SitesBLAST
Comparing WP_207545230.1 NCBI__GCF_900115975.1:WP_207545230.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4kuhA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with acetoacetyl-coa from clostridium butyricum
58% identity, 99% coverage: 3:282/283 of query aligns to 1:280/280 of 4kuhA
4kugA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with NAD from clostridium butyricum
58% identity, 99% coverage: 3:282/283 of query aligns to 1:280/282 of 4kugA
- active site: S117 (= S119), H138 (= H140), E150 (= E152), N188 (= N190)
- binding nicotinamide-adenine-dinucleotide: G10 (= G12), T11 (= T13), M12 (= M14), R30 (= R32), D31 (= D33), A87 (= A89), A88 (≠ V90), E90 (= E92), N115 (= N117), S117 (= S119), H138 (= H140)
6aa8E Crystal structure of (s)-3-hydroxybutyryl-coenzymea dehydrogenase from clostridium acetobutylicum complexed with NAD+ (see paper)
57% identity, 99% coverage: 4:282/283 of query aligns to 1:279/281 of 6aa8E
- active site: S116 (= S119), H137 (= H140), E149 (= E152), N187 (= N190)
- binding nicotinamide-adenine-dinucleotide: I6 (≠ V9), G9 (= G12), T10 (= T13), M11 (= M14), R29 (= R32), D30 (= D33), I31 (≠ V34), A86 (= A89), A87 (≠ V90), E89 (= E92), K94 (= K97), N114 (= N117), S116 (= S119)
4pzeA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with acetoacetyl-coa (see paper)
54% identity, 100% coverage: 2:283/283 of query aligns to 1:282/283 of 4pzeA
4pzdA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with NAD+ (see paper)
54% identity, 100% coverage: 2:283/283 of query aligns to 1:282/283 of 4pzdA
- active site: S118 (= S119), H139 (= H140), E151 (= E152), N189 (= N190)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T12 (= T13), M13 (= M14), D32 (= D33), A88 (= A89), A89 (≠ V90), T90 (≠ I91), E91 (= E92), I99 (≠ L100), N116 (= N117), S118 (= S119), N142 (= N143)
9jheA 3-hydroxybutyryl-coa dehydrogenase with NAD (see paper)
50% identity, 98% coverage: 6:282/283 of query aligns to 3:278/289 of 9jheA
- binding nicotinamide-adenine-dinucleotide: I6 (≠ V9), G7 (= G10), G9 (= G12), T10 (= T13), M11 (= M14), D31 (= D33), I32 (≠ V34), K74 (≠ A76), A87 (= A89), A88 (≠ V90), F89 (≠ I91), E90 (= E92), N115 (= N117), S117 (= S119), H136 (= H140)
9jhyB 3-hydroxybutyryl-coa dehydrogenase mutant (s117a) with acetoacetyl coa (see paper)
51% identity, 98% coverage: 6:282/283 of query aligns to 3:274/285 of 9jhyB
- binding acetoacetyl-coenzyme a: L51 (≠ D53), K54 (= K56), K56 (≠ R58), I57 (≠ M59), H132 (= H140), F134 (= F142), N135 (= N143), R139 (≠ V147), N182 (= N190), L185 (= L193), M218 (≠ I226), I227 (= I235)
P9WNP7 3-hydroxybutyryl-CoA dehydrogenase; Beta-hydroxybutyryl-CoA dehydrogenase; BHBD; EC 1.1.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
44% identity, 99% coverage: 3:282/283 of query aligns to 5:286/286 of P9WNP7
- S122 (= S119) mutation to A: Loss of fatty acyl dehydrogenase activity.
P00348 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; L-3-hydroxyacyl CoA dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Sus scrofa (Pig) (see paper)
40% identity, 99% coverage: 3:283/283 of query aligns to 27:314/314 of P00348
- GGGLMG 34:39 (≠ GAGTMG 10:15) binding NAD(+)
- D57 (= D33) binding NAD(+)
- E122 (= E92) binding NAD(+)
- K127 (= K97) binding NAD(+)
- S149 (= S119) binding NAD(+)
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Homo sapiens (Human) (see 7 papers)
41% identity, 99% coverage: 3:283/283 of query aligns to 27:314/314 of Q16836
- GGGLMG 34:39 (≠ GAGTMG 10:15) binding NAD(+)
- A40 (= A16) to T: in HADH deficiency; dbSNP:rs137853101
- D57 (= D33) binding NAD(+); to E: in HADH deficiency; dbSNP:rs137853102; to G: found in a patient with Reye-like syndrome; does not affect 3-hydroxyacyl-CoA dehydrogenase activity; increases KM value for NADH; does not affect dimerization
- S73 (≠ N49) binding CoA
- K80 (= K56) binding CoA
- L86 (vs. gap) to P: in dbSNP:rs4956145
- E122 (= E92) binding NAD(+)
- K127 (= K97) binding NAD(+); modified: N6-(2-hydroxyisobutyryl)lysine
- S149 (= S119) binding CoA; binding NAD(+)
- Q152 (≠ S122) to H: in dbSNP:rs1051519
- N173 (= N143) binding NAD(+)
- Y226 (≠ M196) to H: found in a patient with Reye-like syndrome; loss of 3-hydroxyacyl-CoA dehydrogenase activity. Does not affect dimerization; dbSNP:rs146036912
- P258 (= P228) to L: in HHF4; loss of 3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137853103
- K305 (= K274) binding NAD(+)
1f0yA L-3-hydroxyacyl-coa dehydrogenase complexed with acetoacetyl-coa and NAD+ (see paper)
41% identity, 99% coverage: 3:283/283 of query aligns to 4:291/291 of 1f0yA
- active site: S126 (= S119), H147 (= H140), E159 (= E152), N197 (= N190)
- binding acetoacetyl-coenzyme a: S50 (≠ N49), K57 (= K56), S126 (= S119), H147 (= H140), F149 (= F142), N150 (= N143), P151 (= P144), P153 (= P146), V154 (= V147), N197 (= N190), P232 (= P225), M233 (≠ I226), L238 (= L231)
- binding nicotinamide-adenine-dinucleotide: G13 (= G12), L14 (≠ T13), M15 (= M14), D34 (= D33), Q35 (≠ V34), A96 (= A89), I97 (≠ V90), E99 (= E92), K104 (= K97), N124 (= N117), S126 (= S119), H147 (= H140), N150 (= N143), V242 (≠ I235), T246 (= T239), K282 (= K274)
1f17A L-3-hydroxyacyl-coa dehydrogenase complexed with nadh (see paper)
41% identity, 99% coverage: 3:283/283 of query aligns to 4:291/293 of 1f17A
- active site: S126 (= S119), H147 (= H140), E159 (= E152), N197 (= N190)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G13 (= G12), L14 (≠ T13), M15 (= M14), D34 (= D33), Q35 (≠ V34), A96 (= A89), I97 (≠ V90), E99 (= E92), K104 (= K97), N124 (= N117), S126 (= S119), H147 (= H140)
1f12A L-3-hydroxyacyl-coa dehydrogenase complexed with 3-hydroxybutyryl-coa (see paper)
41% identity, 99% coverage: 3:283/283 of query aligns to 4:291/293 of 1f12A
- active site: S126 (= S119), H147 (= H140), E159 (= E152), N197 (= N190)
- binding 3-hydroxybutanoyl-coenzyme a: K57 (= K56), S126 (= S119), H147 (= H140), F149 (= F142), N150 (= N143), M155 (= M148), N197 (= N190), L200 (= L193), P232 (= P225), M233 (≠ I226), L238 (= L231)
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80 (see paper)
41% identity, 99% coverage: 3:282/283 of query aligns to 334:616/728 of 8oqrA
Sites not aligning to the query:
- binding 4-cyanobenzenesulfonic acid: 76, 77, 81, 82, 82, 85, 89, 96, 123, 124, 149, 150
8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1 (see paper)
41% identity, 99% coverage: 3:282/283 of query aligns to 333:615/728 of 8oqlA
Sites not aligning to the query:
- binding Hexafluorophosphate anion: 37, 39, 75, 77, 81, 92, 95, 148, 149, 152, 180, 260
- binding formamide: 78, 79
8oqoA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49 (see paper)
41% identity, 99% coverage: 3:282/283 of query aligns to 333:615/727 of 8oqoA