SitesBLAST
Comparing WP_202943321.1 NCBI__GCF_000008645.1:WP_202943321.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3qguA L,l-diaminopimelate aminotransferase from chlamydomonas reinhardtii (see paper)
47% identity, 99% coverage: 3:408/411 of query aligns to 5:403/406 of 3qguA
Sites not aligning to the query:
Q9ZQI7 Aminotransferase ALD1, chloroplastic; AGD2-like defense response protein 1; EC 2.6.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
42% identity, 98% coverage: 6:409/411 of query aligns to 41:438/456 of Q9ZQI7
- Y108 (= Y73) binding pyridoxal 5'-phosphate
- AQ 142:143 (≠ AK 109:110) binding pyridoxal 5'-phosphate
- N223 (= N188) binding pyridoxal 5'-phosphate
- D251 (= D216) binding pyridoxal 5'-phosphate
- Y254 (= Y219) binding pyridoxal 5'-phosphate
- S281 (= S247) binding pyridoxal 5'-phosphate
- S283 (= S249) binding pyridoxal 5'-phosphate
- R292 (= R258) binding pyridoxal 5'-phosphate
- N323 (= N293) binding pyridoxal 5'-phosphate
4fl0B Crystal structure of ald1 from arabidopsis thaliana (see paper)
42% identity, 98% coverage: 6:409/411 of query aligns to 8:405/409 of 4fl0B
- binding pyridoxal-5'-phosphate: G108 (= G108), A109 (= A109), Q110 (≠ K110), F133 (≠ Y133), N190 (= N188), D218 (= D216), Y221 (= Y219), S248 (= S247), S250 (= S249), K251 (= K250), R259 (= R258)
3ei6A Crystal structure of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with plp-dap: an external aldimine mimic (see paper)
43% identity, 99% coverage: 3:409/411 of query aligns to 6:406/410 of 3ei6A
- binding (2S,6S)-2-amino-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]heptanedioic acid: Y19 (= Y16), F21 (= F18), G46 (= G43), Y76 (= Y73), G109 (= G108), A110 (= A109), K111 (= K110), Y134 (= Y133), N191 (= N188), D219 (= D216), Y222 (= Y219), S249 (= S247), S251 (= S249), K252 (= K250), R260 (= R258), N291 (= N293), R386 (= R389)
Q93ZN9 LL-diaminopimelate aminotransferase, chloroplastic; AtDAP-AT; DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase; Protein ABERRANT GROWTH AND DEATH 2; EC 2.6.1.83 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
43% identity, 99% coverage: 3:409/411 of query aligns to 59:459/461 of Q93ZN9
- Y72 (= Y16) binding substrate
- G99 (= G43) binding substrate
- Y129 (= Y73) binding pyridoxal 5'-phosphate
- AK 163:164 (= AK 109:110) binding pyridoxal 5'-phosphate
- K164 (= K110) binding substrate
- Y187 (= Y133) binding pyridoxal 5'-phosphate; binding substrate
- N244 (= N188) binding pyridoxal 5'-phosphate; binding substrate
- Y275 (= Y219) binding pyridoxal 5'-phosphate
- SFS 302:304 (= SFS 247:249) binding pyridoxal 5'-phosphate
- K305 (= K250) modified: N6-(pyridoxal phosphate)lysine; mutation to N: Loss of LL-DAP-aminotransferase activity.; mutation to Q: Loss of LL-DAP-aminotransferase activity.
- R313 (= R258) binding pyridoxal 5'-phosphate
- N344 (= N293) binding pyridoxal 5'-phosphate; binding substrate
- P398 (= P347) mutation to S: In agd2-1; reduced activity and increased resistance to pathogen.
- R439 (= R389) binding substrate
3ei5A Crystal structure of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with plp-glu: an external aldimine mimic (see paper)
43% identity, 99% coverage: 3:409/411 of query aligns to 6:406/408 of 3ei5A
- binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: Y19 (= Y16), F21 (= F18), I45 (= I42), G46 (= G43), Y76 (= Y73), G109 (= G108), A110 (= A109), K111 (= K110), Y134 (= Y133), N191 (= N188), D219 (= D216), Y222 (= Y219), S249 (= S247), S251 (= S249), R260 (= R258), N291 (= N293), R386 (= R389)
2z1zA Crystal structure of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with l-malate ion (see paper)
43% identity, 99% coverage: 3:409/411 of query aligns to 6:406/408 of 2z1zA
- binding pyridoxal-5'-phosphate: Y76 (= Y73), G109 (= G108), A110 (= A109), K111 (= K110), Y134 (= Y133), N191 (= N188), D219 (= D216), Y222 (= Y219), S249 (= S247), S251 (= S249), K252 (= K250), R260 (= R258), N291 (= N293)
3ei9A Crystal structure of k270n variant of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with l-glu: external aldimine form (see paper)
43% identity, 99% coverage: 3:409/411 of query aligns to 6:406/412 of 3ei9A
- binding (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-glutamic acid: Y19 (= Y16), F21 (= F18), I45 (= I42), G46 (= G43), Y76 (= Y73), G109 (= G108), A110 (= A109), K111 (= K110), Y134 (= Y133), N191 (= N188), D219 (= D216), Y222 (= Y219), S249 (= S247), S251 (= S249), R260 (= R258), N291 (= N293), R386 (= R389)
3ei8A Crystal structure of k270n variant of ll-diaminopimelate aminotransferase from arabidopsis thaliana complexed with ll-dap: external aldimine form (see paper)
43% identity, 99% coverage: 3:409/411 of query aligns to 6:406/411 of 3ei8A
- binding (2S,6S)-2-amino-6-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}heptanedioic acid: Y76 (= Y73), N291 (= N293)
- binding pyridoxal-5'-phosphate: G109 (= G108), A110 (= A109), K111 (= K110), Y134 (= Y133), N191 (= N188), D219 (= D216), Y222 (= Y219), S249 (= S247), S251 (= S249), R260 (= R258)
O84395 LL-diaminopimelate aminotransferase; DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase; EC 2.6.1.83 from Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx) (see paper)
39% identity, 98% coverage: 6:406/411 of query aligns to 4:386/394 of O84395
- AK 104:105 (= AK 109:110) binding pyridoxal 5'-phosphate
- N174 (= N188) binding pyridoxal 5'-phosphate
- Y205 (= Y219) binding pyridoxal 5'-phosphate
- SFS 233:235 (= SFS 247:249) binding pyridoxal 5'-phosphate
- K236 (= K250) modified: N6-(pyridoxal phosphate)lysine
6l1oB Product bound bacf structure from bacillus subtillis (see paper)
30% identity, 96% coverage: 18:411/411 of query aligns to 17:389/392 of 6l1oB
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G103 (≠ A109), K104 (= K110), Y128 (= Y133), N174 (≠ C184), D206 (= D216), Y209 (= Y219), S236 (= S247), S238 (= S249), K239 (= K250), R247 (= R258)
- binding tyrosine: F17 (= F18), Q39 (≠ I42), G40 (= G43), K104 (= K110), Y128 (= Y133), E130 (≠ V135), Y325 (= Y348), R367 (= R389)
6l1lB Apo-bacf structure from bacillus subtillis (see paper)
30% identity, 96% coverage: 18:411/411 of query aligns to 17:389/393 of 6l1lB
6l1nA Substrate bound bacf structure from bacillus subtillis (see paper)
30% identity, 96% coverage: 18:411/411 of query aligns to 17:388/393 of 6l1nA
- binding glycine: Y127 (= Y133), N177 (= N188), Y324 (= Y348), R366 (= R389)
- binding pyridoxal-5'-phosphate: G102 (≠ A109), Y127 (= Y133), N173 (≠ C184), N177 (= N188), D205 (= D216), Y208 (= Y219), S235 (= S247), S237 (= S249), R246 (= R258)
Sites not aligning to the query:
1gdeA Crystal structure of pyrococcus protein a-1 e-form (see paper)
27% identity, 90% coverage: 36:406/411 of query aligns to 26:378/388 of 1gdeA
- active site: K232 (= K250)
- binding glutamic acid: F120 (≠ Y133), N170 (= N188), R361 (= R389)
- binding pyridoxal-5'-phosphate: G94 (= G108), A95 (= A109), N96 (= N115), F120 (≠ Y133), N166 (≠ C184), D198 (= D216), Y201 (= Y219), S231 (= S249), K232 (= K250), R240 (= R258)
1gd9A Crystall structure of pyrococcus protein-a1 (see paper)
27% identity, 90% coverage: 36:406/411 of query aligns to 26:378/388 of 1gd9A
- active site: K232 (= K250)
- binding pyridoxal-5'-phosphate: G94 (= G108), A95 (= A109), N96 (= N115), F120 (≠ Y133), N170 (= N188), D198 (= D216), V200 (≠ A218), Y201 (= Y219), S231 (= S249), K232 (= K250), R240 (= R258)
2o1bA Structure of aminotransferase from staphylococcus aureus
27% identity, 91% coverage: 37:411/411 of query aligns to 21:373/376 of 2o1bA
- active site: Y115 (= Y133), D192 (= D216), A194 (= A218), K225 (= K250)
- binding pyridoxal-5'-phosphate: T90 (≠ A109), K91 (= K110), Y115 (= Y133), N164 (= N188), D192 (= D216), A194 (= A218), Y195 (= Y219), S222 (= S247), S224 (= S249), K225 (= K250), R233 (= R258)
2x5dD Crystal structure of a probable aminotransferase from pseudomonas aeruginosa (see paper)
26% identity, 90% coverage: 36:404/411 of query aligns to 18:372/380 of 2x5dD
- active site: Y113 (= Y133), D191 (= D216), A193 (= A218), K225 (= K250)
- binding pyridoxal-5'-phosphate: G87 (= G108), S88 (≠ A109), K89 (= K110), Y113 (= Y133), D191 (= D216), A193 (= A218), Y194 (= Y219), T222 (≠ S247), S224 (= S249), K225 (= K250), R233 (= R258)
3jtxB Crystal structure of aminotransferase (np_283882.1) from neisseria meningitidis z2491 at 1.91 a resolution
25% identity, 91% coverage: 38:409/411 of query aligns to 32:391/393 of 3jtxB
Q9C969 Aromatic aminotransferase ISS1; Methionine aminotransferase ISS1; Phenylalanine aminotransferase ISS1; Protein INDOLE SEVERE SENSITIVE 1; Protein REVERSAL OF SAV3 PHENOTYPE 1; Tryptophan aminotransferase ISS1; Tyrosine aminotransferase ISS1; EC 2.6.1.27; EC 2.6.1.5; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
27% identity, 91% coverage: 18:391/411 of query aligns to 4:364/394 of Q9C969
- P66 (= P75) mutation to L: In vas1-4; suppressor of sav3 mutant plants leading to rescued hypocotyl elongation in response to shade and restored auxin biosynthetic pathway.
- L77 (≠ I86) mutation to F: In vas1-5; suppressor of sav3 mutant plants leading to rescued hypocotyl elongation in response to shade and restored auxin biosynthetic pathway.
- G179 (= G191) mutation to D: In vas1-2; suppressor of sav3 mutant plants leading to rescued hypocotyl elongation in response to shade and restored auxin biosynthetic pathway. Increases levels of auxin (IAA) and indole-3-pyruvic acid (3-IPA).
- C219 (≠ I232) mutation to Y: In vas1-7; suppressor of sav3 mutant plants leading to rescued hypocotyl elongation in response to shade and restored auxin biosynthetic pathway.
- A269 (≠ G294) mutation to T: In vas1-8; suppressor of sav3 mutant plants leading to rescued hypocotyl elongation in response to shade and restored auxin biosynthetic pathway.
- R362 (= R389) mutation to W: In iss1-2; indole-dependent auxin (IAA) overproduction phenotypes including leaf epinasty and adventitious rooting.
1o4sB Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
24% identity, 91% coverage: 36:409/411 of query aligns to 38:381/384 of 1o4sB
- active site: W131 (≠ Y133), D209 (= D216), V211 (≠ A218), K242 (= K250)
- binding pyridoxal-5'-phosphate: G105 (= G108), A106 (= A109), K107 (= K110), W131 (≠ Y133), N181 (= N188), D209 (= D216), V211 (≠ A218), Y212 (= Y219), S241 (= S249), K242 (= K250), R250 (= R258)
Query Sequence
>WP_202943321.1 NCBI__GCF_000008645.1:WP_202943321.1
MMVTVNENYLLLKSSYIFSEINRRVEEFQRKNPDADIIRMGIGDVTRPLPEAVVEAFHRA
VDEMAEEETFRGYGPEQGYPFLREAIAENDYASRGVDITADEIFISDGAKCDTGNIQEIF
GLDNVVAVTDPVYPVYVESNVMAGRAGPADDDGRYSGLVYLPCTEENSFIPSLPEERVDL
IYLCYPNNPTGTTLTEKQLAEWVDYARDSGSLILFDAAYEAYIQEDGIPHSIYEVEGARE
VAIEFRSFSKNAGFTGTRCAFTVVPEELEVPDSSGRMHSVRELWNRRQTTKFNGVSYPVQ
RAAEAVYTPEGQREIRESIDYYMENARIIRESLERAGLRYYGGVNAPYIWIRTPEGMDSW
QFFDTLLNDAEVVGTPGSGFGPSGEGYFRLTAFNSFRNTVKAMERISELSF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory