SitesBLAST
Comparing WP_110206665.1 NCBI__GCF_003194585.1:WP_110206665.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8p84B X-ray structure of thermoanaerobacterales bacterium monoamine oxidase (see paper)
38% identity, 90% coverage: 48:496/500 of query aligns to 3:445/450 of 8p84B
- binding flavin-adenine dinucleotide: V9 (= V54), G10 (= G55), G12 (= G57), A14 (≠ S59), E33 (= E78), A34 (= A79), R35 (= R80), G40 (= G85), R41 (= R86), T42 (≠ L87), G56 (= G102), Q57 (≠ A103), W58 (≠ F104), V234 (= V285), V262 (≠ A313), W383 (= W434), W388 (= W439), C392 (≠ G443), Y393 (≠ P444), G420 (= G471), T421 (= T472), G429 (= G480), Y430 (= Y481), I431 (≠ M482), A434 (= A485)
- binding magnesium ion: E125 (≠ A170), H188 (≠ R240)
1o5wC The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase a (see paper)
34% identity, 89% coverage: 50:496/500 of query aligns to 6:450/512 of 1o5wC
- active site: G62 (= G106), R197 (= R247), K296 (= K345)
- binding flavin-adenine dinucleotide: I10 (≠ V54), G13 (= G57), S15 (= S59), E34 (= E78), A35 (= A79), R36 (= R80), G41 (= G85), R42 (= R86), G57 (= G101), G58 (= G102), A59 (= A103), Y60 (≠ F104), P234 (≠ A284), V235 (= V285), I264 (≠ A313), W388 (= W434), Y393 (≠ W439), C397 (≠ G443), Y398 (≠ P444), G425 (= G471), T426 (= T472), G434 (= G480), Y435 (= Y481), M436 (= M482)
- binding n-[3-(2,4-dichlorophenoxy)propyl]-n-methyl-n-prop-2-ynylamine: I171 (≠ P215), F199 (≠ S249), Q206 (= Q256), C314 (≠ F363), I316 (= I365), I326 (≠ A373), T327 (≠ A374), Y398 (≠ P444), Y435 (= Y481)
3zyxA Crystal structure of human monoamine oxidase b in complex with methylene blue and bearing the double mutation i199a-y326a (see paper)
34% identity, 90% coverage: 48:496/500 of query aligns to 2:448/499 of 3zyxA
- active site: G60 (= G106), R195 (= R247), K294 (= K345)
- binding flavin-adenine dinucleotide: G9 (= G55), G11 (= G57), S13 (= S59), L31 (≠ V77), E32 (= E78), A33 (= A79), R34 (= R80), G39 (= G85), R40 (= R86), G55 (= G101), G56 (= G102), S57 (≠ A103), Y58 (≠ F104), P232 (≠ A284), V233 (= V285), I262 (≠ A313), W386 (= W434), Y391 (≠ W439), C395 (≠ G443), Y396 (≠ P444), G423 (= G471), T424 (= T472), G432 (= G480), Y433 (= Y481), M434 (= M482), A437 (= A485)
- binding 3,7-bis(dimethylamino)phenothiazin-5-ium: L169 (≠ P215), A197 (≠ S249), Q204 (= Q256), T312 (≠ F363), I314 (= I365), F341 (= F390), Y396 (≠ P444)
P56560 Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B; EC 1.4.3.21; EC 1.4.3.4 from Bos taurus (Bovine) (see paper)
35% identity, 90% coverage: 45:496/500 of query aligns to 1:450/520 of P56560
- M1 (≠ L45) modified: Initiator methionine, Removed
- S2 (≠ P46) modified: N-acetylserine
7b0zA Crystal structure of human monoamine oxidase b in complex with (e)-3- phenyl-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one (see paper)
34% identity, 90% coverage: 48:496/500 of query aligns to 3:449/498 of 7b0zA
- binding n-dodecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate: D152 (≠ R196), W156 (≠ I200)
- binding flavin-adenine dinucleotide: V9 (= V54), G10 (= G55), G12 (= G57), S14 (= S59), L32 (≠ V77), E33 (= E78), A34 (= A79), R35 (= R80), G40 (= G85), R41 (= R86), G56 (= G101), G57 (= G102), S58 (≠ A103), Y59 (≠ F104), P233 (≠ A284), V234 (= V285), I263 (≠ A313), W387 (= W434), Y392 (≠ W439), C396 (≠ G443), Y397 (≠ P444), G424 (= G471), T425 (= T472), G433 (= G480), Y434 (= Y481), M435 (= M482)
- binding (E)-3-phenyl-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one: Y59 (≠ F104), L170 (≠ P215), C171 (≠ T216), I198 (≠ S249), Q205 (= Q256), I315 (= I365), Y325 (≠ F375), Y397 (≠ P444), Y434 (= Y481)
7b0vA Crystal structure of human monoamine oxidase b in complex with (e)-3- phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one (see paper)
34% identity, 90% coverage: 48:496/500 of query aligns to 3:449/498 of 7b0vA
- binding n-dodecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate: D152 (≠ R196), K153 (≠ R197), W156 (≠ I200)
- binding flavin-adenine dinucleotide: V9 (= V54), G10 (= G55), G12 (= G57), S14 (= S59), L32 (≠ V77), E33 (= E78), A34 (= A79), R35 (= R80), G40 (= G85), R41 (= R86), G56 (= G101), G57 (= G102), S58 (≠ A103), Y59 (≠ F104), V234 (= V285), I263 (≠ A313), W387 (= W434), Y392 (≠ W439), C396 (≠ G443), Y397 (≠ P444), G424 (= G471), T425 (= T472), G433 (= G480), Y434 (= Y481), M435 (= M482)
- binding (E)-3-phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one: W118 (≠ L162), F167 (≠ W212), L170 (≠ P215), C171 (≠ T216), I198 (≠ S249), Q205 (= Q256), I315 (= I365), Y325 (≠ F375)
7p4hA Crystal structure of monoamine oxidase b in complex with inhibitor (+)-2 (see paper)
34% identity, 90% coverage: 48:496/500 of query aligns to 2:448/499 of 7p4hA
- binding 3,4-dimethyl-7-[[(3~{S})-piperidin-3-yl]methoxy]chromen-2-one: Y58 (≠ F104), L169 (≠ P215), C170 (≠ T216), I197 (≠ S249), Q204 (= Q256), Y324 (≠ A373)
- binding flavin-adenine dinucleotide: G9 (= G55), G11 (= G57), S13 (= S59), L31 (≠ V77), E32 (= E78), A33 (= A79), R34 (= R80), G39 (= G85), R40 (= R86), G55 (= G101), G56 (= G102), S57 (≠ A103), Y58 (≠ F104), P232 (≠ A284), V233 (= V285), I262 (≠ A313), W386 (= W434), Y391 (≠ W439), C395 (≠ G443), Y396 (≠ P444), G423 (= G471), T424 (= T472), G432 (= G480), Y433 (= Y481), M434 (= M482)
7p4fA Crystal structure of monoamine oxidase b in complex with inhibitor 1 (see paper)
34% identity, 90% coverage: 48:496/500 of query aligns to 2:448/499 of 7p4fA
- binding 4-(hydroxymethyl)-7-[[4-[[methyl-(phenylmethyl)amino]methyl]phenyl]methoxy]chromen-2-one: Y58 (≠ F104), F101 (≠ I148), W117 (≠ L162), L162 (= L208), F166 (≠ W212), L169 (≠ P215), I197 (≠ S249), Q204 (= Q256), Y324 (≠ A373), F341 (= F390), Y396 (≠ P444), Y433 (= Y481)
- binding n-dodecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate: D151 (≠ R196), K152 (≠ R197), W155 (≠ I200)
- binding flavin-adenine dinucleotide: G9 (= G55), G11 (= G57), S13 (= S59), E32 (= E78), A33 (= A79), R34 (= R80), G39 (= G85), R40 (= R86), T41 (≠ L87), G55 (= G101), G56 (= G102), S57 (≠ A103), Y58 (≠ F104), P232 (≠ A284), V233 (= V285), I262 (≠ A313), W386 (= W434), Y391 (≠ W439), C395 (≠ G443), Y396 (≠ P444), G423 (= G471), T424 (= T472), G432 (= G480), Y433 (= Y481), M434 (= M482)
6rleA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 97 (see paper)
34% identity, 90% coverage: 48:496/500 of query aligns to 2:448/499 of 6rleA
- active site: G60 (= G106), R195 (= R247), K294 (= K345)
- binding n-dodecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate: D151 (≠ R196), W155 (≠ I200)
- binding flavin-adenine dinucleotide: V8 (= V54), G9 (= G55), G11 (= G57), S13 (= S59), E32 (= E78), A33 (= A79), R34 (= R80), G39 (= G85), R40 (= R86), G55 (= G101), G56 (= G102), S57 (≠ A103), Y58 (≠ F104), V233 (= V285), I262 (≠ A313), W386 (= W434), Y391 (≠ W439), C395 (≠ G443), Y396 (≠ P444), G423 (= G471), T424 (= T472), G432 (= G480), Y433 (= Y481), M434 (= M482)
- binding 4-[2-(4-propan-2-ylphenyl)ethyl]-1-[(~{E})-prop-1-enyl]piperidine: F166 (≠ W212), L169 (≠ P215), I197 (≠ S249), Q204 (= Q256), Y324 (≠ A373), Y396 (≠ P444)
6rkpA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 84 (see paper)
34% identity, 90% coverage: 48:496/500 of query aligns to 2:448/499 of 6rkpA