SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_244151912.1 NCBI__GCF_900142125.1:WP_244151912.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
43% identity, 66% coverage: 105:315/319 of query aligns to 2:214/214 of 4ymwC

query
sites
4ymwC
T
 
T
I
 
V
G
 
D
Y
 
F
I
 
L
A
 
S
E
 
M
W
 
V
R
 
K
A
 
Y
G
 
T
P
 
P
L
 
L
L
 
F
V
 
I
-
 
S
G
 
G
L
 
L
W
 
I
T
 
M
T
 
T
L
 
L
W
 
K
L
 
L
S
 
T
A
 
F
A
 
L
A
 
A
S
 
V
V
 
T
F
 
I
G
 
G
L
 
V
I
 
L
I
 
M
G
 
G
L
 
L
V
 
F
T
 
I
G
 
A
L
 
L
C
 
M
R
 
K
V
 
M
S
 
S
S
 
S
N
 
I
T
 
K
T
 
P
L
 
I
R
 
K
Q
 
L
L
 
V
S
 
A
V
 
S
I
 
S
Y
 
Y
V
 
I
E
 
E
L
 
V
I
 
I
R
 
R
G
 
G
T
 
T
P
 
P
L
 
L
L
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
I
 
L
F
 
I
Y
 
Y
F
 
N
F
 
G
L
 
L
G
 
M
T
 
Q
V
 
F
-
 
G
L
 
M
D
 
N
I
 
I
S
 
P
R
 
A
I
 
F
V
 
T
A
 
A
G
 
G
I
 
V
S
 
S
A
 
A
L
 
L
A
 
A
I
 
I
F
x
N
A
 
S
G
 
S
A
 
A
Y
|
Y
V
 
V
A
 
A
E
 
E
I
 
I
I
 
I
R
 
R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
I
 
V
P
 
D
K
 
P
G
 
G
Q
 
Q
M
 
N
E
 
E
A
 
A
A
 
A
R
 
R
S
 
S
L
 
L
G
 
G
M
 
M
N
 
T
V
 
H
P
 
A
Q
 
M
A
 
A
M
 
M
I
 
R
H
 
Y
I
 
V
I
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
F
 
I
K
 
K
R
 
N
T
 
I
L
 
L
P
 
P
P
 
A
L
 
L
A
 
G
G
 
N
Q
x
E
F
 
F
I
 
I
S
 
V
L
 
M
I
 
L
K
 
K
D
x
E
S
 
S
S
 
A
L
 
I
V
 
V
S
 
S
V
 
V
I
 
I
A
 
G
I
 
F
T
 
A
D
 
D
L
 
L
T
 
T
K
 
R
S
 
Q
G
 
A
R
 
D
E
 
I
V
 
I
I
 
Q
T
 
S
S
 
V
T
 
T
F
 
Y
A
 
R
T
 
Y
F
 
F
E
 
E
I
 
P
W
 
Y
F
 
I
I
 
I
V
 
I
A
 
A
L
 
A
L
 
I
Y
 
Y
L
 
F
L
 
V
L
 
M
T
 
T
L
 
L
S
 
T
L
 
F
S
 
S
Q
 
K
V
 
L
I
 
L
A
 
S
W
 
L
V
 
F
E
 
E
R
 
R
R
 
R
L
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
43% identity, 66% coverage: 105:315/319 of query aligns to 2:214/215 of 4ymtC

query
sites
4ymtC
T
 
T
I
 
V
G
 
D
Y
 
F
I
 
L
A
 
S
E
 
M
W
 
V
R
 
K
A
 
Y
G
 
T
P
 
P
L
 
L
L
 
F
V
 
I
-
 
S
G
 
G
L
 
L
W
 
I
T
 
M
T
 
T
L
 
L
W
 
K
L
 
L
S
 
T
A
 
F
A
 
L
A
 
A
S
 
V
V
 
T
F
 
I
G
 
G
L
 
V
I
 
L
I
 
M
G
 
G
L
 
L
V
 
F
T
 
I
G
 
A
L
 
L
C
 
M
R
 
K
V
 
M
S
 
S
S
 
S
N
 
I
T
 
K
T
 
P
L
 
I
R
 
K
Q
 
L
L
 
V
S
 
A
V
 
S
I
 
S
Y
 
Y
V
 
I
E
 
E
L
 
V
I
 
I
R
 
R
G
 
G
T
 
T
P
|
P
L
|
L
L
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
I
 
L
F
 
I
Y
 
Y
F
 
N
F
 
G
L
 
L
G
 
M
T
 
Q
V
 
F
-
 
G
L
 
M
D
 
N
I
 
I
S
 
P
R
 
A
I
 
F
V
 
T
A
 
A
G
 
G
I
 
V
S
 
S
A
 
A
L
 
L
A
 
A
I
 
I
F
x
N
A
 
S
G
 
S
A
 
A
Y
|
Y
V
 
V
A
 
A
E
 
E
I
 
I
I
 
I
R
 
R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
I
 
V
P
 
D
K
 
P
G
 
G
Q
 
Q
M
 
N
E
 
E
A
 
A
A
 
A
R
 
R
S
 
S
L
 
L
G
 
G
M
 
M
N
 
T
V
 
H
P
 
A
Q
 
M
A
 
A
M
 
M
I
 
R
H
 
Y
I
 
V
I
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
F
 
I
K
 
K
R
 
N
T
 
I
L
 
L
P
 
P
P
 
A
L
 
L
A
 
G
G
 
N
Q
x
E
F
 
F
I
 
I
S
 
V
L
x
M
I
 
L
K
|
K
D
x
E
S
 
S
S
 
A
L
 
I
V
 
V
S
 
S
V
 
V
I
 
I
A
 
G
I
 
F
T
 
A
D
 
D
L
 
L
T
 
T
K
 
R
S
 
Q
G
 
A
R
 
D
E
 
I
V
 
I
I
 
Q
T
 
S
S
 
V
T
 
T
F
 
Y
A
 
R
T
 
Y
F
 
F
E
 
E
I
 
P
W
 
Y
F
 
I
I
 
I
V
 
I
A
 
A
L
 
A
L
 
I
Y
 
Y
L
 
F
L
 
V
L
 
M
T
 
T
L
 
L
S
 
T
L
 
F
S
 
S
Q
 
K
V
 
L
I
 
L
A
 
S
W
 
L
V
 
F
E
 
E
R
 
R
R
 
R
L
 
L

Query Sequence

>WP_244151912.1 NCBI__GCF_900142125.1:WP_244151912.1
MNKNVTSWSWSLLTLLILFALGTGLWIATKKIDYTWRWNRVPQYFVYLNEDAIVVPADAR
VEKVDVVGESANVTVLTEYDETLTYKVDADNVSVYQDETLFEGDTIGYIAEWRAGPLLVG
LWTTLWLSAAASVFGLIIGLVTGLCRVSSNTTLRQLSVIYVELIRGTPLLVQIFIFYFFL
GTVLDISRIVAGISALAIFAGAYVAEIIRAGIQSIPKGQMEAARSLGMNVPQAMIHIILP
QAFKRTLPPLAGQFISLIKDSSLVSVIAITDLTKSGREVITSTFATFEIWFIVALLYLLL
TLSLSQVIAWVERRLAVSD

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory