SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_111605733.1 NCBI__GCF_003259225.1:WP_111605733.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4jdrA Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
56% identity, 98% coverage: 5:465/472 of query aligns to 8:470/471 of 4jdrA

query
sites
4jdrA

L

V

V

V

V

V

L

L

G
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G

S

A

G
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G

P
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P

G
x
A

G

G

Y

Y

A

S

A

A

A

A

F

F

R

R

A

C

A

A

D

D

L

L

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G

L

L

S

E

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T

A

V

M

I

I

V

E
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E

R
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R

H
x
Y

N

N

T

T

L
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L

G

G

G

G

V
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V

C
|
C

L

L

N

N

V

V

G
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G

C
|
C

I

I

P

P

S
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S

K
|
K

A

A

L

L

L

L

H

H

V

V

A

A

G

K

K

V

I

I

L

E

M

E

A

A

E

K

E

A

P

L

A

A

-

E

H

H

G

G

V

I

Q

V

F

F

A

G

K
x
E

P
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P

T

K

I

T

N

D

L

I

E

D

D

K

I

I

R

R

Q

T

H

W

R

K

Q

E

S

K

T

V

V

I

D

N

T

Q

L

L

T

T

G

G

G

G

L

L

T

A

M

G

M

M

A

A

K

K

G

G

R

R

K

K

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T

K

V

V

I

V

H

N

G

G

E
x
L

G
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G

T

K

F

F

D

T

S

G

T

A

N

N

S

T

I

L

T

E

V

V

T

E

K

G

D

E

G

N

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G

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K

Q

T

Q

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V

I

D

N

F

F

K

D

N

N

A

A

I

I

I

I

A

A

V
x
A

G
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G

S

S

R

R

A

P

I

I

K

Q

L

L

P

P

F

F

V

I

P

P

Y

H

D

E

D

D

P

P

R

R

I

I

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D

D

A

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A

A

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L

L

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I

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P

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E

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R

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L

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L

V

V

L

M

G

G

G

G

G

G

I
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I

I
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I

G

G

V

L

E
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E

M

M

A

G

T

T

V

V

Y

Y

Q

H

A

A

L

L

G

G

A

S

K

Q

I

I

T

D

V

V

A

V

E

E

L

M

G

F

E

D

Q

Q

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M

I

T

P

G

A

A

A

D

D

K

K

D

D

L

I

V

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R

K

V

V

F

F

E

T

Q

K

V

R

N

I

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S

D

K

R

K

M

F

S

N

F

L

L

M

T

L

K

E

T

T

Q

K

V

V

T

T

N

A

I

V

E

E

A

A

T

K

P

E

E

D

A

G

L

I

N

Y

V

V

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T

M

M

Q

E

D

G

K

K

D

K

G

A

E

P

-

A

R

E

S

P

L

Q

S

R

V

Y

D

D

A

A

V

V

L

L

V

V

A

A

V

I

G

G

R

R

S

V

P

P

N

N

G

G

K

K

T

N

A

L

G

D

I

A

S

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D

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I

A

G

G

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K

E

L

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D

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R

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G

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F

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D

E

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K

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L

Q

R

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T

S

N

V

V

P

P

N

H

I

I

Y

F

A

A

I

I

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G

D
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D

V

I

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V

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G

G

Q

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P

M
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M

L
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L

A
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A

H
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H

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K

A

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V

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E

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A

A

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A

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Y

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G

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L

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E

E

A

A

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K

N

G

I

I

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I

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A

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F

F

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P

W

W

T

A

A

A

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G

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R

A

A

I

I

A

A

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S

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D

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C

T

A

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D

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G

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M

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T

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K

L

L

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I

Y

F

D

D

E

K

A

E

T

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E

H

R

R

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V

L

I

G

G

A

G

G

A

V

I

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V

G

G

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T

H

N

A

G

G

G

E

E

L

L

L

L

G

G

E

E

L

I

T

G

L

L

A

A

I

I

E

E

F

M

G

G

A

C

T

D

L

A

E

E

D

D

I

I

A

A

L

L

T

T

I

I

H
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H

A

A

H
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H

P

P

S

T

L

L

H

H

E
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E

T

S

V

V

G

G

L

L

A

A

A

A

E

E

L

V

G

F

A

E

G

G

T

S

I

I

T

T

D

D

M

L

P

P

N
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N

K
x
P

K

K

A

A

active site: P15 (= P12), L40 (= L37), C44 (= C41), C49 (= C46), S52 (= S49), E77 (≠ K73), P78 (= P74), I184 (= I180), E188 (= E184), V324 (≠ S319), H442 (= H437), H444 (= H439), E449 (= E444), N467 (= N462), P468 (≠ K463)
binding flavin-adenine dinucleotide: G12 (= G9), G14 (= G11), P15 (= P12), A16 (≠ G13), E35 (= E32), R36 (= R33), Y37 (≠ H34), V43 (= V40), C44 (= C41), G48 (= G45), C49 (= C46), K53 (= K50), L115 (≠ E111), G116 (= G112), A144 (≠ V140), G145 (= G141), I185 (= I181), G311 (= G306), D312 (= D307), M318 (= M313), L319 (= L314), A320 (= A315), H321 (= H316)

P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see 2 papers)
56% identity, 98% coverage: 5:465/472 of query aligns to 9:471/474 of P0A9P0

query
sites
P0A9P0

L

V

V

V

V

V

L

L

G

G

S

A

G

G

P

P

G

A

G

G

Y

Y

A

S

A

A

A

A

F

F

R

R

A

C

A

A

D

D

L

L

G

G

L

L

S

E

V

T

A

V

M

I

I

V

E

E

R

R

H

Y

N

N

T

T

L

L

G

G

G

G

V

V

C

C

L

L

N

N

V

V

G

G

C

C

I

I

P

P

S

S

K

K

A

A

L

L

L

L

H

H

V

V

A

A

G

K

K

V

I

I

L

E

M

E

A

A

E

K

E

A

P

L

A

A

-

E

H

H

G

G

V

I

Q

V

F

F

A

G

K

E

P

P

T

K

I

T

N

D

L

I

E

D

D

K

I

I

R

R

Q

T

H

W

R

K

Q

E

S

K

T

V

V

I

D

N

T

Q

L

L

T

T

G

G

G

G

L

L

T

A

M

G

M

M

A

A

K

K

G

G

R

R

K

K

V

V

T

K

V

V

I

V

H

N

G

G

E

L

G

G

T

K

F

F

D

T

S

G

T

A

N

N

S

T

I

L

T

E

V

V

T

E

K

G

D

E

G

N

Q

G

S

K

Q

T

Q

V

V

I

D

N

F

F

K

D

N

N

A

A

I

I

I

I

A

A

V

A

G

G

S

S

R

R

A

P

I

I

K

Q

L

L

P

P

F

F

V

I

P

P

Y

H

D

E

D

D

P

P

R

R

I

I

L

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D

D

A

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D

A

A

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L

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E

L

L

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P

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E

H

R

L

L

L

L

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V

L

M

G

G

G

G

G

G

I

I

I

I

G

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L

E

E

M

M

A

G

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Y

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H

A

A

L

L

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G

A

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K

Q

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A

V

E

E

L

M

G

F

E

D

Q

Q

I

V

M

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P

G

A

A

A

D

D

K

K

D

D

L

I

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V

R
x
K

V

V

F

F

E

T

Q

K

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R

N

I

K

S

D

K

R

K

M

F

S

N

F

L

L

M

T

L

K

E

T

T

Q

K

V

V

T

T

N

A

I

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E

E

A

A

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P

E

E

D

A

G

L

I

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Y

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T

M

M

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G

K

K

D

K

G

A

E

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-

A

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Y

D

D

A

A

V

V

L

L

V

V

A

A

V

I

G

G

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R

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V

P

P

N

N

G

G

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K

T

N

A

L

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D

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A

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G

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F

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N

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E

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C

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N

H

I

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F

A

A

I

I

G

G

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D

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I

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V

H

G

G

Q

P

P

M

M

L

L

A

A

H

H

K

K

A

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S

V

H

H

Q

E

G

G

H

H

T

V

A

A

A

A

E

E

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V

I

I

A

A

G

G

H

K

K

K

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H

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Y

F

F

Q

D

P

P

L

K

A

V

I

I

P

P

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S

I

I

A

A

Y

Y

T

T

F

E

P

P

E

E

V

V

A

A

W

W

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V

G

G

L

L

T

T

E

E

T

K

E

E

A

A

K

K

K

E

Q

K

N

G

I

I

A

S

I

Y

K

E

T

T

A

A

V

T

F

F

P

P

W

W

T

A

A

A

S

S

G

G

R

R

A

A

I

I

A

A

S

S

G

D

V

C

T

A

Q

D

G

G

K

M

T

T

K

K

L

L

I

I

Y

F

D

D

E

K

A

E

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S

E

H

R

R

V

V

L

I

G

G

A

G

G

A

V

I

V

V

G

G

S

T

H

N

A

G

G

G

E

E

L

L

L

L

G

G

E

E

L

I

T

G

L

L

A

A

I

I

E

E

F

M

G

G

A

C

T

D

L

A

E

E

D

D

I

I

A

A

L

L

T

T

I

I

H

H

A

A

H

H

P

P

S

T

L

L

H

H

E

E

T

S

V

V

G

G

L

L

A

A

A

A

E

E

L

V

G

F

A

E

G

G

T

S

I

I

T

T

D

D

M

L

P

P

N

N

K

P

K

K

A

A

K220 (≠ R215) modified: N6-acetyllysine

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

1bhyA Low temperature middle resolution structure of p64k from masc data (see paper)
49% identity, 98% coverage: 3:464/472 of query aligns to 7:481/482 of 1bhyA

query
sites
1bhyA

Y

Y

D

D

L

V

V

V

V

V

L
|
L

G

G

S

G

G

G

P
|
P

G
|
G

G

G

Y

Y

A

S

A

A

A

A

F

F

R

A

A

A

A

A

D

D

L

E

G

G

L

L

S

K

V

V

A

A

M

I

I

V

E
|
E

R
|
R

H
x
Y

N

K

T

T

L
|
L

G

G

G
|
G

V
|
V

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

H

H

V

N

A

A

G

A

K

V

I

I

L

D

M

E

A

V

E

R

E

H

-

L

P

A

A

A

H

N

G

G

V

I

Q

K

F

Y

A

P

K

E

P

P

T

E

I

L

N

D

L

I

E

D

D

M

I

L

R

R

Q

A

H

Y

R

K

Q

D

S

G

T

V

V

V

D

S

T

R

L

L

T

T

G

G

G

G

L

L

T

A

M

G

M

M

A

A

K

K

G

S

R

R

K

K

V

V

T

D

V

V

I

I

H

Q

G

G

E
x
D

G
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G

T

Q

F

F

D

L

S

D

T

P

N

H

S

H

I

L

T

E

V

V

T

S

-

L

-

T

-

A

-

G

-

D

-

A

-
x
Y

-

E

-

Q

-

A

-

A

K

P

D

T

G

G

Q

E

S

K

Q

K

Q

I

V

V

D

A

F

F

K

K

N

N

A

C

I

I

I

I

A

A

V
x
A

G
|
G

S

S

R

R

A

V

I

T

K

K

L

L

P

P

F

F

V

I

P

P

Y

-

D

E

D

D

P

P

R

R

I

I

L

I

D

D

A

S

T

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S

G

A

A

L

L

Q

A

L

L

E

K

R

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I

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P

P

E

G

H

K

L

L

L

L

V

I

L

I

G

G

G

G

G

G

I
|
I

I

I

G

G

V

L

E
|
E

M

M

A

G

T

T

V

V

Y

Y

Q

S

A

T

L

L

G

G

A

S

K

R

I

L

T

D

V

V

A

V

E

E

L

M

G

M

E

D

Q

G

I

L

M

M

T

Q

G

G

A

A

D

D

K

R

D

D

L

L

V

V

R

K

V

V

F

W

E

Q

Q

K

V

Q

N

N

K

E

D

Y

R

R

M

F

-

D

S

N

F

I

L

M

T

V

K

N

T

T

Q

K

V

T

T

V

N

A

I

V

E

E

A

P

T

K

P

E

E

D

A

G

L

V

N

Y

V

V

T

T

M

F

Q

E

D

G

K

A

D

N

G

A

E

P

R

K

S

E

-

P

L

Q

S

R

V

Y

D

D

A

A

V

V

L

L

V

V

A

A

V

A

G

G

R

R

S

A

P

P

N

N

G

G

K

K

T

L

A

I

G

S

I

A

S

E

D

K

I

A

G

G

V

V

K

A

L

V

D

T

E

D

R

R

G

G

F

F

V

I

L

E

T

V

N

D

E

K

K

Q

C

M

Q

R

T

T

S

N

V

V

P

P

N

H

I

I

Y

Y

A

A

I

I

G

G

D
|
D

V

I

T

V

H

G

G

Q

P

P

M

M

L
|
L

A
|
A

H

H

K

K

A

A

S

V

H

H

Q

E

G

G

H

H

T

V

A

A

A

A

E

E

V

N

I

C

A

A

G

G

H

H

K

K

V

A

D

Y

F

F

Q

D

P

A

L

R

A

V

I

I

P

P

S

G

I

V

A

A

Y

Y

T

T

F

S

P

P

E

E

V

V

A

A

W

W

V

V

G

G

L

E

T

T

E

E

T

L

E

S

A

A

K

K

K

A

Q

S

N

A

I

R

A

K

I

I

K

T

T

K

A

A

V

N

F

F

P

P

W

W

T

A

A

A

S

S

G

G

R

R

A

A

I

I

A

A

S

N

G

G

V

C

T

D

Q

K

G

P

K

F

T

T

K

K

L

L

I

I

Y

F

D

D

E

A

A

E

T

T

E

G

R

R

V

I

L

I

G

G

A

G

G

G

V

I

V

V

G

G

S

P

H

N

A

G

G

G

E

D

L

M

L

I

G

G

E

E

L

V

T

Y

L

L

A

A

I

I

E

E

F

M

G

G

A

C

T

D

L

A

E

A

D

D

I

I

A

G

L

K

T

T

I

I

H
|
H

A

P

H
|
H

P

P

S

T

L

L

H

G

E
|
E

T

S

V

I

G

G

L

M

A

A

A

A

E

E

L

V

G

A

A

L

G

G

T

T

I

C

T

T

D

D

M

L

P

P

N
x
P

K
x
Q

K

K

active site: L41 (= L37), C45 (= C41), C50 (= C46), S53 (= S49), I195 (= I180), E199 (= E184), H454 (= H437), H456 (= H439), E461 (= E444), P479 (≠ N462), Q480 (≠ K463)
binding flavin-adenine dinucleotide: L12 (= L8), P16 (= P12), G17 (= G13), E36 (= E32), R37 (= R33), Y38 (≠ H34), G43 (= G39), V44 (= V40), C45 (= C41), G49 (= G45), C50 (= C46), K54 (= K50), D116 (≠ E111), G117 (= G112), Y135 (vs. gap), A156 (≠ V140), G157 (= G141), D324 (= D307), L331 (= L314), A332 (= A315)

6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
43% identity, 95% coverage: 3:450/472 of query aligns to 7:459/470 of 6uziC

query
sites
6uziC

Y

F

D

D

L

V

V

A

V

V

L
x
I

G
|
G

S

S

G
|
G

P
|
P

G
|
G

G

G

Y

Y

A

V

A

A

A

A

F

I

R

R

A

C

A

A

D

Q

L

L

G

G

L

F

S

K

V

T

A

V

M

I

I

I

E
|
E

R
x
K

H

Y

N

S

T

T

L

L

G

G

G
|
G

V
x
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

H

D

V

S

A

S

G

E

K

H

I

F

L

E

M

N

A

A

E

K

E

H

-

T

-

F

P

A

A

T

H

H

G

G

V

I

Q

L

F

I

A

D

K

E

P

P

T

K

I

V

N

D

L

I

E

A

D

Q

I

M

R

I

Q

S

H

R

R

K

Q

N

S

D

T

V

V

V

D

D

T

Q

L

T

T

T

G

K

G

G

L

I

T

N

M

F

M

L

A

M

K

D

G

K

R

N

K

K

V

I

T

T

V

V

I

L

H

Q

G

G

E
x
V

G
|
G

T

S

F

F

D

E

S

S

T

A

N

T

S

Q

I

I

T

K

V

V

T

T

K

K

-

A

D

D

G

G

Q

S

S

S

Q

E

Q

V

V

I

D

E

F

A

K

K

N

N

A

T

I

I

I

I

A

A

V
x
T

G
|
G

S

S

R

K

A

P

I

S

K

S

L

L

P

P

F

F

V

I

P

T

Y

L

D

D

D

K

P

E

R

R

I

V

L

I

D

T

A

S

T

T

S

E

A

A

L

L

Q

N

L

L

E

K

R

E

I

V

P

P

E

K

H

H

L

L

L

I

V

V

L

I

G

G

G

G

G

G

I
x
V

I
|
I

G

G

V

L

E
|
E

M

L

A

G

T

S

V

V

Y

Y

Q

L

A

R

L

L

G

G

A

S

K

D

I

V

T

T

V

V

A

V

E

E

L

Y

G

L

E

D

Q

K

I

I

M

I

T

P

G

G

A

M

D

D

K

G

D

T

L

L

V

S

R

K

V

E

F

L

E

Q

Q

K

-

T

V

L

N

K

K

K

D

Q

R

G

M

M

S

K

F

F

L

M

T

L

K

S

T

T

Q

A

V

V

T

S

N

G

I

V

E

E

A

R

T

N

P

G

E

D

A

T

L

V

N

K

V

V

T

T

M

A

Q

K

D

D

K

K

D

K

G

G

E

E

R

D

S

V

L

V

-

V

S

E

V

G

D

D

A

Y

V

C

L

L

V

V

A

S

V

V

G

G

R
|
R

S

R

P

P

N

Y

G

T

K

D

T

G

A

L

G

G

I

L

S

E

D

K

I

A

G

G

V

V

K

E

L

L

D

D

E

E

R

R

G

G

F

R

V

V

L

K

T

T

N

N

E

D

K

H

C

L

Q

Q

T

T

S

N

V

V

P

P

N

N

I

I

Y

Y

A

A

I

I

G

G

D
|
D

V

V

T

V

H

K

G

G

P

A

M
|
M

L
|
L

A
|
A

H

H

K

K

A

A

S

E

H

E

Q

E

G

G

H

V

T

F

A

V

A

A

E

E

V

T

I

L

A

A

G

G

H

E

K

K

V

P

D

H

F

V

Q

N

P

Y

L

N

A

L

I

I

P

P

S

G

I

V

A

V

Y

Y

T

T

F

W

P

P

E

E

V

V

A

A

W

G

V

V

G

G

L

K

T

T

E

E

T

E

E

Q

A

L

K

K

K

E

Q

A

N

G

I

V

A

A

I

Y

K

K

T

T

A

G

V

S

F

F

P

P

W

M

T

R

A

A

S

L

G

G

R

R

A

S

I

R

A

A

S

S

G

M

V

D

T

T

Q

D

G

G

K

V

T

I

K

K

L

I

I

L

Y

A

D

D

E

E

A

K

T

T

E

D

R

E

V

I

L

L

G

G

A

V

G

H

V

M

V

I

G

G

S

A

H

R

A

A

G

A

E

D

L

M

L

I

G

A

E

E

L

A

T

V

L

V

A

A

I

M

E

E

F

F

G

R

A

A

T

S

L

A

E

E

D

D

I

I

A

A

L

R

T

I

I

S

H

H

A

A

H
|
H

P

P

S

T

L

Y

H

T

E
|
E

T

A

V

I

G

K

L

E

A

A

A

A

active site: C45 (= C41), C50 (= C46), S53 (= S49), V187 (≠ I180), E191 (= E184), H448 (= H439), E453 (= E444)
binding flavin-adenine dinucleotide: I12 (≠ L8), G13 (= G9), G15 (= G11), P16 (= P12), G17 (= G13), E36 (= E32), K37 (≠ R33), G43 (= G39), T44 (≠ V40), C45 (= C41), G49 (= G45), C50 (= C46), S53 (= S49), K54 (= K50), V117 (≠ E111), G118 (= G112), T147 (≠ V140), G148 (= G141), I188 (= I181), R276 (= R267), D316 (= D307), M322 (= M313), L323 (= L314), A324 (= A315)
binding zinc ion: H448 (= H439), E453 (= E444)

P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
42% identity, 96% coverage: 4:456/472 of query aligns to 11:463/470 of P11959

query
sites
P11959

D

E

L

T

V

L

V

V

L

V

G

G

S

A

G

G

P

P

G

G

G

G

Y

Y

A

V

A

A

A

A

F

I

R

R

A

A

A

A

D

Q

L

L

G

G

L

Q

S

K

V

V

A

T

M

I

I

V

E
|
E

R
x
K

H
x
G

N
|
N

T

-

L
|
L

G
|
G

G
|
G

V
|
V

C
|
C

L

L

N

N

V

V

G

G

C

C

I

I

P

P

S

S

K
|
K

A

A

L

L

L

I

H

S

V

A

A

S

G

H

K

R

I

Y

L

E

M

Q

A

A

E

K

E

H

P

S

A

E

H

E

-

M

G

G

V

I

Q

K

F

A

A

E

K

N

P

V

T

T

I

I

N

D

L

F

E

A

D

K

I

V

R

Q

Q

E

H

W

R

K

Q

A

S

S

T

V

V

V

D

K

T

K

L

L

T

T

G

G

G

G

L

V

T

E

M

G

M

L

A

L

K

K

G

G

R

N

K

K

V

V

T

E

V

I

I

V

H

K

G

G

E

E

G

A

T

Y

F

F

D

V

S

D

T

A

N

N

S

T

I

V

T

R

V

V

T

V

K

N

D

G

G

D

Q

S

S

A

Q

Q

Q

T

V

Y

D

T

F

F

K

K

N

N

A

A

I

I

I

I

A

A

V

T

G

G

S

S

R

R

A

P

I

I

K

E

L

L

P

P

F

N

V

F

P

K

Y

F

D

S

D

N

P

-

R

R

I

I

L

L

D

D

A

S

T

T

S

G

A

A

L

L

Q

N

L

L

E

G

R

E

I

V

P

P

E

K

H

S

L

L

L

V

V

V

L

I

G

G

G

G

G

G

I

Y

I

I

G

G

V

I

E

E

M

L

A

G

T

T

V

A

Y

Y

Q

A

A

N

L

F

G

G

A

T

K

K

I

V

T

T

V

I

A

L

E

E

L

G

G

A

E

G

Q

E

I

I

M

L

T

S

G

G

A

F

D

E

K

K

D

Q

L

M

V

A

R

A

V

I

F

I

E

K

Q

K

-

R

V

L

N

K

K

K

D

K

R

G

M

V

S

E

F

V

L

V

T

T

K

N

T

A

Q

L

V

A

T

K

N

G

I

A

E

E

A

E

T

R

P

E

E

D

A

G

L

V

N

T

V

V

T

T

M

Y

Q

E

D

A

K

N

D

G

G

E

E

T

R

K

S

T

L

I

S

D

V

A

D

D

A

Y

V

V

L

L

V

V

A

T

V

V

G

G

R

R

S

R

P

P

N

N

G

T

K

D

T

E

A

L

G

G

I

L

S

E

D

Q

I

I

G

G

V

I

K

K

L

M

D

T

E

N

R

R

G

G

F

L

V

I

L

E

T

V

N

D

E

Q

K

Q

C

C

Q

R

T

T

S

S

V

V

P

P

N

N

I

I

Y

F

A

A

I

I

G

G

D
|
D

V

I

T

V

H

P

G

G

P

P

M

A

L

L

A
|
A

H

H

K

K

A

A

S

S

H

Y

Q

E

G

G

H

K

T

V

A

A

A

A

E

E

V

A

I

I

A

A

G

G

H

H

K

P

V

S

D

A

F

V

Q

D

P

Y

L

V

A

A

I

I

P

P

S

A

I

V

A

V

Y

F

T

S

F

D

P

P

E

E

V

C

A

A

W

S

V

V

G

G

L

Y

T

F

E

E

T

Q

E

Q

A

A

K

K

K

D

Q

E

N

G

I

I

A

D

I

V

K

I

T

A

A

A

V

K

F

F

P

P

W

F

T

A

A

A

S

N

G

G

R

R

A

A

I

L

A

A

S

L

G

N

V

D

T

T

Q

D

G

G

K

F

T

L

K

K

L

L

I

V

Y

V

D

R

E

K

A

E

T

D

E

G

R

V

V

I

L

I

G

G

A

A

G

Q

V

I

V

I

G

G

S

P

H

N

A

A

G

S

E

D

L

M

L

I

G

A

E

E

L

L

T

G

L

L

A

A

I

I

E

E

F

A

G

G

A

M

T

T

L

A

E

E

D

D

I

I

A

A

L

L

T

T

I

I

H

H

A

A

H

H

P

P

S

T

L

L

H

G

E

E

T

I

V

A

G

M

L

E

A

A

A

A

E

E

L

V

G

A

A

L

G

G

T

T

39:47 (vs. 32:41, 70% identical) binding FAD
K56 (= K50) binding FAD
D314 (= D307) binding FAD
A322 (= A315) binding FAD

1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
42% identity, 95% coverage: 4:452/472 of query aligns to 5:453/455 of 1ebdA

query
sites
1ebdA

D

E

L

T

V

L

V

V

L

V

G
|
G

S

A

G
|
G

P
|
P

G

G

G

G

Y

Y

A

V

A

A

A

A

F

I

R

R

A

A

A

A

D

Q

L

L

G

G

L

Q

S

K

V

V

A

T

M

I

I
x
V

E
|
E

R
x
K

H

G

N

N

T

-

L
|
L

G

G

G
|
G

V
|
V

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

I

H

S

V

A

A

S

G

H

K

R

I

Y

L

E

M

Q

A

A

E

K

E

H

P

S

A

E

H

E

-

M

G

G

V

I

Q

K

F

A

A

E

K
x
N

P
x
V

T

T

I

I

N

D

L

F

E

A

D

K

I

V

R

Q

Q

E

H

W

R

K

Q

A

S

S

T

V

V

V

D

K

T

K

L

L

T

T

G

G

G

G

L

V

T

E

M

G

M

L

A

L

K

K

G

G

R

N

K

K

V

V

T

E

V

I

I

V

H

K

G

G

E
|
E

G
x
A

T

Y

F

F

D

V

S

D

T

A

N

N

S

T

I

V

T

R

V

V

T

V

K

N

D

G

G

D

Q

S

S

A

Q

Q

Q

T

V

Y

D

T

F

F

K

K

N

N

A

A

I

I

I

I

A

A

V
x
T

G
|
G

S

S

R

R

A

P

I

I

K

E

L

L

P

P

F

N

V

F

P

K

Y

F

D

S

D

N

P

-

R

R

I

I

L

L

D

D

A

S

T

T

S

G

A

A

L

L

Q

N

L

L

E

G

R

E

I

V

P

P

E

K

H

S

L

L

L

V

V

V

L

I

G

G

G

G

G

G

I
x
Y

I
|
I

G

G

V

I

E
|
E

M

L

A

G

T

T

V

A

Y

Y

Q

A

A

N

L

F

G

G

A

T

K

K

I

V

T

T

V

I

A

L

E

E

L

G

G

A

E

G

Q

E

I

I

M

L

T

S

G

G

A

F

D

E

K

K

D

Q

L

M

V

A

R

A

V

I

F

I

E

K

Q

K

-

R

V

L

N

K

K

K

D

K

R

G

M

V

S

E

F

V

L

V

T

T

K

N

T

A

Q

L

V

A

T

K

N

G

I

A

E

E

A

E

T

R

P

E

E

D

A

G

L

V

N

T

V

V

T

T

M

Y

Q

E

D

A

K

N

D

G

G

E

E

T

R

K

S

T

L

I

S

D

V

A

D

D

A

Y

V

V

L

L

V

V

A

T

V

V

G

G

R
|
R

S

R

P

P

N

N

G

T

K

D

T

E

A

L

G

G

I

L

S

E

D

Q

I

I

G

G

V

I

K

K

L

M

D

T

E

N

R

R

G

G

F

L

V

I

L

E

T

V

N

D

E

Q

K

Q

C

C

Q

R

T

T

S

S

V

V

P

P

N

N

I

I

Y

F

A

A

I

I

G

G

D
|
D

V

I

T

V

H

P

G

G

P

P

M
x
A

L
|
L

A
|
A

H

H

K

K

A

A

S
|
S

H

Y

Q

E

G

G

H

K

T

V

A

A

A

A

E

E

V

A

I

I

A

A

G

G

H

H

K

P

V

S

D

A

F

V

Q

D

P

Y

L

V

A

A

I

I

P

P

S

A

I

V

A

V

Y

F

T

S

F

D

P

P

E

E

V

C

A

A

W

S

V

V

G

G

L

Y

T

F

E

E

T

Q

E

Q

A

A

K

K

K

D

Q

E

N

G

I

I

A

D

I

V

K

I

T

A

A

A

V

K

F

F

P

P

W

F

T

A

A

A

S

N

G

G

R

R

A

A

I

L

A

A

S

L

G

N

V

D

T

T

Q

D

G

G

K

F

T

L

K

K

L

L

I

V

Y

V

D

R

E

K

A

E

T

D

E

G

R

V

V

I

L

I

G

G

A

A

G

Q

V

I

V

I

G

G

S

P

H

N

A

A

G

S

E

D

L

M

L

I

G

A

E

E

L

L

T

G

L

L

A

A

I

I

E

E

F

A

G

G

A

M

T

T

L

A

E

E

D

D

I

I

A

A

L

L

T

T

I

I

H
|
H

A

A

H
|
H

P

P

S

T

L

L

H

G

E
|
E

T

I

V

A

G

M

L

E

A

A

A

A

E

E

L

V

active site: P13 (= P12), L37 (= L37), C41 (= C41), C46 (= C46), S49 (= S49), N74 (≠ K73), V75 (≠ P74), Y180 (≠ I180), E184 (= E184), S320 (= S319), H438 (= H437), H440 (= H439), E445 (= E444)
binding flavin-adenine dinucleotide: G10 (= G9), G12 (= G11), P13 (= P12), V32 (≠ I31), E33 (= E32), K34 (≠ R33), G39 (= G39), V40 (= V40), C41 (= C41), G45 (= G45), C46 (= C46), K50 (= K50), E112 (= E111), A113 (≠ G112), T141 (≠ V140), G142 (= G141), Y180 (≠ I180), I181 (= I181), R268 (= R267), D308 (= D307), A314 (≠ M313), L315 (= L314), A316 (= A315)

P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
41% identity, 98% coverage: 3:464/472 of query aligns to 5:476/478 of P14218

query
sites
P14218

Y

F

D

D

L

V

V

V

V

V

L

I

G

G

S

A

G

G

P

P

G

G

G

G

Y

Y

A

V

A

A

A

A

F

I

R

R

A

A

A

A

D

Q

L

L

G

G

L

L

S

K

V

T

A

A

M

C

I

I

E
|
E

R
x
K

H
x
Y

-
x
I

-
x
G

-
x
K

-
x
E

-
x
G

-
x
K

N
x
V

T
x
A

L
|
L

G
|
G

G
|
G

V
x
T

C
|
C

L

L

N

N

V

V

G

G

C
|
C

I

I

P

P

S

S

K
|
K

A

A

L

L

L

L

H

D

V

S

A

S

G

Y

K

K

I

Y

L

H

M

E

A

A

E

K

E

E

-

A

-

F

P

K

A

V

H

H

G

G

V

I

Q

E

F

A

A

K

K

G

P

V

T

T

I

I

N

D

L

V

E

P

D

A

I

M

R

V

Q

A

H

R

R

K

Q

A

S

N

T

I

V

V

D

K

T

N

L

L

T

T

G

G

G

G

L

I

T

A

M

T

M

L

A

F

K

K

G

A

R

N

K

G

V

V

T

T

V

S

I

F

H

E

G

G

E

H

G
|
G

T

K

F

L

D

L

S

A

T

N

N

K

S

Q

I

V

T

E

V

V

T

T

K

G

-

L

D

D

G

G

Q

K

S

T

Q

Q

Q

V

V

L

D

E

F

A

K

E

N

N

A

V

I

I

I

I

A

A

V

S

G

G

S

S

R

R

A

P

I

V

K

E

L

I

P

P

F

P

V

A

P

P

Y

L

D

S

D

D

P

D

R

I

I

I

L

V

D

D

A

S

T

T

S

G

A

A

L

L

Q

E

L

F

E

Q

R

A

I

V

P

P

E

K

H

K

L

L

L

G

V

V

L

I

G

G

G

A

G

G

I

V

I

I

G

G

V

L

E

E

M

L

A

G

T

S

V

V

Y

W

Q

A

A

R

L

L

G

G

A

A

K

E

I

V

T

T

V

V

A

L

E

E

L

A

G

L

E

D

Q

K

I

F

M

L

T

P

G

A

A

A

D

D

K

-

D

-

L

-

V

-

R

-

V

-

F

-

E

E

Q

Q

V

I

N

A

K

K

D

E

R

A

M

L

S

K

F

V

L

L

T

T

K

K

-

Q

-

G

-

L

-

N

-

I

-

R

-

L

-

G

T

A

Q

R

V

V

T

T

N

A

I

S

E

E

A

V

T

K

P

K

E

K

A

Q

L

V

N

T

V

V

T

T

M

F

Q

T

D

D

K

A

D

N

G

G

E

E

R

Q

S

K

L

E

S

T

V

F

D

D

A

K

V

L

L

I

V

V

A

A

V

V

G

G

R

R

S

R

P

P

N

V

G

T

K

T

T

D

A

L

G

L

I

A

S

A

D

D

I

S

G

G

V

V

K

T

L

L

D

D

E

E

R

R

G

G

F

F

V

I

L

Y

T

V

N

D

E

D

K

H

C

C

Q

K

T

T

S

S

V

V

P

P

N

G

I

V

Y

F

A

A

I

I

G

G

D
|
D

V

V

T

V

H

R

G

G

P

A

M

M

L

L

A
|
A

H

H

K

K

A

A

S

S

H

E

Q

E

G

G

H

V

T

M

A

V

A

A

E

E

V

R

I

I

A

A

G

G

H

H

K

K

V

A

D

Q

F

M

Q

N

P

Y

L

D

A

L

I

I

P

P

S

S

I

V

A

I

Y

Y

T

T

F

H

P

P

E

E

V

I

A

A

W

W

V

V

G

G

L

K

T

T

E

E

T

Q

E

T

A

L

K

K

K

A

Q

E

N

G

I

V

A

E

I

V

K

N

T

V

A

G

V

T

F

F

P

P

W

F

T

A

A

A

S

S

G

G

R

R

A

A

I

M

A

A

S

A

G

N

V

D

T

T

Q

T

G

G

K

L

T

V

K

K

L

V

I

I

Y

A

D

D

E

A

A

K

T

T

E

D

R

R

V

V

L

L

G

G

A

V

G

H

V

V

V

I

G

G

S

P

H

S

A

A

G

A

E

E

L

L

L

V

G

Q

E

Q

L

G

T

A

L

I

A

G

I

M

E

E

F

F

G

G

A

T

T

S

L

A

E

E

D

D

I

L

A

G

L

M

T

M

I

V

H

F

A

S

H

H

P

P

S

T

L

L

H

S

E

E

T

A

V

L

G

H

L

E

A

A

A

A

E

L

L

A

G

V

A

N

G

G

T

H

I

A

T

I

D

H

M

I

P

A

N

N

K

R

K

K

34:49 (vs. 32:41, 31% identical) binding FAD
C49 (= C41) modified: Disulfide link with 54, Redox-active
C54 (= C46) modified: Disulfide link with 49, Redox-active
K58 (= K50) binding FAD
G122 (= G112) binding FAD
D319 (= D307) binding FAD
A327 (= A315) binding FAD

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

6hg8B Crystal structure of the r460g disease-causing mutant of the human dihydrolipoamide dehydrogenase.
41% identity, 95% coverage: 4:453/472 of query aligns to 16:477/482 of 6hg8B

query
sites
6hg8B

D

D

L

V

V

T

V

V

L
x
I

G

G

S

S

G
|
G

P
|
P

G
|
G

G

G

Y

Y

A

V

A

A

A

A

F

I

R

K

A

A

A

A

D

Q

L

L

G

G

L

F

S

K

V

T

A

V

M

C

I

I

E
|
E

R
x
K

H
x
N

N

E

T

T

L

L

G

G

G
|
G

V
x
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

H

N

V

N

A

S

G

H

K

Y

I

Y

L

H

M

M

A

A

-

H

-

G

-

K

E

D

E

F

P

A

A

S

H

R

G

G

V

I

Q

E

F

M

A

S

K

E

P

V

T

R

I

L

N

N

L

L

E

D

D

K

I

M

R

M

Q

E

H

Q

R

K

Q

S

S

T

T

A

V

V

D

K

T

A

L

L

T

T

G

G

G

G

L

I

T

A

M

H

M

L

A

F

K

K

G

Q

R

N

K

K

V

V

T

V

V

H

I

V

H

N

G

G

E
x
Y

G
|
G

T

K

F

I

D

T

S

G

T

K

N

N

S

Q

I

V

T

T

V

A

T

T

K

K

-

A

D

D

G

G

Q

G

S

T

Q

Q

Q

V

V

I

D

D

F

T

K

K

N

N

A

I

I

L

I

I

A

A

V
x
T

G
|
G

S

S

R

E

A

V

I

T

K

P

L

F

P

P

F

G

V

I

P

T

Y

I

D

D

D

E

P

D

R

T

I

I

L

V

D

S

A

S

T

T

S

G

A

A

L

L

Q

S

L

L

E

K

R

K

I

V

P

P

E

E

H

K

L

M

L

V

V

V

L

I

G

G

G

A

G

G

I
x
V

I
|
I

G

G

V

V

E
|
E

M

L

A

G

T

S

V

V

Y

W

Q

Q

A

R

L

L

G

G

A

A

K

D

I

V

T

T

V

A

A

V

E

E

-

F

L

L

G

G

E

H

Q

V

I

G

M

G

T

V

G

G

A

I

D

D

K

M

D

E

L

I

V

S

R

K

V

N

F

F

E

Q

Q

R

V

I

-

L

N

Q

K

K

D

Q

R

G

M

F

S

K

F

F

L

K

T

L

K

N

T

T

Q

K

V

V

T

T

N

G

I

A

E

T

A

K

T

K

P

S

E

D

A

G

-

K

L

I

N

D

V

V

T

S

M

I

Q

E

D

A

K

A

D

S

G

G

E

G

R

K

S

A

-

E

-

V

L

I

S

T

V

C

D

D

A

V

V

L

L

L

V

V

A

C

V

I

G

G

R
|
R

S

R

P

P

N
x
F

G

T

K

K

T

N

A

L

G

G

I

L

S

E

D

E

I

L

G

G

V

I

K

E

L

L

D

D

E

P

R

R

G

G

F

R

V

I

L

P

T

V

N

N

E

T

K

R

C

F

Q

Q

T

T

S

K

V

I

P

P

N

N

I

I

Y

Y

A

A

I

I

G
|
G

D
|
D

V

V

T

V

H

A

G

G

P

P

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

S

E

H

D

Q

E

G

G

H

I

T

I

A

C

A

V

E

E

V

G

I

M

A

A

G

G

H

G

K

A

V

V

D

H

F

I

Q

D

P

Y

L

N

A

C

I

V

P

P

S

S

I

V

A

I

Y

Y

T

T

F

H

P

P

E

E

V

V

A

A

W

W

V

V

G

G

L

K

T

S

E

E

T

E

E

Q

A

L

K

K

K

E

Q

E

N

G

I

I

A

E

I

Y

K

K

T

V

A

G

V

K

F

F

P

P

W

F

T

A

A

A

S

N

G

S

R

R

A

A

I

K

A

T

S

N

G

A

V

D

T

T

Q

D

G

G

K

M

T

V

K

K

L

I

I

L

Y

G

D

Q

E

K

A

S

T

T

E

D

R

R

V

V

L

L

G

G

A

A

G

H

V

I

V

L

G

G

S

P

H

G

A

A

G

G

E

E

L

M

L

V

G

N

E

E

L

A

T

A

L

L

A

A

I

L

E

E

F

Y

G

G

A

A

T

S

L

C

E

E

D

D

I

I

A

A

L

R

T

V

I

C

H

H

A

A

H
|
H

P

P

S

T

L

L

H

S

E
|
E

T

A

V

F

G

G

-

E

-

A

-

N

L

L

A

A

A

A

E

S

L

F

G

G

active site: C53 (= C41), C58 (= C46), S61 (= S49), V196 (≠ I180), E200 (= E184), H460 (= H439), E465 (= E444)
binding flavin-adenine dinucleotide: I20 (≠ L8), G23 (= G11), P24 (= P12), G25 (= G13), E44 (= E32), K45 (≠ R33), N46 (≠ H34), G51 (= G39), T52 (≠ V40), C53 (= C41), G57 (= G45), C58 (= C46), K62 (= K50), Y126 (≠ E111), G127 (= G112), T156 (≠ V140), G157 (= G141), I197 (= I181), R288 (= R267), F291 (≠ N270), G327 (= G306), D328 (= D307), M334 (= M313), L335 (= L314), A336 (= A315), H337 (= H316)

5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
42% identity, 95% coverage: 3:450/472 of query aligns to 4:461/473 of 5u8wA

query
sites
5u8wA

Y

F

D

D

L

V

V

V

V

V

L
x
I

G

G

S

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

A

V

A

A

A

A

F

I

R

R

A

A

A

A

D

Q

L

L

G

G

L

L

S

K

V

T

A

A

M

C

I

I

E
|
E

R
x
K

H

Y

-

I

-

G

-

K

-

E

-

G

-

K

N

V

T

A

L
|
L

G

G

G
|
G

V
x
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

H

D

V

S

A

S

G

Y

K

K

I

Y

L

H

M

E

A

A

E

K

E

E

-

A

-

F

P

K

A

V

H

H

G

G

V

I

Q

E

F

A

A

K

K
x
G

P
x
V

T

T

I

I

N

D

L

V

E

P

D

A

I

M

R

V

Q

A

H

R

R

K

Q

A

S

N

T

I

V

V

D

K

T

N

L

L

T

T

G

G

G

G

L

I

T

A

M

T

M

L

A

F

K

K

G

A

R

N

K

G

V

V

T

T

V

S

I

F

H

E

G

G

E
x
H

G
|
G

T

K

F

L

D

L

S

A

T

N

N

K

S

Q

I

V

T

E

V

V

T

T

K

G

-

L

D

D

G

G

Q

K

S

T

Q

Q

Q

V

V

L

D

E

F

A

K

E

N

N

A

V

I

I

I

I

A
|
A

V
x
S

G
|
G

S

S

R

R

A

P

I

V

K

E

L

I

P

P

F

P

V

A

P

P

Y

L

D

T

D

D

P

D

R

I

I

I

L

V

D

D

A
x
S

T

T

S

G

A

A

L

L

Q

E

L

F

E

Q

R

A

I

V

P

P

E

K

H

K

L

L

L

G

V

V

L
x
I

G

G

G

A

G
|
G

I
x
V

I
|
I

G

G

V

L

E
|
E

M

L

A

G

T

S

V

V

Y

W

Q

A

A

R

L

L

G

G

A

A

K

E

I

V

T

T

V

V

A

L

E
|
E

L
x
A

G
x
L

E

D

Q

K

I

F

M

L

T

P

G

A

A

A

D

D

K

-

D

-

L

-

V

-

R

-

V

-

F

-

E

E

Q

Q

V

I

N

A

K

K

D

E

R

A

M

L

S

K

F

V

L

L

T

T

K

K

-

Q

-

G

-

L

-

N

-

I

-

R

-

L

-

G

T

A

Q

R

V

V

T

T

N

A

I

S

E

E

A

V

T

K

P

K

E

K

A

Q

L

V

N

T

V

V

T

T

M

F

Q

T

D

D

K

A

D

N

G

G

E

E

R

Q

S

K

L

E

S

T

V

F

D

D

A

K

V

L

L

I

V

V

A
|
A

V
|
V

G
|
G

R
|
R

S

R

P

P

N

V

G

T

K

T

T

D

A

L

G

L

I

A

S

A

D

D

I

S

G

G

V

V

K

T

L

L

D

D

E

E

R

R

G

G

F

F

V

I

L

Y

T

V

N

D

E

D

K

H

C

C

Q

K

T

T

S

S

V

V

P

P

N

G

I

V

Y

F

A

A

I

I

G
|
G

D
|
D

V

V

T

V

H

R

G

G

P

A

M
|
M

L
|
L

A
|
A

H
|
H

K

K

A

A

S
|
S

H

E

Q

E

G

G

H

V

T

M

A

V

A

A

E

E

V

R

I

I

A

A

G

G

H

H

K

K

V

A

D

Q

F

M

Q

N

P

Y

L

D

A

L

I

I

P

P

S

S

I
x
V

A

I

Y
|
Y

T

T

F

H

P

P

E

E

V

I

A

A

W

W

V

V

G

G

L

K

T

T

E

E

T

Q

E

T

A

L

K

K

K

A

Q

E

N

G

I

V

A

E

I

V

K

N

T

V

A

G

V

T

F

F

P

P

W

F

T

A

A

A

S

S

G

G

R

R

A

A

I

M

A

A

S

A

G

N

V

D

T

T

Q

T

G

G

K

L

T

V

K

K

L

V

I

I

Y

A

D

D

E

A

A

K

T

T

E

D

R

R

V

V

L

L

G

G

A

V

G

H

V

V

V

I

G

G

S

P

H

S

A

A

G

A

E

E

L

L

L

V

G

Q

E

Q

L

G

T

A

L

I

A

G

I

M

E

E

F

F

G

G

A

T

T

S

L

A

E

E

D

D

I

L

A

G

L

M

T

M

I

V

H
x
F

A

S

H
|
H

P
|
P

S

T

L

L

H

S

E
|
E

T

A

V

L

G

H

L

E

A

A

A

A

active site: P13 (= P12), L44 (= L37), C48 (= C41), C53 (= C46), S56 (= S49), G82 (≠ K73), V83 (≠ P74), V190 (≠ I180), E194 (= E184), S330 (= S319), F448 (≠ H437), H450 (= H439), E455 (= E444)
binding flavin-adenine dinucleotide: I9 (≠ L8), G12 (= G11), P13 (= P12), G14 (= G13), E33 (= E32), K34 (≠ R33), G46 (= G39), T47 (≠ V40), C48 (= C41), G52 (= G45), C53 (= C46), K57 (= K50), H120 (≠ E111), G121 (= G112), A149 (= A139), S150 (≠ V140), G151 (= G141), S170 (≠ A160), G317 (= G306), D318 (= D307), M324 (= M313), L325 (= L314), A326 (= A315), H327 (= H316), Y357 (= Y346), H450 (= H439), P451 (= P440)
binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (≠ L176), G189 (= G179), V190 (≠ I180), I191 (= I181), E194 (= E184), E210 (= E200), A211 (≠ L201), L212 (≠ G202), A275 (= A264), V276 (= V265), G277 (= G266), R278 (= R267), M324 (= M313), L325 (= L314), V355 (≠ I344), Y357 (= Y346)

Sites not aligning to the query:

active site: 473

5u8uD Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
42% identity, 95% coverage: 3:450/472 of query aligns to 7:464/477 of 5u8uD

query
sites
5u8uD

Y

F

D

D

L

V

V

V

V

V

L
x
I

G

G

S

A

G
|
G

P
|
P

G
|
G

G

G

Y

Y

A

V

A

A

A

A

F

I

R

R

A

A

A

A

D

Q

L

L

G

G

L

L

S

K

V

T

A

A

M

C

I

I

E
|
E

R
x
K

H

Y

-

I

-

G

-

K

-

E

-

G

-

K

N

V

T

A

L
|
L

G

G

G
|
G

V
x
T

C
|
C

L

L

N

N

V

V

G
|
G

C
|
C

I

I

P

P

S
|
S

K
|
K

A

A

L

L

L

L

H

D

V

S

A

S

G

Y

K

K

I

Y

L

H

M

E

A

A

E

K

E

E

-

A

-

F

P

K

A

V

H

H

G

G

V

I

Q

E

F

A

A

K

K
x
G

P
x
V

T

T

I

I

N