SitesBLAST

AGV 44:46 (≠ SAI 43:45) mutation to VTP: 2-fold increase in substrate specificity towards ornithine. 5-fold increase in substrate specificity towards ornithine; when associated with D-54. 70-fold increase in substrate specificity towards ornithine; when associated with D-54 and A-322. 16-fold increase in substrate specificity towards ornithine; when associated with D-54; T-322 and L-326.
P54 (= P53) mutation to D: 3-fold increase in substrate specificity towards ornithine. 5-fold increase in substrate specificity towards ornithine; when associated with 44-V--P-46. 70-fold increase in substrate specificity towards ornithine; when associated with 44-V--P-46 and A-322. 16-fold increase in substrate specificity towards ornithine; when associated with 44-V--P-46; T-322 and L-326.
G319 (≠ A323) mutation to W: 7-fold increase in substrate specificity towards ornithine.
S322 (≠ T326) mutation to A: 29-fold increase in substrate specificity towards ornithine. 70-fold increase in substrate specificity towards ornithine; when associated with 44-V--P-46 and D-54.; mutation to T: 16-fold increase in substrate specificity towards ornithine; when associated with L-326. 16-fold increase in substrate specificity towards ornithine; when associated with 44-V--P-46; D-54 and L-326.
I326 (≠ A330) mutation to L: 16-fold increase in substrate specificity towards ornithine; when associated with T-322. 16-fold increase in substrate specificity towards ornithine; when associated with 44-V--P-46; D-54 and T-322.
G350 (= G357) mutation to D: Loss of dimer formation and decarboxylase activity.

5gjoA Crystal structure of srldc mutant (a225c/t302c) in complex with plp (see paper)
36% identity, 94% coverage: 15:371/379 of query aligns to 17:364/385 of 5gjoA

query
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5gjoA

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active site: K52 (= K50), H180 (= H178), E256 (= E255)
binding pyridoxal-5'-phosphate: A50 (= A48), K52 (= K50), D71 (= D69), H180 (= H178), S183 (= S181), G219 (= G217), G220 (= G218), E256 (= E255), G258 (= G257), R259 (= R258), Y353 (= Y359)

5gjpA Crystal structure of srldc in complex with plp and cadaverine (see paper)
35% identity, 94% coverage: 15:371/379 of query aligns to 16:355/381 of 5gjpA

query
sites
5gjpA

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active site: K51 (= K50), H171 (= H178), E247 (= E255)
binding pentane-1,5-diamine: Y290 (≠ D301), D291 (≠ E302), Y344 (= Y359)
binding pyridoxal-5'-phosphate: A49 (= A48), K51 (= K50), H171 (= H178), S174 (= S181), G211 (= G218), E247 (= E255), G249 (= G257), R250 (= R258), Y344 (= Y359)

5gjnA Crystal structure of lysine decarboxylase from selenomonas ruminantium in p43212 space group (see paper)
35% identity, 94% coverage: 15:371/379 of query aligns to 16:352/369 of 5gjnA

query
sites
5gjnA

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active site: K51 (= K50), H170 (= H178), E244 (= E255)
binding magnesium ion: G210 (= G218), F236 (≠ I249), P237 (= P250), D238 (≠ E251), T239 (= T252), Y248 (≠ G259)

2pljA Crystal structure of lysine/ornithine decarboxylase complexed with putrescine from vibrio vulnificus (see paper)
32% identity, 93% coverage: 19:372/379 of query aligns to 29:365/376 of 2pljA

query
sites
2pljA

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A

K

R

A

A

Y

A

R

P

D

G

D

A

V

R

E

V

L

F

L

C

V

R

R

V

L

L

-

T

-

D

-

G

-

E

-

G

-

A

-

E

-

W

-

P

S

L

F

S

S

R

K

K

K

F

F

G

G

C

C

V

S

P

P

Q

E

M

Q

A

A

V

L

D

V

V

I

L

I

V

E

Y

T

A

A

H

K

Q

E

L

W

G

N

L

I

A

R

S

I

Y

K

G

G

V

L

S

S

F

F

H
|
H

V

V

G

G

S
|
S

Q

Q

M

T

T

T

K

N

L

P

D

N

A

K

W

Y

D

V

A

E

A

A

L

I

A

H

D

T

A

C

K

R

R

H

V

V

F

M

V

E

Q

Q

L

V

A

V

K

E

Q

R

G

G

I

L

E

P

-

A

L

L

K

S

M

T

V

L

N

D

M

I

G

G

G
|
G

F

F

P

P

T

V

K

N

Y

Y

L

T

R

Q

D

Q

V

V

P

M

S

P

A

I

E

D

A

Q

Y

F

G

C

Q

A

A

P

I

I

F

N

G

E

A

A

L

L

K

S

K

L

H

-

F

-

G

-

N

-

I

L

P

P

E

E

T

T

I

V

-

H

-

V

-

L

I

A

E
|
E

P

P

G
|
G

R
|
R

G

F

M

I

V

C

G

A

N

P

A

A

G

-

V

-

I

-

K

V

A

T

E

S

V

V

V

A

L

S

V

V

S

M

K

G

K

Q

S

A

D

E

N

R

D

E

S

G

H

Q

R

I

W

W

V

Y

F

Y

L

L

D

D

I

D

G

G

K

I

F

Y

G

G

G

S

L

F

A

S

E

G

T

L

M

M

D

F

E
x
D

A

D

I

A

R

R

Y

Y

P

P

I

L

R

T

T

T

A

I

R

K

D

Q

A

G

D

G

A

E

M

L

E

I

P

P

C

S

V

V

L

L

A

S

G

G

P

P

T

T

C

C

D

D

S

S

A

V

D

D

V

V

L

I

Y

A

E

E

K

N

N

I

M

L

Y

L

P

P

L

-

P

-

I

-

S

K

L

L

T

N

I

N

G

G

D

D

E

L

V

V

L

I

I

G

E

R

G

T

T

M

G

G

A

A

Y
|
Y

T

T

T

S

T

A

Y

-

S

T

A

A

V

T

A

D

F

F

N

N

G

F

F

F

E

K

active site: K60 (= K50), H179 (= H178), E255 (= E255)
binding (4-{[(4-aminobutyl)amino]methyl}-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate: K60 (= K50), H179 (= H178), S182 (= S181), G220 (= G218), E255 (= E255), G257 (= G257), R258 (= R258), D299 (≠ E302), Y353 (= Y359)

2plkA Crystal structure of lysine/ornithine decarboxylase complexed with cadaverine from vibrio vulnificus (see paper)
32% identity, 93% coverage: 19:372/379 of query aligns to 25:360/370 of 2plkA

query
sites
2plkA

G

A

P

P

C

L

L

L

V

L

D

D

L

C

D

D

V

V

V

I

R

R

D

Q

N

Q

F

Y

K

R

A

A

F

L

R

K

H

N

A

A

L

L

P

P

D

N

S

V

A

T

I

L

Y

H

Y

Y

A

A

V

L

K
|
K

A

P

N

L

P

P

A

H

P

P

E

V

V

V

L

V

R

R

L

T

L

L

A

L

S

A

L

E

G

G

S

A

N

S

F

F

D

D

C

L

A

A

S

T

V

T

A

G

E

E

I

V

E

E

M

L

A

V

L

A

D

S

A

E

G

G

A

V

T

P

P

A

N

D

R

L

I

T

S

I

Y

H

G

T

N

H

T

P

I

I

K

K

K

R

E

D

R

A

D

D

V

I

A

R

R

D

A

A

H

L

T

A

L

Y

G

G

I

C

S

N

L

V

F

F

A

V

V

V

D

D

S

N

H

L

E

N

E

E

V

L

E

E

K

K

I

F

A

K

R

A

A

Y

A

R

P

D

G

D

A

V

R

E

V

L

F

L

C

V

R

R

V

L

L

S

T

F

D

-

G

-

E

-

G

-

A

-

E

-

W

-

P

-

L

-

S

-

R

K

K

K

F

F

G

G

C

C

V

S

P

P

Q

E

M

Q

A

A

V

L

D

V

V

I

L

I

V

E

Y

T

A

A

H

K

Q

E

L

W

G

N

L

I

A

R

S

I

Y

K

G

G

V

L

S

S

F

F

H
|
H

V

V

G

G

S
|
S

Q

Q

M

T

T

T

K

N

L

P

D

N

A

K

W

Y

D

V

A

E

A

A

L

I

A

H

D

T

A

C

K

R

R

H

V

V

F

M

V

E

Q

Q

L

V

A

V

K

E

Q

R

G

G

I

L

-

P

E

A

L

L

K

S

M

T

V

L

N

D

M

I

G

G

G
|
G

F

F

P

P

T

V

K

N

Y

Y

L

T

R

Q

D

Q

V

V

P

M

S

P

A

I

E

D

A

Q

Y

F

G

C

Q

A

A

P

I

I

F

N

G

E

A

A

L

L

K

S

K

L

H

-

F

-

G

-

N

-

I

L

P

P

E

E

T

T

I

V

-

H

-

V

-

L

I

A

E
|
E

P

P

G
|
G

R
|
R

G

F

M

I

V

C

G

A

N

P

A

A

G

-

V

-

I

-

K

V

A

T

E

S

V

V

V

A

L

S

V

V

S

M

K

G

K

Q

S

A

D

E

N

R

D

E

S

G

H

Q

R

I

W

W

V

Y

F

Y

L

L

D

D

I

D

G

G

K

I

F

Y

G

G

G

S

L

F

A

S

E

G

T

L

M

M

D

F

E
x
D

A

D

I

A

R

R

Y

Y

P

P

I

L

R

T

T

T

A

I

R

K

D

Q

A

G

D

G

A

E

M

L

E

I

P

P

C

S

V

V

L

L

A

S

G

G

P

P

T

T

C

C

D

D

S

S

A

V

D

D

V

V

L

I

Y

A

E

E

K

N

N

I

M

L

Y

L

P

P

L

-

P

-

I

-

S

K

L

L

T

N

I

N

G

G

D

D

E

L

V

V

L

I

I

G

E

R

G

T

T

M

G

G

A

A

Y
|
Y

T

T

T

S

T

A

Y

-

S

T

A

A

V

T

A

D

F

F

N

N

G

F

F

F

E

K

active site: K56 (= K50), H174 (= H178), E250 (= E255)
binding (4-{(e)-[(5-aminopentyl)imino]methyl}-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate: H174 (= H178), S177 (= S181), G215 (= G218), E250 (= E255), G252 (= G257), R253 (= R258), D294 (≠ E302), Y348 (= Y359)

P07805 Ornithine decarboxylase; ODC; EC 4.1.1.17 from Trypanosoma brucei brucei (see 3 papers)
33% identity, 97% coverage: 12:379/379 of query aligns to 29:407/423 of P07805

query
sites
P07805

L

M

N

N

T

T

R

C

R

D

P

E

E

G

G

D

P

P

C

F

L

F

V

V

V

A

D

D

L

L

-

G

D

D

V

I

V

V

R

R

D

K

N

H

F

-

K

E

A

T

F

W

R

K

H

K

A

C

L

L

P

P

D

R

S

V

A

T

I

P

Y

F

Y

Y

A

A

V

V

K
|
K

A

C

N

N

P

D

A

D

P

W

E

R

V

V

L

L

R

G

L

T

L

L

A

A

S

A

L

L

G

G

S

T

N

G

F

F

D

D

C

C

A

A

S

S

V

N

A

T

E

E

I

I

E

Q

M

R

A

V

L

R

D

G

A

I

G

G

A

V

T

P

P

P

N

E

R

K

I

I

S

I

Y

Y

G

A

N

N

T

P

I

C

K

K

K

Q

E

I

R

S

D

H

V

I

A

R

R

Y

A

A

H

R

T

D

L

S

G

G

I

V

S

D

L

V

F

M

A

T

V

F

D

D

S

C

H

V

E

D

E

E

V

L

E

E

K

K

I

V

A

A

R

K

A

T

A

H

P

P

G

K

A

A

R

K

V

M

F

V

C

L

R

R

V

I

L

S

T

T

D

D

G

D

E

S

G

L

A

A

E

R

W

C

P

R

L

L

S

S

R

V

K

K

F

F

G

G

C

A

V

K

P

V

Q

E

M

D

A

C

V

R

D

F

V

I

L

L

V

E

Y

Q

A

A

H

K

Q

K

L

L

G

N

L

I

A

D

S

V

Y

T

G

G

V

V

S

S

F

F

H

H

V

V

G

G

S
|
S

Q

G

M

S

T

T

K

D

L

A

D

S

A

T

W

F

D

A

A

Q

A

A

L

I

A

S

D

D

A

S

K

R

R

F

V

V

F

F

V

D

Q

M

L

G

A

T

K

E

Q

L

G

G

I

F

E

N

L

M

K

H

M

I

V

L

N

D

M

I

G

G

G
|
G

F

F

P

P

T

G

K

T

Y

-

L

-

R

R

D

D

V

A

P

P

-

L

S

K

A

F

E

E

A

E

Y

I

G

A

Q

G

A

V

I

I

F

N

G

N

A

A

L

L

K

E

K

K

H

H

F

F

G

P

N

P

N

D

I

L

P

K

E

L

T

T

I

I

I

V

-

A

E
|
E

P
|
P

G
|
G

R
|
R

G

Y

M

Y

V

V

G

A

N

S

A

A

G

F

V

T

I

L

K

A

A

V

E

N

V

V

V

I

L

A

-

K

-

V

-

T

-

P

-

G

-

V

-

Q

-

T

-

D

V

V

S

G

K

A

K

H

S

A

D

E

N

S

D

N

S

A

H

Q

R

S

W

F

V

M

-

Y

F

Y

L

V

D

N

I

D

G

G

K

V

F

Y

G

G

G

S

L

F

A

N

E

C

T

I

M

L

-
x
Y

D
|
D

E

H

A

A

I

V

R

V

Y

R

P

P

I

L

-

P

-

Q

R

R

T

E

A

P

R

I

D

P

A

N

D

E

A

K

M

L

E

Y

P

P

C

S

V

S

L

V

A

W

G

G

P

P

T

T

C
|
C

D
|
D

S

G

A

L

D

D

V

Q

L

I

Y

V

E

E

K

R

N

-

M

-

Y

Y

P

Y

L

L

P

P

I

-

S

E

L

M

T

Q

I

V

G

G

D

E

E

W

V

L

L

L

I

F

E

E

G

D

T

M

G

G

A

A

Y
|
Y

T

T

T

V

Y

G

S

T

A

S

V

-

A

S

F

F

N

N

G

G

F

F

E

Q

-

S

P

P

L

T

K

I

A

Y

Y

Y

V

V

I

V

K67 (= K50) modified: N6-(pyridoxal phosphate)lysine
S198 (= S181) binding pyridoxal 5'-phosphate
G235 (= G218) binding pyridoxal 5'-phosphate
EPGR 272:275 (= EPGR 255:258) binding pyridoxal 5'-phosphate
YD 329:330 (≠ -D 301) binding in other chain
C358 (= C327) active site, Proton donor; shared with dimeric partner; mutation C->S,A: Converts the enzyme into a decarboxylation-dependent transaminase, producing gamma-aminobutyaldehyde (gamma-ABA) and pyridoxamine 5-phosphate (PMP) instead of putrescine.
D359 (= D328) binding substrate
Y387 (= Y359) binding pyridoxal 5'-phosphate

1f3tB Crystal structure of trypanosoma brucei ornithine decarboxylase (odc) complexed with putrescine, odc's reaction product. (see paper)
34% identity, 98% coverage: 7:379/379 of query aligns to 1:368/381 of 1f3tB

query
sites
1f3tB

R

R

I

F

I

L

D

E

F

G

L

F

N

N

T

T

R

R

-

D

-

A

-

L

-

C

-

K

R

K

P

I

E

S

G

G

-

D

P

P

C

F

L

F

V

V

V

A

D

D

L

L

-

G

D

D

V

I

V

V

R

R

D

K

N

H

F

-

K

E

A

T

F

W

R

K

H

K

A

C

L

L

P

P

D

R

S

V

A

T

I

P

Y

F

Y

Y

A

A

V

V

K
|
K

A

C

N

N

P

D

A

D

P

W

E

R

V

V

L

L

R

G

L

T

L

L

A

A

S

A

L

L

G

G

S

T

N

G

F

F

D

D

C

C

A

A

S

S

V

N

A

T

E

E

I

I

E

Q

M

R

A

V

L

R

D

G

A

I

G

G

A

V

T

P

P

P

N

E

R

K

I

I

S

I

Y

Y

G

A

N

N

T

P

I

C

K

K

K

Q

E

I

R

S

D

H

V

I

A

R

R

Y

A

A

H

R

T

D

L

S

G

G

I

V

S

D

L

V

F

M

A

T

V

F

D

D

S

C

H

V

E

D

E

E

V

L

E

E

K

K

I

V

A

A

R

K

A

T

A

H

P

P

G

K

A

A

R

K

V

M

F

V

C

L

R
|
R

V

I

L

S

T

T

D

D

G

-

E

-

G

-

A

-

E

-

W

-

P

-

L

L

S

S

R

V

K

K

F

F

G

G

C

A

V

K

P

V

Q

E

M

D

A

C

V

R

D

F

V

I

L

L

V

E

Y

Q

A

A

H

K

Q

K

L

L

G

N

L

I

A

D

S

V

Y

T

G

G

V

V

S

S

F

F

H
|
H

V

V

G

G

S

S

Q

G

M

S

T

T

K

D

L

A

D

S

A

T

W

F

D

A

A

Q

A

A

L

I

A

S

D

D

A

S

K

R

R

F

V

V

F

F

V

D

Q

M

L

G

A

T

K

E

Q

L

G

G

I

F

E

N

L

M

K

H

M

I

V

L

N

D

M

I

G

G

G
|
G

F

F

P

P

T

G

K

T

Y

-

L

-

R

R

D

D

V

A

P

P

-

L

S

K

A

F

E

E

A

E

Y

I

G

A

Q

G

A

V

I

I

F

N

G

N

A

A

L

L

K

E

K

K

H

H

F

F

G

P

N

P

N

D

I

L

P

K

E

L

T

T

I

I

I

V

-

A

E
|
E

P

P

G
|
G

R
|
R

G

Y

M

Y

V

V

G

A

N

S

A

A

G

F

V

T

I

L

K

A

A

V

E

N

V

V

V

-

L

-

V

I

S

A

K

K

S

V

D

T

N

Q

D

S

S

F

H

M

R

Y

W

Y

V

V

F

-

L

-

D

N

I

D

G

G

K

V

F

Y

G

G

G

S

L

F

A

N

E

C

T

I

M

L

-

Y

D
|
D

E

H

A

A

I

V

R

V

Y

R

P

P

I

L

-

P

-

Q

R

R

T

E

A

P

R

I

D

P

A

N

D

E

A

K

M

L

E

Y

P

P

C

S

V

S

L

V

A

W

G

G

P

P

T

T

C

C

D

D

S

G

A

L

D

D

V

Q

L

I

Y

V

E

E

K

R

N

-

M

-

Y

Y

P

Y

L

L

P

P

I

-

S

E

L

M

T

Q

I

V

G

G

D

E

E

W

V

L

L

L

I

F

E

E

G

D

T

M

G

G

A

A

Y
|
Y

T

T

T

V

Y

G

S

T

A

S

V

-

A

S

F

F

N

N

G

G

F

F

E

Q

-

S

P

P

L

T

K

I

A

Y

Y

Y

V

V

I

V

active site: K50 (= K50), H171 (= H178), E248 (= E255)
binding pyridoxal-5'-phosphate: K50 (= K50), R135 (= R135), H171 (= H178), G210 (= G217), G211 (= G218), E248 (= E255), G250 (= G257), R251 (= R258), Y348 (= Y359)
binding 1,4-diaminobutane: D291 (= D301), Y348 (= Y359)

2todA Ornithine decarboxylase from trypanosoma brucei k69a mutant in complex with alpha-difluoromethylornithine (see paper)
33% identity, 95% coverage: 20:379/379 of query aligns to 3:352/353 of 2todA

query
sites
2todA

P

P

C

F

L

F

V

V

V

A

D

D

L

L

-

G

D

D

V

I

V

V

R

R

D

K

N

H

F

-

K

E

A

T

F

W

R

K

H

K

A

C

L

L

P

P

D

R

S

V

A

T

I

P

Y

F

Y

Y

A

A

V

V

K
x
A

A

C

N

N

P

D

A

D

P

W

E

R

V

V

L

L

R

G

L

T

L

L

A

A

S

A

L

L

G

G

S

T

N

G

F

F

D

D

C

C

A

A

S

S

V

N

A

T

E

E

I

I

E

Q

M

R

A

V

L

R

D

G

A

I

G

G

A

V

T

P

P

P

N

E

R

K

I

I

S

I

Y

Y

G

A

N

N

T

P

I

C

K

K

K

Q

E

I

R

S

D

H

V

I

A

R

R

Y

A

A

H

R

T

D

L

S

G

G

I

V

S

D

L

V

F

M

A

T

V

F

D

D

S

C

H

V

E

D

E

E

V

L

E

E

K

K

I

V

A

A

R

K

A

T

A

H

P

P

G

K

A

A

R

K

V

M

F

V

C

L

R

R

V

I

L

S

T

T

D

-

G

-

E

-

G

-

A

-

E

-

W

-

P

-

L

L

S

S

R

V

K

K

F

F

G

G

C

A

V

K

P

V

Q

E

M

D

A

C

V

R

D

F

V

I

L

L

V

E

Y

Q

A

A

H

K

Q

K

L

L

G

N

L

I

A

D

S

V

Y

T

G

G

V

V

S

S

F

F

H
|
H

V

V

G

G

S
|
S

Q

G

M

S

T

T

K

D

L

A

D

S

A

T

W

F

D

A

A

Q

A

A

L

I

A

S

D

D

A

S

K

R

R

F

V

V

F

F

V

D

Q

M

L

G

A

T

K

E

Q

L

G

G

I

F

E

N

L

M

K

H

M

I

V

L

N

D

M

I

G

G

G
|
G

F

F

P

P

T

G

K

T

Y

-

L

-

R

R

D

D

V

A

P

P

-

L

S

K

A

F

E

E

A

E

Y

I

G

A

Q

G

A

V

I

I

F

N

G

N

A

A

L

L

K

E

K

K

H

H

F

F

G

P

N

P

N

D

I

L

P

K

E

L

T

T

I

I

I

V

-

A

E
|
E

P

P

G
|
G

R
|
R

G

Y

M

Y

V

V

G

A

N

S

A

A

G

F

V

T

I

L

K

A

A

V

E

N

V

V

V

-

L

-

V

I

S

A

K

K

S

V

D

T

N

P

D

A

S

Q

H

S

R

F

W

M

V

Y

F

Y

L

V

D

N

I

D

G

G

K

V

F

Y

G

G

G

S

L

F

A

N

E

C

T

I

M

L

-

Y

D
|
D

E

H

A

A

I

V

R

V

Y

R

P

P

I

L

-

P

-

Q

R

R

T

E

A

P

R

I

D

P

A

N

D

E

A

K

M

L

E

Y

P

P

C

S

V

S

L

V

A

W

G

G

P

P

T

T

C
|
C

D
|
D

S

G

A

L

D

D

V

Q

L

I

Y

V

E

E

K

R

N

-

M

-

Y

Y

P

Y

L

L

P

P

I

-

S

E

L

M

T

Q

I

V

G

G

D

E

E

W

V

L

L

L

I

F

E

E

G

D

T

M

G

G

A

A

Y
|
Y

T

T

T

V

Y

G

S

T

A

S

V

-

A

S

F
|
F

N

N

G

G

F

F

E

Q

-

S

P

P

L

T

K

I

A

Y

Y

Y

V

V

I

V

active site: A33 (≠ K50), H153 (= H178), E230 (= E255)
binding alpha-difluoromethylornithine: D275 (= D301), C303 (= C327), D304 (= D328), Y332 (= Y359), F340 (= F368)
binding pyridoxal-5'-phosphate: H153 (= H178), S156 (= S181), G192 (= G217), G193 (= G218), E230 (= E255), G232 (= G257), R233 (= R258), Y332 (= Y359)

2oo0A A structural insight into the inhibition of human and leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane (see paper)
33% identity, 94% coverage: 23:379/379 of query aligns to 52:406/419 of 2oo0A

query
sites
2oo0A

V

V

V

A

D

D

L

L

-

G

D

D

V

I

V

L

R

K

D

K

N

H

F

L

K

R

A

W

F

L

R

K

H

-

A

A

L

L

P

P

D

R

S

V

A

T

I

P

Y

F

Y

Y

A
|
A

V

V

K
|
K

A

C

N

N

P

D

A

S

P

K

E

A

V

I

L

V

R

K

L

T

L

L

A

A

S

A

L

T

G

G

S

T

N

G

F

F

D
|
D

C

C

A

A

S

S

V

K

A

T

E

E

I

I

E

Q

M

L

A

V

L

Q

D

S

A

L

G

G

A

V

T

P

P

P

N

E

R

R

I

I

S

I

Y

Y

G

A

N

N

T

P

I

C

K

K

K

Q

E

V

R

S

D

Q

V

I

A

K

R

Y

A

A

H

A

T

N

L

N

G

G

I

V

S

Q

L

M

F

M

A

T

V

F

D

D

S

S

H

E

E

V

E

E

V

L

E

M

K

K

I

V

A

A

R

R

A

A

A

H

P

P

G

K

A

A

R

K

V

L

F

V

C

L

R

R

V

I

L

A

T

T

D

D

G

D

E

S

G

K

A

A

E

V

W
x
C

P

R

L

L

S

S

R

V

K

K

F

F

G

G

C

A

V

T

P

L

Q

R

M

T

A

S

V

R

D

L

V

L

L

L

V

E

Y

R

A

A

H

K

Q

E

L

L

G

N

L

I

A

D

S

V

Y

V

G

G

V

V

S

S

F

F

H
|
H

V

V

G

G

S
|
S

Q

G

M

C

T

T

K

D

L

P

D

E

A

T

W

F

D

V

A

Q

A

A

L

I

A

S

D

D

A

A

K

R

R

C

V

V

F

F

V

D

Q

M

L

G

A

A

K

E

Q

V

G

G

I

F

E

S

L

M

K

Y

M

L

V

L

N

D

M

I

G

G

G
|
G

F

F

P
|
P

T
x
G

K
x
S

Y

E

L

D

R
x
V

D

K

V

L

P

K

S

F

A

E

E

E

A

I

Y

T

G

G

Q

-

A

V

I

I

F

N

G

P

A

A

L

L

K

D

K

K

H

Y

F

F

G

P

N

S

N

D

I

S

P

G

E

V

T

R

I

I

-

A

E
|
E

P

P

G
|
G

R
|
R

G

Y

M

Y

V

V

G

A

N

S

A

A

G

F

V

T

I

L

K

A

A

-

E

-

V

V

V

N

L

I

V

I

S

A

K

K

S

I

D

V

N

L

D

E

S

Q

H

T

R

F

W

M

V

Y

F

Y

L

V

D

N

I

D

G

G

K

V

F

Y

G

G

G

S

L

F

A

N

E

C

T

I

M

L

-

Y

D
|
D

E

H

A

A

I

H

R

V

Y

K

P

P

I

L

R

L

T

Q

A

K

R

R

D

P

A

K

-

P

-

D

D

E

A

K

M

Y

E

Y

P

S

C

S

V

S

L

I

A

W

G

G

P

P

T

T

C

C

D

D

S

G

A

L

D

D

V

R

L

I

Y

V

E

E

K

R

N

C

M

D

Y

L

P

P

L

-

P

-

I

-

S

E

L

M

T

H

I

V

G

G

D

D

E

W

V

M

L

L

I

F

E

E

G
x
N

T

M

G

G

A

A

Y
|
Y

T

T

T

V

T

A

Y

-

S

A

A

A

V

S

A

T

F

F

N

N

G

G

F

F

E

Q

-

R

P

P

L

T

K

I

A

Y

Y

Y

V

V

I

M

active site: K79 (= K50), H207 (= H178), E284 (= E255)
binding pentane-1,5-diamine: P249 (= P220), G250 (≠ T221), S251 (≠ K222), V254 (≠ R225), R287 (= R258), N382 (≠ G355)
binding pyridoxal-5'-phosphate: A77 (= A48), K79 (= K50), D98 (= D69), H207 (= H178), S210 (= S181), G247 (= G218), E284 (= E255), G286 (= G257), R287 (= R258), Y386 (= Y359)
binding 3-aminooxy-1-aminopropane: C174 (≠ W145), D329 (= D301), Y386 (= Y359)

P11926 Ornithine decarboxylase; ODC; EC 4.1.1.17 from Homo sapiens (Human) (see 5 papers)
33% identity, 94% coverage: 23:379/379 of query aligns to 42:409/461 of P11926

query
sites
P11926

V

V

V

A

D

D

L

L

-

G

D

D

V

I

V

L

R

K

D

K

N

H

F

L

K

R

A

W

F

L

R

K

H

-

A

A

L

L

P

P

D

R

S

V

A

T

I

P

Y

F

Y

Y

A

A

V

V

K
|
K

A

C

N

N

P

D

A

S

P

K

E

A

V

I

L

V

R

K

L

T

L

L

A

A

S

A

L

T

G

G

S

T

N

G

F

F

D

D

C

C

A

A

S

S

V

K

A

T

E

E

I

I

E

Q

M

L

A

V

L

Q

D

S

A

L

G

G

A

V

T

P

P

P

N

E

R

R

I

I

S

I

Y

Y

G

A

N

N

T

P

I

C

K

K

K

Q

E

V

R

S

D

Q

V

I

A

K

R

Y

A

A

H

A

T

N

L

N

G

G

I

V

S

Q

L

M

F

M

A

T

V

F

D

D

S

S

H

E

E

V

E

E

V

L

E

M

K

K

I

V

A

A

R

R

A

A

A

H

P

P

G

K

A

A

R

K

V

L

F

V

C

L

R

R

V

I

L

A

T

T

D

D

G

D

E

S

G

K

A

A

E

V

W

C

P

R

L

L

S

S

R

V

K

K

F

F

G

G

C

A

V

T

P

L

Q

R

M

T

A

S

V

R

D

L

V

L

L

L

V

E

Y

R

A

A

H

K

Q

E

L

L

G

N

L

I

A

D

S

V

Y

V

G

G

V

V

S

S

F

F

H

H

V

V

G

G

S
|
S

Q

G

M

C

T

T

K

D

L

P

D

E

A

T

W

F

D

V

A

Q

A

A

L

I

A

S

D

D

A

A

K

R

R

C

V

V

F

F

V

D

Q

M

L

G

A

A

K

E

Q

V

G

G

I

F

E

S

L

M

K

Y

M

L

V

L

N

D

M

I

G

G

G
|
G

F

F

P

P

T

G

K

S

Y

E

L

D

R

V

D

K

V

L

P

K

S

F

A

E

E

E

A

I

Y

T

G

G

Q

-

A

V

I

I

F

N

G

P

A

A

L

L

K

D

K

K

H

Y

F

F

G

P

N

S

N

D

I

S

P

G

E

V

T

R

I

I

-

A

E
|
E

P
|
P

G
|
G

R
|
R

G

Y

M

Y

V

V

G

A

N

S

A

A

-

F

-

T

-

L

-

A

-

V

G

N

V

I

I

I

K

A

A

K

E

K

V

I

V

V

L

L

V

K

S

E

K

Q

K

T

S

G

D

S

N

D

D

D

S

E

H

D

R

E

-

S

-

E

-

Q

-

T

-

F

W

M

V

Y

F

Y

L

V

D

N

I

D

G

G

K

V

F

Y

G

G

G

S

L

F

A

N

E

C

T

I

M

L

-

Y

D

D

E

H

A

A

I

H

R

V

Y

K

P

P

I

L

R

L

T

Q

A

K

R

R

D

P

A

K

-

P

-

D

D

E

A

K

M

Y

E

Y

P

S

C

S

V

S

L

I

A

W

G

G

P

P

T

T

C
|
C

D

D

S

G

A

L

D

D

V

R

L

I

Y

V

E

E

K

R

N

C

M

D

Y

L

P

P

L

-

P

-

I

-

S

E

L

M

T

H

I

V

G

G

D

D

E

W

V

M

L

L

I

F

E

E

G

N

T

M

G

G

A

A

Y
|
Y

T

T

T

V

T

A

Y

-

S

A

A

A

V

S

A

T

F

F

N

N

G

G

F

F

E

Q

-

R

P

P

L

T

K

I

A

Y

Y

Y

V

V

I

M

K69 (= K50) modified: N6-(pyridoxal phosphate)lysine
S200 (= S181) binding pyridoxal 5'-phosphate
G237 (= G218) binding pyridoxal 5'-phosphate
EPGR 274:277 (= EPGR 255:258) binding pyridoxal 5'-phosphate
C360 (= C327) mutation to A: 25% decrease of in vitro nitrosylation level.
Y389 (= Y359) binding pyridoxal 5'-phosphate

Sites not aligning to the query:

448:461 natural variant: Missing (in BABS; gain-of-function variant resulting in increased putrescine biosynthesis as indicated by higher amount of putrescine in patient red blood cells compared to controls; increased ODC1 protein levels in patient red blood cells)

Q9FPK5 Ornithine decarboxylase, chloroplastic; Lysine decarboxylase; EC 4.1.1.17; EC 4.1.1.18 from Nicotiana glutinosa (Tobacco) (see paper)
33% identity, 93% coverage: 20:372/379 of query aligns to 65:418/432 of Q9FPK5

query
sites
Q9FPK5

P

P

C

F

L

Y

V

V

V

L

D

D

L

L

D

G

V

E

V

V

R

V

D

S

N

L

F

M

K

D

A

Q

F

W

R

K

H

S

A

S

L

L

P

P

D

N

S

I

A

R

I

P

Y

F

Y

Y

A

A

V

V

K
|
K

A
x
C

N

N

P

P

A

E

P

P

E

S

V

F

L

L

R

S

L

I

L

L

A

S

S

A

L

M

G

G

S

S

N

N

F

F

D

D

C

C

A

A

S

S

V

R

A

A

E

E

I

I

E

E

M

Y

A

V

L

L

D

A

A

L

G

G

A

I

T

S

P

P

N

D

R

R

I

I

S

V

Y

F

G

A

N

N

T

P

I

C

K

K

K

P

E

E

R

S

D

D

V

I

A

I

R

F

A

A

H

A

T

K

L

V

G

G

I

V

S

N

L

L

F

T

A

T

V

Y

D

D

S

S

H

E

E

D

E

E

V

V

E

Y

K

K

I

I

A

R

R

K

A

H

P

P

G

K

A

S

R

E

V

L

F

L

C

P

R

R

V

I

-

K

-

P

L

M

T

F

D

D

G

G

E

N

G

-

A

A

E

R

W

C

P

P

L

M

S

G

R

P

K

K

F

Y

G

G

C

A

V

L

P

P

Q

E

M

E

A

V

V

E

D

P

V

L

L

L

V

R

Y

A

A

A

H

Q

Q

A

L

A

G

R

L

L

A

T

S

V

Y

S

G

G

V

V

S

S

F

F

H

H

V

I

G

G

S

S

Q

G

M

D

T

A

K

D

L

S

D

N

A

A

W

Y

D

L

A

G

A

A

L

I

A

A

D

A

A

A

K

K

R

E

V

V

F

F

V

E

Q

T

L

A

A

A

K

K

Q

L

G

G

I

M

-

S

E

K

L

M

K

T

M

V

V

L

N

D

M

V

G

G

F

F

P

T

T

S

K

G

Y

H

L

Q

R

F

D

T

V

T

P

A

S

A

A

V

E

-

A

-

Y

-

G

-

Q

-

A

A

I

V

F

K

G

S

A

A

L

L

K

K

K

Q

H

H

F

F

G

D

N

D

N

E

I

P

P

E

E

L

T

T

I

I

-

A

E

E

P

P

G

G

R

R

G

F

M

F

V

A

G

E

N

T

A

A

G

F

V

T

I

L

K

A

A

T

E

T

V

V

V

I

L

-

V

-

S

-

K

G

K

K

S

R

D

V

N

R

D

G

S

E

H

L

R

R

W

E

V

Y

F

W

L

I

D

N

I

D

G

G

K

L

F

Y

G

G

G

S

L

M

A

N

E
x
C

T

V

M

L

-

Y

D

D

E

H

A

A

I

T

-

V

-

N

R

A

Y

T

P

P

I

L

R

A

T

V

A

L

R

S

D

N

A

R

D

T

A

N

M

V

E

T

-

C

-

G

-

S

-

K

-

T

-

F

P

P

C

T

V

T

L

V

A

F

G

G

P

P

T

T

C
|
C

D

D

S

A

A

L

D

D

V

T

L

V

Y

L

E

R

K

D

N

-

M

-

Y

Y

P

Q

L

L

P

P

I

-

S

E

L

L

T

Q

I

V

G

N

D

D

E

W

V

L

L

V

I

F

E

P

G

N

T

M

G

G

A

A

Y

Y

T

T

T

K

T

A

Y

-

S

A

A

G

V

S

A

N

F

F

N

N

G

G

F

F

E

N

K95 (= K50) mutation to A: Loss of activity.
C96 (≠ A51) mutation to A: Almost unchanged activity.
C338 (≠ E298) mutation to A: Loss of activity.
C377 (= C327) mutation to A: Loss of activity.

4zgyA Structure of human ornithine decarboxylase in complex with a c- terminal fragment of antizyme (see paper)
33% identity, 94% coverage: 23:379/379 of query aligns to 18:371/383 of 4zgyA

query
sites
4zgyA

V

V

V

A

D

D

L

L

-

G

D

D

V

I

V

L

R

K

D

K

N

H

F

L

K

R

A

W

F

L

R

K

H

-

A

A

L

L

P

P

D

R

S

V

A

T

I

P

Y

F

Y

Y

A

A

V

V

K
|
K

A

C

N

N

P

D

A

S

P

K

E

A

V

I

L

V

R

K

L

T

L

L

A

A

S

A

L

T

G

G

S

T

N

G

F

F

D
|
D

C

C

A

A

S

S

V

K

A

T

E

E

I

I

E

Q

M

L

A

V

L

Q

D

S

A

L

G

G

A

V

T

P

P

P

N

E

R

R

I

I

S

I

Y

Y

G

A

N

N

T

P

I

C

K

K

K

Q

E

V

R

S

D

Q

V

I

A

K

R

Y

A

A

H

A

T

N

L

N

G

G

I

V

S

Q

L

M

F

M

A

T

V

F

D

D

S

S

H

E

E

V

E

E

V

L

E

M

K

K

I

V

A

A

R

R

A

A

A

H

P

P

G

K

A

A

R

K

V

L

F

V

C

L

R

R

V

I

L

A

T

T

D

D

G

D

E

S

G

C

A

R

E

-

W

-

P

-

L

L

S

S

R

V

K

K

F

F

G

G

C

A

V

T

P

L

Q

R