SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_156804462.1 NCBI__GCF_000299915.1:WP_156804462.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8j5qD Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- translocation state (see paper)
42% identity, 96% coverage: 5:252/258 of query aligns to 348:601/611 of 8j5qD

query
sites
8j5qD

L

V

L

V

E

R

V

V

T

R

D

H

L

L

S

V

K

K

T

T

F

Y

V

R

N

L

R

A

R

K

G

G

L

V

F

V

K

L

R

R

E

R

T

A

I

I

-

G

-

E

-

V

E

R

A

A

V

V

A

D

P

G

L

I

S

S

F

L

S

E

L

L

E

R

A

Q

G

G

Q

R

T

T

L

L

A

G

I

I

C

V

G

G

E

E

T

S

G

G

S

S

G

G

K

K

T

S

T

T

V

T

A

L

K

H

L

E

L

I

V

L

G

E

A

L

E

A

V

A

P

P

T

Q

T

S

G

G

V

S

V

I

K

E

-

V

L

L

G

G

D

T

E

D

P

V

L

A

A

T

L

L

H

G

S

T

A

A

E

E

S

R

C

R

-

S

-

L

-

R

R

R

S

D

I

I

R

Q

M

V

I

V

F

F

Q

Q

D

D

P

P

S

V

T

A

S

S

L

L

N

D

P

P

R

R

V

L

T

P

V

V

G

F

R

D

Q

L

L

I

E

A

E

E

P

P

L

L

K

Q

L

A

N

N

T

G

T

-

L

F

T

G

A

K

A

N

Q

E

R

T

Q

H

A

A

K

R

I

V

E

A

A

E

T

L

L

L

V

D

R

I

V

V

G

G

L

L

L

R

A

H

E

G

H

D

A

A

D

S

Y

R

Y

Y

P

P

H

A

M

E

I

F

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

I

A

G

L

I

A

A

R

R

A

A

L

L

I

A

L

L

G

Q

P

P

K

K

V

I

L

L

V

A

C

L

D

D

E

E

A

P

L

V

A

S

A

A

L

L

D

D

V

V

S

S

L

I

R

Q

G

A

Q

G

I

I

L

I

N

N

F

L

L

L

L

L

D

D

E

L

Q

Q

R

E

K

Q

Q

F

Q

G

L

L

G

S

Y

Y

V

L

F

F

V

V

S

S

H

H

N

D

M

L

G

S

I

V

V

V

Q

K

H

H

I

L

S

A

D

H

Y

Q

V

V

L

A

I

V

M

M

H

L

H

A

G

G

Q

T

V

V

V

V

E

E

R

Q

G

G

P

D

T

S

K

E

E

E

V

V

F

F

S

G

N

N

P

P

Q

K

H

H

E

E

V

Y

T

T

K

R

R

R

M

L

L

L

M

G

A

A

Sites not aligning to the query:

binding iron/sulfur cluster: 285, 291, 298, 316, 318

8j5tD Cryo-em structure of mycobacterium tuberculosis oppabcd in the catalytic intermediate state (see paper)
41% identity, 96% coverage: 5:252/258 of query aligns to 348:601/608 of 8j5tD

query
sites
8j5tD

L

V

L

V

E

R

V

V

T

R

D

H

L

L

S

V

K

K

T

T

F
x
Y

V

R

N

L

R

A

R

K

G

G

L

V

F

V

K

L

R

R

E

R

T

A

I

I

-

G

-

E

-

V

E

R

A

A

V

V

A

D

P

G

L

I

S

S

F

L

S

E

L

L

E

R

A

Q

G

G

Q

R

T

T

L

L

A

G

I

I

C

V

G

G

E

E

T
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

V

T

A

L

K

H

L

E

L

I

V

L

G

E

A

L

E

A

V

A

P

P

T

Q

T

S

G

G

V

S

V

I

K

E

-

V

L

L

G

G

D

T

E

D

P

V

L

A

A

T

L

L

H

G

S

T

A

A

E

E

S

R

C

R

-

S

-

L

-

R

R

R

S

D

I

I

R

Q

M

V

I

V

F

F

Q
|
Q

D

D

P

P

S

V

T

A

S

S

L

L

N

D

P

P

R

R

V

L

T

P

V

V

G

F

R

D

Q

L

L

I

E

A

E

E

P

P

L

L

K

Q

L

A

N

N

T

G

T

-

L

F

T

G

A

K

A

N

Q

E

R

T

Q

H

A

A

K

R

I

V

E

A

A

E

T

L

L

L

V

D

R

I

V

V

G

G

L

L

L

R

A

H

E

G

H

D

A

A

D

S

Y
x
R

Y

Y

P

P

H

A

M
x
E

I

F

S
|
S

G

G

G
|
G

Q

Q

K

K

Q

Q

R

R

V

I

A

G

L

I

A

A

R

R

A

A

L

L

I

A

L

L

G

Q

P

P

K

K

V

I

L

L

V

A

C

L

D

D

E

D

A

P

L

V

A

S

A

A

L

L

D

D

V

V

S

S

L

I

R

Q

G

A

Q

G

I

I

L

I

N

N

F

L

L

L

L

L

D

D

E

L

Q

Q

R

E

K

Q

Q

F

Q

G

L

L

G

S

Y

Y

V

L

F

F

V

V

S

S

H
|
H

N

D

M

L

G

S

I

V

V

V

Q

K

H

H

I

L

S

A

D

H

Y

Q

V

V

L

A

I

V

M

M

H

L

H

A

G

G

Q

T

V

V

V

V

E

E

R

Q

G

G

P

D

T

S

K

E

E

E

V

V

F

F

S

G

N

N

P

P

Q

K

H

H

E

E

V

Y

T

T

K

R

R

R

M

L

L

L

M

G

A

A

binding adenosine-5'-triphosphate: Y358 (≠ F15), S395 (≠ T49), G396 (= G50), S397 (= S51), G398 (= G52), K399 (= K53), S400 (≠ T54), T401 (= T55), Q444 (= Q94), R494 (≠ Y145), E498 (≠ M149), S500 (= S151), G502 (= G153), H557 (= H208)
binding magnesium ion: S400 (≠ T54), Q444 (= Q94)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13, 42, 43, 45, 46, 47, 48, 95, 146, 153, 155, 157, 158, 212
binding magnesium ion: 47, 95
binding iron/sulfur cluster: 248, 285, 288, 291, 298, 316, 318

8j5sD Cryo-em structure of mycobacterium tuberculosis oppabcd in the pre- catalytic intermediate state (see paper)
41% identity, 96% coverage: 5:252/258 of query aligns to 348:601/608 of 8j5sD

query
sites
8j5sD

L

V

L

V

E

R

V

V

T

R

D

H

L

L

S

V

K

K

T

T

F
x
Y

V

R

N

L

R

A

R

K

G

G

L

V

F

V

K

L

R

R

E

R

T

A

I

I

-

G

-

E

-

V

E

R

A
|
A

V

V

A

D

P

G

L

I

S

S

F

L

S

E

L

L

E

R

A

Q

G

G

Q

R

T

T

L

L

A

G

I

I

C

V

G

G

E

E

T

S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

V

T

A

L

K

H

L

E

L

I

V

L

G

E

A

L

E

A

V

A

P

P

T

Q

T

S

G

G

V

S

V

I

K

E

-

V

L

L

G

G

D

T

E

D

P

V

L

A

A

T

L

L

H

G

S

T

A

A

E

E

S

R

C

R

-

S

-

L

-

R

R

R

S

D

I

I

R

Q

M

V

I

V

F

F

Q
|
Q

D

D

P

P

S

V

T

A

S

S

L

L

N

D

P

P

R

R

V

L

T

P

V

V

G

F

R

D

Q

L

L

I

E

A

E

E

P

P

L

L

K

Q

L

A

N

N

T

G

T

-

L

F

T

G

A

K

A

N

Q

E

R

T

Q

H

A

A

K

R

I

V

E

A

A

E

T

L

L

L

V

D

R

I

V

V

G

G

L

L

L

R

A

H

E

G

H

D

A

A

D

S

Y

R

Y

Y

P

P

H

A

M

E

I

F

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

I

A

G

L

I

A

A

R

R

A

A

L

L

I

A

L

L

G

Q

P

P

K

K

V

I

L

L

V

A

C

L

D

D

E

D

A

P

L

V

A

S

A

A

L

L

D

D

V

V

S

S

L

I

R

Q

G

A

Q

G

I

I

L

I

N

N

F

L

L

L

L

L

D

D

E

L

Q

Q

R

E

K

Q

Q

F

Q

G

L

L

G

S

Y

Y

V

L

F

F

V

V

S

S

H

H

N

D

M

L

G

S

I

V

V

V

Q

K

H

H

I

L

S

A

D

H

Y

Q

V

V

L

A

I

V

M

M

H

L

H

A

G

G

Q

T

V

V

V

V

E

E

R

Q

G

G

P

D

T

S

K

E

E

E

V

V

F

F

S

G

N

N

P

P

Q

K

H

H

E

E

V

Y

T

T

K

R

R

R

M

L

L

L

M

G

A

A

binding phosphoaminophosphonic acid-adenylate ester: Y358 (≠ F15), A375 (= A29), G396 (= G50), S397 (= S51), G398 (= G52), K399 (= K53), S400 (≠ T54), T401 (= T55), Q444 (= Q94)
binding magnesium ion: S400 (≠ T54), Q444 (= Q94)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 13, 20, 22, 41, 42, 43, 44, 45, 46, 47, 48, 60, 95, 278
binding magnesium ion: 47, 95
binding iron/sulfur cluster: 285, 291, 298, 316, 318

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
35% identity, 96% coverage: 5:252/258 of query aligns to 1:243/343 of P30750

query
sites
P30750

L

M

L

I

E

K

V

L

T

S

D

N

L

I

S

T

K

K

T

V

F

F

V

-

N

-

R

H

R

Q

G

G

L

-

F

-

K

-

R

T

E

R

T

T

I

I

E

Q

A

A

V

L

A

N

P

N

L

V

S

S

F

L

S

H

L

V

E

P

A

A

G

G

Q

Q

T

I

L

Y

A

G

I

V

C

I

G

G

E

A

T
x
S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

A

I

K

R

L

C

L

V

V

N

G

L

A

L

E

E

V

R

P

P

T

T

T

E

G

G

V

S

V

V

K

L

L

V

-

D

G

G

D

Q

E

E

P

L

L

T

A

T

L

L

H

S

S

E

A

S

E

E

-

L

-

T

-

K

S

A

C

R

R

R

S

Q

I

I

R

G

M

M

I

I

F

F

Q

Q

D

H

P

F

S

N

T

L

S

-

L

L

N

S

P

S

R

R

V

T

T

V

V

F

G

G

R

-

Q

N

L

V

E

A

E

L

P

P

L

L

K

E

L

L

N

D

T

N

T

T

L

-

T

P

A

K

A

D

Q

E

R

V

Q

K

A

R

K

R

I

V

E

T

A

E

T

L

L

L

V

S

R

L

V

V

G

G

L

L

L

G

A

D

E

K

H

H

A

-

D

D

Y

S

Y

Y

P

P

H

S

M

N

I

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

I

A

L

S

G

N

P

P

K

K

V

V

L

L

V

L

C

C

D

D

E
|
E

A

A

L

T

A

S

A

A

L

L

D

D

V

P

S

A

L

T

R

T

G

R

Q

S

I

I

L

L

N

E

F

L

L

L

L

K

D

D

E

I

Q

N

R

R

K

R

Q

L

Q

G

L

L

G

T

Y

I

V

L

F

L

V

I

S

T

H

H

N

E

M

M

G

D

I

V

V

V

Q

K

H

R

I

I

S

C

D

D

Y

C

V

V

L

A

I

V

M

I

H

S

H

N

G

G

Q

E

V

L

V

I

E

E

R

Q

G

D

P

T

T

V

K

S

E

E

V

V

F

F

S

S

N

H

P

P

Q

K

H

T

E

P

V

L

T

A

K

Q

R

K

M

F

L

I

M

Q

A

S

40:46 (vs. 49:55, 57% identical) binding ATP
E166 (= E175) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
35% identity, 96% coverage: 5:252/258 of query aligns to 2:244/344 of 3tuzC

query
sites
3tuzC

L

M

L

I

E

K

V

L

T

S

D

N

L

I

S

T

K

K

T

V

F
|
F

V

-

N

-

R

H

R
x
Q

G

G

L

-

F

-

K

-

R

T

E

R

T

T

I

I

E

Q

A

A

V

L

A

N

P

N

L

V

S

S

F

L

S

H

L

V

E

P

A

A

G

G

Q

Q

T

I

L

Y

A

G

I

V

C

I

G

G

E

A

T

S

G
|
G

S

A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

A

I

K

R

L

C

L

V

V

N

G

L

A

L

E

E

V

R

P

P

T

T

T

E

G

G

V

S

V

V

K

L

L

V

-

D

G

G

D

Q

E

E

P

L

L

T

A

T

L

L

H

S

S

E

A

S

E

E

-

L

-

T

-

K

S

A

C

R

R

R

S

Q

I

I

R

G

M

M

I

I

F

F

Q

Q

D

H

P

F

S

N

T

L

S

-

L

L

N

S

P

S

R

R

V

T

T

V

V

F

G

G

R

-

Q

N

L

V

E

A

E

L

P

P

L

L

K

E

L

L

N

D

T

N

T

T

L

-

T

P

A

K

A

D

Q

E

R

V

Q

K

A

R

K

R

I

V

E

T

A

E

T

L

L

L

V

S

R

L

V

V

G

G

L

L

L

G

A

D

E

K

H

H

A

-

D

D

Y

S

Y

Y

P

P

H

S

M

N

I

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

I

A

L

S

G

N

P

P

K

K

V

V

L

L

V

L

C

C

D

D

E

Q

A

A

L

T

A

S

A

A

L

L

D

D

V

P

S

A

L

T

R

T

G

R

Q

S

I

I

L

L

N

E

F

L

L

L

L

K

D

D

E

I

Q

N

R

R

K

R

Q

L

Q

G

L

L

G

T

Y

I

V

L

F

L

V

I

S

T

H

H

N

E

M

M

G

D

I

V

V

V

Q

K

H

R

I

I

S

C

D

D

Y

C

V

V

L

A

I

V

M

I

H

S

H

N

G

G

Q

E

V

L

V

I

E

E

R

Q

G

D

P

T

T

V

K

S

E

E

V

V

F

F

S

S

N

H

P

P

Q

K

H

T

E

P

V

L

T

A

K

Q

R

K

M

F

L

I

M

Q

A

S

binding adenosine-5'-diphosphate: F12 (= F15), Q14 (≠ R19), G42 (= G50), G44 (= G52), K45 (= K53), S46 (≠ T54), T47 (= T55)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
35% identity, 96% coverage: 5:252/258 of query aligns to 2:244/344 of 3tuiC

query
sites
3tuiC

L

M

L

I

E

K

V

L

T

S

D

N

L

I

S

T

K

K

T

V

F
|
F

V

-

N

-

R

H

R

Q

G

G

L

-

F

-

K

-

R

T

E

R

T

T

I

I

E

Q

A

A

V

L

A

N

P

N

L

V

S

S

F

L

S

H

L

V

E

P

A

A

G

G

Q

Q

T

I

L

Y

A

G

I

V

C

I

G

G

E

A

T

S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

A

I

K

R

L

C

L

V

V

N

G

L

A

L

E

E

V

R

P

P

T

T

T

E

G

G

V

S

V

V

K

L

L

V

-

D

G

G

D

Q

E

E

P

L

L

T

A

T

L

L

H

S

S

E

A

S

E

E

-

L

-

T

-

K

S

A

C

R

R

R

S

Q

I

I

R

G

M

M

I

I

F

F

Q

Q

D

H

P

F

S

N

T

L

S

-

L

L

N

S

P

S

R

R

V

T

T

V

V

F

G

G

R

-

Q

N

L

V

E

A

E

L

P

P

L

L

K

E

L

L

N

D

T

N

T

T

L

-

T

P

A

K

A

D

Q

E

R

V

Q

K

A

R

K

R

I

V

E

T

A

E

T

L

L

L

V

S

R

L

V

V

G

G

L

L

L

G

A

D

E

K

H

H

A

-

D

D

Y

S

Y

Y

P

P

H

S

M

N

I

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

I

A

L

S

G

N

P

P

K

K

V

V

L

L

V

L

C

C

D

D

E

Q

A

A

L

T

A

S

A

A

L

L

D

D

V

P

S

A

L

T

R

T

G

R

Q

S

I

I

L

L

N

E

F

L

L

L

L

K

D

D

E

I

Q

N

R

R

K

R

Q

L

Q

G

L

L

G

T

Y

I

V

L

F

L

V

I

S

T

H

H

N

E

M

M

G

D

I

V

V

V

Q

K

H

R

I

I

S

C

D

D

Y

C

V

V

L

A

I

V

M

I

H

S

H

N

G

G

Q

E

V

L

V

I

E

E

R

Q

G

D

P

T

T

V

K

S

E

E

V

V

F

F

S

S

N

H

P

P

Q

K

H

T

E

P

V

L

T

A

K

Q

R

K

M

F

L

I

M

Q

A

S

binding adenosine-5'-diphosphate: F12 (= F15), G42 (= G50), A43 (≠ S51), G44 (= G52), K45 (= K53), S46 (≠ T54), T47 (= T55)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
35% identity, 96% coverage: 5:252/258 of query aligns to 2:244/344 of 6cvlD

query
sites
6cvlD

L

M

L

I

E

K

V

L

T

S

D

N

L

I

S

T

K

K

T

V

F
|
F

V

-

N

-

R

H

R
x
Q

G

G

L

-

F

-

K

-

R

T

E

R

T

T

I
|
I

E

Q

A

A

V

L

A

N

P

N

L

V

S

S

F

L

S

H

L

V

E

P

A

A

G

G

Q

Q

T

I

L

Y

A

G

I

V

C

I

G

G

E

A

T
x
S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

A

I

K

R

L

C

L

V

V

N

G

L

A

L

E

E

V

R

P

P

T

T

T

E

G

G

V

S

V

V

K

L

L

V

-

D

G

G

D

Q

E

E

P

L

L

T

A

T

L

L

H

S

S

E

A

S

E

E

-

L

-

T

-

K

S

A

C

R

R

R

S

Q

I

I

R

G

M

M

I

I

F

F

Q

Q

D

H

P

F

S

N

T

L

S

-

L

L

N

S

P

S

R

R

V

T

T

V

V

F

G

G

R

-

Q

N

L

V

E

A

E

L

P

P

L

L

K

E

L

L

N

D

T

N

T

T

L

-

T

P

A

K

A

D

Q

E

R

V

Q

K

A

R

K

R

I

V

E

T

A

E

T

L

L

L

V

S

R

L

V

V

G

G

L

L

L

G

A

D

E

K

H

H

A

-

D

D

Y

S

Y

Y

P

P

H

S

M
x
N

I

L

S
|
S

G

G

G

G

Q
|
Q

K

K

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

I

A

L

S

G

N

P

P

K

K

V

V

L

L

V

L

C

C

D

D

E

Q

A

A

L

T

A

S

A

A

L

L

D

D

V

P

S

A

L

T

R

T

G

R

Q

S

I

I

L

L

N

E

F

L

L

L

L

K

D

D

E

I

Q

N

R

R

K

R

Q

L

Q

G

L

L

G

T

Y

I

V

L

F

L

V

I

S

T

H
|
H

N

E

M

M

G

D

I

V

V

V

Q

K

H

R

I

I

S

C

D

D

Y

C

V

V

L

A

I

V

M

I

H

S

H

N

G

G

Q

E

V

L

V

I

E

E

R

Q

G

D

P

T

T

V

K

S

E

E

V

V

F

F

S

S

N

H

P

P

Q

K

H

T

E

P

V

L

T

A

K

Q

R

K

M

F

L

I

M

Q

A

S

binding phosphothiophosphoric acid-adenylate ester: F12 (= F15), Q14 (≠ R19), I19 (= I27), S41 (≠ T49), G42 (= G50), A43 (≠ S51), G44 (= G52), K45 (= K53), S46 (≠ T54), T47 (= T55), N141 (≠ M149), S143 (= S151), Q146 (= Q154), H200 (= H208)

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
33% identity, 93% coverage: 4:243/258 of query aligns to 16:241/378 of P69874

query
sites
P69874

P

P

L

L

L

V

E

Q

V

L

T

A

D

G

L

I

S

R

K

K

T
x
C

F
|
F

V

D

N

G

R

K

R

-

G

-

L

-

F

-

K

-

R

-

E

-

T

-

I

-

E

E

A

V

V

I

A

P

P

Q

L

L

S

D

F

L

S

T

L

I

E

N

A

N

G

G

Q

E

T
x
F

L

L

A

T

I

L

C

L

G

G

E

P

T

S

G

G

S
x
C

G

G

K

K

T

T

T

T

V

V

A
x
L

K

R

L

L

L

I

V

A

G

G

A

L

E

E

V

T

P

V

T

D

T

S

G

G

V

R

V

I

K

M

L
|
L

G

D

D

N

E

E

P

D

L

I

A

T

L

H

H

V

S

P

A

A

E

E

S

N

C

-

R

R

S

Y

I

V

R

N

M

T

I

V

F

F

Q

Q

D

-

P

-

S

S

T

Y

S

A

L

L

N

F

P

P

R

H

V

M

T

T

V

V

G

F

R

E

Q

N

L

V

E

A

E

F

P

G

L

L

K

R

L

M

N

Q

T

K

T

T

L

P

T

A

A

A

A

E

Q

I

R

T

Q

P

A

R

K

V

I

M

E

E

A

A

T

-

L

-

V

L

R

R

V

M

G
x
V

L

Q

L

L

A

E

E

T

H

F

A

A

D

Q

Y

R

Y

K

P

P

H

H

M

Q

I

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

V

I

V

L

N

G

K

P

P

K

R

V

L

L

L

V

L

C

L

D
|
D

E

E

A

S

L

L

A

S

A

A

L

L

D

D

V

Y

S

K

L

L

R

R

G

K

Q

Q

I

M

L

Q

N

N

F

E

L

L

L

K

D

A

E

L

Q

Q

R

R

K

K

Q

L

Q

G

L

I

G

T

Y

F

V

V

F

F

V

V

S

T

H

H

N

D

M

Q

G

E

I

E

V

A

Q

L

H

T

I

M

S

S

D

D

Y

R

V

I

L

V

I

V

M

M

H

R

H

D

G

G

Q

R

V

I

V

E

E

Q

R

D

G

G

P

T

T

P

K

R

E

E

V

I

F

Y

S

E

N

E

P

P

Q

K

H

N

C26 (≠ T14) mutation to A: Lower ATPase activity and transport efficiency.
F27 (= F15) mutation to L: Lower ATPase activity and transport efficiency.
F45 (≠ T42) mutation to L: Lower ATPase activity and transport efficiency.
C54 (≠ S51) mutation to T: Loss of ATPase activity and transport.
L60 (≠ A57) mutation to F: Lower ATPase activity and transport efficiency.
L76 (= L73) mutation to P: Lower ATPase activity and transport efficiency.
V135 (≠ G137) mutation to M: Loss of ATPase activity and transport.
D172 (= D174) mutation to N: Loss of ATPase activity and transport.

Sites not aligning to the query:

276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp (see paper)
32% identity, 95% coverage: 4:247/258 of query aligns to 2:241/250 of 7z18I

query
sites
7z18I

P

P

L

L

L

L

E

S

V

V

T

N

D

N

L

L

S

T

K

H

T

L

F
x
Y

V

A

N

P

R

G

R

K

G

G

L

F

F

-

K

-

R

-

E

-

T

-

I

-

E

-

A

-

V

-

A

S

P

D

L

V

S

S

F

F

S

D

L

L

E

W

A

P

G

G

Q

E

T

V

L

L

A

G

I

I

C

V

G

G

E

E

T
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
|
T

T
|
T

V

L

A

L

K

K

L

S

L

I

V

S

G

A

A

R

E

L

V

T

P

P

T

Q

T

Q

G

G

V

E

V

I

K

H

L

Y

G

E

D

N

E

R

P

S

L

L

-

Y

A

A

L

M

H

S

S

E

A

A

E

D

S

R

C

R

R

R

S

L

I

L

R

R

-

T

-

E

-

W

-

G

M

V

I

V

F

H

Q
|
Q

D

H

P

P

S

L

T

D

S

G

L

L

N

R

P

R

R

Q

V

V

T

S

V

A

G

G

R

G

Q

N

L

I

E

G

E

E

P

R

L

L

K

-

L

-

N

-

T

-

T

M

L

A

T

T

A

G

A

A

Q

R

R

H

Q

Y

A

G

K

D

I

I

E

R

A

A

T

T

-

A

-

Q

-

K

-

W

L

L

V

E

R

E

V

V

G

E

L

I

L

P

A

A

E

N

H
x
R

A

I

D

D

Y

D

Y

L

P

P

H

T

M
x
T

I

F

S
|
S

G

G

G
|
G

Q
x
M

K

Q

Q

Q

R

R

V

L

A

Q

L

I

A

A

R

R

A

N

L

L

I

V

L

T

G

H

P

P

K

K

V

L

L

V

V

F

C

M

D

D

E

E

A

P

L

T

A

G

A

G

L

L

D

D

V

V

S

S

L

V

R

Q

G

A

Q

R

I

L

L

L

N

D

F

L

L

L

L

R

D

G

E

L

Q

V

R

V

K

E

Q

L

Q

N

L

L

G

A

Y

V

V

V

F

I

V

V

S

T

H
|
H

N

D

M

L

G

G

I

V

V

A

Q

R

H

L

I

L

S

A

D

D

Y

R

V

L

L

L

I

V

M

M

H

K

H

Q

G

G

Q

Q

V

V

V

V

E

E

R

S

G

G

P

L

T

T

K

D

E

R

V

V

F

L

S

D

N

D

P

P

Q

H

H

H

E

P

V

Y

T

T

K

Q

binding adenosine-5'-triphosphate: Y13 (≠ F15), S38 (≠ T49), G39 (= G50), S40 (= S51), G41 (= G52), K42 (= K53), T43 (= T54), T44 (= T55), Q88 (= Q94), R136 (≠ H142), T143 (≠ M149), S145 (= S151), G147 (= G153), M148 (≠ Q154), H202 (= H208)
binding magnesium ion: T43 (= T54), Q88 (= Q94)

7z15I E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
32% identity, 95% coverage: 4:247/258 of query aligns to 2:241/253 of 7z15I

query
sites
7z15I

P

P

L

L

L

L

E

S

V

V

T

N

D

N

L

L

S

T

K

H

T

L

F
x
Y

V

A

N

P

R

G

R
x
K

G
|
G

L

F

F

-

K

-

R

-

E

-

T

-

I

-

E

-

A

-

V

-

A

S

P

D

L

V

S

S

F

F

S

D

L

L

E

W

A

P

G

G

Q

E

T

V

L

L

A

G

I

I

C

V

G

G

E

E

T
x
S

G
|
G

S

S

G
|
G

K
|
K

T
|
T

T
|
T

V

L

A

L

K

K

L

S

L

I

V

S

G

A

A

R

E

L

V

T

P

P

T

Q

T

Q

G

G

V

E

V

I

K

H

L

Y

G

E

D

N

E

R

P

S

L

L

-

Y

A

A

L

M

H

S

S

E

A

A

E

D

S

R

C

R

R

R

S

L

I

L

R

R

-

T

-

E

-

W

-

G

M

V

I

V

F

H

Q
|
Q

D

H

P

P

S

L

T

D

S

G

L

L

N

R

P

R

R

Q

V

V

T

S

V

A

G

G

R

G

Q

N

L

I

E

G

E

E

P

R

L

L

K

-

L

-

N

-

T

-

T

M

L

A

T

T

A

G

A

A

Q

R

R

H

Q

Y

A

G

K

D

I

I

E

R

A

A

T

T

-

A

-

Q

-

K

-

W

L

L

V

E

R

E

V

V

G

E

L

I

L

P

A

A

E

N

H
x
R

A

I

D

D

Y

D

Y

L

P

P

H

T

M
x
T

I

F

S
|
S

G

G

G

G

Q
x
M

K

Q

Q

Q

R

R

V

L

A

Q

L

I

A

A

R

R

A

N

L

L

I

V

L

T

G

H

P

P

K

K

V

L

L

V

V

F

C

M

D

D

E

E

A

P

L

T

A

G

A

G

L

L

D

D

V

V

S

S

L

V

R

Q

G

A

Q

R

I

L

L

L

N

D

F

L

L

L

L

R

D

G

E

L

Q

V

R

V

K

E

Q

L

Q

N

L

L

G

A

Y

V

V

V

F

I

V

V

S

T

H

H

N

D

M

L

G

G

I

V

V

A

Q

R

H

L

I

L

S

A

D

D

Y

R

V

L

L

L

I

V

M

M

H

K

H

Q

G

G

Q

Q

V

V

V

V

E

E

R

S

G

G

P

L

T

T

K

D

E

R

V

V

F

L

S

D

N

D

P

P

Q

H

H

H

E

P

V

Y

T

T

K

Q

binding adenosine-5'-diphosphate: Y13 (≠ F15), K17 (≠ R19), G18 (= G20), S38 (≠ T49), G39 (= G50), G41 (= G52), K42 (= K53), T43 (= T54), T44 (= T55), R136 (≠ H142), T143 (≠ M149), S145 (= S151), M148 (≠ Q154)
binding magnesium ion: T43 (= T54), Q88 (= Q94)

7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation (see paper)
32% identity, 95% coverage: 4:247/258 of query aligns to 2:241/250 of 7z16I

query
sites
7z16I

P

P

L

L

L

L

E

S

V

V

T

N

D

N

L

L

S

T

K

H

T

L

F
x
Y

V

A

N

P

R

G

R
x
K

G

G

L

F

F

-

K

-

R

-

E

-

T

-

I

-

E

-

A

-

V

-

A

S

P

D

L

V

S

S

F

F

S

D

L

L

E

W

A

P

G

G

Q

E

T

V

L

L

A

G

I

I

C

V

G

G

E

E

T
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
|
T

T
|
T

V

L

A

L

K

K

L

S

L

I

V

S

G

A

A

R

E

L

V

T

P

P

T

Q

T

Q

G

G

V

E

V

I

K

H

L

Y

G

E

D

N

E

R

P

S

L

L

-

Y

A

A

L

M

H

S

S

E

A

A

E

D

S

R

C

R

R

R

S

L

I

L

R

R

-

T

-

E

-

W

-

G

M

V

I

V

F

H

Q

Q

D

H

P

P

S

L

T

D

S

G

L

L

N

R

P

R

R

Q

V

V

T

S

V

A

G

G

R

G

Q

N

L

I

E

G

E

E

P

R

L

L

K

-

L

-

N

-

T

-

T

M

L

A

T

T

A

G

A

A

Q

R

R

H

Q

Y

A

G

K

D

I

I

E

R

A

A

T

T

-

A

-

Q

-

K

-

W

L

L

V

E

R

E

V

V

G

E

L

I

L

P

A

A

E

N

H
x
R

A

I

D

D

Y

D

Y

L

P

P

H

T

M
x
T

I

F

S
|
S

G

G

G
|
G

Q
x
M

K

Q

Q

Q

R

R

V

L

A

Q

L

I

A

A

R

R

A

N

L

L

I

V

L

T

G

H

P

P

K

K

V

L

L

V

V

F

C

M

D

D

E

Q

A

P

L

T

A

G

A

G

L

L

D

D

V

V

S

S

L

V

R

Q

G

A

Q

R

I

L

L

L

N

D

F

L

L

L

L

R

D

G

E

L

Q

V

R

V

K

E

Q

L

Q

N

L

L

G

A

Y

V

V

V

F

I

V

V

S

T

H
|
H

N

D

M

L

G

G

I

V

V

A

Q

R

H

L

I

L

S

A

D

D

Y

R

V

L

L

L

I

V

M

M

H

K

H

Q

G

G

Q

Q

V

V

V

V

E

E

R

S

G

G

P

L

T

T

K

D

E

R

V

V

F

L

S

D

N

D

P

P

Q

H

H

H

E

P

V

Y

T

T

K

Q

binding phosphoaminophosphonic acid-adenylate ester: Y13 (≠ F15), K17 (≠ R19), S38 (≠ T49), G39 (= G50), S40 (= S51), G41 (= G52), K42 (= K53), T43 (= T54), T44 (= T55), R136 (≠ H142), T143 (≠ M149), S145 (= S151), G147 (= G153), M148 (≠ Q154), H202 (= H208)

7ahhC Opua inhibited inward-facing, sbd docked (see paper)
33% identity, 85% coverage: 29:247/258 of query aligns to 41:260/382 of 7ahhC

query
sites
7ahhC

A
x
G

V

V

A

Y

P

D

L

T

S

N

F

F

S

E

L

I

E

N

A

E

G

G

Q

E

T

I

L

F

A

V

I

I

C

M

G

G

E

L

T

S

G
|
G

S

S

G
|
G

K
|
K

T

S

T

T

V

L

A

L

K

R

L

L

L

L

V

N

G

R

A

L

E

I

V

E

P

P

T

T

T

S

G

G

V

K

V

I

K

F

L

I

G

D

D

N

E

Q

P

D

L

V

A

A

L

T

H

L

S

N

A

K

E

E

S

D

C

L

R

L

S

Q

I

V

R

R

-

R

-

K

-

T

-

M

-

S

M

M

I

V

F

F

Q

Q

D

-

P

-

S

N

T

F

S

G

L

L

N

F

P

P

R

H

V

R

T

T

V

I

G

L

R

E

Q

N

L

T

E

E

E

Y

P

G

L

L

K

E

L

V

N

Q

T

N

T

-

L

V

T

P

A

K

A

E

Q

E

R

R

Q

R

A

K

K

R

I

A

E

E

A

K

T

A

L

L

V

D

R

N

V

A

G

N

L

L

L

L

A

-

E

D

H

F

A

K

D

D

Y

Q

Y

Y

P

P

H

K

M

Q

I

L

S

S

G

G

G

G

Q

M

K

Q

Q

Q

R

R

V

V

A

G

L

L

A

A

R

R

A

A

L

L

I

A

L

N

G

D

P

P

K

E

V

I

L

L

V

L

C

M

D
|
D

E
|
E

A

A

L

F

A

S

A

A

L

L

D

D

V

P

S

L

L

I

R

R

G

R

Q

E

I

M

L

Q

N

D

F

E

L

L

L

L

D

E

E

L

Q

Q

R

A

K

K

Q

F

Q

Q

L

K

G

T

Y

I

V

I

F

F

V

V

S

S

H

H

N

D

M

L

G

N

I

E

V

A

Q

L

H

R

I

I

S

G

D

D

Y

R

V

I

L

A

I

I

M

M

H

K

H

D

G

G

Q

K

V

I

V

M

E

Q

R

I

G

G

P

T

T

G

K

E

E

E

V

I

F

L

S

T

N

N

P

P

Q

A

H

N

E

D

V

Y

T

V

K

K

binding phosphoaminophosphonic acid-adenylate ester: G41 (≠ A29), G62 (= G50), G64 (= G52), K65 (= K53), D187 (= D174), E188 (= E175)

Sites not aligning to the query:

7aheC Opua inhibited inward facing (see paper)
33% identity, 85% coverage: 29:247/258 of query aligns to 41:260/382 of 7aheC

query
sites
7aheC

A

G

V

V

A

Y

P

D

L

T

S

N

F

F

S

E

L

I

E

N

A

E

G

G

Q

E

T

I

L

F

A

V

I

I

C

M

G

G

E

L

T

S

G

G

S

S

G

G

K

K

T

S

T

T

V

L

A

L

K

R

L

L

L

L

V

N

G

R

A

L

E

I

V

E

P

P

T

T

T

S

G

G

V

K

V

I

K

F

L

I

G

D

D

N

E

Q

P

D

L

V

A

A

L

T

H

L

S

N

A

K

E

E

S

D

C

L

R

L

S

Q

I

V

R

R

-

R

-

K

-

T

-

M

-

S

M

M

I

V

F

F

Q

Q

D

-

P

-

S

N

T

F

S

G

L

L

N

F

P

P

R

H

V

R

T

T

V

I

G

L

R

E

Q

N

L

T

E

E

E

Y

P

G

L

L

K

E

L

V

N

Q

T

N

T

-

L

V

T

P

A

K

A

E

Q

E

R

R

Q

R

A

K

K

R

I

A

E

E

A

K

T

A

L

L

V

D

R

N

V

A

G

N

L

L

L

L

A

-

E

D

H

F

A

K

D

D

Y

Q

Y

Y

P

P

H

K

M

Q

I

L

S

S

G

G

G

G

Q

M

K

Q

Q

Q

R

R

V

V

A

G

L

L

A

A

R

R

A

A

L

L

I

A

L

N

G

D

P

P

K

E

V

I

L

L

V

L

C

M

D

D

E

E

A

A

L

F

A

S

A

A

L

L

D

D

V

P

S

L

L

I

R

R

G

R

Q

E

I

M

L

Q

N

D

F

E

L

L

L

L

D

E

E

L

Q

Q

R

A

K

K

Q

F

Q

Q

L

K

G

T

Y

I

V

I

F

F

V

V

S

S

H

H

N

D

M

L

G

N

I

E

V

A

Q

L

H

R

I

I

S

G

D

D

Y

R

V

I

L

A

I

I

M

M

H

K

H

D

G

G

Q

K

V

I

V

M

E

Q

R

I

G

G

P

T

T

G

K

E

E

E

V

I

F

L

S

T

N

N

P

P

Q

A

H

N

E

D

V

Y

T

V

K

K

Sites not aligning to the query:

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: 275, 297, 298

7ahdC Opua (e190q) occluded (see paper)
32% identity, 85% coverage: 29:247/258 of query aligns to 41:260/260 of 7ahdC

query
sites
7ahdC

A

G

V

V

A

Y

P

D

L

T

S

N

F

F

S

E

L

I

E

N

A

E

G

G

Q

E

T

I

L

F

A

V

I

I

C

M

G

G

E

L

T
x
S

G
|
G

S

S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

A

L

K

R

L

L

L

L

V

N

G

R

A

L

E

I

V

E

P

P

T

T

T

S

G

G

V

K

V

I

K

F

L

I

G

D

D

N

E

Q

P

D

L

V

A

A

L

T

H

L

S

N

A

K

E

E

S

D

C

L

R

L

S

Q

I

V

R

R

-

R

-

K

-

T

-

M

-

S

M

M

I

V

F

F

Q
|
Q

D

-

P

-

S

N

T

F

S

G

L

L

N

F

P

P

R

H

V

R

T

T

V

I

G

L

R

E

Q

N

L

T

E

E

E

Y

P

G

L

L

K

E

L

V

N

Q

T

N

T

-

L

V

T

P

A

K

A

E

Q

E

R

R

Q

R

A

K

K

R

I

A

E

E

A

K

T

A

L

L

V

D

R

N

V

A

G

N

L

L

L

L

A

-

E

D

H

F

A

K

D

D

Y

Q

Y

Y

P

P

H
x
K

M
x
Q

I

L

S
|
S

G

G

G
|
G

Q
x
M

K

Q

Q

Q

R

R

V

V

A

G

L

L

A

A

R

R

A

A

L

L

I

A

L

N

G

D

P

P

K

E

V

I

L

L

V

L

C

M

D

D

E
x
Q

A

A

L

F

A

S

A

A

L

L

D

D

V

P

S

L

L

I

R

R

G

R

Q

E

I

M

L

Q

N

D

F

E

L

L

L

L

D

E

E

L

Q

Q

R

A

K

K

Q

F

Q

Q

L

K

G

T

Y

I

V

I

F

F

V

V

S

S

H
|
H

N

D

M

L

G

N

I

E

V

A

Q

L

H

R

I

I

S

G

D

D

Y

R

V

I

L

A

I

I

M

M

H

K

H

D

G

G

Q

K

V

I

V

M

E

Q

R

I

G

G

P

T

T

G

K

E

E

E

V

I

F

L

S

T

N

N

P

P

Q

A

H

N

E

D

V

Y

T

V

K

K

binding adenosine-5'-triphosphate: S61 (≠ T49), G62 (= G50), G64 (= G52), K65 (= K53), S66 (≠ T54), T67 (= T55), Q111 (= Q94), K161 (≠ H148), Q162 (≠ M149), S164 (= S151), G166 (= G153), M167 (≠ Q154), Q188 (≠ E175), H221 (= H208)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12, 39

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
31% identity, 96% coverage: 4:250/258 of query aligns to 1:236/241 of 4u00A

query
sites
4u00A

P

P

L

I

L

I

E

R

V

I

T

R

D

N

L

L

S

H

K

K

T

W

F
|
F

V

-

N

-

R

-

R

-

G

-

L

-

F

-

K

-

R

-

E

G

T

P

I

L

E

H

A
x
V

V

L

A

K

P

G

L

I

S

H

F

L

S

E

L

V

E

A

A

P

G

G

Q

E

T

K

L

L

A

V

I

I

C

I

G

G

E

P

T
x
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

A

I

K

R

L

T

L

I

V

N

G

R

A

L

E

E

V

D

P

F

T

Q

T

E

G

G

V

E

V

V

K

V

L

V

G

-

D

-

E

D

P

G

L

L

A

S

L

V

H

K

S

D

A

D

E

R

S

A

C

L

R

R

S

E

I

I

R

R

-

R

-

E

-

V

-

G

M

M

I

V

F

F

Q

Q

D

-

P

-

S

Q

T

F

S

N

L

L

N

F

P

P

R

H

V

M

T

T

V

V

G

L

R

E

Q

N

L

V

E

T

-

L

E

A

P

P

L

M

K

R

L

V

N

R

T

R

T

W

L

P

T

R

A

E

A

K

Q

A

R

E

Q

K

A

K

K

A

I

L

E

E

A

-

T

L

L

L

V

E

R

R

V

V

G

G

L

I

L

L

A

-

E

D

H

Q

A

A

D

R

Y

K

Y

Y

P

P

H

A

M

Q

I

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

L

I

A

A

R

R

A

A

L

L

I

A

L

M

G

E

P

P

K

K

V

I

L

M

V

L

C

F

D

D

E

E

A

P

L

T

A

S

A

A

L

L

D

D

V

P

S

E

L

M

R

V

G

G

Q

E

I

V

L

L

N

D

F

V

L

M

L

R

D

D

E

L

Q

A

R

-

K

Q

Q

G

Q

G

L

M

G

T

Y

M

V

V

F

V

V

V

S

T

H

H

N

E

M

M

G

G

I

F

V

A

Q

R

H

E

I

V

S

A

D

D

Y

R

V

V

L

V

I

F

M

M

H

D

H

G

G

G

Q

Q

V

I

V

V

E

E

R

E

G

G

P

R

T

P

K

E

E

E

V

I

F

F

S

T

N

R

P

P

Q

K

H

E

E

E

V

R

T

T

K

R

R

S

M

F

L

L

binding adenosine-5'-diphosphate: F12 (= F15), V17 (≠ A29), S37 (≠ T49), G38 (= G50), S39 (= S51), G40 (= G52), K41 (= K53), S42 (≠ T54), T43 (= T55)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 87% coverage: 17:241/258 of query aligns to 8:232/353 of 1oxvD

query
sites
1oxvD

N

N

R

V

R

S

G

K

L

V

F
|
F

K

K

R

K

E

G

T

K

I

V

E

V

A

A

V

L

A

D

P

N

L

V

S

N

F

I

S

N

L

I

E

E

A

N

G

G

Q

E

T

R

L

F

A

G

I

I

C

L

G

G

E

P

T
x
S

G
|
G

S

A

G
|
G

K
|
K

T
|
T

T
|
T

V

F

A

M

K

R

L

I

L

I

V

A

G

G

A

L

E

D

V

V

P

P

T

S

T

T

G

G

V

E

V

L

K

Y

L

F

G

D

D

D

E

R

P

L

L

V

A

A

-

S

-

N

-

G

-

K

L

L

H

I

S

V

A

P

E

P

S

E

C

D

R

R

S

K

I

I

R

G

M

M

I

V

F

F

Q
|
Q

D

-

P

-

S

T

T

W

S

A

L

L

N

Y

P

P

R

N

V

L

T

T

V

A

G

F

R

E

Q

N

L

I

E

A

E

F

P

P

L

L

K

T

L

-

N

N

T

M

T

K

L

M

T

S

A

K

A

E

Q

E

R

I

Q

R

A

K

K

R

I

V

E

E

A

-

T

E

L

V

V

A

R

K

V

I

G

L

L

D

L

I

A

H

E

H

H

V

A

L

D

N

Y

H

Y

F

P

P

H

R

M

E

I

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

L

L

A

A

R

R

A

A

L

L

I

V

L

K

G

D

P

P

K

S

V

L

L

L

V

L

C

L

D

D

E
|
E

A

P

L

F

A

S

A

N

L

L

D

D

V

A

S

R

L

M

R

R

G

D

Q

S

I

A

L

R

N

A

F

L

L

V

L

K

D

E

E

V

Q

Q

R

S

K

R

Q

L

Q

G

L

V

G

T

Y

L

V

L

F

V

V

V

S

S

H

H

N

D

M

P

G

A

I

D

V

I

Q

F

H

A

I

I

S

A

D

D

Y

R

V

V

L

G

I

V

M

L

H

V

H

K

G

G

Q

K

V

L

V

V

E

Q

R

V

G

G

P

K

T

P

K

E

E

D

V

L

F

Y

S

D

N

N

P

P

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F22), S40 (≠ T49), G41 (= G50), G43 (= G52), K44 (= K53), T45 (= T54), T46 (= T55), Q89 (= Q94), E166 (= E175)
binding magnesium ion: T45 (= T54), Q89 (= Q94)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 87% coverage: 17:241/258 of query aligns to 8:232/353 of 1oxvA

query
sites
1oxvA

N

N

R

V

R

S

G

K

L

V

F
|
F

K

K

R

K

E

G

T

K

I

V

E

V

A

A

V

L

A

D

P

N

L

V

S

N

F

I

S

N

L

I

E

E

A

N

G

G

Q

E

T

R

L

F

A

G

I

I

C

L

G

G

E

P

T
x
S

G
|
G

S

A

G
|
G

K
|
K

T
|
T

T
|
T

V

F

A

M

K

R

L

I

L

I

V

A

G

G

A

L

E

D

V

V

P

P

T

S

T

T

G

G

V

E

V

L

K

Y

L

F

G

D

D

D

E

R

P

L

L

V

A

A

-

S

-

N

-

G

-

K

L

L

H

I

S

V

A

P

E

P

S

E

C

D

R

R

S

K

I

I

R

G

M

M

I

V

F

F

Q

Q

D

-

P

-

S

T

T

W

S

A

L

L

N

Y

P

P

R

N

V

L

T

T

V

A

G

F

R

E

Q

N

L

I

E

A

E

F

P

P

L

L

K

T

L

-

N

N

T

M

T

K

L

M

T

S

A

K

A

E

Q

E

R

I

Q

R

A

K

K

R

I

V

E

E

A

-

T

E

L

V

V

A

R

K

V

I

G

L

L

D

L

I

A

H

E

H

H

V

A

L

D

N

Y

H

Y

F

P

P

H

R

M

E

I

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

L

L

A

A

R

R

A

A

L

L

I

V

L

K

G

D

P

P

K

S

V

L

L

L

V

L

C

L

D

D

E
|
E

A

P

L

F

A

S

A

N

L

L

D

D

V

A

S

R

L

M

R

R

G

D

Q

S

I

A

L

R

N

A

F

L

L

V

L

K

D

E

E

V

Q

Q

R

S

K

R

Q

L

Q

G

L

V

G

T

Y

L

V

L

F

V

V

V

S

S

H

H

N

D

M

P

G

A

I

D

V

I

Q

F

H

A

I

I

S

A

D

D

Y

R

V

V

L

G

I

V

M

L

H

V

H

K

G

G

Q

K

V

L

V

V

E

Q

R

V

G

G

P

K

T

P

K

E

E

D

V

L

F

Y

S

D

N

N

P

P

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F22), S40 (≠ T49), G41 (= G50), G43 (= G52), K44 (= K53), T45 (= T54), T46 (= T55), E166 (= E175)

1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 87% coverage: 17:241/258 of query aligns to 8:232/353 of 1oxuA

query
sites
1oxuA

N

N

R

V

R

S

G

K

L

V

F
|
F

K

K

R

K

E

G

T

K

I

V

E

V

A
|
A

V

L

A

D

P

N

L

V

S

N

F

I

S

N

L

I

E

E

A

N

G

G

Q

E

T

R

L

F

A

G

I

I

C

L

G

G

E

P

T

S

G
|
G

S

A

G
|
G

K
|
K

T
|
T

T
|
T

V

F

A

M

K

R

L

I

L

I

V

A

G

G

A

L

E

D

V

V

P

P

T

S

T

T

G

G

V

E

V

L

K

Y

L

F

G

D

D

D

E

R

P

L

L

V

A

A

-

S

-

N

-

G

-

K

L

L

H

I

S

V

A

P

E

P

S

E

C

D

R

R

S

K

I

I

R

G

M

M

I

V

F

F

Q

Q

D

-

P

-

S

T

T

W

S

A

L

L

N

Y

P

P

R

N

V

L

T

T

V

A

G

F

R

E

Q

N

L

I

E

A

E

F

P

P

L

L

K

T

L

-

N

N

T

M

T

K

L

M

T

S

A

K

A

E

Q

E

R

I

Q

R

A

K

K

R

I

V

E

E

A

-

T

E

L

V

V

A

R

K

V

I

G

L

L

D

L

I

A

H

E

H

H

V

A

L

D

N

Y

H

Y

F

P

P

H

R

M

E

I

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

L

L

A

A

R

R

A

A

L

L

I

V

L

K

G

D

P

P

K

S

V

L

L

L

V

L

C

L

D

D

E

E

A

P

L

F

A

S

A

N

L

L

D

D

V

A

S

R

L

M

R

R

G

D

Q

S

I

A

L

R

N

A

F

L

L

V

L

K

D

E

E

V

Q

Q

R

S

K

R

Q

L

Q

G

L

V

G

T

Y

L

V

L

F

V

V

V

S

S

H

H

N

D

M

P

G

A

I

D

V

I

Q

F

H

A

I

I

S

A

D

D

Y

R

V

V

L

G

I

V

M

L

H

V

H

K

G

G

Q

K

V

L

V

V

E

Q

R

V

G

G

P

K

T

P

K

E

E

D

V

L

F

Y

S

D

N

N

P

P

binding adenosine-5'-diphosphate: F13 (= F22), A20 (= A29), G41 (= G50), G43 (= G52), K44 (= K53), T45 (= T54), T46 (= T55)

Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
29% identity, 87% coverage: 17:241/258 of query aligns to 8:232/353 of Q97UY8

query
sites
Q97UY8

N

N

R

V

R

S

G

K

L

V

F

F

K

K

R

K

E

G

T

K

I

V

E

V

A

A

V

L

A

D

P

N

L

V

S

N

F

I

S

N

L

I

E

E

A

N

G

G

Q

E

T

R

L

F

A

G

I

I

C

L

G

G

E

P

T

S

G

G

S

A

G

G

K

K

T

T

T

T

V

F