SitesBLAST
Comparing WP_164926914.1 NCBI__GCF_000006985.1:WP_164926914.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
Q55415 Bicarbonate transporter BicA from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa) (see paper)
30% identity, 92% coverage: 16:549/580 of query aligns to 10:547/564 of Q55415
- T69 (= T75) binding hydrogencarbonate; mutation to A: Alters bicarbonate transport.
- D258 (≠ E260) binding Na(+); mutation D->A,E: Alters bicarbonate transport.
- T262 (≠ S264) binding Na(+); mutation to A: Alters bicarbonate transport.
- G300 (= G302) binding Na(+)
- A301 (= A303) binding hydrogencarbonate
- T302 (≠ I304) binding Na(+); mutation to A: Alters bicarbonate transport.
- A471 (≠ S472) mutation to N: Alters bicarbonate transport.
- L476 (≠ M478) mutation to S: Alters bicarbonate transport.
- A486 (≠ G488) mutation to E: Alters bicarbonate transport.
- L490 (= L492) mutation to Q: Alters bicarbonate transport.
5da0A Structure of the the slc26 transporter slc26dg in complex with a nanobody (see paper)
28% identity, 85% coverage: 20:512/580 of query aligns to 10:457/467 of 5da0A
Sites not aligning to the query:
7v74A Thermostabilized human prestin in complex with sulfate (see paper)
28% identity, 94% coverage: 10:553/580 of query aligns to 14:597/597 of 7v74A
6ki1B The transmembrane domain of a cyanobacterium bicarbonate transporter bica (see paper)
33% identity, 65% coverage: 16:394/580 of query aligns to 9:391/392 of 6ki1B
7v75A Thermostabilized human prestin in complex with salicylate (see paper)
28% identity, 94% coverage: 10:553/580 of query aligns to 14:605/605 of 7v75A
7lhvA Structure of arabidopsis thaliana sulfate transporter atsultr4;1 (see paper)
27% identity, 91% coverage: 16:542/580 of query aligns to 24:571/575 of 7lhvA
- binding 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine: L126 (≠ S111), R127 (≠ H112), W130 (≠ S115)
- binding (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate: L128 (= L113), L131 (= L116), E409 (≠ T391), L413 (≠ E395), G417 (≠ L399), A421 (≠ I403)
- binding sulfate ion: A84 (≠ I81), S321 (≠ A303), F322 (≠ I304)
Q9BXS9 Solute carrier family 26 member 6; Anion exchange transporter; Pendrin-like protein 1; Pendrin-L1 from Homo sapiens (Human) (see 3 papers)
28% identity, 75% coverage: 28:464/580 of query aligns to 100:561/759 of Q9BXS9
- N167 (= N92) modified: carbohydrate, N-linked (GlcNAc) asparagine; mutation to Q: Reduced chloride oxalate exchanger activity.
- N172 (≠ A97) modified: carbohydrate, N-linked (GlcNAc) asparagine; mutation to Q: Reduced chloride oxalate exchanger activity.
- V206 (≠ L116) to M: in dbSNP:rs13324142
- ATV 547:549 (≠ GPL 450:452) mutation to NVN: Does not inhibit cell membrane localization. Inhibits interaction with CA2 and bicarbonate transport.
- N553 (≠ A456) mutation to A: Does not inhibit interaction with CA2. Inhibits interaction with CA2 and bicarbonate transport in PMA-induced cells.
Sites not aligning to the query:
- 582 S→A: Does not inhibit interaction with CA2. Does not inhibit interaction with CA2 and bicarbonate transport in PMA-induced cells.
Q8CIW6 Solute carrier family 26 member 6; Anion exchange transporter; Chloride-formate exchanger; Pendrin-L1; Pendrin-like protein 1; Putative anion transporter-1; Pat-1 from Mus musculus (Mouse) (see paper)
27% identity, 75% coverage: 28:464/580 of query aligns to 102:562/758 of Q8CIW6
- F552 (= F454) mutation to A: Does not inhibit formate transport in PMA-induced cells.
A0FKN5 Prestin; Solute carrier family 26 member 5 from Gallus gallus (Chicken) (see paper)
25% identity, 82% coverage: 3:480/580 of query aligns to 59:578/742 of A0FKN5
- S404 (≠ A305) Controls the anion transport; mutation to A: Alters anion selectivity.; mutation to C: Abolishes sulfate transport. Does not affect oxalate transport. Is accesible both from extracellular and intracellular side by methane-thiosulphonate (MTS) reagents. Inhibits divalent transport upon extracellular application of (2-sulphonatoethyl)methane-thiosulphonate (MTSES) but not [2-(trimethylammonium)ethyl]methane-thiosulphonate (MTSET). Abolishes anion transport upon intracellular MTSET application.
- R405 (= R306) mutation to C: Fully abolishes anion transport.
7xujA Human slc26a3 in complex with uk5099
25% identity, 82% coverage: 15:489/580 of query aligns to 63:564/703 of 7xujA