SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_238374197.1 NCBI__GCF_000008645.1:WP_238374197.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

1nsjA Crystal structure of phosphoribosyl anthranilate isomerase from thermotoga maritima (see paper)
30% identity, 83% coverage: 14:216/244 of query aligns to 2:192/205 of 1nsjA

query
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1nsjA
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1piiA Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (see paper)
27% identity, 85% coverage: 17:224/244 of query aligns to 258:447/452 of 1piiA

query
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1piiA
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Q

Sites not aligning to the query:

1lbmA Crystal structure of phosphoribosyl anthranilate isomerase (prai) in complex with reduced 1-(o-carboxyphenylamino)-1-deoxyribulose 5- phosphate (rcdrp) (see paper)
28% identity, 83% coverage: 14:216/244 of query aligns to 2:181/194 of 1lbmA

query
sites
1lbmA
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A
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H

Query Sequence

>WP_238374197.1 NCBI__GCF_000008645.1:WP_238374197.1
MNSLNSSHESLADVLVKICGIKRPEDAILADKLGADLLGLIHVERSPRHLTGRELEDILS
LIPPEKAVIVLEPSDPVEVAEVIERTGVERVQLHSISCEDARGIKRVLTENGFNPGITVA
VPPEPGSLDVLDHIPCSCVMLDSSSGGRTGGTGRMIPPELALGMLRLIRSHESAPEVALA
GGLGPSTVRLNPEYLLEFDCLDFNSGIEAAPGIKDHAMMFELMEYMGRTGGLQKPSRLQR
GELS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory