SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_110208468.1 NCBI__GCF_003194585.1:WP_110208468.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7chaI Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
40% identity, 90% coverage: 25:270/273 of query aligns to 2:247/262 of 7chaI

query
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7chaI

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binding phosphoaminophosphonic acid-adenylate ester: R13 (≠ F36), S38 (= S61), G39 (= G62), C40 (≠ T63), G41 (= G64), K42 (= K65), T43 (≠ S66), T44 (≠ V67)

7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation (see paper)
41% identity, 89% coverage: 27:270/273 of query aligns to 5:248/263 of 7d0aB

query
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7d0aB

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binding adenosine-5'-diphosphate: S39 (= S61), T41 (= T63), G42 (= G64), K43 (= K65), E140 (= E162), S142 (= S164), M145 (= M167)

7d08B Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
41% identity, 89% coverage: 27:270/273 of query aligns to 5:248/263 of 7d08B

query
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7d08B

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binding adenosine-5'-triphosphate: R14 (≠ F36), R17 (≠ S39), G40 (= G62), T41 (= T63), K43 (= K65), T44 (≠ S66), T45 (≠ V67), E166 (= E188)

6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp (see paper)
41% identity, 89% coverage: 27:270/273 of query aligns to 3:246/253 of 6z5uK

query
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6z5uK

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binding phosphoaminophosphonic acid-adenylate ester: R12 (≠ F36), S37 (= S61), G38 (= G62), G40 (= G64), K41 (= K65), T42 (≠ S66), T43 (≠ V67), Q86 (= Q110), E164 (= E188), H197 (= H221)
binding magnesium ion: Q86 (= Q110), E164 (= E188)

7ch8I Cryo-em structure of p.Aeruginosa mlafebd with adp-v (see paper)
39% identity, 90% coverage: 25:270/273 of query aligns to 2:244/259 of 7ch8I

query
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7ch8I

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A

I

P

P

D

D

G

G

P

P

L

V

binding adp metavanadate: R13 (≠ F36), R16 (≠ S39), S37 (= S61), G40 (= G64), K41 (= K65), T42 (≠ S66), T43 (≠ V67)

7ch6C Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
40% identity, 90% coverage: 25:270/273 of query aligns to 3:248/265 of 7ch6C

query
sites
7ch6C

H

N

T

L

V

V

E

D

V

M

R

R

N

D

V

V

H

S

K

F

R

T

F
x
R

G

G

S

N

S
x
R

E

C

I

I

L

F

K

D

G

N

L

I

T

S

V

L

D

T

F

V

R

P

D

R

N

G

A

K

I

I

T

T

T

A

V

I

L

M

G

G

P

P

S

S

G
|
G

T

I

G
|
G

K
|
K

S
x
T

V

T

L

L

L

L

K

R

H

L

I

I

V

G

G

G

L

Q

L

I

E

A

P

P

D

D

Q

H

G

G

E

E

V

I

R

L

V

F

F

D

G

G

Q

E

N

N

I

I

W

P

Q

A

V

M

P

S

E

R

I

S

E

R

R

L

Y

Y

E

T

L

V

R

R

K

K

R

R

F

M

G

S

V

M

L

L

F

F

Q

Q

D

S

G

G

A

A

L

L

F

F

G

T

S

D

M

M

N

N

I

V

Y

F

D

D

N

N

V

V

A

A

F

Y

P

P

L

L

R

R

K

E

H

H

T

T

Q

Q

K

L

T

P

E

A

R

P

E

L

I

L

R

H

E

S

I

T

V

V

M

M

D

M

N

K

L

L

C

E

V

A

V

V

G

G

L

L

E

R

Q

G

A

A

I

A

H

K

K

L

A

M

P

P

N

S

E

E

I

L

S

S

G

G

G

G

M

M

R

A

K

R

R

R

A

A

G

A

F

L

A

A

R

R

A

A

L

I

V

A

M

L

K

E

P

P

D

D

V

L

V

I

L

M

F

F

D

D

E
|
E

P

P

D

F

S

V

G

G

L

Q

D

D

P

P

V

I

R

T

T

M

K

G

L

V

L

L

S

V

Q

K

L

L

I

I

A

S

K

E

I

L

H

N

E

S

E

A

Y

L

G

G

G

V

T

T

Y

C

I

V

V

V

I

V

T

S

H

H

D

D

I

V

P

P

T

E

A

V

R

L

T

S

V

I

S

A

D

D

Y

H

V

A

A

W

V

I

L

L

W

A

K

D

G

K

E

K

I

I

V

V

H

A

Y

H

S

G

D

S

A

A

D

Q

G

A

A

L

F

Q

G

A

S

N

Q

P

D

D

P

P

F

R

V

V

R

R

Q

Q

F

F

L

L

A

D

G

G

A

I

P

A

D

D

G

G

P

P

L

V

binding phosphoaminophosphonic acid-adenylate ester: R14 (≠ F36), R17 (≠ S39), G40 (= G62), G42 (= G64), K43 (= K65), T44 (≠ S66), E166 (= E188)

6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state (see paper)
40% identity, 90% coverage: 25:270/273 of query aligns to 3:248/264 of 6xgyA

query
sites
6xgyA

H

N

T

L

V

V

E

D

V

M

R

R

N

D

V

V

H

S

K

F

R

T

F
x
R

G

G

S

N

S

R

E

C

I

I

L

F

K

D

G

N

L

I

T

S

V

L

D

T

F

V

R

P

D

R

N

G

A

K

I

I

T

T

T

A

V

I

L

M

G

G

P

P

S

S

G
|
G

T

I

G
|
G

K
|
K

S
x
T

V
x
T

L

L

L

L

K

R

H

L

I

I

V

G

G

G

L

Q

L

I

E

A

P

P

D

D

Q

H

G

G

E

E

V

I

R

L

V

F

F

D

G

G

Q

E

N

N

I

I

W

P

Q

A

V

M

P

S

E

R

I

S

E

R

R

L

Y

Y

E

T

L

V

R

R

K

K

R

R

F

M

G

S

V

M

L

L

F

F

Q

Q

D

S

G

G

A

A

L

L

F

F

G

T

S

D

M

M

N

N

I

V

Y

F

D

D

N

N

V

V

A

A

F

Y

P

P

L

L

R

R

K

E

H

H

T

T

Q

Q

K

L

T

P

E

A

R

P

E

L

I

L

R

H

E

S

I

T

V

V

M

M

D

M

N

K

L

L

C

E

V

A

V

V

G

G

L

L

E

R

Q

G

A

A

I

A

H

K

K

L

A

M

P

P

N

S

E

E

I

L

S

S

G

G

G

G

M

M

R

A

K

R

R

R

A

A

G

A

F

L

A

A

R

R

A

A

L

I

V

A

M

L

K

E

P

P

D

D

V

L

V

I

L

M

F

F

D
|
D

E
|
E

P

P

D

F

S

V

G

G

L

Q

D

D

P

P

V

I

R

T

T

M

K

G

L

V

L

L

S

V

Q

K

L

L

I

I

A

S

K

E

I

L

H

N

E

S

E

A

Y

L

G

G

G

V

T

T

Y

C

I

V

V

V

I

V

T

S

H

H

D

D

I

V

P

P

T

E

A

V

R

L

T

S

V

I

S

A

D

D

Y

H

V

A

A

W

V

I

L

L

W

A

K

D

G

K

E

K

I

I

V

V

H

A

Y

H

S

G

D

S

A

A

D

Q

G

A

A

L

F

Q

G

A

S

N

Q

P

D

D

P

P

F

R

V

V

R

R

Q

Q

F

F

L

L

A

D

G

G

A

I

P

A

D

D

G

G

P

P

L

V

binding adenosine-5'-diphosphate: R14 (≠ F36), G40 (= G62), G42 (= G64), K43 (= K65), T44 (≠ S66), T45 (≠ V67)
binding magnesium ion: D165 (= D187), E166 (= E188)

7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf) (see paper)
40% identity, 90% coverage: 25:270/273 of query aligns to 3:248/263 of 7cgnB

query
sites
7cgnB

H

N

T

L

V

V

E

D

V

M

R

R

N

D

V

V

H

S

K

F

R

T

F
x
R

G

G

S

N

S

R

E

C

I

I

L

F

K

D

G

N

L

I

T

S

V

L

D

T

F

V

R

P

D

R

N

G

A

K

I

I

T

T

T

A

V

I

L

M

G

G

P

P

S

S

G
|
G

T
x
I

G

G

K
|
K

S
x
T

V
x
T

L

L

L

L

K

R

H

L

I

I

V

G

G

G

L

Q

L

I

E

A

P

P

D

D

Q

H

G

G

E

E

V

I

R

L

V

F

F

D

G

G

Q

E

N

N

I

I

W

P

Q

A

V

M

P

S

E

R

I

S

E

R

R

L

Y

Y

E

T

L

V

R

R

K

K

R

R

F

M

G

S

V

M

L

L

F

F

Q

Q

D

S

G

G

A

A

L

L

F

F

G

T

S

D

M

M

N

N

I

V

Y

F

D

D

N

N

V

V

A

A

F

Y

P

P

L

L

R

R

K

E

H

H

T

T

Q

Q

K

L

T

P

E

A

R

P

E

L

I

L

R

H

E

S

I

T

V

V

M

M

D

M

N

K

L

L

C

E

V

A

V

V

G

G

L

L

E

R

Q

G

A

A

I

A

H

K

K

L

A

M

P

P

N

S

E

E

I

L

S

S

G

G

G

G

M

M

R

A

K

R

R

R

A

A

G

A

F

L

A

A

R

R

A

A

L

I

V

A

M

L

K

E

P

P

D

D

V

L

V

I

L

M

F

F

D

D

E

Q

P

P

D

F

S

V

G

G

L

Q

D

D

P

P

V

I

R

T

T

M

K

G

L

V

L

L

S

V

Q

K

L

L

I

I

A

S

K

E

I

L

H

N

E

S

E

A

Y

L

G

G

G

V

T

T

Y

C

I

V

V

V

I

V

T

S

H

H

D

D

I

V

P

P

T

E

A

V

R

L

T

S

V

I

S

A

D

D

Y

H

V

A

A

W

V

I

L

L

W

A

K

D

G

K

E

K

I

I

V

V

H

A

Y

H

S

G

D

S

A

A

D

Q

G

A

A

L

F

Q

G

A

S

N

Q

P

D

D

P

P

F

R

V

V

R

R

Q

Q

F

F

L

L

A

D

G

G

A

I

P

A

D

D

G

G

P

P

L

V

binding adenosine-5'-triphosphate: R14 (≠ F36), G40 (= G62), I41 (≠ T63), K43 (= K65), T44 (≠ S66), T45 (≠ V67)

Q9AT00 Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic; ABC transporter I family member 13; ABC transporter ABCI.13; AtABCI13; Non-intrinsic ABC protein 11; AtNAP11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 89% coverage: 27:270/273 of query aligns to 85:343/345 of Q9AT00

query
sites
Q9AT00

V

I

E

E

V

C

R

R

N

D

V

V

H

Y

K

K

R

S

F
|
F

G

G

S

E

S

K

E

H

I

I

L

L

K

K

G

G

L

V

T

S

V

F

D

K

F

I

R

R

D

H

N

G

A

E

I

A

T

V

T

G

V

V

L

I

G

G

P

P

S

S

G

G

T

T

G

G

K

K

S

S

V

T

L

I

L

L

K

K

H

I

I

M

V

A

G

G

L

L

L

L

E

A

P

P

D

D

Q

K

G

G

E

E

V

V

R

Y

V

I

F

R

G

G

Q

K

N

K

I

-

W

-

Q

R

V

A

P

G

E

L

I

I

E

S

R

D

Y

E

E

E

L

I

R

S

K

G

-

L

R

R

F

I

G

G

V

L

L

V

F

F

Q

Q

D

S

G

A

A

A

L

L

F

F

G

D

S

S

M

L

N

S

I

V

Y

R

D

E

N

N

V

V

A

G

F

F

P

L

L

L

R

Y

K

E

H

R

T

S

Q

K

K

M

T

S

E

E

R

N

E

Q

I

I

R

S

E

E

I

L

V

V

M

T

D

Q

N

T

L

L

C

A

V

A

V

V

G

G

L

L

E

K

Q

G

A

V

I

E

H

N

K

R

A

L

P

P

N

S

E

E

I

L

S

S

G

G

G

G

M

M

R

K

K

K

R

R

A

V

G

A

F

L

A

A

R

R

A

S

L

L

-

I

-

F

-

D

-

T

-

T

-

K

-

E

V

V

M

I

K

E

P

P

D

E

V

V

V

L

L

L

F

Y

D

D

E

E

P

P

D

T

S

A

G

G

L

L

D

D

P

P

V

I

R

A

T

S

K

T

L

V

L

V

S

E

Q

D

L

L

I

I

A

R

K

S

I

V

H

H

-

M

-

T

-

D

E

E

E

D

Y

A

G

V

G

G

-

K

-

P

-

G

-

K

-

I

-

A

T

S

Y

Y

I

L

V

V

I

V

T

T

H

H

D

Q

I

H

P

S

T

T

A

I

R

Q

T

R

V

A

S

V

D

D

Y

R

V

L

A

L

V

F

L

L

W

Y

K

E

G

G

E

K

I

I

V

V

H

W

Y

Q

S

G

D

M

A

T

D

H

G

E

A

F

F

T

G

T

S

S

Q

T

D

N

P

P

F

I

V

V

R

Q

Q

Q

F

F

L

A

A

T

G

G

A

S

P

L

D

D

G

G

P

P

L

I

F94 (= F36) mutation to A: Reduced ATPase activity and transport properties.

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
36% identity, 86% coverage: 29:263/273 of query aligns to 4:237/240 of 4ymuJ

query
sites
4ymuJ

V

V

R

N

N

D

V

V

H

Y

K

K

R

N

F
|
F

G

G

S

S

S

L

E

E

I
x
V

L

L

K

K

G

G

L

V

T

T

V

L

D

K

F

V

R

N

D

K

N

G

A

E

I

V

T

V

T

V

V

I

L

I

G

G

P

P

S
|
S

G
|
G

T
x
S

G
|
G

K
|
K

S
|
S

V
x
T

L

L

L

L

K

R

H

C

I

I

V

N

G

L

L

L

L

E

E

E

P

P

D

T

Q

K

G

G

E

E

V

V

R

F

V

I

F

D

G

G

Q

V

N

K

I

I

W

N

Q

N

V

-

P

G

E

K

I

V

E

N

R

I

Y

N

E

K

L

V

R

R

K

Q

R

K

F

V

G

G

V

M

L

V

F

F

Q

Q

D

H

G

F

A

N

L

L

F

F

G

P

S

H

M

L

N

T

I

A

Y

I

D

E

N

N

V

I

A

T

F

L

P

A

L

P

R

V

K

K

H

V

T

K

Q

K

K

M

T

N

E

K

R

K

E

E

I

A

R

E

E

E

I

L

V

A

M

V

D

D

N

L

L

L

C

A

V

K

V

V

G

G

L

L

E

L

Q

D

A

K

I

K

H

D

K

Q

A

Y

P

P

N

I

E

K

I

L

S

S

G

G

G

G

M

Q

R

K

K

Q

R

R

A

L

G

A

F

I

A

A

R

R

A

A

L

L

V

A

M

M

K

Q

P

P

D

E

V

V

V

M

L

L

F

F

D

D

E
|
E

P

P

D

T

S

S

G

A

L

L

D

D

P

P

V

E

R

M

T

V

K

K

L

E

L

V

S

L

Q

N

L

V

I

M

A

K

K

Q

I

L

H

A

E

N

E

E

Y

-

G

G

G

M

T

T

Y

M

I

V

V

V

I

V

T

T

H
|
H

D

E

I

M

P

G

T

F

A

A

R

R

T

E

V

V

S

G

D

D

Y

R

V

V

A

I

V

F

L

M

W

D

K

D

G

G

E

V

I

I

V

V

H

E

Y

E

S

G

D

T

A

P

D

E

G

E

A

I

F

F

-

Y

G

R

S

A

Q

K

D

N

P

E

F

R

V

T

R

R

Q

E

F

F

L

L

A

S

binding adenosine-5'-triphosphate: F11 (= F36), V16 (≠ I41), S36 (= S61), G37 (= G62), S38 (≠ T63), G39 (= G64), K40 (= K65), S41 (= S66), T42 (≠ V67), E162 (= E188), H194 (= H221)
binding magnesium ion: S41 (= S66), E162 (= E188)

2d62A Crystal structure of multiple sugar binding transport atp-binding protein
34% identity, 89% coverage: 24:266/273 of query aligns to 4:247/375 of 2d62A

query
sites
2d62A

L

M

H

A

T

E

V

V

E

K

V

L

R

I

N

N

V

I

H

W

K

K

R

R

F

F

G

G

S

D

S

V

E

T

I

A

L

V

K

K

G

D

L

L

T

S

V

L

D

E

F

I

R

K

D

D

N

G

A

E

I

F

T

L

T

V

V

L

L

L

G

G

P

P

S

S

G
|
G

T
x
C

G
|
G

K
|
K

S
x
T

V
x
T

L

T

L

L

K

R

H

M

I

I

V

A

G

G

L

L

L

E

E

E

P

P

D

T

Q

R

G

G

E

Q

V

I

R

Y

V

I

F

-

G

E

Q

D

N

N

I

L

W

V

Q

A

V

D

P

P

E

E

I

K

E

G

R

V

Y

F

E

V

L

P

R

P

K

K

R

E

-

R

-

D

F

V

G

A

V

M

L

V

F

F

Q

Q

D

S

G

Y

A

A

L

L

F

Y

G

P

S

H

M

M

N

T

I

V

Y

Y

D

D

N

N

V

I

A

A

F

F

P

P

L

L

R

K

K

L

H

R

T

K

-

V

-

P

-

K

Q

Q

K

E

T

I

E

D

R

K

E

R

I

V

R

R

E

E

I

V

V

A

M

E

D

-

N

-

L

-

C

-

V

M

V

L

G

G

L

L

E

T

Q

E

A

L

I

L

H

N

K

R

A

K

P

P

N

R

E

E

I

L

S

S

G

G

G

G

M

Q

R

R

K

Q

R

R

A

V

G

A

F

L

A

G

R

R

A

A

L

I

V

I

M

R

K

R

P

P

D

K

V

V

V

F

L

L

F

M

D

D

E

E

P

P

D

L

S

S

G

N

L

L

D

D

P

A

-

K

V

L

R

R

T

V

K

K

L

M

L

R

S

A

Q

E

L

L

I

-

A

K

K

K

I

L

H

Q

E

R

E

Q

Y

L

G

G

G

V

T

T

Y

T

I

I

V

Y

I

V

T

T

H

H

D

D

I

Q

P

V

T

E

A

A

R

M

T

T

V

M

S

G

D

D

Y

R

V

I

A

A

V

V

L

M

W

N

K

K

G

G

E

E

I

L

V

Q

H

Q

Y

V

S

G

D

T

A

P

D

D

G

E

A

V

F

Y

G

Y

S

K

Q

P

-

V

D

N

P

T

F

F

V

V

R

A

Q

G

F

F

L

I

A

G

G

S

A

P

P

P

binding pyrophosphate 2-: G42 (= G62), C43 (≠ T63), G44 (= G64), K45 (= K65), T46 (≠ S66), T47 (≠ V67)

P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12) (see paper)
33% identity, 82% coverage: 27:251/273 of query aligns to 11:240/257 of P0AAH0

query
sites
P0AAH0

V

I

E

Q

V

V

R

R

N

N

V

L

H

N

K

F

R

Y

F

Y

G

G

S

K

S

F

E

H

I

A

L

L

K

K

G

N

L

I

T

N

V

L

D

D

F

I

R

A

D

K

N

N

A

Q

I

V

T

T

T

A

V

F

L

I

G

G

P

P

S

S

G

G

T

C

G
|
G

K
|
K

S

S

V

T

L

L

L

L

K

R

H

T

I

F

V

N

G

K

L

M

L

F

E

E

-

L

-

Y

P

P

D

E

Q

Q

-

R

-

A

-

E

G

G

E

E

V

I

R

L

V

L

F

D

G

G

Q

D

N

N

I

I

W

L

Q

T

V

N

P

S

E

Q

I

-

E

D

R

I

Y

A

E

L

L

L

R

R

K

A

R

K

F

V

G

G

V

M

L

V

F

F

Q

Q

D

K

G

P

A

T

L

P

F

F

G

-

S

P

M

M

N

S

I

I

Y

Y

D

D

N

N

V

I

A

A

F

F

P

G

L

V

R

R

K

L

H

F

T

E

Q

K

K

L

T

S

E

R

R

A

E

D

I

M

R

D

E

E

I

R

V

V

M

Q

D

W

N

A

L

L

C

T

V

K

V

A

G

A

L

L

-

W

-

N

-

E

-

T

E

K

Q

D

A

K

I

L

H

H

K

Q

A

S

P

G

N

Y

E

S

I

L

S

S

G

G

G

G

M

Q

R

Q

K

Q

R

R

A

L

G

C

F

I

A

A

R

R

A

G

L

I

V

A

M

I

K

R

P

P

D

E

V

V

V

L

L

L

F

L

D

D

E

E

P

P

D

C

S

S

G

A

L

L

D

D

P

P

V

I

R

S

T

T

K

G

L

R

L

I

S

E

Q

E

L

L

I

I

A

T

K

E

I

L

H

K

E

Q

E

D

Y

Y

G

-

G

-

T

T

Y

V

I

V

V

I

I

V

T

T

H

H

D

N

I

M

P

Q

T

Q

A

A

R

A

T

R

V

C

S

S

D

D

Y

H

V

T

A

A

V

F

L

M

W

Y

K

L

G

G

E

E

I

L

V

I

H

E

Y

F

S

S

D

N

A

T

D

D

G

D

A

L

F

F

G48 (= G64) mutation to I: Loss of phosphate transport.
K49 (= K65) mutation to Q: Loss of phosphate transport.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

3c4jA Abc protein artp in complex with atp-gamma-s
35% identity, 84% coverage: 24:251/273 of query aligns to 1:226/242 of 3c4jA

query
sites
3c4jA

L

L

H

Q

T

M

V

I

E

D

V

V

R

H

N

Q

V

L

H

K

K

K

R

S

F
|
F

G

G

S

S

S

L

E

E

I
x
V

L

L

K

K

G

G

L

I

T

N

V

V

D

H

F

I

R

R

D

E

N

G

A

E

I

V

T

V

T

V

V

V

L

I

G

G

P

P

S
|
S

G
|
G

T
x
S

G
|
G

K
|
K

S
|
S

V
x
T

L

F

L

L

K

R

H

C

I

L

V

N

G

L

L

L

L

E

E

D

P

F

D

D

Q

E

G

G

E

E

V

I

R

I

V

I

F

D

G

G

Q

I

N

N

I

L

W

-

Q

K

V

A

P

K

E

D

I

T

E

N

R

L

Y

N

E

K

L

V

R

R

K

E

R

E

F

V

G

G

V

M

L

V

F

F

Q

Q

D

R

G

F

A

N

L

L

F

F

G

P

S

H

M

M

N

T

I

V

Y

L

D

N

N

N

V

I

A

T

F

L

-

A

P

P

L

M

R

K

K

-

H

-

T

V

Q

R

K

K

T

W

E

P

R

R

E

E

I

K

R

A

E

E

I

A

-

K

V

A

M

M

D

E

N

L

L

L

C

D

V

K

V

V

G

G

L

L

E

K

Q

D

A

K

I

A

H

H

K

A

A

Y

P

P

N

D

E

S

I

L

S

S

G

G

G

G

M

Q

R

A

K

Q

R

R

A

V

G

A

F

I

A

A

R

R

A

A

L

L

V

A

M

M

K

E

P

P

D

K

V

I

V

M

L

L

F

F

D

D

E

E

P

P

D

T

S

S

G

A

L

L

D

D

P

P

V

E

R

M

T

V

K

G

L

E

L

V

S

L

Q

S

L

V

I

M

A

K

K

Q

I

L

H

A

E

N

E

E

Y

-

G

G

G

M

T

T

Y

M

I

V

V

V

I

V

T

T

H

H

D

E

I

M

P

G

T

F

A

A

R

R

T

E

V

V

S

G

D

D

Y

R

V

V

A

L

V

F

L

M

W

D

K

G

G

G

E

Y

I

I

V

I

H

E

Y

E

S

G

D

K

A

P

D

E

G

D

A

L

F

F

binding phosphothiophosphoric acid-adenylate ester: F13 (= F36), V18 (≠ I41), S38 (= S61), G39 (= G62), S40 (≠ T63), G41 (= G64), K42 (= K65), S43 (= S66), T44 (≠ V67)

3c41J Abc protein artp in complex with amp-pnp/mg2+
35% identity, 84% coverage: 24:251/273 of query aligns to 1:226/242 of 3c41J

query
sites
3c41J

L

L

H

Q

T

M

V

I

E

D

V

V

R

H

N

Q

V

L

H

K

K

K

R

S

F
|
F

G

G

S

S

S

L

E

E

I
x
V

L

L

K

K

G

G

L

I

T

N

V

V

D

H

F

I

R

R

D

E

N

G

A

E

I

V

T

V

T

V

V

V

L

I

G

G

P

P

S
|
S

G
|
G

T

S

G
|
G

K
|
K

S
|
S

V
x
T

L

F

L

L

K

R

H

C

I

L

V

N

G

L

L

L

L

E

E

D

P

F

D

D

Q

E

G

G

E

E

V

I

R

I

V

I

F

D

G

G

Q

I

N

N

I

L

W

-

Q

K

V

A

P

K

E

D

I

T

E

N

R

L

Y

N

E

K

L

V

R

R

K

E

R

E

F

V

G

G

V

M

L

V

F

F

Q

Q

D

R

G

F

A

N

L

L

F

F

G

P

S

H

M

M

N

T

I

V

Y

L

D

N

N

N

V

I

A

T

F

L

-

A

P

P

L

M

R

K

K

-

H

-

T

V

Q

R

K

K

T

W

E

P

R

R

E

E

I

K

R

A

E

E

I

A

-

K

V

A

M

M

D

E

N

L

L

L

C

D

V

K

V

V

G

G

L

L

E

K

Q

D

A

K

I

A

H

H

K

A

A

Y

P

P

N

D

E

S

I

L

S

S

G

G

G

G

M

Q

R

A

K

Q

R

R

A

V

G

A

F

I

A

A

R

R

A

A

L

L

V

A

M

M

K

E

P

P

D

K

V

I

V

M

L

L

F

F

D
|
D

E

E

P

P

D

T

S

S

G

A

L

L

D

D

P

P

V

E

R

M

T

V

K

G

L

E

L

V

S

L

Q

S

L

V

I

M

A

K

K

Q

I

L

H

A

E

N

E

E

Y

-

G

G

G

M

T

T

Y

M

I

V

V

V

I

V

T

T

H

H

D

E

I

M

P

G

T

F

A

A

R

R

T

E

V

V

S

G

D

D

Y

R

V

V

A

L

V

F

L

M

W

D

K

G

G

G

E

Y

I

I

V

I

H

E

Y

E

S

G

D

K

A

P

D

E

G

D

A

L

F

F

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F36), V18 (≠ I41), S38 (= S61), G39 (= G62), G41 (= G64), K42 (= K65), S43 (= S66), T44 (≠ V67)
binding magnesium ion: S43 (= S66), D163 (= D187)

2olkA Abc protein artp in complex with adp-beta-s
35% identity, 84% coverage: 24:251/273 of query aligns to 1:226/242 of 2olkA

query
sites
2olkA

L

L

H

Q

T

M

V

I

E

D

V

V

R

H

N

Q

V

L

H

K

K

K

R

S

F
|
F

G

G

S

S

S

L

E

E

I
x
V

L

L

K

K

G

G

L

I

T

N

V

V

D

H

F

I

R

R

D

E

N

G

A

E

I

V

T

V

T

V

V

V

L

I

G

G

P

P

S
|
S

G
|
G

T
x
S

G
|
G

K
|
K

S
|
S

V
x
T

L

F

L

L

K

R

H

C

I

L

V

N

G

L

L

L

L

E

E

D

P

F

D

D

Q

E

G

G

E

E

V

I

R

I

V

I

F

D

G

G

Q

I

N

N

I

L

W

-

Q

K

V

A

P

K

E

D

I

T

E

N

R

L

Y

N

E

K

L

V

R

R

K

E

R

E

F

V

G

G

V

M

L

V

F

F

Q

Q

D

R

G

F

A

N

L

L

F

F

G

P

S

H

M

M

N

T

I

V

Y

L

D

N

N

N

V

I

A

T

F

L

-

A

P

P

L

M

R

K

K

-

H

-

T

V

Q

R

K

K

T

W

E

P

R

R

E

E

I

K

R

A

E

E

I

A

-

K

V

A

M

M

D

E

N

L

L

L

C

D

V

K

V

V

G

G

L

L

E

K

Q

D

A

K

I

A

H

H

K

A

A

Y

P

P

N

D

E

S

I

L

S

S

G

G

G

G

M

Q

R

A

K

Q

R

R

A

V

G

A

F

I

A

A

R

R

A

A

L

L

V

A

M

M

K

E

P

P

D

K

V

I

V

M

L

L

F

F

D

D

E

E

P

P

D

T

S

S

G

A

L

L

D

D

P

P

V

E

R

M

T

V

K

G

L

E

L

V

S

L

Q

S

L

V

I

M

A

K

K

Q

I

L

H

A

E

N

E

E

Y

-

G

G

G

M

T

T

Y

M

I

V

V

V

I

V

T

T

H

H

D

E

I

M

P

G

T

F

A

A

R

R

T

E

V

V

S

G

D

D

Y

R

V

V

A

L

V

F

L

M

W

D

K

G

G

G

E

Y

I

I

V

I

H

E

Y

E

S

G

D

K

A

P

D

E

G

D

A

L

F

F

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F36), V18 (≠ I41), S38 (= S61), G39 (= G62), S40 (≠ T63), G41 (= G64), K42 (= K65), S43 (= S66), T44 (≠ V67)

2oljA Abc protein artp in complex with adp/mg2+
35% identity, 84% coverage: 24:251/273 of query aligns to 1:226/242 of 2oljA

query
sites
2oljA

L

L

H

Q

T

M

V

I

E

D

V

V

R

H

N

Q

V

L

H

K

K

K

R

S

F
|
F

G

G

S

S

S

L

E

E

I
x
V

L

L

K

K

G

G

L

I

T

N

V

V

D

H

F

I

R

R

D

E

N

G

A

E

I

V

T

V

T

V

V

V

L

I

G

G

P

P

S
|
S

G
|
G

T
x
S

G
|
G

K
|
K

S
|
S

V
x
T

L

F

L

L

K

R

H

C

I

L

V

N

G

L

L

L

L

E

E

D

P

F

D

D

Q

E

G

G

E

E

V

I

R

I

V

I

F

D

G

G

Q

I

N

N

I

L

W

-

Q

K

V

A

P

K

E

D

I

T

E

N

R

L

Y

N

E

K

L

V

R

R

K

E

R

E

F

V

G

G

V

M

L

V

F

F

Q

Q

D

R

G

F

A

N

L

L

F

F

G

P

S

H

M

M

N

T

I

V

Y

L

D

N

N

N

V

I

A

T

F

L

-

A

P

P

L

M

R

K

K

-

H

-

T

V

Q

R

K

K

T

W

E

P

R

R

E

E

I

K

R

A

E

E

I

A

-

K

V

A

M

M

D

E

N

L

L

L

C

D

V

K

V

V

G

G

L

L

E

K

Q

D

A

K

I

A

H

H

K

A

A

Y

P

P

N

D

E

S

I

L

S

S

G

G

G

G

M

Q

R

A

K

Q

R

R

A

V

G

A

F

I

A

A

R

R

A

A

L

L

V

A

M

M

K

E

P

P

D

K

V

I

V

M

L

L

F

F

D

D

E

E

P

P

D

T

S

S

G

A

L

L

D

D

P

P

V

E

R

M

T

V

K

G

L

E

L

V

S

L

Q

S

L

V

I

M

A

K

K

Q

I

L

H

A

E

N

E

E

Y

-

G

G

G

M

T

T

Y

M

I

V

V

V

I

V

T

T

H

H

D

E

I

M

P

G

T

F

A

A

R

R

T

E

V

V

S

G

D

D

Y

R

V

V

A

L

V

F

L

M

W

D

K

G

G

G

E

Y

I

I

V

I

H

E

Y

E

S

G

D

K

A

P

D

E

G

D

A

L

F

F

binding adenosine-5'-diphosphate: F13 (= F36), V18 (≠ I41), S38 (= S61), G39 (= G62), S40 (≠ T63), G41 (= G64), K42 (= K65), S43 (= S66), T44 (≠ V67)

1g291 Malk (see paper)
33% identity, 88% coverage: 27:266/273 of query aligns to 4:244/372 of 1g291

query
sites
1g291

V

V

E

R

V

L

R

V

N

D

V

V

H

W

K

K

R

V

F

F

G

G

S

E

S

V

E

T

I

A

L

V

K

R

G

E

L

M

T

S

V

L

D

E

F

V

R

K

D

D

N

G

A

E

I

F

T

M

T

I

V

L

L

L

G

G

P

P

S
|
S

G
|
G

T
x
C

G
|
G

K
|
K

S
x
T

V
x
T

L

T

L

L

K

R

H

M

I

I

V

A

G

G

L

L

L

E

E

E

P

P

D

S

Q

R

G

G

E

Q

V

I

R

Y

V

I

F

-

G

G

Q

D

N

K

I

L

W

V

Q

A

V
x
D

P

P

E
|
E

I
x
K

E

G

R

I

Y

F

E

V

L

P

R

P

K
|
K

R
x
D

-

R

-

D

F

I

G

A

V

M

L

V

F

F

Q

Q

D

S

G

Y

A

A

L

L

F

Y

G

P

S

H

M

M

N

T

I

V

Y

Y

D

D

N

N

V

I

A

A

F

F

P

P

L

L

R

K

K

L

H

R

T

K

-

V

-

P

-

R

Q

Q

K

E

T

I

E

D

R

Q

E

R

I

V

R

R

E

E

I

V

V

A

M

E

D

-

N

-

L

-

C

-

V

L

V

L

G

G

L

L

E

T

Q

E

A

L

I

L

H

N

K

R

A

K

P

P

N

R

E

E

I

L

S

S

G

G

G

G

M

Q

R

R

K

Q

R

R

A

V

G

A

F

L

A

G

R

R

A

A

L

I

V

V

M

R

K

K

P

P

D

Q

V

V

V

F

L

L

F

M

D

D

E

E

P

P

D

L

S

S

G

N

L

L

D

D

P

A

-

K

V

L

R

R

T

V

K

R

L

M

L

R

S

A

Q

E

L

L

I

-

A

K

K

K

I

L

H

Q

E

R

E

Q

Y

L

G

G

G

V

T

T

Y

T

I

I

V

Y

I

V

T

T

H

H

D

D

I

Q

P

V

T

E

A

A

R

M

T

T

V

M

S

G

D

D

Y

R

V

I

A

A

V

V

L

M

W

N

K

R

G

G

E

V

I

L

V

Q

H

Q

Y

V

S

G

D

S

A

P

D

D

G

E

A

V

F

Y

G

D

S

K

-

P

Q

A

D

N

P

T

F

F

V

V

R

A

Q

G

F

F

L

I

A

G

G

S

A

P

P

P

binding magnesium ion: D69 (≠ V93), E71 (= E95), K72 (≠ I96), K79 (= K103), D80 (≠ R104)
binding pyrophosphate 2-: S38 (= S61), G39 (= G62), C40 (≠ T63), G41 (= G64), K42 (= K65), T43 (≠ S66), T44 (≠ V67)

Sites not aligning to the query:

binding magnesium ion: 292, 293, 359

P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
36% identity, 88% coverage: 27:265/273 of query aligns to 7:256/258 of P02915

query
sites
P02915

V

L

E

H

V

V

R

I

N

D

V

L

H

H

K

K

R

R

F

Y

G

G

S

G

S

H

E

E

I

V

L

L

K

K

G

G

L

V

T

S

V

L

D

Q

F

A

R

R

D

A

N

G

A

D

I

V

T

I

T

S

V

I

L

I

G

G

P

S

S
|
S

G
|
G

T

S

G
|
G

K
|
K

S
|
S

V
x
T

L

F

L

L

K

R

H

C

I

I

V

N

G

F

L

L

L

E

E

K

P

P

D

S

Q

E

G

G

E

A

V

I

R

I

V

V

F

N

G

G

Q

Q

N

N

I

I

-

N

-

L

-

V

-

R

-

D

-

K

-

D

W

G

Q

Q

V

L

P

K

E

V

I

A

E

D

R

K

Y

N

E

Q

-

L

-

R

-

L

L

L

R

R

K

T

R

R

F

L

G

T

V

M

L

V

F

F

Q

Q

D

H

G

F

A

N

L

L

F

W

G

S

S

H

M

M

N

T

I

V

Y

L

D

E

N

N

V

V

A

M

F

E

P

A

L

P

R

I

K

Q

H

V

T

L

Q

G

K

L

T

S

E

K

R

H

E

D

I

A

R

R

E

E

I

R

V

A

M

L

D

K

N

Y

L

L

C

A

V

K

V

V

G

G

L

I

-

D

E

E

Q

R

A

A

I

Q

H

G

K

K

A

Y

P

P

N

V

E

H

I

L

S

S

G

G

G

G

M

Q

R

Q

K

Q

R

R

A

V

G

S

F

I

A

A

R

R

A

A

L

L

V

A

M

M

K

E

P

P

D

D

V

V

V

L

L

L

F

F

D

D

E

E

P

P

D

T

S

S

G

A

L

L

D

D

P

P

V

E

R

L

T

V

K

G

L

E

L

V

S

L

Q

R

L

I

I

M

A

Q

K

Q

I

L

H

A

E

E

E

E

Y

-

G

G

G

K

T

T

Y

M

I

V

V

V

I

V

T

T

H

H

D

E

I

M

P

G

T

F

A

A

R

R

T

H

V

V

S

S

D

S

Y

H

V

V

A

I

V

F

L

L

W

H

K

Q

G

G

E

K

I

I

V

E

H

E

Y

E

S

G

D

D

A

P

D

E

G

Q

A

V

F

F

G

G

S

N

-

P

Q

Q

D

S

P

P

F

R

V

L

R

Q

Q

Q

F

F

L

L

A

K

G

G

A

S

S41 (= S61) binding ATP
G42 (= G62) binding ATP
G44 (= G64) binding ATP
K45 (= K65) binding ATP
S46 (= S66) binding ATP
T47 (≠ V67) binding ATP

1b0uA Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
36% identity, 88% coverage: 27:265/273 of query aligns to 3:252/258 of 1b0uA

query
sites
1b0uA

V

L

E

H

V

V

R

I

N

D

V

L

H

H

K

K

R

R

F
x
Y

G

G

S

G

S
x
H

E

E

I

V

L

L

K

K

G

G

L

V

T

S

V

L

D

Q

F

A

R

R

D

A

N

G

A

D

I

V

T

I

T

S

V

I

L

I

G

G

P

S

S
|
S

G
|
G

T

S

G
|
G

K
|
K

S
|
S

V
x
T

L

F

L

L

K

R

H

C

I

I

V

N

G

F

L

L

L

E

E

K

P

P

D

S

Q

E

G

G

E

A

V

I

R

I

V

V

F

N

G

G

Q

Q

N

N

I

I

-

N

-

L

-

V

-

R

-

D

-

K

-

D

W

G

Q

Q

V

L

P

K

E

V

I

A

E

D

R

K

Y

N

E

Q

-

L

-

R

-

L

L

L

R

R

K

T

R

R

F

L

G

T

V

M

L

V

F

F

Q

Q

D

H

G

F

A

N

L

L

F

W

G

S

S

H

M

M

N

T

I

V

Y

L

D

E

N

N

V

V

A

M

F

E

P

A

L

P

R

I

K

Q

H

V

T

L

Q

G

K

L

T

S

E

K

R

H

E

D

I

A

R

R

E

E

I

R

V

A

M

L

D

K

N

Y