SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_110207906.1 NCBI__GCF_003194585.1:WP_110207906.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1 (see paper)
55% identity, 96% coverage: 20:727/737 of query aligns to 12:727/728 of 8oqlA

query
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8oqlA

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binding Hexafluorophosphate anion: V37 (≠ T45), N39 (≠ H47), G75 (= G83), D77 (= D85), M81 (≠ I89), V92 (≠ F100), T95 (≠ H103), P148 (= P156), E149 (= E157), L152 (= L160), Q180 (≠ S188), Q260 (≠ K262), K362 (≠ M364), D363 (= D365), V364 (≠ T366), V430 (= V432), D476 (= D478), K477 (≠ R479), M478 (= M480), P479 (= P481), K506 (= K508)
binding formamide: V78 (≠ L86), K79 (≠ N87)

8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80 (see paper)
55% identity, 96% coverage: 20:727/737 of query aligns to 13:728/728 of 8oqrA

query
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E

L

L

P

M

R

H

A

K

V

I

R

A

E

V

E

A

A

T

K

R

A

K

A

G

A

V

E

E

A

D

A

A

G

G

L

G

D

T

W

Y

L

Q

A

P

H

H

P

P

S

A

H

E

A

A

I

V

F

V

D

E

R

K

L

M

I

I

D

-

E

E

F

L

G

G

R

R

V

S

G

G

R

R

A

L

G

K

G

G

G

A

G

G

F

F

Y

Y

D

E

Y

Y

D

A

D

D

Q

-

G

G

K

K

R

R

T

S

G

G

F

L

W

W

P

P

G

G

L

L

A

R

S

E

S

T

F

F

P

K

T

S

L

G

D

S

T

S

M

Q

P

P

P

P

L

L

P

Q

D

D

L

M

V

I

D

D

R

R

L

M

L

L

F

F

A

A

E

E

V

A

L

L

E

E

A

T

W

Q

A

K

A

C

H

L

V

D

A

E

G

G

V

V

I

L

E

T

A

S

P

T

S

A

D

D

A

A

N

N

V

I

G

G

S

S

L

I

L

M

G

G

I

I

G

G

F

F

P

P

A

P

W

W

T

T

G

G

G

G

V

S

L

A

R

Q

F

F

L

I

D

V

Q

G

Y

Y

D

S

G

G

-

P

-

A

-

G

-

T

G

G

R

K

A

A

G

A

F

F

V

V

A

A

R

R

A

A

E

R

Q

E

L

L

A

A

A

A

R

A

Y

Y

G

G

D

D

R

R

F

F

L

L

P

P

P

P

A

E

T

S

L

L

L

L

binding 4-cyanobenzenesulfonic acid: G76 (= G83), G77 (= G84), T81 (≠ E88), M82 (≠ I89), M82 (≠ I89), A85 (≠ L92), D89 (= D96), T96 (≠ H103), L123 (= L130), G124 (= G131), P149 (= P156), E150 (= E157), S366 (≠ T367), L367 (= L368), E368 (≠ A369), A420 (= A421), V421 (= V422), F422 (= F423)

8oqsB Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83 (see paper)
55% identity, 96% coverage: 20:727/737 of query aligns to 19:734/735 of 8oqsB

query
sites
8oqsB

S

N

I

T

I

I

T

Q

W

W

S

D

R

K

D

D

E

A

D

D

G

G

V

I

V

V

V

T

V

L

T

T

L

M

D

D

D

D

P

P

T

S

Q

G

E

S

V

T

N

N

T

V

V
x
M

H

N

T

E

G

A

F

Y

V
x
I

H

E

E

S

L

M

G

G

A

K

L

A

V

V

E

D

H

R

L

L

Q

V

A

A

E

E

R

K

E

D

G

S

L

I

A

T

G

G

V

V

V

V

I

V

T

A

S

S

A

A

K

K

S

K

T

T

F

F

V

F

A

A

G
|
G

G
|
G

D
|
D

L

V

N

K

E
x
T

I
x
M

V

I

T

Q

L
x
A

G

R

L

P

A

E

D
|
D

A

A

A

G

R
x
D

F
x
V

T

F

R

N

H
x
T

L

V

N

E

N

T

L

I

K

K

A

R

T

Q

L

L

R

R

T

T

L

L

E

E

T

T

L

L

G

G

V

K

P

P

V

V

V

V

A

A

A

A

I

I

N

N

G

G

S

A

A

A

L

L

G

G

G

G

G

G

L

L

E
|
E

L

I

A

A

L

L

A

A

A

C

H

H

H

H

R

R

I

I

V

A

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D

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K

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G

V

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Q

Q

L

L

G

G

L

L

P

P

E
|
E

V

V

G

T

L
|
L

G

G

L

L

L

L

P

P

A

G

S

G

G

G

G

G

I

V

V

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R

R

T

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V

R

R

M

M

L

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G

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Q

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N

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V

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L

L

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G

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F

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K

P

P

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A

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A

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K

D

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L

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V

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D

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A

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V

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A

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D

E

L

L

L

V

P

P

R

A

A

A

K

K

A

A

W

W

I

I

A

K

E

E

-

E

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L

-

K

-

A

H

N

P

P

D

D

A

G

-

A

-

G

T

V

Q

Q

P

P

W

W

D

D

V

K

K

K

G

G

F

Y

R

K

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M

P

P

G

G

G

G

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T

Q

P

A

S

S

S

G

P

A

G

L

L

A

A

S

A

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I

L

L

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P

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L

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L

L

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K

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K

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G

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P

A

M

P

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R

R

A

A

I

I

L

L

A

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A

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G

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A

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Q

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V

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D

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D

D

A

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A

A

G

S

L

R

I

I

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S

R

R

Y

Y

F
|
F

I

A

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S

I

L

A

V

T

T

A

G

P

Q

I

V

S

A

K

K

N

N

L

M

I

M

N

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L

A

T

F

F
|
F

F

F

D

D

M

L

Q

Q

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A

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K

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M

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K

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D

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L

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A

A

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K

G

G

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R

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A

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D

L

F

A

K

G

G

V

V

D

D

F

F

V

V

I

I

E

E

A

A

V

V

F

F

E

E

N

N

A

Q

A

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L

L

K

K

A

H

E

K

V

V

F

F

A

G

S

E

V

I

E

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D

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I

V

V

G

E

A

P

E

N

A

A

V

I

L

L

G

G

S

S

N

N

T

T

S
|
S

T
|
T

L

L

P

P

I

I

S

T

S

G

L

L

A

A

A

T

G

G

V

V

A

K

R

R

P

Q

Q

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D

D

F

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I

G

G

V

I

H

H

F

F

F

F

S

S

P

P

V

V

D

D

R

K

M
|
M

P
|
P

L

L

V

V

E

E

I

I

I

I

R

K

G

G

E

E

A

K

T

T

S

S

D

D

A

E

T

A

L

L

A

A

K

R

A

V

F

F

D

D

L

Y

V

T

L

L

Q

A

L

I

G

G

K

K

T

T

P

P

I

I

V

V

V

V

N

N

D

D

S

S

R

R

G
|
G

F

F

F

F

T

T

S
|
S

R

R

V

V

I

I

I

G

A

T

R

F

L

V

N
|
N

E

E

A

A

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L

A

A

M

M

V

L

G

G

E

E

G

G

V

V

P

E

C

P

P

A

S

S

I

I

E

E

Q

Q

A

A

S

G

L

S

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Q

A

A

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G

Y

Y

P
|
P

A

A

G

P

A

P

L

L

Q

Q

L

L

L

S

D

D

E

E

L

L

T

N

L

L

T

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L

L

P
x
M

R

H

A

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x
I

R

A

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A

A

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K

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A

K

A

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A

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E

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D

A

A

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G

L

G

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W

Y

L

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A

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H

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P

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A

H

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A

A

I

V

F

V

D

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R

K

L

M

I

I

D

-

E

E

F

L

G

G

R

R

V

S

G

G

R

R

A

L

G

K

G

G

G

A

G

G

F

F

Y

Y

D

E

Y

Y

D

A

D

D

Q

-

G

G

K

K

R

R

T

S

G

G

F

L

W

W

P

P

G

G

L

L

A

R

S

E

S

T

F

F

P

K

T

S

L

G

D

S

T

S

M

Q

P

P

P

P

L

L

P

Q

D

D

L

M

V

I

D

D

R

R

L

M

L

L

F

F

A

A

E

E

V

A

L

L

E

E

A

T

W

Q

A

K

A

C

H

L

V

D

A

E

G

G

V

V

I

L

E

T

A

S

P

T

S

A

D

D

A

A

N

N

V

I

G

G

S

S

L
x
I

L
x
M

G

G

I

I

G
|
G

F

F

P

P

A

P

W

W

T

T

G

G

G

G

V

S

L

A

R

Q

F

F

L

I

D

V

Q

G

Y

Y

D

S

G

G

-

P

-

A

-

G

-

T

G

G

R

K

A

A

G

A

F

F

V

V

A

A

R

R

A

A

E

R

Q

E

L

L

A

A

A

A

R

A

Y

Y

G

G

D

D

R

R

F

F

L

L

P

P

P

P

A

E

T

S

L

L

L

L

binding 4-phenylbenzenesulfonic acid: M45 (≠ V46), I50 (≠ V51), G82 (= G83), G83 (= G84), D84 (= D85), T87 (≠ E88), T87 (≠ E88), M88 (≠ I89), M88 (≠ I89), A91 (≠ L92), D95 (= D96), D98 (≠ R99), V99 (≠ F100), T102 (≠ H103), T102 (≠ H103), E134 (= E135), E156 (= E157), L159 (= L160), F302 (= F297), F302 (= F297), F319 (= F314), S456 (= S451), T457 (= T452), M485 (= M480), P486 (= P481), G523 (= G518), S527 (= S522), N535 (= N530), P560 (= P555), M575 (≠ P570), I578 (≠ V573), I578 (≠ V573), I682 (≠ L679), M683 (≠ L680), G686 (= G683)

Sites not aligning to the query:

binding 4-phenylbenzenesulfonic acid: 7, 10, 11, 16, 17

4b3iA Crystal structure of mycobacterium tuberculosis fatty acid beta- oxidation complex with coenzymea bound at the hydratase active sites (see paper)
55% identity, 96% coverage: 20:727/737 of query aligns to 15:730/731 of 4b3iA

query
sites
4b3iA

S

N

I

T

I

I

T

Q

W

W

S

D

R

K

D

D

E

A

D

D

G

G

V

I

V

V

V

T

V

L

T

T

L

M

D

D

D

D

P

P

T

S

Q

G

E

S

V
x
T

N

N

T
x
V

V

M

H

N

T

E

G

A

F

Y

V

I

H

E

E

S

L

M

G

G

A

K

L

A

V

V

E

D

H

R

L

L

Q

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A

A

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E

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K

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D

G

S

L

I

A

T

G

G

V

V

V

V

I

V

T

A

S

S

A

A

K

K

S

K

T

T

F

F

V

F

A
|
A

G

G

G
|
G

D
|
D

L
x
V

N

K

E

T

I

M

V

I

T

Q

L

A

G

R

L

P

A

E

D

D

A

A

A

G

R

D

F

V

T

F

R

N

H

T

L

V

N
x
E

N

T

L

I

K

K

A
x
R

T

Q

L

L

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R

T

T

L

L

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E

T

T

L

L

G

G

V

K

P

P

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V

V

A

A

A

A

I

I

N

N

G

G

S

A

A

A

L

L

G

G

G
|
G

G

G

L

L

E
|
E

L

I

A

A

L

L

A

A

A

C

H

H

H

H

R

R

I

I

V

A

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D

D

S

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K

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S

Q

Q

L

L

G

G

L

L

P
|
P

E
|
E

V

V

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T

L

L

G

G

L

L

L

L

P

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A
x
G

S

G

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W

W

I

I

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A

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N

P

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D

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A

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K

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|
F

F

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|
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A

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Y

S

S

A

E

K

K

V

L

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G

A

R

K

A

A

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A

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R

G

G

Q

R

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T

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Q

Q

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A

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D

D

Q

A

V

L

V

L

A

A

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R

I

I

T

T

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P

T

T

D

A

D

D

V

A

Q

A

D

D

L

F

A

K

G

G

V

V

D

D

F

F

V

V

I

I

E

E

A

A

V

V

F

F

E

E

N

N

A

Q

A

E

L

L

K

K

A

H

E

K

V

V

F

F

A

G

S

E

V

I

E

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Q

D

V

I

V

V

G

E

A

P

E

N

A

A

V

I

L

L

G

G

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S

N

N

T

T

S
|
S

T

T

L

L

P

P

I

I

S

T

S

G

L

L

A

A

A

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G

G

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V

A

K

R

R

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Q

Q

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D

D

F

F

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H
|
H

F

F

F

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S

P

P

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V

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D

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M

M

P

P

L

L

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|
E

I

I

I

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G

G

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S

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D

A

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A

L

L

A

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A

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F

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D

L

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L

L

Q

A

L

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G

G

K

K

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P

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I

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V

V

V

N

N

D

D

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S

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R

G

G

F

F

F

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T

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|
S

R

R

V

V

I

I

I

G

A

T

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L

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N

N

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E

A

A

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L

A

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M

M

V

L

G

G

E

E

G

G

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V

P

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C

P

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S

I

I

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Q

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L

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Q

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A

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G

Y

Y

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P

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A

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L

L

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Q

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D

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M

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A

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L

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E

E

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L

G

G

R

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S

G

G

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R

A

L

G

K

G

G

G

A

G

G

F

F

Y

Y

D

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Y

Y

D

A

D

D

Q

-

G

G

K

K

R

R

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S

G

G

F

L

W

W

P

P

G

G

L

L

A

R

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S

T

F

F

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K

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L

G

D

S

T

S

M
x
Q

P
|
P

P
|
P

L
|
L

P
x
Q

D

D

L

M

V

I

D

D

R

R

L

M

L

L

F

F

A

A

E

E

V

A

L

L

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E

A

T

W

Q

A

K

A

C

H

L

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D

A

E

G

G

V

V

I

L

E

T

A

S

P

T

S

A

D

D

A

A

N

N

V

I

G

G

S

S

L

I

L

M

G

G

I

I

G

G

F

F

P

P

A

P

W

W

T

T

G

G

G

G

V

S

L

A

R

Q

F

F

L

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D

V

Q

G

Y

Y

D

S

G

G

-

P

-

A

-

G

-

T

G

G

R

K

A

A

G

A

F

F

V

V

A

A

R

R

A

A

E

R

Q

E

L

L

A

A

A

A

R

A

Y

Y

G

G

D

D

R

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F

F

L

L

P

P

P

P

A

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L

L

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active site: G79 (= G84), E100 (≠ N105), R104 (≠ A109), G127 (= G132), E130 (= E135), P151 (= P156), E152 (= E157), G160 (≠ A165), S452 (= S451), H473 (= H472), E485 (= E484), S523 (= S522)
binding adenosine-5'-diphosphate: Q640 (≠ M641), P641 (= P642), P642 (= P643), L643 (= L644), Q644 (≠ P645)
binding coenzyme a: T38 (≠ V43), V40 (≠ T45), A77 (= A82), G79 (= G84), D80 (= D85), V81 (≠ L86), E152 (= E157), F315 (= F314), Q319 (= Q318)

8oqoA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49 (see paper)
55% identity, 96% coverage: 20:727/737 of query aligns to 12:727/727 of 8oqoA

query
sites
8oqoA

S

N

I

T

I

I

T

Q

W

W

S

D

R

K

D

D

E

A

D

D

G

G

V

I

V

V

V

T

V

L

T

T

L

M

D

D

D

D

P

P

T

S

Q

G

E

S

V

T

N

N

T

V

V

M

H

N

T

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G

A

F

Y

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I

H

E

E

S

L

M

G

G

A

K

L

A

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V

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L

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A

A

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G

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V

V

V

I

V

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A

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S

A

A

K

K

S

K

T

T

F

F

V

F

A

A

G
|
G

G

G

D

D

L

V

N

K

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I

M

V

I

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K

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L

G

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A

A

A

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I

N

N

G

G

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A

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L

L

G

G

G

G

G

G

L

L

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A

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|
E

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W

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|
L

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N

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M

M

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G

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L

L

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G

K

K

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P

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V

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N

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D

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G

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-

E

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G

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G

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K

G

G

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F

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K

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F

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L

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G

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T

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D

D

A

A

N

N

V

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G

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L

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G

G

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W

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A

A

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A

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L

A

A

A

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A

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Y

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G

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D

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F

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L

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P

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T

S

L

L

L

L

binding pyridine-3-sulfonic acid: G75 (= G83), E149 (= E157), Q180 (≠ S188), L257 (= L259), Q260 (≠ K262)

8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72 (see paper)
55% identity, 96% coverage: 20:727/737 of query aligns to 13:728/729 of 8pf8A

query
sites
8pf8A

S

N

I

T

I

I

T

Q

W

W

S

D

R

K

D

D

E

A

D

D

G

G

V

I

V

V

V

T

V

L

T

T

L

M

D

D

D

D

P

P

T

S

Q

G

E

S

V

T

N

N

T

V

V
x
M

H
x
N

T
x
E

G

A

F

Y

V

I

H

E

E

S

L

M

G

G

A

K

L

A

V

V

E

D

H

R

L

L

Q

V

A

A

E

E

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K

E

D

G

S

L

I

A

T

G

G

V

V

V

V

I

V

T

A

S

S

A

A

K

K

S

K

T

T

F

F

V

F

A

A

G
|
G

G
|
G

D
|
D

L

V

N

K

E
x
T

I
x
M

V

I

T

Q

L

A

G

R

L

P

A

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D

D

A

A

A

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R
x
D

F
x
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T

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N

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L

V

N

E

N

T

L

I

K

K

A

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Q

L

L

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T

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L

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L

L

G

G

V

K

P

P

V

V

V

V

A

A

A

A

I

I

N

N

G

G

S

A

A

A

L

L

G

G

G

G

G

G

L

L

E

E

L

I

A

A

L

L

A

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A

C

H

H

H

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A

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Q

L

L

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G

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L

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P

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x
T

L

L

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G

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L

L

L

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G

G

G

G

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M

M

L
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F

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G

A

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N

A

A

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x
S

V

V

L

L

L

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G

G

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T

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|
R

F

F

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P

P

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A

A

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x
I

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L

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L

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A

A

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K

K

A

A

W

W

I

I

A

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E

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-

E

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L

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A

H

N

P

P

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binding [2-methyl-5-(trifluoromethyl)pyrazol-3-yl]boronic acid: G76 (= G83), F169 (≠ L176), N173 (≠ R180), S177 (≠ E184), I193 (≠ L200), F313 (= F314)
binding bis[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-bis(oxidanyl)boranuide: M39 (≠ V46), N40 (≠ H47), E41 (≠ T48), T81 (≠ E88), D92 (≠ R99), V93 (≠ F100)
binding [(2~{R})-2,3-bis(oxidanyl)propoxy]-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]borinic acid: M39 (≠ V46), G77 (= G84), D78 (= D85), M82 (≠ I89), V93 (≠ F100)
binding (2~{R})-3-bis[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]boranyloxypropane-1,2-diol: T152 (≠ G159), R184 (= R191), A311 (≠ L312), F312 (≠ T313), I673 (≠ V676)

Sites not aligning to the query:

binding bis[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-bis(oxidanyl)boranuide: 5

8oquA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-92 (see paper)
55% identity, 96% coverage: 20:727/737 of query aligns to 14:729/730 of 8oquA

query
sites
8oquA

S

N

I

T

I

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Q

W

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|
G

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