SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_111606038.1 NCBI__GCF_003259225.1:WP_111606038.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
72% identity, 100% coverage: 2:241/241 of query aligns to 1:240/240 of 6mjpA

query
sites
6mjpA

A

A

I

I

L

L

E

K

A

A

K

Q

H

H

L

L

A

A

K

K

S

S

Y

Y

K

K

R

R

Q

K

V

V

K

S

D

D

V

V

S

S

I

L

A

Q

V

V

E

E

S

S

G

G

E

Q

A

I

V

V

G

G

L

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

C

S

F

F

Y

Y

M

M

I

I

V

V

G

G

M

L

V

V

A

A

N

R

D

D

A

E

G

G

G

T

I

I

F

T

I

I

D

D

G

D

Q

N

D

D

I

I

T

S

H

I

D

L

A

P

M

M

H

H

T

S

R

R

A

S

Q

R

K

M

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F

F

R

R

K

K

M

L

S

S

V

V

E

E

D

D

N

N

I

I

L

M

A

A

I

V

L

L

E

Q

T

T

R

R

K

E

E

E

L

L

N

T

K

H

A
x
E

Q

E

Q

R

E

Q

E
x
D

R

K

L

L

E

E

E

D

L

L

E

E

F

F

H

H

I

I

N

Q

H

H

I

I

R

R

T

K

N

S

L

A

G

G

M

M

A

A

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

M

A

N

N

P

P

K

Q

F

F

I

I

L

L

D

D

E

Q

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

K

I

I

K

E

H

H

L

L

Q

R

E

D

S

R

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

D

I

V

C

C

D

E

K

K

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

R

I

L

I

I

A

A

S

E

G

G

D

T

A

P

N

Q

T

D

V

V

I

L

N

N

E

E

Q

Q

V

V

K

K

K

Q

V

V

Y

Y

L

L

G

G

D

E

D

Q

F

F

R

R

L

L

binding calcium ion: E111 (≠ A112), D115 (≠ E116)

6mbnA Lptb e163q in complex with atp (see paper)
66% identity, 100% coverage: 2:241/241 of query aligns to 2:241/241 of 6mbnA

query
sites
6mbnA

A

A

I

T

L

L

E

T

A

A

K

K

H

N

L

L

A

A

K

K

S

A

Y
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Y

K

K

K

G

R
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R

Q

R

V
|
V

V

V

K

E

D

D

V

V

S

S

I

L

A

T

V

V

E

N

S

S

G

G

E

E

A

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
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K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

M

I

V

V

A

P

N

R

D

D

A

A

G

G

G

N

I

I

F

I

I

I

D

D

G

D

Q

D

D

D

I

I

T

S

H

L

D

L

A

P

M

L

H

H

T

A

R

R

A

A

Q

R

K

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

M

L

S

S

V

V

E

Y

D

D

N

N

I

L

L

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

N

S

K

A

A

E

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Q

Q

R

E

E

E

D

R

R

L

A

E

N

E

E

L

L

L

M

E

E

F

F

H

H

I

I

N

E

H

H

I

L

R

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T

D

N

S

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M

G

G

M

Q

A

S

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L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

M

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

Q

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

R

I

I

K

E

H

H

L

L

Q

R

E

D

S

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H
|
H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

D

E

K

R

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

H

I

L

I

I

A

A

S

H

G

G

D

T

A

P

N

T

T

E

V

I

I

L

N

Q

N

D

E

E

Q

H

V

V

K

K

K

R

V

V

Y

Y

L

L

G

G

D

E

D

D

F

F

R

R

L

L

binding adenosine-5'-triphosphate: Y13 (= Y13), R16 (= R16), V18 (= V18), N38 (= N38), G39 (= G39), G41 (= G41), K42 (= K42), T43 (= T43), T44 (= T44), H195 (= H195)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
66% identity, 99% coverage: 2:239/241 of query aligns to 1:238/238 of 6s8nB

query
sites
6s8nB

A

A

I

T

L

L

E

T

A

A

K

K

H

N

L

L

A

A

K

K

S

A

Y

Y

K

K

K

G

R

R

Q

R

V

V

K

E

D

D

V

V

S

S

I

L

A

T

V

V

E

N

S

S

G

G

E

E

A

I

V

V

G

G

L

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

M

I

V

V

A

P

N

R

D

D

A

A

G

G

G

N

I

I

F

I

I

I

D

D

G

D

Q

D

D

D

I

I

T

S

H

L

D

L

A

P

M

L

H

H

T

A

R

R

A

A

Q

R

K

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F

F

R
|
R

K

R

M

L

S

S

V

V

E

Y

D

D

N

N

I

L

L

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

N

S

K

A

A

E

Q

Q

Q

R

E

E

E

D

R

R

L

A

E

N

E

E

L

L

L

M

E

E

F

F

H

H

I

I

N

E

H

H

I

L

R

R

T

D

N

S

L
x
M

G
|
G

M
x
Q

A

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

M

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

R

I

I

K

E

H

H

L

L

Q

R

E

D

S

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

D

E

K

R

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

H

I

L

I

I

A

A

S

H

G

G

D

T

A

P

N

T

T

E

V

I

I

L

N

Q

N

D

E

E

Q

H

V

V

K

K

K

R

V

V

Y

Y

L

L

G

G

D

E

D

D

F

F

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (= R91), M133 (≠ L134), G134 (= G135), Q135 (≠ M136)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
66% identity, 99% coverage: 2:239/241 of query aligns to 1:238/238 of 6s8gA

query
sites
6s8gA

A

A

I

T

L

L

E

T

A

A

K

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

K

G

R
|
R

Q

R

V

V

K

E

D

D

V

V

S

S

I

L

A

T

V

V

E

N

S

S

G

G

E

E

A

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

M

I

V

V

A

P

N

R

D

D

A

A

G

G

G

N

I

I

F

I

I

I

D

D

G

D

Q

D

D

D

I

I

T

S

H

L

D

L

A

P

M

L

H

H

T

A

R

R

A

A

Q

R

K

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q
|
Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

M

L

S

S

V

V

E

Y

D

D

N

N

I

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L

M

A

A

I

V

L

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E

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T

I

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R

K

D

E

D

L

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S

K

A

A

E

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Q

Q

R

E

E

E

D

R

R

L

A

E

N

E

E

L

L

L

M

E

E

F

F

H

H

I

I

N

E

H

H

I

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T

D

N

S

L

M

G

G

M

Q

A
x
S

L

L

S
|
S

G

G

E
|
E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

M

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

R

I

I

K

E

H

H

L

L

Q

R

E

D

S

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

D

E

K

R

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

H

I

L

I

I

A

A

S

H

G

G

D

T

A

P

N

T

T

E

V

I

I

L

N

Q

N

D

E

E

Q

H

V

V

K

K

K

R

V

V

Y

Y

L

L

G

G

D

E

D

D

F

F

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y13), R15 (= R16), N37 (= N38), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44), Q84 (= Q85), S136 (≠ A137), S138 (= S139), E141 (= E142)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
66% identity, 98% coverage: 2:236/241 of query aligns to 1:235/235 of 6mhzA

query
sites
6mhzA

A

A

I

T

L

L

E

T

A

A

K

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

K

G

R

R

Q

R

V

V

K

E

D

D

V

V

S

S

I

L

A

T

V

V

E

N

S

S

G

G

E

E

A

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

M

I

V

V

A

P

N

R

D

D

A

A

G

G

G

N

I

I

F

I

I

I

D

D

G

D

Q

D

D

D

I

I

T

S

H

L

D

L

A

P

M

L

H

H

T

A

R

R

A

A

Q

R

K

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q
|
Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

M

L

S

S

V

V

E

Y

D

D

N

N

I

L

L

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

N

S

K

A

A

E

Q

Q

Q

R

E

E

E

D

R

R

L

A

E

N

E

E

L

L

L

M

E

E

F

F

H

H

I

I

N

E

H

H

I

L

R

R

T

D

N

S

L

M

G

G

M

Q

A
x
S

L

L

S
|
S

G
|
G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

M

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E
|
E

P

P

F

F

A

A

G
|
G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

R

I

I

K

E

H

H

L

L

Q

R

E

D

S

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H
|
H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

D

E

K

R

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

H

I

L

I

I

A

A

S

H

G

G

D

T

A

P

N

T

T

E

V

I

I

L

N

Q

N

D

E

E

Q

H

V

V

K

K

K

R

V

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y13), N37 (= N38), G38 (= G39), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44), Q84 (= Q85), S136 (≠ A137), S138 (= S139), G139 (= G140), G140 (= G141), E162 (= E163), G166 (= G167), H194 (= H195)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
66% identity, 97% coverage: 2:235/241 of query aligns to 1:234/234 of 6b89A

query
sites
6b89A

A

A

I

T

L

L

E

T

A

A

K

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

K

G

R
|
R

Q

R

V
|
V

V

V

K

E

D

D

V

V

S

S

I

L

A

T

V

V

E

N

S

S

G

G

E

E

A

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

M

I

V

V

A

P

N

R

D

D

A

A

G

G

G

N

I

I

F

I

I

I

D

D

G

D

Q

D

D

D

I

I

T

S

H

L

D

L

A

P

M
x
L

H
|
H

T

A

R

R

A

A

Q

R

K

R

G

G

I

I

G

G

Y

Y

L

L

P
|
P

Q
|
Q

E

E

A
|
A

S
|
S

I

I

F
|
F

R
|
R

K
x
R

M
x
L

S

S

V

V

E

Y

D

D

N

N

I

L

L

M

A

A

I
x
V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

N

S

K

A

A

E

Q

Q

Q

R

E

E

E

D

R

R

L

A

E

N

E

E

L

L

L

M

E

E

F

F

H

H

I

I

N

E

H

H

I

L

R

R

T

D

N

S

L

M

G

G

M
x
Q

A

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R
|
R

A

A

L

L

A

A

M

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

R

I

I

K

E

H

H

L

L

Q

R

E

D

S

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

D

E

K

R

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

H

I

L

I

I

A

A

S

H

G

G

D

T

A

P

N

T

T

E

V

I

I

L

N

Q

N

D

E

E

Q

H

V

V

K

K

K

R

V

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y13), R15 (= R16), V17 (= V18), N37 (= N38), G38 (= G39), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44)
binding magnesium ion: T42 (= T43), Q84 (= Q85)
binding novobiocin: L71 (≠ M72), H72 (= H73), P83 (= P84), A86 (= A87), S87 (= S88), F89 (= F90), R90 (= R91), R91 (≠ K92), L92 (≠ M93), V101 (≠ I102), Q135 (≠ M136), R149 (= R150)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
66% identity, 97% coverage: 2:235/241 of query aligns to 1:234/234 of 4p31A

query
sites
4p31A

A

A

I

T

L

L

E

T

A

A

K

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

K

G

R
|
R

Q

R

V
|
V

V

V

K

E

D

D

V

V

S

S

I

L

A

T

V

V

E

N

S

S

G

G

E

E

A

I

V

V

G

G

L

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

M

I

V

V

A

P

N

R

D

D

A

A

G

G

G

N

I

I

F

I

I

I

D

D

G

D

Q

D

D

D

I

I

T

S

H

L

D

L

A

P

M

L

H

H

T

A

R

R

A

A

Q

R

K

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q
|
Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

M

L

S

S

V

V

E

Y

D

D

N

N

I

L

L

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

N

S

K

A

A

E

Q

Q

Q

R

E

E

E

D

R

R

L

A

E

N

E

E

L

L

L

M

E

E

F

F

H

H

I

I

N

E

H

H

I

L

R

R

T

D

N

S

L

M

G

G

M

Q

A

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

M

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

R

I

I

K

E

H

H

L

L

Q

R

E

D

S

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

D

E

K

R

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

H

I

L

I

I

A

A

S

H

G

G

D

T

A

P

N

T

T

E

V

I

I

L

N

Q

N

D

E

E

Q

H

V

V

K

K

K

R

V

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y13), R15 (= R16), V17 (= V18), G38 (= G39), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44)
binding magnesium ion: T42 (= T43), Q84 (= Q85)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
66% identity, 97% coverage: 2:234/241 of query aligns to 1:233/233 of 6b8bA

query
sites
6b8bA

A

A

I

T

L

L

E

T

A

A

K

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

K

G

R
|
R

Q

R

V
|
V

V

V

K

E

D

D

V

V

S

S

I

L

A

T

V

V

E

N

S

S

G

G

E

E

A

I

V

V

G

G

L

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

M

I

V

V

A

P

N

R

D

D

A

A

G

G

G

N

I

I

F

I

I

I

D

D

G

D

Q

D

D

D

I

I

T

S

H

L

D

L

A

P

M

L

H

H

T

A

R

R

A

A

Q

R

K

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F
|
F

R
|
R

K
x
R

M

L

S

S

V

V

E

Y

D

D

N

N

I

L

L

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

N

S

K

A

A

E

Q

Q

Q

R

E

E

E

D

R

R

L

A

E

N

E

E

L

L

L

M

E

E

F

F

H

H

I

I

N

E

H

H

I

L

R

R

T

D

N

S

L

M

G

G

M

Q

A

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

M

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

L

R

I

I

K

E

H

H

L

L

Q

R

E

D

S

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

D

E

K

R

A

A

Y

Y

I

I

V

V

G

S

N

Q

G

G

Y

H

I

L

I

I

A

A

S

H

G

G

D

T

A

P

N

T

T

E

V

I

I

L

N

Q

N

D

E

E

Q

H

V

V

K

K

K

R

V

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y13), R15 (= R16), V17 (= V18), G38 (= G39), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F90), R90 (= R91), R91 (≠ K92)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
33% identity, 97% coverage: 3:236/241 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

I

V

L

L

E

E

A

V

K

Q

H

S

L

L

A

H

K

V

S

Y

Y
|
Y

K

G

K

A

R

I

Q

H

V

A

V

I

K

K

D

G

V

I

S

D

I

L

A

K

V

V

E

P

S

R

G

G

E

Q

A

I

V

V

G

T

L

L

L

I

G

G

P

A

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

L

Y

S

M

A

I

I

V

A

G

G

M

L

V

V

A

R

N

A

D

Q

A

K

G

G

G

K

I

I

F

I

I

F

D

N

G

G

Q

Q

D

D

I

I

T

T

H

N

D

K

A

P

M

A

H

H

T

V

R

I

A

N

Q

R

K

M

G

G

I

I

G

A

Y

L

L

V

P

P

Q
x
E

E

G

A

R

S

R

I

I

F

F

R

P

K

E

M

L

S

T

V

V

E

Y

D

E

N

N

I

L

L

M

A

M

I

G

L

A

E

Y

T

N

R

R

K

K

E

-

L

-

N

D

K

K

A

E

Q

G

Q

I

E

K

E

R

R

D

L

L

E

E

E

W

L

I

L

F

E

S

E

L

F

F

-

P

H

R

I

L

N

K

H

E

I

R

R

L

T

K

N

Q

L

L

G

G

M

G

A

T

L

L

S

S

G

G

E

E

R

Q

R

M

V

L

E

A

I

I

A

G

R

R

A

A

L

L

A

M

M

S

N

R

P

P

K

K

F

L

I

L

L

M

D

D

E
|
E

P

P

F

S

A

L

G

G

V

L

D

A

P

P

I

I

S

L

V

V

G

S

D

E

I

V

K

F

L

E

I

V

I

I

K

Q

H

K

L

I

Q

N

E

Q

S

E

G

G

I

T

G

T

V

I

L

L

I

L

T

V

D

E

H

Q

N

N

V

A

R

L

E

G

T

A

L

L

D

K

I

V

C

A

D

H

K

Y

A

G

Y

Y

I

V

V

L

G

E

N

T

G

G

Y

Q

I

I

I

V

A

L

S

E

G

G

D

K

A

A

N

S

T

E

V

L

I

L

N

D

N

N

E

E

Q

M

V

V

K

R

K

K

V

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y13), G42 (= G39), G44 (= G41), K45 (= K42), T46 (= T43), T47 (= T44), E88 (≠ Q85), E165 (= E163)

7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation (see paper)
33% identity, 90% coverage: 2:219/241 of query aligns to 3:223/263 of 7d0aB

query
sites
7d0aB

A

S

I

L

L

I

E

E

A

V

K

K

H

N

L

L

A

S

K

F

S

N

Y

R

K

G

K

E

R

R

Q

V

V

I

V

Y

K

D

D

N

V

I

S

S

I

L

A

N

V

I

E

R

S

R

G

G

E

Q

A

I

V

T

G

A

L

I

L

M

G

G

P

P

N
x
S

G

G

A
x
T

G
|
G

K
|
K

T

T

C

L

F

L

Y

R

M

L

I

I

V

G

G

G

M

Q

V

L

A

V

N

P

D

D

A

Q

G

G

G

E

I

V

F

L

I

L

D

D

G

G

Q

K

D

D

I

I

T

A

H

Q

D

M

A

S

M

R

H

Q

T

E

-

L

-

F

R

A

A

A

Q

R

K

A

G

R

I

M

G

G

Y

M

L

L

P

F

Q

Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

M

M

S

S

V

V

E

Y

D

E

N

N

I

V

L

A

A

F

I

P

L

I

E

R

T

A

R

H

K

T

E

K

L

L

N

S

K

E

A

N

Q

L

Q

I

E

A

E

E

R

L

L

V

E

A

E

L

L

K

L

L

E

E

E

S

F

V

H

G

I

L

N

R

H

G

I

T

R

E

T

Q

N

L

L

M

G

P

M

T

A
x
E

L

L

S
|
S

G

G

E
x
M

R

N

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

M

L

N

D

P

P

K

D

F

L

I

I

L

M

L

Y

D

D

E

E

P

P

F

F

A

A

G

G

V

Q

D

D

P

P

I

I

S

V

V

K

G

G

D

V

I

L

K

T

L

R

I

L

I

I

K

R

H

S

L

L

Q

R

E

E

S

A

-

L

G

D

I

L

G

T

V

T

L

I

I

I

T

V

D

S

H

H

N

D

V

V

R

P

E

E

T

T

L

L

D

S

I

I

C

A

D

D

K

Y

A

I

Y

Y

I

V

V

V

G

A

N

E

G

G

Y

K

I

I

I

Q

A

G

S

E

G

G

binding adenosine-5'-diphosphate: S39 (≠ N38), T41 (≠ A40), G42 (= G41), K43 (= K42), E140 (≠ A137), S142 (= S139), M145 (≠ E142)

7d08B Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
33% identity, 90% coverage: 2:219/241 of query aligns to 3:223/263 of 7d08B

query
sites
7d08B

A

S

I

L

L

I

E

E

A

V

K

K

H

N

L

L

A

S

K

F

S

N

Y
x
R

K

G

K

E

R
|
R

Q

V

V

I

V

Y

K

D

D

N

V

I

S

S

I

L

A

N

V

I

E

R

S

R

G

G

E

Q

A

I

V

T

G

A

L

I

L

M

G

G

P

P

N

S

G
|
G

A
x
T

G

G

K
|
K

T
|
T

C

L

F

L

Y

R

M

L

I

I

V

G

G

G

M

Q

V

L

A

V

N

P

D

D

A

Q

G

G

G

E

I

V

F

L

I

L

D

D

G

G

Q

K

D

D

I

I

T

A

H

Q

D

M

A

S

M

R

H

Q

T

E

-

L

-

F

R

A

A

A

Q

R

K

A

G

R

I

M

G

G

Y

M

L

L

P

F

Q

Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

M

M

S

S

V

V

E

Y

D

E

N

N

I

V

L

A

A

F

I

P

L

I

E

R

T

A

R

H

K

T

E

K

L

L

N

S

K

E

A

N

Q

L

Q

I

E

A

E

E

R

L

L

V

E

A

E

L

L

K

L

L

E

E

E

S

F

V

H

G

I

L

N

R

H

G

I

T

R

E

T

Q

N

L

L

M

G

P

M

T

A

E

L

L

S

S

G

G

E

M

R

N

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

M

L

N

D

P

P

K

D

F

L

I

I

L

M

L

Y

D

D

E
|
E

P

P

F

F

A

A

G

G

V

Q

D

D

P

P

I

I

S

V

V

K

G

G

D

V

I

L

K

T

L

R

I

L

I

I

K

R

H

S

L

L

Q

R

E

E

S

A

-

L

G

D

I

L

G

T

V

T

L

I

I

I

T

V

D

S

H

H

N

D

V

V

R

P

E

E

T

T

L

L

D

S

I

I

C

A

D

D

K

Y

A

I

Y

Y

I

V

V

V

G

A

N

E

G

G

Y

K

I

I

I

Q

A

G

S

E

G

G

binding adenosine-5'-triphosphate: R14 (≠ Y13), R17 (= R16), G40 (= G39), T41 (≠ A40), K43 (= K42), T44 (= T43), T45 (= T44), E166 (= E163)

6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp (see paper)
33% identity, 90% coverage: 2:219/241 of query aligns to 1:221/253 of 6z5uK

query
sites
6z5uK

A

S

I

L

L

I

E

E

A

V

K

K

H

N

L

L

A

S

K

F

S

N

Y
x
R

K

G

K

E

R

R

Q

V

V

I

V

Y

K

D

D

N

V

I

S

S

I

L

A

N

V

I

E

R

S

R

G

G

E

Q

A

I

V

T

G

A

L

I

L

M

G

G

P

P

N
x
S

G
|
G

A

T

G
|
G

K
|
K

T
|
T

C

L

F

L

Y

R

M

L

I

I

V

G

G

G

M

Q

V

L

A

V

N

P

D

D

A

Q

G

G

G

E

I

V

F

L

I

L

D

D

G

G

Q

K

D

D

I

I

T

A

H

Q

D

M

A

S

M

R

H

Q

T

E

-

L

-

F

R

A

A

A

Q

R

K

A

G

R

I

M

G

G

Y

M

L

L

P

F

Q
|
Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

M

M

S

S

V

V

E

Y

D

E

N

N

I

V

L

A

A

F

I

P

L

I

E

R

T

A

R

H

K

T

E

K

L

L

N

S

K

E

A

N

Q

L

Q

I

E

A

E

E

R

L

L

V

E

A

E

L

L

K

L

L

E

E

E

S

F

V

H

G

I

L

N

R

H

G

I

T

R

E

T

Q

N

L

L

M

G

P

M

T

A

E

L

L

S

S

G

G

E

M

R

N

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

M

L

N

D

P

P

K

D

F

L

I

I

L

M

L

Y

D

D

E
|
E

P

P

F

F

A

A

G

G

V

Q

D

D

P

P

I

I

S

V

V

K

G

G

D

V

I

L

K

T

L

R

I

L

I

I

K

R

H

S

L

L

Q

R

E

E

S

A

-

L

G

D

I

L

G

T

V

T

L

I

I

I

T

V

D

S

H
|
H

N

D

V

V

R

P

E

E

T

T

L

L

D

S

I

I

C

A

D

D

K

Y

A

I

Y

Y

I

V

V

V

G

A

N

E

G

G

Y

K

I

I

I

Q

A

G

S

E

G

G

binding phosphoaminophosphonic acid-adenylate ester: R12 (≠ Y13), S37 (≠ N38), G38 (= G39), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44), Q86 (= Q85), E164 (= E163), H197 (= H195)
binding magnesium ion: Q86 (= Q85), E164 (= E163)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 98% coverage: 1:237/241 of query aligns to 2:254/254 of 1g6hA

query
sites
1g6hA

M

M

A

E

I

I

L

L

E

R

A

T

K

E

H

N

L

I

A

V

K

K

S

Y

Y
x
F

K

G

K

E

R
x
F

Q

K

V

A

V

L

K

D

D

G

V

V

S

S

I

I

A

S

V

V

E

N

S

K

G

G

E

D

A

V

V

T

G

L

L

I

G

G

P

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

C

L

F

I

Y

N

M

V

I

I

V

T

G

G

M

F

V

L

A

K

N

A

D

D

A

E

G

G

G

R

I

V

F

Y

I

F

D

E

G

N

Q

K

D

D

I

I

T

T

H

N

D

K

A

E

M

P

H

A

T

E

R

L

A

Y

Q

H

K

Y

G

G

I

I

G

V

Y

R

L

T

P

F

Q

Q

E

T

A

P

S

Q

I

P

F

L

R

K

K

E

M

M

S

T

V

V

E

L

D

E

N

N

I

L

L

L

-

I

-

G

A

E

I

I

L

C

E

P

T

G

R

E

K

S

E

P

L

L

N

N

K

S

-

L

-

F

-

Y

-

K

-

W

-

I

A

P

Q

K

Q

E

E

E

R

M

L

V

E

E

E

K

-

A

-

F

-

K

L

I

L

L

E

E

E

F

F

L

H

K

I

L

N

S

H

H

I

L

R

Y

T

D

N

R

L

K

G

A

M

G

A

E

L

L

S

S

G

G

E

Q

R

M

R

K

R

L

V

V

E

E

I

I

A

G

R

R

A

A

L

L

A

M

M

T

N

N

P

P

K

K

F

M

I

I

L

V

L

M

D

D

E

E

P

P

F

I

A

A

G

G

V

V

D

A

P

P

I

G

S

L

V

A

G

H

D

D

I

I

K

F

L

N

I

H

I

V

K

L

H

E

L

L

Q

K

E

A

S

K

G

G

I

I

G

T

V

F

L

L

I

I

T

I

D

E

H

H

N

R

V

L

R

D

E

I

T

V

L

L

D

N

I

Y

C

I

D

D

K

H

A

L

Y

Y

I

V

V

M

G

F

N

N

G

G

Y

Q

I

I

A

A

S

E

G

G

-

R

-

G

-

E

D

E

A

I

N

K

T

N

V

V

I

L

N

S

N

D

E

P

Q

K

V

V

K

V

K

E

V

I

Y

Y

L

I

G

G

D

E

binding adenosine-5'-diphosphate: F14 (≠ Y13), F17 (≠ R16), N39 (= N38), G40 (= G39), G42 (= G41), K43 (= K42), S44 (≠ T43), T45 (= T44)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 98% coverage: 1:236/241 of query aligns to 2:253/253 of 1g9xB

query
sites
1g9xB

M

M

A

E

I

I

L

L

E

R

A

T

K

E

H

N

L

I

A

V

K

K

S

Y

Y
x
F

K

G

K

E

R
x
F

Q

K

V

A

V

L

K

D

D

G

V

V

S

S

I

I

A

S

V

V

E

C

S

K

G

G

E

D

A

V

V

T

G

L

L

I

G

G

P

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

C

L

F

I

Y

N

M

V

I

I

V

T

G

G

M

F

V

L

A

K

N

A

D

D

A

E

G

G

G

R

I

V

F

Y

I

F

D

E

G

N

Q

K

D

D

I

I

T

T

H

N

D

K

A

E

M

P

H

A

T

E

R

L

A

Y

Q

H

K

Y

G

G

I

I

G

V

Y

R

L

T

P

F

Q

Q

E

T

A

P

S

Q

I

P

F

L

R

K

K

E

M

M

S

T

V

V

E

L

D

E

N

N

I

L

L

L

-

I

-

G

A

E

I

I

L

N

E

P

T

G

R

E

K

S

E

P

L

L

N

N

K

S

-

L

-

F

-

Y

-

K

-

W

-

I

A

P

Q

K

Q

E

E

E

R

M

L

V

E

E

E

K

-

A

-

F

-

K

L

I

L

L

E

E

E

F

F

L

H

K

I

L

N

S

H

H

I

L

R

Y

T

D

N

R

L

K

G

A

M

G

A

E

L

L

S

S

G

G

E

Q

R

M

R

K

R

L

V

V

E

E

I

I

A

G

R

R

A

A

L

L

A

M

M

T

N

N

P

P

K

K

F

M

I

I

L

V

L

M

D

D

E
|
E

P

P

F

I

A

A

G

G

V

V

D

A

P

P

I

G

S

L

V

A

G

H

D

D

I

I

K

F

L

N

I

H

I

V

K

L

H

E

L

L

Q

K

E

A

S

K

G

G

I

I

G

T

V

F

L

L

I

I

T

I

D

E

H

H

N

R

V

L

R

D

E

I

T

V

L

L

D

N

I

Y

C

I

D

D

K

H

A

L

Y

Y

I

V

V

M

G

F

N

N

G

G

Y

Q

I

I

A

A

S

E

G

G

-

R

-

G

-

E

D

E

A

I

N

K

T

N

V

V

I

L

N

S

N

D

E

P

Q

K

V

V

K

V

K

E

V

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y13), F17 (≠ R16), G40 (= G39), S41 (≠ A40), G42 (= G41), K43 (= K42), S44 (≠ T43), T45 (= T44)
binding magnesium ion: S44 (≠ T43), E176 (= E163)

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 95% coverage: 1:229/241 of query aligns to 1:230/242 of 3c4jA

query
sites
3c4jA

M

L

A

Q

I

M

L

I

E

D

A

V

K

H

H

Q

L

L

A

K

K

K

S

S

Y
x
F

K

G

K

S

R

L

Q

E

V
|
V

V

L

K

K

D

G

V

I

S

N

I

V

A

H

V

I

E

R

S

E

G

G

E

E

A

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

C

F

F

L

Y

R

M

C

I

L

V

N

G

L

M

L

V

E

A

D

N

F

D

D

A

E

G

G

G

E

I

I

F

I

I

I

D

D

G

G

Q

I

D

N

I

L

-

K

T

A

H

K

D

D

A

T

M

N

H

L

T

N

R

K

A

V

Q

R

K

E

G

E

I

V

G

G

Y

M

L

V

P

F

Q

Q

E

R

A

F

S

N

I

L

F

F

R

P

K

H

M

M

S

T

V

V

E

L

D

N

N

N

I

I

-

T

L

L

A

A

I

P

L

M

E

K

T

V

R

R

K

K

E

-

L

W

N

P

K

R

A

E

Q

K

Q

A

E

E

E

A

R

K

L

A

E

M

E

E

L

L

E

D

E

K

F

V

H

G

I

L

N

K

H

D

I

K

R

A

T

H

N

A

L

Y

G

P

M

D

A

S

L

L

S

S

G

G

E

Q

R

A

R

Q

R

R

V

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

N

E

P

P

K

K

F

I

I

M

L

L

L

F

D

D

E

E

P

P

F

T

A

S

G

A

V

L

D

D

P

P

I

E

S

M

V

V

G

G

D

E

I

V

K

L

L

S

I

V

I

M

K

K

H

Q

L

L

Q

A

E

N

S

E

G

G

I

M

G

T

V

M

L

V

I

V

T

V

D

T

H

H

N

E

V

M

R

G

E

F

T

A

L

R

D

E

I

V

C

G

D

D

K

R

A

V

Y

L

I

F

V

M

G

D

N

G

G

G

Y

Y

I

I

A

E

S

E

G

G

D

K

A

P

N

E

T

D

V

L

I

F

N

D

N

R

E

P

Q

Q

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y13), V18 (= V18), S38 (≠ N38), G39 (= G39), S40 (≠ A40), G41 (= G41), K42 (= K42), S43 (≠ T43), T44 (= T44)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 95% coverage: 1:229/241 of query aligns to 1:230/242 of 3c41J

query
sites
3c41J

M

L

A

Q

I

M

L

I

E

D

A

V

K

H

H

Q

L

L

A

K

K

K

S

S

Y
x
F

K

G

K

S

R

L

Q

E

V
|
V

V

L

K

K

D

G

V

I

S

N

I

V

A

H

V

I

E

R

S

E

G

G

E

E

A

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

C

F

F

L

Y

R

M

C

I

L

V

N

G

L

M

L

V

E

A

D

N

F

D

D

A

E

G

G

G

E

I

I

F

I

I

I

D

D

G

G

Q

I

D

N

I

L

-

K

T

A

H

K

D

D

A

T

M

N

H

L

T

N

R

K

A

V

Q

R

K

E

G

E

I

V

G

G

Y

M

L

V

P

F

Q

Q

E

R

A

F

S

N

I

L

F

F

R

P

K

H

M

M

S

T

V

V

E

L

D

N

N

N

I

I

-

T

L

L

A

A

I

P

L

M

E

K

T

V

R

R

K

K

E

-

L

W

N

P

K

R

A

E

Q

K

Q

A

E

E

E

A

R

K

L

A

E

M

E

E

L

L

E

D

E

K

F

V

H

G

I

L

N

K

H

D

I

K

R

A

T

H

N

A

L

Y

G

P

M

D

A

S

L

L

S

S

G

G

E

Q

R

A

R

Q

R

R

V

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

N

E

P

P

K

K

F

I

I

M

L

L

L

F

D
|
D

E

E

P

P

F

T

A

S

G

A

V

L

D

D

P

P

I

E

S

M

V

V

G

G

D

E

I

V

K

L

L

S

I

V

I

M

K

K

H

Q

L

L

Q

A

E

N

S

E

G

G

I

M

G

T

V

M

L

V

I

V

T

V

D

T

H

H

N

E

V

M

R

G

E

F

T

A

L

R

D

E

I

V

C

G

D

D

K

R

A

V

Y

L

I

F

V

M

G

D

N

G

G

G

Y

Y

I

I

A

E

S

E

G

G

D

K

A

P

N

E

T

D

V

L

I

F

N

D

N

R

E

P

Q

Q

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y13), V18 (= V18), S38 (≠ N38), G39 (= G39), G41 (= G41), K42 (= K42), S43 (≠ T43), T44 (= T44)
binding magnesium ion: S43 (≠ T43), D163 (= D162)

2olkA Abc protein artp in complex with adp-beta-s
30% identity, 95% coverage: 1:229/241 of query aligns to 1:230/242 of 2olkA

query
sites
2olkA

M

L

A

Q

I

M

L

I

E

D

A

V

K

H

H

Q

L

L

A

K

K

K

S

S

Y
x
F

K

G

K

S

R

L

Q

E

V
|
V

V

L

K

K

D

G

V

I

S

N

I

V

A

H

V

I

E

R

S

E

G

G

E

E

A

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

C

F

F

L

Y

R

M

C

I

L

V

N

G

L

M

L

V

E

A

D

N

F

D

D

A

E

G

G

G

E

I

I

F

I

I

I

D

D

G

G

Q

I

D

N

I

L

-

K

T

A

H

K

D

D

A

T

M

N

H

L

T

N

R

K

A

V

Q

R

K

E

G

E

I

V

G

G

Y

M

L

V

P

F

Q

Q

E

R

A

F

S

N

I

L

F

F

R

P

K

H

M

M

S

T

V

V

E

L

D

N

N

N

I

I

-

T

L

L

A

A

I

P

L

M

E

K

T

V

R

R

K

K

E

-

L

W

N

P

K

R

A

E

Q

K

Q

A

E

E

E

A

R

K

L

A

E

M

E

E

L

L

E

D

E

K

F

V

H

G

I

L

N

K

H

D

I

K

R

A

T

H

N

A

L

Y

G

P

M

D

A

S

L

L

S

S

G

G

E

Q

R

A

R

Q

R

R

V

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

N

E

P

P

K

K

F

I

I

M

L

L

L

F

D

D

E

E

P

P

F

T

A

S

G

A

V

L

D

D

P

P

I

E

S

M

V

V

G

G

D

E

I

V

K

L

L

S

I

V

I

M

K

K

H

Q

L

L

Q

A

E

N

S

E

G

G

I

M

G

T

V

M

L

V

I

V

T

V

D

T

H

H

N

E

V

M

R

G

E

F

T

A

L

R

D

E

I

V

C

G

D

D

K

R

A

V

Y

L

I

F

V

M

G

D

N

G

G

G

Y

Y

I

I

A

E

S

E

G

G

D

K

A

P

N

E

T

D

V

L

I

F

N

D

N

R

E

P

Q

Q

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y13), V18 (= V18), S38 (≠ N38), G39 (= G39), S40 (≠ A40), G41 (= G41), K42 (= K42), S43 (≠ T43), T44 (= T44)

2oljA Abc protein artp in complex with adp/mg2+
30% identity, 95% coverage: 1:229/241 of query aligns to 1:230/242 of 2oljA

query
sites
2oljA

M

L

A

Q

I

M

L

I

E

D

A

V

K

H

H

Q

L

L

A

K

K

K

S

S

Y
x
F

K

G

K

S

R

L

Q

E

V
|
V

V

L

K

K

D

G

V

I

S

N

I

V

A

H

V

I

E

R

S

E

G

G

E

E

A

V

V

V

G

V

L

V

L

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

C

F

F

L

Y

R

M

C

I

L

V

N

G

L

M

L

V

E

A

D

N

F

D

D

A

E

G

G

G

E

I

I

F

I

I

I

D

D

G

G

Q

I

D

N

I

L

-

K

T

A

H

K

D

D

A

T

M

N

H

L

T

N

R

K

A

V

Q

R

K

E

G

E

I

V

G

G

Y

M

L

V

P

F

Q

Q

E

R

A

F

S

N

I

L

F

F

R

P

K

H

M

M

S

T

V

V

E

L

D

N

N

N

I

I

-

T

L

L

A

A

I

P

L

M

E

K

T

V

R

R

K

K

E

-

L

W

N

P

K

R

A

E

Q

K

Q

A

E

E

E

A

R

K

L

A

E

M

E

E

L

L

E

D

E

K

F

V

H

G

I

L

N

K

H

D

I

K

R

A

T

H

N

A

L

Y

G

P

M

D

A

S

L

L

S

S

G

G

E

Q

R

A

R

Q

R

R

V

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

N

E

P

P

K

K

F

I

I

M

L

L

L

F

D

D

E

E

P

P

F

T

A

S

G

A

V

L

D

D

P

P

I

E

S

M

V

V

G

G

D

E

I

V

K

L

L

S

I

V

I

M

K

K

H

Q

L

L

Q

A

E

N

S

E

G

G

I

M

G

T

V

M

L

V

I

V

T

V

D

T

H

H

N

E

V

M

R

G

E

F

T

A

L

R

D

E

I

V

C

G

D

D

K

R

A

V

Y

L

I

F

V

M

G

D

N

G

G

G

Y

Y

I

I

A

E

S

E

G

G

D

K

A

P

N

E

T

D

V

L

I

F

N

D

N

R

E

P

Q

Q

binding adenosine-5'-diphosphate: F13 (≠ Y13), V18 (= V18), S38 (≠ N38), G39 (= G39), S40 (≠ A40), G41 (= G41), K42 (= K42), S43 (≠ T43), T44 (= T44)

7chaI Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
29% identity, 92% coverage: 4:224/241 of query aligns to 4:227/262 of 7chaI

query
sites
7chaI

L

V

E

E

A

L

K

K

H

G

L

L

A

T

K

F

S

K

Y
x
R

K

G

K

S

R

R

Q

A

V

I

V

F

K

D

D

N

V

I

S

D

I

V

A

R

V

I

E

P

S

R

G

G

E

K

A

V

V

T

G

G

L

I

L

M

G

G

P

P

N
x
S

G
|
G

A
x
C

G
|
G

K
|
K

T
|
T

C

L

F

L

Y

R

M

L

I

I

V

A

G

S

M

Q

V

L

A

R

N

P

D

S

A

K

G

G

G

E

I

V

F

W

I

V

D

N

G

G

Q

Q

D

N

I

L

T

P

H

Q

-

L

-

S

-

R

-

G

D

D

A

L

M

F

H

D

T

M

R

R

A

K

Q

Q

K

F

G

G

I

V

G

L

Y

F

L

-

P

-

Q

Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

M

L

S

D

V

V

E

F

D

E

N

N

I

V

L

A

A

F

I

P

L

L

E

R

T

V

R

H

K

T

E

Q

L

L

N

P

K

E

A

E

Q

M

Q

I

E

R

E

D

R

I

L

V

E

L

E

M

L

K

L

L

E

Q

E

A

F

V

H

G

I

L

N

R

H

G

I

A

R

V

T

E

N

L

L

M

G

P

M

D

A

E

L

L

S

S

G

G

E

M

R

K

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

M

L

N

D

P

P

K

Q

F

I

I

L

L

L

L

Y

D

D

E

E

P

P

F

F

A

V

G

G

V

Q

D

D

P

P

I

I

S

A

V

M

G

G

D

V

I

L

K

V

L

R

I

L

I

I

K

R

H

L

L

L

Q

N

E

D

S

A

-

L

G

G

I

I