P

T

D

D

L

T

G

G

I

V

S

E

A

K

-

V

-

S

-

R

-

C

-

G

-

K

-

E

-

M

-

T

-

P

-

V

-

E

-

S

-
x
N

-

S

-

V

-

I

-

G

-

E

-

F

-

D

-

W

-

D

-

K

E

Q

L

T

F

T

G

G

F

M

I

V

S

L

G

S

I

S

F

F

I

Y

G

G

Y

Y

L

I

I

G

F

S

E

Q

V

I

P

I

S

G

N

G

I

H

I

L

M

A

Q

S

K

R

V

Y

G

G

A

G

R

K

I

R

W

V

I

V

G

F

R

V

I

T

M

I

I

L

S

G

W

S

G

A

L

L

V

L

A

T

V

L

L

L

-

N

-

P

M

V

G

A

F

A

V

R

Q

T

S

S

P

E

E

Y

H

A

L

L

I

A

I

I

L

L

R

R

F

A

L

A

L

I

G

G

I

F

A

L

E

Q

A

G

G

A

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T

F

F

P

P

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M

M

I

H

W

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Y

M

L

W

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V

W

W

F

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P

H

P

R

L

Y

E

L

L

A

S

R

V

S

L

I

T

A

G

L

V

F

T

S

Y

T

A

A

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I

A

V

Q

I

I

S

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N

N

I

V

I

I

G

V

A

L

P

P

L

L

S

S

M

G

Y

F

I

L

L

C

D

E

T

-

V

-

N

-

W

Y

G

G

S

F

V

D

A

G

S

G

W

W

R

P

W

S

L

I

F

F

I

Y

I

I

E

I

G

G

I

V

P

F

A

G

I

V

L

L

F

W

G

T

V

A

L

V

S

W

L

W

F

Y

I

V

L

S

K

S

N

D

R

K

P

P

A

A

D

T

A

H

G

P

W

R

L

I

D

T

S

P

D

E

Q

E

K

K

Q

Q

W

Y

L

I

V

V

S

T

E

A

L

V

E

E

S

A

G

S

-

M

-

G

-

K

-

D

T

T

I

G

R

K

M

V

K

P

S

S

H

T

R

P

L

W

G

I

D

K

I

I

L

L

T

T

D

S

T

P

R

A

V

V

L

W

L

A

F

C

S

W

G

A

T

G

Y

H

F

F

A

A

V

G

T

D

V

W

G

G

M

A

Y

Y

A

T

I

M

I

L

F

V

F

S

L

L

P

P

T

-

L

-

S

-

S

S

F

F

L

L

H

K

D

D

-

V

-

L

-

G

L

L

D

N

M

L

R

S

V

S

I

L

G

G

L

A

I

V

L

A

M

S

I

I

P

P

Y

Y

I

I

V

A

N69 (vs. gap) modified: carbohydrate, N-linked (GlcNAc...) asparagine

Query Sequence

>WP_109968169.1 NCBI__GCF_003173355.1:WP_109968169.1
MLVSQESEKRIISLIRLHIIPFALLLYIVAFLDRVNLGYAAIVMNPDLGISAELFGFISG
IFFIGYLIFEVPSNIIMQKVGARIWIGRIMISWGLVAVLMGFVQSPEHLIILRFLLGIAE
AGFFPGMIWYLGTWFPHRYLARSIALFSTAIVISNIIGAPLSMYILDTVNWGSVASWRWL
FIIEGIPAILFGVLSLFILKNRPADAGWLDSDQKQWLVSELESGTIRMKSHRLGDILTDT
RVLLFSGTYFAVTVGMYAIIFFLPTLSSSFLHDLDMRVIGLILMIPYIVTLICMFLVSSH
SDLRGERLYHIIILFFIAGAGLTLDQLAEDPILSLLGITIALSGILSIIGPFWSYVLSVF
TPDEQPVGVAVINSIGNLGGFVGPVITGYLISLFKTLDSGWPVITFILCLGAVMIFMAGK
KGIRM

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory