SitesBLAST
Comparing WP_110207836.1 NCBI__GCF_003194585.1:WP_110207836.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8p84B X-ray structure of thermoanaerobacterales bacterium monoamine oxidase (see paper)
39% identity, 99% coverage: 2:430/432 of query aligns to 2:450/450 of 8p84B
- binding flavin-adenine dinucleotide: V9 (= V9), G10 (= G10), G12 (= G12), A14 (≠ S14), E33 (= E33), A34 (= A34), R35 (≠ A35), G40 (= G40), R41 (= R41), T42 (= T42), G56 (= G57), Q57 (≠ T58), W58 (= W59), V234 (= V216), V262 (= V244), W383 (= W363), W388 (≠ Y368), C392 (≠ G372), Y393 (= Y373), G420 (= G400), T421 (≠ A401), G429 (= G409), Y430 (= Y410), I431 (≠ L411), A434 (= A414)
- binding magnesium ion: E125 (vs. gap), H188 (≠ S171)
6lqlA Complex structure of chao with product from erythrobacteraceae bacterium (see paper)
34% identity, 98% coverage: 6:429/432 of query aligns to 6:449/450 of 6lqlA
- binding 1-[(4-methoxyphenyl)methyl]-3,4,5,6,7,8-hexahydroisoquinoline: W60 (= W59), I170 (≠ V152), I198 (≠ L180), Q205 (= Q187), L292 (≠ V274), W322 (≠ A303), F324 (= F305), F339 (≠ L319), Y430 (= Y410)
- binding flavin-adenine dinucleotide: G10 (= G10), G12 (= G12), P13 (≠ L13), S14 (= S14), E33 (= E33), A34 (= A34), K35 (≠ A35), G40 (= G40), R41 (= R41), G57 (= G56), G58 (= G57), W60 (= W59), P233 (≠ R215), V234 (= V216), A266 (≠ V248), W383 (= W363), G420 (= G400), T421 (≠ A401), G429 (= G409), Y430 (= Y410), I431 (≠ L411), A434 (= A414)
6lqcA Crystal structure of cyclohexylamine oxidase from erythrobacteraceae bacterium (see paper)
34% identity, 98% coverage: 6:429/432 of query aligns to 6:449/450 of 6lqcA
- binding flavin-adenine dinucleotide: G10 (= G10), G12 (= G12), P13 (≠ L13), S14 (= S14), E33 (= E33), A34 (= A34), K35 (≠ A35), G40 (= G40), R41 (= R41), G58 (= G57), W60 (= W59), P233 (≠ R215), V234 (= V216), A266 (≠ V248), W383 (= W363), P393 (≠ Y373), G420 (= G400), G429 (= G409), Y430 (= Y410), I431 (≠ L411), A434 (= A414)
2z5xA Crystal structure of human monoamine oxidase a with harmine (see paper)
30% identity, 98% coverage: 6:430/432 of query aligns to 5:453/513 of 2z5xA
- active site: G60 (= G61), R195 (≠ T178), K294 (= K276)
- binding decyl(dimethyl)phosphine oxide: V104 (≠ A106), W105 (≠ G107), Y110 (≠ L112)
- binding flavin-adenine dinucleotide: I8 (≠ V9), G9 (= G10), G11 (= G12), I12 (≠ L13), S13 (= S14), L31 (≠ A32), E32 (= E33), A33 (= A34), R34 (≠ A35), G39 (= G40), R40 (= R41), G55 (= G56), G56 (= G57), A57 (≠ T58), Y58 (≠ W59), P232 (≠ R215), V233 (= V216), I262 (≠ V244), L266 (≠ V248), W386 (= W363), Y391 (= Y368), C395 (≠ G372), Y396 (= Y373), G423 (= G400), T424 (≠ A401), G432 (= G409), Y433 (= Y410), M434 (≠ L411)
- binding 7-methoxy-1-methyl-9h-beta-carboline: I169 (≠ V152), F197 (≠ L180), Q204 (= Q187), I324 (≠ A303), L326 (≠ F305), F341 (≠ G322), Y396 (= Y373)
Sites not aligning to the query:
P21397 Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; EC 1.4.3.21; EC 1.4.3.4 from Homo sapiens (Human) (see 6 papers)
30% identity, 98% coverage: 6:430/432 of query aligns to 16:464/527 of P21397
- C165 (≠ P138) mutation to S: No loss of activity.
- E188 (≠ R160) to K: in dbSNP:rs77698881
- C266 (≠ A237) to F: found in a family with Brunner syndrome-like behavioral disturbances; likely pathogenic; reduced activity; dbSNP:rs587777457; mutation to S: No loss of activity.
- C306 (≠ A277) mutation to S: No loss of activity.
- C321 (≠ G292) mutation to S: No loss of activity.
- C323 (≠ L294) mutation to S: No loss of activity.
- C374 (≠ L341) mutation to S: Complete loss of activity.
- C398 (≠ H364) mutation to S: No loss of activity.
- C406 (≠ G372) modified: S-8alpha-FAD cysteine; mutation to S: Complete loss of activity.
Sites not aligning to the query:
- 1 modified: N-acetylmethionine
- 15 D → E: in a breast cancer sample; somatic mutation; dbSNP:rs2033179927
1o5wC The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase a (see paper)
30% identity, 98% coverage: 6:430/432 of query aligns to 7:455/512 of 1o5wC
- active site: G62 (= G61), R197 (≠ T178), K296 (= K276)
- binding flavin-adenine dinucleotide: I10 (≠ V9), G13 (= G12), S15 (= S14), E34 (= E33), A35 (= A34), R36 (≠ A35), G41 (= G40), R42 (= R41), G57 (= G56), G58 (= G57), A59 (≠ T58), Y60 (≠ W59), P234 (≠ R215), V235 (= V216), I264 (≠ V244), W388 (= W363), Y393 (= Y368), C397 (≠ G372), Y398 (= Y373), G425 (= G400), T426 (≠ A401), G434 (= G409), Y435 (= Y410), M436 (≠ L411)
- binding n-[3-(2,4-dichlorophenoxy)propyl]-n-methyl-n-prop-2-ynylamine: I171 (≠ V152), F199 (≠ L180), Q206 (= Q187), C314 (≠ L294), I316 (≠ L296), I326 (≠ A303), T327 (≠ V304), Y398 (= Y373), Y435 (= Y410)
2c64B Mao inhibition by rasagiline analogues (see paper)
31% identity, 99% coverage: 2:430/432 of query aligns to 1:453/494 of 2c64B
- active site: G60 (= G61), R195 (≠ T178), K294 (= K276)
- binding flavin-adenine dinucleotide: V8 (= V9), G9 (= G10), G11 (= G12), S13 (= S14), L31 (≠ A32), E32 (= E33), A33 (= A34), R34 (≠ A35), G39 (= G40), R40 (= R41), G55 (= G56), G56 (= G57), S57 (≠ T58), Y58 (≠ W59), V233 (= V216), I262 (≠ V244), W386 (= W363), Y391 (= Y368), C395 (≠ G372), Y396 (= Y373), G423 (= G400), T424 (≠ A401), G432 (= G409), Y433 (= Y410), M434 (≠ L411)
- binding (1r)-6-hydroxy-n-methyl-n-[(1z)-prop-2-en-1-ylidene]indan-1-aminium: L169 (≠ V152), C170 (≠ S153), I196 (≠ M179), Q204 (= Q187), Y324 (≠ F305), F341 (≠ L319), Y396 (= Y373)
7p4hA Crystal structure of monoamine oxidase b in complex with inhibitor (+)-2 (see paper)
31% identity, 99% coverage: 2:430/432 of query aligns to 1:453/499 of 7p4hA
- binding 3,4-dimethyl-7-[[(3~{S})-piperidin-3-yl]methoxy]chromen-2-one: Y58 (≠ W59), L169 (≠ V152), C170 (≠ S153), I197 (≠ L180), Q204 (= Q187), Y324 (≠ F305)
- binding flavin-adenine dinucleotide: G9 (= G10), G11 (= G12), S13 (= S14), L31 (≠ A32), E32 (= E33), A33 (= A34), R34 (≠ A35), G39 (= G40), R40 (= R41), G55 (= G56), G56 (= G57), S57 (≠ T58), Y58 (≠ W59), P232 (≠ R215), V233 (= V216), I262 (≠ V244), W386 (= W363), Y391 (= Y368), C395 (≠ G372), Y396 (= Y373), G423 (= G400), T424 (≠ A401), G432 (= G409), Y433 (= Y410), M434 (≠ L411)
7p4fA Crystal structure of monoamine oxidase b in complex with inhibitor 1 (see paper)
31% identity, 99% coverage: 2:430/432 of query aligns to 1:453/499 of 7p4fA
- binding 4-(hydroxymethyl)-7-[[4-[[methyl-(phenylmethyl)amino]methyl]phenyl]methoxy]chromen-2-one: Y58 (≠ W59), F101 (≠ L86), W117 (≠ R94), L162 (= L145), F166 (≠ L149), L169 (≠ V152), I197 (≠ L180), Q204 (= Q187), Y324 (≠ F305), F341 (≠ L319), Y396 (= Y373), Y433 (= Y410)
- binding n-dodecyl-n,n-dimethyl-3-ammonio-1-propanesulfonate: D151 (≠ G135), K152 (≠ R136), W155 (vs. gap)
- binding flavin-adenine dinucleotide: G9 (= G10), G11 (= G12), S13 (= S14), E32 (= E33), A33 (= A34), R34 (≠ A35), G39 (= G40), R40 (= R41), T41 (= T42), G55 (= G56), G56 (= G57), S57 (≠ T58), Y58 (≠ W59), P232 (≠ R215), V233 (= V216), I262 (≠ V244), W386 (= W363), Y391 (= Y368), C395 (≠ G372), Y396 (= Y373), G423 (= G400), T424 (≠ A401), G432 (= G409), Y433 (= Y410), M434 (≠ L411)
6rleA Crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 97 (see paper)
31% identity, 99% coverage: 2:430/432 of query aligns to 1:453/499 of 6rleA