SitesBLAST
Comparing WP_171817373.1 NCBI__GCF_000828635.1:WP_171817373.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5ahkA Crystal structure of acetohydroxy acid synthase pf5 from pseudomonas protegens
31% identity, 93% coverage: 1:557/602 of query aligns to 1:542/555 of 5ahkA
- active site: L22 (= L22), G24 (= G24), G25 (= G25), M26 (≠ G26), I27 (≠ A27), E48 (= E48), T73 (= T71), K110 (≠ D108), R111 (= R109), F118 (≠ V116), Q119 (= Q117), M168 (≠ L166), A253 (≠ V259), Q280 (≠ I286), V384 (≠ T393), G410 (= G422), M412 (= M424), D436 (= D449), N463 (= N476), S465 (≠ G478), L466 (≠ Y479), M468 (≠ S481), V469 (≠ I482), F472 (≠ T485), D535 (≠ K550)
- binding flavin-adenine dinucleotide: R158 (= R156), G208 (= G213), G209 (≠ H214), G210 (= G215), S234 (≠ T239), L235 (≠ W240), M250 (≠ R256), L251 (≠ P257), Y254 (≠ V260), G273 (= G279), S274 (≠ C280), R275 (= R281), D277 (= D283), R279 (≠ I285), Q280 (≠ I286), D298 (= D304), L299 (≠ V305), Q303 (≠ E309), E317 (≠ D324), L318 (≠ A325), M389 (≠ L398), G407 (≠ S419)
- binding magnesium ion: D436 (= D449), N463 (= N476), S465 (≠ G478)
- binding thiamine diphosphate: I23 (≠ P23), E48 (= E48), P76 (= P74), V384 (≠ T393), G385 (= G394), N386 (≠ S395), N387 (≠ S396), G410 (= G422), M412 (= M424), D436 (= D449), G437 (= G450), G438 (≠ S451), N463 (= N476), S465 (≠ G478), L466 (≠ Y479), G467 (≠ C480), M468 (≠ S481), V469 (≠ I482)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
32% identity, 92% coverage: 4:556/602 of query aligns to 9:527/539 of 6lpiB
- active site: I27 (≠ L22), G29 (= G24), G30 (= G25), S31 (≠ G26), I32 (≠ A27), E53 (= E48), C76 (≠ T71), F115 (≠ V116), Q116 (= Q117), E117 (= E118), K165 (≠ L166), M256 (≠ V259), A283 (≠ I286), V375 (vs. gap), G401 (= G422), M403 (= M424), D428 (= D449), N455 (= N476), A457 (≠ G478), L458 (≠ Y479), L460 (≠ S481), V461 (≠ I482), Q464 (≠ T485)
- binding flavin-adenine dinucleotide: R155 (= R156), G212 (= G213), G213 (≠ H214), G214 (= G215), T236 (= T239), L237 (≠ W240), M238 (≠ N241), L254 (≠ P257), M256 (≠ V259), H257 (≠ V260), G276 (= G279), A277 (≠ C280), R278 (= R281), D280 (= D283), R282 (≠ I285), A283 (≠ I286), D300 (= D304), I301 (≠ V305), D319 (≠ P322), V320 (= V323), M380 (≠ L398), G398 (vs. gap)
- binding magnesium ion: D428 (= D449), N455 (= N476)
- binding thiamine diphosphate: E53 (= E48), C76 (≠ T71), P79 (= P74), G376 (= G394), Q377 (≠ S395), H378 (≠ S396), G401 (= G422), M403 (= M424), G427 (≠ S448), D428 (= D449), G429 (= G450), S430 (= S451), M433 (≠ L454), N455 (= N476), A457 (≠ G478), L458 (≠ Y479), G459 (≠ C480), L460 (≠ S481), V461 (≠ I482)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 94:643/664 of P09114
- P191 (≠ K101) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ T485) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
31% identity, 92% coverage: 4:556/602 of query aligns to 97:646/667 of P09342
- C161 (≠ A68) modified: Disulfide link with 307
- P194 (≠ K101) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V216) modified: Disulfide link with 161
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 14:563/582 of 3ea4A
- active site: Y32 (≠ L22), G34 (= G24), G35 (= G25), A36 (≠ G26), S37 (≠ A27), E58 (= E48), T81 (= T71), F120 (≠ V116), Q121 (= Q117), E122 (= E118), K170 (≠ L166), M265 (≠ V259), V292 (≠ I286), V399 (≠ L398), G425 (= G422), M427 (= M424), D452 (= D449), N479 (= N476), H481 (≠ G478), L482 (≠ Y479), M484 (≠ S481), V485 (≠ I482), W488 (≠ T485), H557 (≠ K550)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (≠ N284), R291 (≠ I285), W488 (≠ T485)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R156), G221 (= G213), G222 (≠ H214), G223 (= G215), T245 (= T239), L246 (≠ W240), M247 (≠ N241), L263 (≠ P257), G264 (= G258), M265 (≠ V259), H266 (≠ V260), G285 (= G279), R287 (= R281), D289 (= D283), R291 (≠ I285), D309 (= D304), I310 (≠ V305), G327 (≠ I317), D328 (= D318), V329 (≠ L319), M404 (≠ F403), G422 (vs. gap)
- binding magnesium ion: D452 (= D449), N479 (= N476), H481 (≠ G478)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ L398), G400 (= G399), Q401 (≠ V400), H402 (≠ E401), M427 (= M424), G451 (≠ S448), D452 (= D449), G453 (= G450), S454 (= S451), N479 (= N476), H481 (≠ G478), L482 (≠ Y479), G483 (≠ C480), M484 (≠ S481), V485 (≠ I482)
Sites not aligning to the query:
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 14:563/582 of 3e9yA
- active site: Y32 (≠ L22), G34 (= G24), G35 (= G25), A36 (≠ G26), S37 (≠ A27), E58 (= E48), T81 (= T71), F120 (≠ V116), Q121 (= Q117), E122 (= E118), K170 (≠ L166), M265 (≠ V259), V292 (≠ I286), V399 (≠ L398), G425 (= G422), M427 (= M424), D452 (= D449), N479 (= N476), H481 (≠ G478), L482 (≠ Y479), M484 (≠ S481), V485 (≠ I482), W488 (≠ T485), H557 (≠ K550)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (≠ N284), R291 (≠ I285), W488 (≠ T485)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R156), G221 (= G213), G222 (≠ H214), G223 (= G215), T245 (= T239), L246 (≠ W240), M247 (≠ N241), L263 (≠ P257), G285 (= G279), R287 (= R281), D289 (= D283), R291 (≠ I285), D309 (= D304), I310 (≠ V305), G327 (≠ I317), D328 (= D318), V329 (≠ L319), M404 (≠ F403), G422 (vs. gap)
- binding magnesium ion: D452 (= D449), N479 (= N476), H481 (≠ G478)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ L398), G400 (= G399), Q401 (≠ V400), H402 (≠ E401), M427 (= M424), G451 (≠ S448), G453 (= G450), S454 (= S451), N479 (= N476), H481 (≠ G478), L482 (≠ Y479), G483 (≠ C480), M484 (≠ S481), V485 (≠ I482)
Sites not aligning to the query:
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ V259), R292 (≠ I285), W489 (≠ T485)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), G426 (= G422), M428 (= M424), G452 (≠ S448), D453 (= D449), G454 (= G450), S455 (= S451), L483 (≠ Y479), G484 (≠ C480), M485 (≠ S481), V486 (≠ I482)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), M263 (≠ R256), L264 (≠ P257), M266 (≠ V259), H267 (≠ V260), G286 (= G279), R288 (= R281), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap)
- binding magnesium ion: A37 (≠ G26), T82 (= T71), S83 (≠ T72), Q122 (= Q117), Y381 (≠ H376), D453 (= D449), M458 (≠ L454), Q461 (= Q457), N480 (= N476), H482 (≠ G478), K533 (≠ P525)
Sites not aligning to the query:
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
31% identity, 92% coverage: 4:556/602 of query aligns to 100:649/670 of P17597
- A122 (≠ G26) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (= M28) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E48) binding
- S186 (= S90) binding
- P197 (≠ K101) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (= R109) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q117) binding
- K220 (= K130) binding
- R246 (= R156) binding ; binding
- K256 (≠ L166) binding
- G308 (≠ H214) binding
- TL 331:332 (≠ TW 239:240) binding
- C340 (≠ W248) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ PGVV 257:260) binding
- GVRFD 371:375 (≠ GCRLD 279:283) binding
- DR 376:377 (≠ NI 284:285) binding
- DI 395:396 (≠ DV 304:305) binding
- DV 414:415 (≠ DL 318:319) binding
- QH 487:488 (≠ VE 400:401) binding
- GG 508:509 (≠ -G 420) binding
- GAM 511:513 (= GAM 422:424) binding
- D538 (= D449) binding
- DGS 538:540 (= DGS 449:451) binding
- N565 (= N476) binding
- NQHLGM 565:570 (≠ NGGYCS 476:481) binding
- H567 (≠ G478) binding
- W574 (≠ T485) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
Sites not aligning to the query:
- 653 binding ; S→A: No effect on catalytic activity or sensitivity to herbicides.; S→F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; S→N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; S→T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), G426 (= G422), M428 (= M424), G452 (≠ S448), D453 (= D449), G454 (= G450), S455 (= S451), M458 (≠ L454), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), G484 (≠ C480), M485 (≠ S481), V486 (≠ I482)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), M266 (≠ V259), H267 (≠ V260), G286 (= G279), V287 (≠ C280), R288 (= R281), D290 (= D283), R292 (≠ I285), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap)
- binding magnesium ion: F370 (= F366), D453 (= D449), M458 (≠ L454), Q461 (= Q457), N480 (= N476), H482 (≠ G478), K533 (≠ P525)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ V259), R292 (≠ I285), M485 (≠ S481), W489 (≠ T485)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 5wj1A
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), M263 (≠ R256), L264 (≠ P257), G286 (= G279), R288 (= R281), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap), G424 (= G420)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ V259), D291 (≠ N284), R292 (≠ I285), M485 (≠ S481), W489 (≠ T485)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), M428 (= M424), D453 (= D449), G454 (= G450), S455 (= S451), M458 (≠ L454), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), G484 (≠ C480), M485 (≠ S481), V486 (≠ I482)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 5k6tA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ V260), R292 (≠ I285), M485 (≠ S481), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), G286 (= G279), R288 (= R281), D290 (= D283), R292 (≠ I285), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), Q404 (≠ A402), M405 (≠ F403), G423 (vs. gap)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), G426 (= G422), M428 (= M424), G452 (≠ S448), G454 (= G450), S455 (= S451), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), G484 (≠ C480)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 5k6rA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (≠ I285), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), M266 (≠ V259), G286 (= G279), R288 (= R281), R292 (≠ I285), V293 (≠ I286), D310 (= D304), I311 (≠ V305), G328 (≠ I317), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), G426 (= G422), M428 (= M424), D453 (= D449), G454 (= G450), S455 (= S451), M458 (≠ L454), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), G484 (≠ C480), M485 (≠ S481), V486 (≠ I482)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 1z8nA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K130), R161 (= R156), Y191 (= Y181), R194 (≠ E184), D291 (≠ N284), R292 (≠ I285), D312 (= D306), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), G265 (= G258), M266 (≠ V259), H267 (≠ V260), G286 (= G279), V287 (≠ C280), R288 (= R281), D290 (= D283), R292 (≠ I285), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap), G424 (= G420)
- binding magnesium ion: D453 (= D449), N480 (= N476)
- binding thiamine diphosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), G426 (= G422), M428 (= M424), G452 (≠ S448), G454 (= G450), S455 (= S451), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), G484 (≠ C480), M485 (≠ S481), V486 (≠ I482)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 1yi1A
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (≠ N284), R292 (≠ I285), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), M263 (≠ R256), L264 (≠ P257), G265 (= G258), M266 (≠ V259), H267 (≠ V260), G286 (= G279), V287 (≠ C280), R288 (= R281), D290 (= D283), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap), G424 (= G420)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 1yi0A
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N284), R292 (≠ I285), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), G265 (= G258), M266 (≠ V259), H267 (≠ V260), G286 (= G279), V287 (≠ C280), R288 (= R281), D290 (= D283), R292 (≠ I285), V293 (≠ I286), D310 (= D304), I311 (≠ V305), G328 (≠ I317), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap), G424 (= G420)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 1yhzA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (≠ N284), R292 (≠ I285), M485 (≠ S481), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), M266 (≠ V259), H267 (≠ V260), G286 (= G279), V287 (≠ C280), R288 (= R281), D290 (= D283), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), Q404 (≠ A402), M405 (≠ F403), G423 (vs. gap), G424 (= G420)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 1yhyA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N284), R292 (≠ I285), V486 (≠ I482), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), G265 (= G258), M266 (≠ V259), H267 (≠ V260), G286 (= G279), V287 (≠ C280), R288 (= R281), D290 (= D283), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), Q404 (≠ A402), M405 (≠ F403), G423 (vs. gap), G424 (= G420)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
Sites not aligning to the query:
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/582 of 1ybhA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ V259), D291 (≠ N284), R292 (≠ I285), M485 (≠ S481), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), M266 (≠ V259), H267 (≠ V260), G286 (= G279), V287 (≠ C280), R288 (= R281), D290 (= D283), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), Q404 (≠ A402), M405 (≠ F403), G423 (vs. gap), G424 (= G420)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
Sites not aligning to the query:
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/583 of 5k3sA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (≠ I285), M485 (≠ S481), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), M266 (≠ V259), G286 (= G279), R288 (= R281), D290 (= D283), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), M405 (≠ F403), G423 (vs. gap)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), G426 (= G422), M428 (= M424), D453 (= D449), G454 (= G450), S455 (= S451), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), G484 (≠ C480), M485 (≠ S481), V486 (≠ I482)
Sites not aligning to the query:
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
31% identity, 92% coverage: 4:556/602 of query aligns to 15:564/585 of 5k2oA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ G26), S38 (≠ A27), E59 (= E48), T82 (= T71), F121 (≠ V116), Q122 (= Q117), E123 (= E118), K171 (≠ L166), M266 (≠ V259), V293 (≠ I286), V400 (≠ L398), G426 (= G422), M428 (= M424), D453 (= D449), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), M485 (≠ S481), V486 (≠ I482), W489 (≠ T485), H558 (≠ K550)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ V259), R292 (≠ I285), W489 (≠ T485)
- binding flavin-adenine dinucleotide: R161 (= R156), G222 (= G213), G223 (≠ H214), G224 (= G215), T246 (= T239), L247 (≠ W240), M248 (≠ N241), L264 (≠ P257), G286 (= G279), R288 (= R281), D290 (= D283), V293 (≠ I286), D310 (= D304), I311 (≠ V305), D329 (= D318), V330 (≠ L319), Q404 (≠ A402), M405 (≠ F403), G423 (vs. gap)
- binding magnesium ion: D453 (= D449), N480 (= N476), H482 (≠ G478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ L398), G401 (= G399), Q402 (≠ V400), H403 (≠ E401), M428 (= M424), D453 (= D449), G454 (= G450), S455 (= S451), N480 (= N476), H482 (≠ G478), L483 (≠ Y479), G484 (≠ C480), M485 (≠ S481), V486 (≠ I482)
Sites not aligning to the query:
Query Sequence
>WP_171817373.1 NCBI__GCF_000828635.1:WP_171817373.1
MRVADYLMSHLAGLGIDHVFVLPGGGAMHLNDGLACEPRITAIPCHHEQACGIAAEAWGR
VAGKFGVAMVTTGPGATNVVTPVTGAWIESVPMLVISGQVKRPDLLRDRPLRQGGVQEVD
IVPIVRSITKYAVTVQDPATIRYHLERALHQMQDGRAGPVWLDIPLDVQAAQIVPAELTG
YIPEAEVQPGLDEPIQQTLELIAAAERPLILAGHGVRLAGAAKRFLALAEKLDIPVVTTW
NALDLIPWAHPLCVGRPGVVALRAANFAVQNCDLLISIGCRLDNIITAYNPRGFARTARK
IVVDVDPEEIAKLDMDIDLRLPVDAGSFIDALAAHTGSSSLPDRPAWRQRCSDWKRRYAV
GEGKPFHTDGPISHYHFVSALSDAAPPETLVSTGSSGLGVEAFYTVFRNKPGQRVFLTSG
LGAMGYGLPAAIGACLAGNRRPAIAIESDGSLQLNLQELATVKAQKLPICLVIMDNGGYC
SIRNTQRNYFQERYLGIDPASGLWLPDLEKIAAAYGLPFLRIDDPGNIDAALKEALALPR
PCLIDVRLMKDETLAPKSAAVPQPDGSMISMPLEDMSPLLPLDQLRAEMLIPLMPQSLGT
IR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory