SitesBLAST

P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see 2 papers)
31% identity, 47% coverage: 16:257/513 of query aligns to 7:246/265 of P07821

query
sites
P07821

H

H

Y

S

D

D

G

T

E

T

F

F

I

A

L

L

E

R

V

N

D

I

G

S

V

F

R

R

K

-

E

-

F

V

P

P

G

G

V

R

V

T

A

L

L

L

D

H

N

P

V

L

Q

S

L

L

K

T

I

F

R

P

P

A

G

G

S

K

V

V

H

T

A

G

L

L

M

I

G

G

E

H

N

N

G

G

A

S

G

G

K
|
K

S

S

T

T

L

L

M

L

K

K

I

M

I

L

A

G

G

R

V

H

Y

Q

N

P

P

P

D

S

R

E

G

G

E

E

V

I

R

L

F

L

A

D

G

A

E

Q

K

P

L

L

V

E

I

S

R

W

T

S

P

S

I

-

D

K

A

A

L

F

N

A

C

R

G

K

I

V

A

A

M

Y

I

L

H

P

Q

Q

E

Q

L

L

N

P

L

P

M

A

N

E

T

G

M

M

T

T

V

V

A

R

E

E

N

L

V

V

W

A

I

I

R

G

R

R

E

Y

P

P

K

W

-

H

-

G

-

A

-

L

G

G

A

R

F

F

G

G

L

A

I

A

D

D

H

R

A

E

R

K

M

V

G

-

T

-

M

-

T

-

A

-

E

E

L

E

F

A

A

I

S

S

L

L

N

-

I

V

H

G

L

L

D

K

P

P

L

L

A

A

-

H

-

R

I

L

V

V

G

D

D

S

L

L

T

S

V

G

A

G

Q

E

K

R

Q

Q

M

R

I

A

E

W

I

I

A

A

K

M

A

L

V

V

S

A

Y

Q

N

D

S

S

D

R

V

C

L

L

I

L

M

L

D
|
D

E
|
E

P

P

T

T

S

S

A

A

I

L

-

D

T

I

E

A

T

H

E

Q

V

V

E

D

H

V

L

L

F

S

A

L

I

V

I

H

R

R

D

L

L

S

R

Q

A

E

R

R

G

G

V

L

G

T

I

V

V

I

Y

A

I

V

T

L

H

H

K

D

M

I

N

N

E

M

I

A

F

A

E

R

I

Y

A

C

D

D

E

Y

L

L

T

V

V

A

F

L

R

R

D

G

G

G

K

E

Y

M

I

I

S

A

T

Q

V

G

P

T

A

P

S

A

E

E

V

I

T

M

R

R

D

G

D

E

I

T

I

L

R

E

M

M

M

I

V

Y

G

G

K50 (= K61) mutation to Q: Lack of activity.
D172 (= D184) mutation to E: Lack of activity.
E173 (= E185) mutation to A: Lack of activity.

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
30% identity, 41% coverage: 25:235/513 of query aligns to 4:212/240 of 4ymuJ

query
sites
4ymuJ

V

V

D

N

G

D

V

V

R

Y

K

K

E

N

F
|
F

P

G

G

S

V

L

V

E

A
x
V

L

L

D

K

N

G

V

V

Q

T

L

L

K

K

I

V

R

N

P

K

G

G

S

E

V

V

H

V

A

V

L

I

M

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

K

R

I

C

I

I

A

N

G

L

V

L

Y

E

N

E

P

P

D

T

R

K

G

G

E

E

V

V

R

F

F

I

A

D

G

G

E

V

K

K

L

I

V

N

I

N

-

G

R

K

T

V

P

N

I

I

D

N

A

K

L

V

N

R

C

Q

G

K

I

V

A

G

M

M

I

V

H

F

Q

Q

E

H

L

F

N

N

L

L

M

F

N

P

T

H

M

L

T

T

V

A

A

I

E

E

N

N

V

I

W

T

I

L

R

-

E

-

P

-

K

-

G

-

A

-

F

-

G

A

L

P

I

V

D

K

H

V

A

K

R

K

M

M

G

N

T

K

M

K

T

E

A

A

E

E

L

E

F

L

A

A

S

-

L

-

N

-

I

-

H

-

L

V

D

D

P

L

L

L

A

A

I

K

V

V

G

G

-

L

-

D

-

K

-

D

-

Q

-

Y

-

P

-

I

D

K

L

L

T

S

V

G

A

G

Q

Q

K

K

Q

Q

M

R

I

L

E

A

I

I

A

A

K

R

A

A

V

L

S

A

Y

M

N

Q

S

P

D

E

V

V

L

M

I

L

M

F

D

D

E
|
E

P

P

T

T

S

S

A

A

I

L

T

D

E

P

T

E

E

M

V

V

E

K

H

E

L

V

F

L

A

N

I

V

I

M

R

K

D

Q

L

L

R

A

A

N

R

E

G

G

V

M

G

T

I

M

V

V

Y

V

I

V

T

T

H
|
H

K

E

M

M

N

G

E

F

I

A

F

R

E

E

I

V

A

G

D

D

E

R

L

V

T

I

V

F

F

M

R

D

D

D

G

G

binding adenosine-5'-triphosphate: F11 (= F32), V16 (≠ A37), S36 (≠ N57), G37 (= G58), S38 (≠ A59), G39 (= G60), K40 (= K61), S41 (= S62), T42 (= T63), E162 (= E185), H194 (= H217)
binding magnesium ion: S41 (= S62), E162 (= E185)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 41% coverage: 35:246/513 of query aligns to 18:228/343 of P30750

query
sites
P30750

V

I

V

Q

A

A

L

L

D

N

N

N

V

V

Q

S

L

L

K

H

I

V

R

P

P

A

G

G

S

Q

V

I

H

Y

A

G

L

V

M

I

G

G

E

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

I

C

I

V

A

N

G

L

V

L

Y

E

N

R

P

P

D

T

R

E

G

G

E

S

V

V

R

L

F

V

A

D

G

G

E

Q

K

E

L

L

V

T

I

T

-

L

-

S

R

E

T

S

P

E

I

L

D

T

A

K

L

A

N

R

C

R

G

Q

I

I

A

G

M

M

I

I

H

F

Q

Q

E

H

L

F

N

N

L

L

M

L

N

S

T

S

M

R

T

T

V

V

A

F

E

G

N

N

V

V

W

A

I

L

R

P

R

L

E

E

-

L

-

D

-

N

-

T

P

P

K

K

G

D

A

-

F

-

G

-

L

-

I

-

D

-

H

-

A

-

R

E

M

V

G

K

T

R

M

R

T

V

A

T

E

E

L

L

F

L

A

S

S

L

L

V

N

G

I

L

H

G

L

D

D

K

P

H

L

D

A

S

I

Y

V

P

G

S

D

N

L

L

T

S

V

G

A

G

Q

Q

K

K

Q

Q

M

R

I

V

E

A

I

I

A

A

K

R

A

A

V

L

S

A

Y

S

N

N

S

P

D

K

V

V

L

L

I

L

M

C

D

D

E
|
E

P

A

T

T

S

S

A

A

I

L

T

D

E

P

T

A

E

T

V

T

E

R

H

S

L

I

F

L

A

E

I

L

R

K

D

D

L

I

R

N

A

R

R

R

-

L

G

G

V

L

G

T

I

I

V

L

Y

L

I

I

T

T

H

H

K

E

M

M

N

D

E

V

I

V

F

K

E

R

I

I

A

C

D

D

E

C

L

V

T

A

V

V

F

I

R

S

D

N

G

G

K

E

Y

L

I

I

S

E

T

Q

V

D

P

T

A

V

S

S

E

E

V

V

40:46 (vs. 57:63, 86% identical) binding ATP
E166 (= E185) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

5x40A Structure of a cbio dimer bound with amppcp (see paper)
30% identity, 44% coverage: 22:249/513 of query aligns to 4:230/280 of 5x40A

query
sites
5x40A

I

I

L

L

E

A

V

A

D

E

G

A

V

L

R

T

K

Y

E

A

F
|
F

P

P

G

G

-

G

V
|
V

V

K

A
|
A

L

L

D

D

N

D

V

L

Q

S

L

L

K

A

I

V

R

P

P

K

G

G

S

E

V

S

H

L

A

A

L

I

M

L

G

G

E

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

L

K

L

I

H

I

L

A

N

G

G

V

T

Y

L

N

R

P

P

D

Q

R

S

G

G

E

R

V

V

R

L

F

L

A

G

G

G

E

T

K

A

L

T

V

G

-

H

I

S

R

R

T

K

P

D

I

L

D

T

A

G

L

W

N

R

C

R

G

R

I

V

A

G

M

L

I

V

H

L

Q
|
Q

E

D

L

A

N

D

-

D

L

Q

M

L

N

F

T

A

M

T

T

T

V

V

A

F

E

E

N

D

V

V

W

-

I

-

R

-

E

-

P

-

K

-

G

-

A

S

F

F

G

G

L

P

I

L

D

N

H

-

A

-

R

-

M

L

G

G

T

L

M

S

T

E

A

A

E

E

L

A

F

R

A

A

S

R

L

V

N

E

I

E

H

A

L

L

D

A

P

A

L

L

A

S

I

I

-

S

-

D

-

L

-

R

-

D

-

R

-

P

V

T

G
x
H

D
x
M

L
|
L

T
x
S

V

G

A
x
G

Q
|
Q

K

K

Q

R

M

R

I

V

E

A

I

I

A

A

K

G

A

A

V

V

S

A

Y

M

N

R

S

P

D

E

V

V

L

L

I

L

M

L

D

D

E
x
Q

P

P

T

T

S

A

A

G

I

L

T

D

E

L

T

A

E

G

V

T

E

E

H

Q

L

L

F

L

A

T

I

L

R

R

D

G

L

L

R

R

A

A

R

A

G

G

V

M

G

T

I

L

V

V

Y

F

I

S

T

T

H
|
H

K

D

M

V

N

E

E

L

I

A

F

A

E

A

I

L

A

A

D

D

E

R

L

V

T

A

V

L

F

F

R

R

D

T

G

G

K

R

Y

V

I

L

S

A

T

E

V

G

P

A

A

A

S

E

E

A

V

V

T

L

R

S

D

D

binding phosphomethylphosphonic acid adenylate ester: F14 (= F32), V18 (= V35), A20 (= A37), N40 (= N57), G41 (= G58), G43 (= G60), K44 (= K61), S45 (= S62), T46 (= T63), Q88 (= Q104), H139 (≠ G158), M140 (≠ D159), L141 (= L160), S142 (≠ T161), G144 (≠ A163), Q145 (= Q164), Q166 (≠ E185), H198 (= H217)
binding magnesium ion: S45 (= S62), Q88 (= Q104)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
29% identity, 41% coverage: 35:246/513 of query aligns to 19:229/344 of 6cvlD

query
sites
6cvlD

V
x
I

V

Q

A

A

L

L

D

N

N

N

V

V

Q

S

L

L

K

H

I

V

R

P

P

A

G

G

S

Q

V

I

H

Y

A

G

L

V

M

I

G

G

E

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

I

C

I

V

A

N

G

L

V

L

Y

E

N

R

P

P

D

T

R

E

G

G

E

S

V

V

R

L

F

V

A

D

G

G

E

Q

K

E

L

L

V

T

I

T

-

L

-

S

R

E

T

S

P

E

I

L

D

T

A

K

L

A

N

R

C

R

G

Q

I

I

A

G

M

M

I

I

H

F

Q

Q

E

H

L

F

N

N

L

L

M

L

N

S

T

S

M

R

T

T

V

V

A

F

E

G

N

N

V

V

W

A

I

L

R

P

R

L

E

E

-

L

-

D

-

N

-

T

P

P

K

K

G

D

A

-

F

-

G

-

L

-

I

-

D

-

H

-

A

-

R

E

M

V

G

K

T

R

M

R

T

V

A

T

E

E

L

L

F

L

A

S

S

L

L

V

N

G

I

L

H

G

L

D

D

K

P

H

L

D

A

S

I

Y

V

P

G

S

D
x
N

L

L

T
x
S

V

G

A

G

Q
|
Q

K

K

Q

Q

M

R

I

V

E

A

I

I

A

A

K

R

A

A

V

L

S

A

Y

S

N

N

S

P

D

K

V

V

L

L

I

L

M

C

D

D

E

Q

P

A

T

T

S

S

A

A

I

L

T

D

E

P

T

A

E

T

V

T

E

R

H

S

L

I

F

L

A

E

I

L

R

K

D

D

L

I

R

N

A

R

R

R

-

L

G

G

V

L

G

T

I

I

V

L

Y

L

I

I

T

T

H
|
H

K

E

M

M

N

D

E

V

I

V

F

K

E

R

I

I

A

C

D

D

E

C

L

V

T

A

V

V

F

I

R

S

D

N

G

G

K

E

Y

L

I

I

S

E

T

Q

V

D

P

T

A

V

S

S

E

E

V

V

binding phosphothiophosphoric acid-adenylate ester: I19 (≠ V35), S41 (≠ N57), G42 (= G58), A43 (= A59), G44 (= G60), K45 (= K61), S46 (= S62), T47 (= T63), N141 (≠ D159), S143 (≠ T161), Q146 (= Q164), H200 (= H217)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 12, 14

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
29% identity, 41% coverage: 35:246/513 of query aligns to 19:229/344 of 3tuzC

query
sites
3tuzC

V

I

V

Q

A

A

L

L

D

N

N

N

V

V

Q

S

L

L

K

H

I

V

R

P

P

A

G

G

S

Q

V

I

H

Y

A

G

L

V

M

I

G

G

E

A

N

S

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

I

C

I

V

A

N

G

L

V

L

Y

E

N

R

P

P

D

T

R

E

G

G

E

S

V

V

R

L

F

V

A

D

G

G

E

Q

K

E

L

L

V

T

I

T

-

L

-

S

R

E

T

S

P

E

I

L

D

T

A

K

L

A

N

R

C

R

G

Q

I

I

A

G

M

M

I

I

H

F

Q

Q

E

H

L

F

N

N

L

L

M

L

N

S

T

S

M

R

T

T

V

V

A

F

E

G

N

N

V

V

W

A

I

L

R

P

R

L

E

E

-

L

-

D

-

N

-

T

P

P

K

K

G

D

A

-

F

-

G

-

L

-

I

-

D

-

H

-

A

-

R

E

M

V

G

K

T

R

M

R

T

V

A

T

E

E

L

L

F

L

A

S

S

L

L

V

N

G

I

L

H

G

L

D

D

K

P

H

L

D

A

S

I

Y

V

P

G

S

D

N

L

L

T

S

V

G

A

G

Q

Q

K

K

Q

Q

M

R

I

V

E

A

I

I

A

A

K

R

A

A

V

L

S

A

Y

S

N

N

S

P

D

K

V

V

L

L

I

L

M

C

D

D

E

Q

P

A

T

T

S

S

A

A

I

L

T

D

E

P

T

A

E

T

V

T

E

R

H

S

L

I

F

L

A

E

I

L

R

K

D

D

L

I

R

N

A

R

R

R

-

L

G

G

V

L

G

T

I

I

V

L

Y

L

I

I

T

T

H

H

K

E

M

M

N

D

E

V

I

V

F

K

E

R

I

I

A

C

D

D

E

C

L

V

T

A

V

V

F

I

R

S

D

N

G

G

K

E

Y

L

I

I

S

E

T

Q

V

D

P

T

A

V

S

S

E

E

V

V

binding adenosine-5'-diphosphate: G42 (= G58), G44 (= G60), K45 (= K61), S46 (= S62), T47 (= T63)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 14
binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
29% identity, 41% coverage: 35:246/513 of query aligns to 19:229/344 of 3tuiC

query
sites
3tuiC

V

I

V

Q

A

A

L

L

D

N

N

N

V

V

Q

S

L

L

K

H

I

V

R

P

P

A

G

G

S

Q

V

I

H

Y

A

G

L

V

M

I

G

G

E

A

N

S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

M

I

K

R

I

C

I

V

A

N

G

L

V

L

Y

E

N

R

P

P

D

T

R

E

G

G

E

S

V

V

R

L

F

V

A

D

G

G

E

Q

K

E

L

L

V

T

I

T

-

L

-

S

R

E

T

S

P

E

I

L

D

T

A

K

L

A

N

R

C

R

G

Q

I

I

A

G

M

M

I

I

H

F

Q

Q

E

H

L

F

N

N

L

L

M

L

N

S

T

S

M

R

T

T

V

V

A

F

E

G

N

N

V

V

W

A

I

L

R

P

R

L

E

E

-

L

-

D

-

N

-

T

P

P

K

K

G

D

A

-

F

-

G

-

L

-

I

-

D

-

H

-

A

-

R

E

M

V

G

K

T

R

M

R

T

V

A

T

E

E

L

L

F

L

A

S

S

L

L

V

N

G

I

L

H

G

L

D

D

K

P

H

L

D

A

S

I

Y

V

P

G

S

D

N

L

L

T

S

V

G

A

G

Q

Q

K

K

Q

Q

M

R

I

V

E

A

I

I

A

A

K

R

A

A

V

L

S

A

Y

S

N

N

S

P

D

K

V

V

L

L

I

L

M

C

D

D

E

Q

P

A

T

T

S

S

A

A

I

L

T

D

E

P

T

A

E

T

V

T

E

R

H

S

L

I

F

L

A

E

I

L

R

K

D

D

L

I

R

N

A

R

R

R

-

L

G

G

V

L

G

T

I

I

V

L

Y

L

I

I

T

T

H

H

K

E

M

M

N

D

E

V

I

V

F

K

E

R

I

I

A

C

D

D

E

C

L

V

T

A

V

V

F

I

R

S

D

N

G

G

K

E

Y

L

I

I

S

E

T

Q

V

D

P

T

A

V

S

S

E

E

V

V

binding adenosine-5'-diphosphate: G42 (= G58), A43 (= A59), G44 (= G60), K45 (= K61), S46 (= S62), T47 (= T63)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c (see paper)
33% identity, 42% coverage: 23:235/513 of query aligns to 331:543/569 of 7ph2A

query
sites
7ph2A

L

V

E

E

V

F

D

R

G

N

V

V

R

T

K

F

E

T

F

Y

P

P

G

G

-

R

-

D

V

V

V

P

A

A

L

L

D

R

N

N

V

I

Q

N

L

L

K

K

I

I

R

P

P

A

G

G

S

K

V

T

H

V

A

A

L

L

M

V

G

G

E

R

N

S

G

G

A

S

G

G

K

K

S

S

T

T

L

I

M

A

K

S

I

L

I

I

A

T

G

R

V

F

Y

Y

N

D

P

I

D

D

R

E

G

G

E

E

V

I

R

L

F

M

A

D

G

G

E

H

K

D

L

L

V

R

I

E

R

Y

T

T

P

-

I

L

D

A

A

S

L

L

N

R

C

N

G

Q

I

V

A

A

M

L

I

V

H

S

Q

Q

E

N

L

V

N

H

L

L

M

F

N

N

T

D

M

-

T

T

V

V

A

A

E

N

N

N

V

I

W

A

I

Y

R

A

R

R

E

T

P

E

K

Q

G

Y

A

S

F

R

G

E

L

Q

I

I

D

E

H

E

A

A

R

A

M

R

G

M

T

A

M

Y

T

A

A

M

E

D

L

F

F

I

A

N

S

K

L

M

N

D

I

N

H

G

L

L

D

D

P

-

L

-

A

T

I

V

V

I

G

G

D

E

-

N

-

G

-

V

-

L

L

L

T

S

V

G

A

G

Q

Q

K

R

Q

Q

M

R

I

I

E

A

I

I

A

A

K

R

A

A

V

L

S

L

Y

R

N

D

S

S

D

P

V

I

L

L

I

I

M

L

D

D

E

E

P

A

T

T

S

S

A

A

I

L

T

-

E

D

T

T

E

E

V

S

E

E

H

R

L

A

F

I

A

Q

I

A

R

L

D

D

L

E

R

L

A

Q

R

K

G

N

V

R

G

T

I

S

V

L

Y

V

I

I

T

A

H

H

K

R

M

L

N

S

E

T

I

I

F

-

E

E

I

K

A

A

D

D

E

E

L

I

T

V

V

V

F

V

R

E

D

D

G

G

Sites not aligning to the query:

binding (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{S},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,5-bis(oxidanyl)oxan-2-yl]oxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-4-[(3~{R})-3-nonanoyloxytetradecanoyl]oxy-5-[[(3~{R})-3-octanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{S},5~{S},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanylnonanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-oxan-2-yl]methoxy]-5-oxidanyl-oxane-2-carboxylic acid: 30, 37, 277, 282, 285

8dmmA Structure of the vanadate-trapped msba bound to kdl (see paper)
33% identity, 42% coverage: 23:235/513 of query aligns to 338:550/576 of 8dmmA

query
sites
8dmmA

L

V

E

E

V

F

D

R

G

N

V

V

R

T

K

F

E

T

F
x
Y

P

P

G

G

-
x
R

-

D

V

V

V

P

A

A

L

L

D

R

N

N

V

I

Q

N

L

L

K

K

I

I

R

P

P

A

G

G

S

K

V

T

H

V

A

A

L

L

M

V

G

G

E

R

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

I

M

A

K

S

I

L

I

I

A

T

G

R

V

F

Y

Y

N

D

P

I

D

D

R

E

G

G

E

E

V

I

R

L

F

M

A

D

G

G

E

H

K

D

L

L

V

R

I

E

R

Y

T

T

P

-

I

L

D

A

A

S

L

L

N

R

C

N

G

Q

I

V

A

A

M

L

I

V

H

S

Q
|
Q

E

N

L

V

N

H

L

L

M

F

N

N

T

D

M

-

T

T

V

V

A

A

E

N

N

N

V

I

W

A

I

Y

R

A

R

R

E

T

P

E

K

Q

G

Y

A

S

F

R

G

E

L

Q

I

I

D

E

H

E

A

A

R

A

M

R

G

M

T

A

M

Y

T

A

A

M

E

D

L

F

F

I

A

N

S

K

L

M

N

D

I

N

H

G

L

L

D

D

P

-

L

-

A

T

I

V

V

I

G

G

D

E

-

N

-

G

-

V

-
x
L

L

L

T
x
S

V
x
G

A
x
G

Q

Q

K

R

Q

Q

M

R

I

I

E

A

I

I

A

A

K

R

A

A

V

L

S

L

Y

R

N

D

S

S

D

P

V

I

L

L

I

I

M

L

D

D

E

E

P

A

T

T

S

S

A

A

I

L

T

-

E

D

T

T

E

E

V

S

E

E

H

R

L

A

F

I

A

Q

I

A

R

L

D

D

L

E

R

L

A

Q

R

K

G

N

V

R

G

T

I

S

V

L

Y

V

I

I

T

A

H
|
H

K

R

M

L

N

S

E

T

I

I

F

-

E

E

I

K

A

A

D

D

E

E

L

I

T

V

V

V

F

V

R

E

D

D

G

G

binding adp orthovanadate: Y347 (≠ F32), R350 (vs. gap), S374 (≠ N57), G375 (= G58), S376 (≠ A59), G377 (= G60), K378 (= K61), S379 (= S62), T380 (= T63), Q420 (= Q104), L476 (vs. gap), S478 (≠ T161), G479 (≠ V162), G480 (≠ A163), H533 (= H217)

Sites not aligning to the query:

binding (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid: 25, 79, 83, 184, 234, 239, 246, 250

6bppA E. Coli msba in complex with lps and inhibitor g092 (see paper)
33% identity, 42% coverage: 23:235/513 of query aligns to 339:551/576 of 6bppA

query
sites
6bppA

L

V

E

E

V

F

D

R

G

N

V

V

R

T

K

F

E

T

F

Y

P

P

G

G

-

R

-

D

V

V

V

P

A

A

L

L

D

R

N

N

V

I

Q

N

L

L

K

K

I

I

R

P

P

A

G

G

S

K

V

T

H

V

A

A

L

L

M

V

G

G

E

R

N

S

G

G

A

S

G

G

K

K

S

S

T

T

L

I

M

A

K

S

I

L

I

I

A

T

G

R

V

F

Y

Y

N

D

P

I

D

D

R

E

G

G

E

E

V

I

R

L

F

M

A

D

G

G

E

H

K

D

L

L

V

R

I

E

R

Y

T

T

P

-

I

L

D

A

A

S

L

L

N

R

C

N

G

Q

I

V

A

A

M

L

I

V

H

S

Q

Q

E

N

L

V

N

H

L

L

M

F

N

N

T

D

M

-

T

T

V

V

A

A

E

N

N

N

V

I

W

A

I

Y

R

A

R

R

E

T

P

E

K

Q

G

Y

A

S

F

R

G

E

L

Q

I

I

D

E

H

E

A

A

R

A

M

R

G

M

T

A

M

Y

T

A

A

M

E

D

L

F

F

I

A

N

S

K

L

M

N

D

I

N

H

G

L

L

D

D

P

-

L

-

A

T

I

V

V

I

G

G

D

E

-

N

-

G

-

V

-

L

L

L

T

S

V

G

A

G

Q

Q

K

R

Q

Q

M

R

I

I

E

A

I

I

A

A

K

R

A

A

V

L

S

L

Y

R

N

D

S

S

D

P

V

I

L

L

I

I

M

L

D

D

E

E

P

A

T

T

S

S

A

A

I

L

T

-

E

D

T

T

E

E

V

S

E

E

H

R

L

A

F

I

A

Q

I

A

R

L

D

D

L

E

R

L

A

Q

R

K

G

N

V

R

G

T

I

S

V

L

Y

V

I

I

T

A

H

H

K

R

M

L

N

S

E

T

I

I

F

-

E

E

I

K

A

A

D

D

E

E

L

I

T

V

V

V

F

V

R

E

D

D

G

G

Sites not aligning to the query:

binding (2E)-3-{6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid: 168, 172, 175, 176, 179, 256, 288, 291, 292, 296

6bplA E. Coli msba in complex with lps and inhibitor g907 (see paper)
33% identity, 42% coverage: 23:235/513 of query aligns to 339:551/576 of 6bplA

query
sites
6bplA

L

V

E

E

V

F

D

R

G

N

V

V

R

T

K

F

E

T

F

Y

P

P

G

G

-

R

-

D

V

V

V

P

A

A

L

L

D

R

N

N

V

I

Q

N

L

L

K

K

I

I

R

P

P

A

G

G

S

K

V

T

H

V

A

A

L

L

M

V

G

G

E

R

N

S

G

G

A

S

G

G

K

K

S

S

T

T

L

I

M

A

K

S

I

L

I

I

A

T

G

R

V

F

Y

Y

N

D

P

I

D

D

R

E

G

G

E

E

V

I

R

L

F

M

A

D

G

G

E

H

K

D

L

L

V

R

I

E

R

Y

T

T

P

-

I

L

D

A

A

S

L

L

N

R

C

N

G

Q

I

V