SitesBLAST
Comparing WP_110804622.1 NCBI__GCF_003217355.1:WP_110804622.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9FLY0 Protein SAR DEFICIENT 4; Ornithine cyclodeaminase-like protein; AtOCD from Arabidopsis thaliana (Mouse-ear cress) (see paper)
31% identity, 81% coverage: 58:304/304 of query aligns to 68:324/325 of Q9FLY0
- G89 (= G79) mutation to E: In sard4-3; compromises systemic acquired resistance (SAR).
- G138 (= G128) mutation to D: In sard4-4; compromises systemic acquired resistance (SAR).
- S205 (≠ A185) mutation to N: In sard4-1; compromises systemic acquired resistance (SAR).
4bv9A Crystal structure of the NADPH form of mouse mu-crystallin. (see paper)
31% identity, 75% coverage: 73:301/304 of query aligns to 79:301/303 of 4bv9A
- active site: S220 (≠ F212)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S82 (≠ T76), H83 (≠ V77), T111 (= T105), G134 (= G128), G136 (= G130), V137 (≠ K131), Q138 (≠ V132), N159 (= N153), R160 (= R154), T161 (≠ S155), V195 (≠ T187), T196 (= T188), M197 (= M189), A198 (= A190), V217 (≠ I209), G218 (= G210), S283 (≠ N283), L284 (≠ G284), G285 (= G285)
- binding pyruvic acid: R110 (≠ K104)
Sites not aligning to the query:
4bvaA Crystal structure of the NADPH-t3 form of mouse mu-crystallin. (see paper)
31% identity, 74% coverage: 78:301/304 of query aligns to 83:300/303 of 4bvaA
- active site: S219 (≠ F212)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: T106 (= T101), R109 (≠ K104), T110 (= T105), G135 (= G130), V136 (≠ K131), Q137 (≠ V132), N158 (= N153), R159 (= R154), T160 (≠ S155), N163 (≠ G158), V194 (≠ T187), T195 (= T188), M196 (= M189), A197 (= A190), V216 (≠ I209), S282 (≠ N283), L283 (≠ G284), G284 (= G285)
- binding 3,5,3'triiodothyronine: S219 (≠ F212), R220 (= R213), W223 (≠ M216), E247 (≠ H240)
Sites not aligning to the query:
Q14894 Ketimine reductase mu-crystallin; NADP-regulated thyroid-hormone-binding protein; EC 1.5.1.25 from Homo sapiens (Human) (see paper)
30% identity, 75% coverage: 74:301/304 of query aligns to 89:310/314 of Q14894
2i99A Crystal structure of human mu_crystallin at 2.6 angstrom (see paper)
30% identity, 75% coverage: 74:301/304 of query aligns to 88:309/312 of 2i99A
- active site: S228 (≠ F212)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S90 (≠ T76), H91 (≠ V77), R118 (≠ K104), T119 (= T105), G142 (= G128), A143 (= A129), G144 (= G130), V145 (≠ K131), Q146 (≠ V132), N167 (= N153), R168 (= R154), T169 (≠ S155), V203 (≠ T187), T204 (= T188), L205 (≠ M189), A206 (= A190), V225 (≠ I209), G226 (= G210), S291 (≠ N283), L292 (≠ G284), G293 (= G285)
Sites not aligning to the query:
6t3eB Structure of thermococcus litoralis delta(1)-pyrroline-2-carboxylate reductase in complex with nadh and l-proline (see paper)
27% identity, 93% coverage: 21:302/304 of query aligns to 28:315/325 of 6t3eB
- binding 1,4-dihydronicotinamide adenine dinucleotide: S82 (≠ T76), T111 (= T105), G136 (= G130), V137 (≠ K131), Q138 (≠ V132), D159 (≠ N153), I160 (≠ R154), A199 (≠ T187), T200 (= T188), T201 (≠ M189), A202 (= A190), V206 (≠ W194), V221 (≠ I209), G222 (= G210), W223 (≠ A211), S296 (≠ N283), V297 (≠ G284), G298 (= G285)
- binding proline: R39 (≠ A32), M54 (≠ T48), K67 (= K61), R110 (≠ K104)
1omoA Alanine dehydrogenase dimer w/bound NAD (archaeal) (see paper)
29% identity, 78% coverage: 67:304/304 of query aligns to 71:311/320 of 1omoA
- active site: D219 (≠ F212)
- binding nicotinamide-adenine-dinucleotide: T109 (= T105), G134 (= G130), T135 (≠ K131), Q136 (≠ V132), Y156 (≠ W152), D157 (≠ N153), V158 (≠ R154), R159 (≠ S155), T195 (= T188), P196 (≠ M189), G217 (= G210), D219 (≠ F212), K223 (≠ M216), S290 (≠ N283), T291 (≠ G284), G292 (= G285)
Sites not aligning to the query:
O28608 Alanine dehydrogenase; AlaDH; EC 1.4.1.1 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
29% identity, 78% coverage: 67:304/304 of query aligns to 71:311/322 of O28608
5yu4A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
30% identity, 51% coverage: 58:211/304 of query aligns to 74:235/344 of 5yu4A
- binding 2,4-diaminobutyric acid: K77 (= K61), R121 (≠ K104)
- binding nicotinamide-adenine-dinucleotide: Y81 (≠ I65), T93 (= T76), I94 (≠ V77), R121 (≠ K104), T122 (= T105), G147 (= G130), A148 (≠ K131), Q149 (≠ V132), D170 (≠ N153), T171 (≠ R154), H175 (≠ G158), A208 (≠ T187), T209 (= T188), S210 (vs. gap), V211 (vs. gap), V218 (≠ W194), V233 (≠ I209), A235 (= A211)
Sites not aligning to the query:
5yu3A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
30% identity, 51% coverage: 58:211/304 of query aligns to 74:235/344 of 5yu3A
- binding nicotinamide-adenine-dinucleotide: Y81 (≠ I65), T93 (= T76), I94 (≠ V77), T122 (= T105), G147 (= G130), A148 (≠ K131), Q149 (≠ V132), D170 (≠ N153), T171 (≠ R154), A208 (≠ T187), T209 (= T188), S210 (vs. gap), V211 (vs. gap), V233 (≠ I209), A235 (= A211)
- binding proline: K77 (= K61), R121 (≠ K104)
Sites not aligning to the query:
5gzlA Cyclodeaminase_pa
30% identity, 51% coverage: 58:211/304 of query aligns to 78:239/357 of 5gzlA
- binding nicotinamide-adenine-dinucleotide: Y85 (≠ I65), T97 (= T76), I98 (≠ V77), T126 (= T105), G151 (= G130), A152 (≠ K131), Q153 (≠ V132), D174 (≠ N153), T175 (≠ R154), H179 (≠ G158), A212 (≠ T187), T213 (= T188), S214 (vs. gap), V222 (≠ W194), V237 (≠ I209), G238 (= G210), A239 (= A211)
Sites not aligning to the query:
- binding lysine: 55, 57, 65, 67, 240, 267, 268
- binding nicotinamide-adenine-dinucleotide: 240, 244, 305, 306, 307
5gziA Cyclodeaminase_pa
30% identity, 51% coverage: 58:211/304 of query aligns to 78:239/354 of 5gziA
- binding nicotinamide-adenine-dinucleotide: Y85 (≠ I65), T97 (= T76), R125 (≠ K104), T126 (= T105), G151 (= G130), A152 (≠ K131), Q153 (≠ V132), D174 (≠ N153), T175 (≠ R154), H179 (≠ G158), A212 (≠ T187), T213 (= T188), S214 (vs. gap), V215 (vs. gap), V237 (≠ I209), G238 (= G210), A239 (= A211)
- binding (2S)-piperidine-2-carboxylic acid: K81 (= K61), R125 (≠ K104), A239 (= A211)
Sites not aligning to the query:
6rqaB Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
30% identity, 69% coverage: 50:258/304 of query aligns to 62:269/322 of 6rqaB
- binding Tb-Xo4: N76 (≠ G68)
- binding nicotinamide-adenine-dinucleotide: T113 (= T105), G138 (= G130), Q140 (≠ V132), P162 (≠ R154), H163 (≠ S155), I199 (≠ T187), T200 (= T188), S201 (≠ M189), S202 (≠ A190), M221 (≠ I209), G222 (= G210), D224 (≠ F212), K228 (≠ M216)
Sites not aligning to the query:
6rqaA Crystal structure of the iminosuccinate reductase of paracoccus denitrificans in complex with NAD+ (see paper)
30% identity, 69% coverage: 50:258/304 of query aligns to 62:269/322 of 6rqaA
- binding nicotinamide-adenine-dinucleotide: H85 (≠ V77), T113 (= T105), G138 (= G130), H139 (≠ K131), Q140 (≠ V132), N161 (= N153), P162 (≠ R154), H163 (≠ S155), M166 (≠ G158), I199 (≠ T187), T200 (= T188), S201 (≠ M189), S202 (≠ A190), M221 (≠ I209), G222 (= G210), D224 (≠ F212), K228 (≠ M216)
Sites not aligning to the query:
A1B8Z0 Iminosuccinate reductase; EC 1.4.1.- from Paracoccus denitrificans (strain Pd 1222) (see paper)
30% identity, 69% coverage: 50:258/304 of query aligns to 60:267/320 of A1B8Z0
- R110 (≠ K104) binding NAD(+)
- HQ 137:138 (≠ KV 131:132) binding NAD(+)
- N159 (= N153) binding NAD(+)
- S199 (≠ M189) binding NAD(+)
- MGTD 219:222 (≠ IGAF 209:212) binding NAD(+)
- K226 (≠ M216) binding NAD(+)
Sites not aligning to the query:
4mp6A Staphyloferrin b precursor biosynthetic enzyme sbnb bound to citrate and NAD+ (see paper)
24% identity, 73% coverage: 79:300/304 of query aligns to 94:321/334 of 4mp6A
- active site: M236 (≠ I209)
- binding nicotinamide-adenine-dinucleotide: R120 (≠ K104), T121 (= T105), G146 (= G130), L147 (≠ K131), I148 (≠ V132), D170 (≠ N153), Q171 (≠ R154), C211 (≠ T187), T212 (= T188), V213 (≠ M189), I233 (= I206), G306 (= G285)
Sites not aligning to the query:
4mpdA Staphyloferrin b precursor biosynthetic enzyme sbnb bound a- ketoglutarate and NAD+ (see paper)
24% identity, 73% coverage: 79:300/304 of query aligns to 82:305/318 of 4mpdA
Sites not aligning to the query:
4m54A The structure of the staphyloferrin b precursor biosynthetic enzyme sbnb bound to n-(1-amino-1-carboxyl-2-ethyl)-glutamic acid and nadh (see paper)
24% identity, 73% coverage: 79:300/304 of query aligns to 89:297/310 of 4m54A
Sites not aligning to the query:
1x7dA Crystal structure analysis of ornithine cyclodeaminase complexed with NAD and ornithine to 1.6 angstroms (see paper)
25% identity, 56% coverage: 67:237/304 of query aligns to 74:252/340 of 1x7dA