SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_245795086.1 NCBI__GCF_900129305.1:WP_245795086.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

6j2lA Crystal structure of bi-functional enzyme (see paper)
46% identity, 94% coverage: 6:124/126 of query aligns to 10:133/200 of 6j2lA

query
sites
6j2lA
D
 
D
F
 
W
S
 
E
K
 
K
G
 
T
D
 
D
G
 
G
L
 
L
L
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
D
 
H
A
 
A
E
 
V
T
 
S
G
 
G
Q
 
E
V
 
V
L
 
L
M
 
M
M
 
L
A
 
G
Y
 
Y
M
 
M
N
 
N
R
 
P
E
 
E
A
 
A
W
 
L
E
 
D
K
 
K
T
 
T
V
 
I
E
 
E
T
 
S
G
 
G
T
 
K
V
 
V
H
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
R
 
Q
K
 
R
L
 
L
W
 
W
L
 
I
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
G
H
 
N
V
 
F
Q
 
L
K
 
N
V
 
V
V
 
V
D
 
S
I
 
I
L
 
A
V
 
P
D
|
D
C
 
C
D
|
D
L
 
N
D
|
D
T
 
T
I
 
L
L
 
L
V
 
V
K
 
L
V
 
A
H
 
N
Q
 
P
L
 
I
G
 
-
G
 
G
A
 
P
A
 
T
C
|
C
H
 
H
E
 
K
G
 
G
Y
 
T
K
 
S
S
 
S
C
|
C
F
 
F
F
 
G
R
 
N
R
 
T
L
 
A
K
 
H
D
 
Q
G
 
W
A
 
L
F
 
F
-
 
L
-
 
Y
-
 
Q
-
 
L
-
 
E
-
 
Q
E
 
L
I
 
L
T
 
A
E
 
E
D
 
R
K
 
K
V
 
Y
F
 
A
D
 
D
P
 
P
E
 
E
E
 
T
V
 
S
Y
 
Y

Sites not aligning to the query:

6j2lB Crystal structure of bi-functional enzyme (see paper)
51% identity, 70% coverage: 6:93/126 of query aligns to 9:96/185 of 6j2lB

query
sites
6j2lB
D
 
D
F
 
W
S
 
E
K
 
K
G
 
T
D
 
D
G
 
G
L
 
L
L
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
D
 
H
A
 
A
E
 
V
T
 
S
G
 
G
Q
 
E
V
 
V
L
 
L
M
 
M
M
 
L
A
 
G
Y
 
Y
M
 
M
N
 
N
R
 
P
E
 
E
A
 
A
W
 
L
E
 
D
K
 
K
T
 
T
V
 
I
E
 
E
T
 
S
G
 
G
T
 
K
V
 
V
H
 
T
Y
 
F
W
 
F
S
 
S
R
 
R
S
 
T
R
 
K
R
 
Q
K
 
R
L
 
L
W
 
W
L
 
I
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
G
H
 
N
V
 
F
Q
 
L
K
 
N
V
 
V
V
 
V
D
 
S
I
 
I
L
 
A
V
 
P
D
|
D
C
 
C
D
|
D
L
 
N
D
|
D
T
 
T
I
 
L
L
 
L
V
 
V
K
 
L
V
 
A
H
 
N
Q
 
P
L
 
I
G
 
G
G
 
P
A
 
S
A
 
S
C
 
C

Sites not aligning to the query:

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
42% identity, 72% coverage: 12:102/126 of query aligns to 15:104/204 of 7bgnA

query
sites
7bgnA
G
 
G
L
 
L
L
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
D
 
N
A
 
V
E
 
D
T
 
T
G
 
G
Q
 
A
V
 
I
L
 
L
M
 
M
M
 
Q
A
 
G
Y
 
F
M
 
A
N
 
N
R
 
R
E
 
E
A
 
A
W
 
V
E
 
A
K
 
T
T
 
T
V
 
I
E
 
S
T
 
S
G
 
R
T
 
K
V
 
A
H
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
R
 
S
K
 
S
L
 
L
W
|
W
L
 
T
K
|
K
G
|
G
E
 
E
T
|
T
S
|
S
G
 
N
H
 
N
V
 
F
Q
 
I
K
 
N
V
 
V
V
 
H
D
 
D
I
 
V
L
 
F
V
 
L
D
|
D
C
 
C
D
|
D
L
 
R
D
|
D
T
 
S
I
 
I
L
 
-
V
 
I
K
 
Y
V
 
L
H
 
G
Q
 
K
L
 
P
G
 
D
G
 
G
A
 
P
A
x
T
C
|
C
H
|
H
E
 
T
G
 
G
Y
 
A
K
 
E
S
 
T
C
|
C
F
 
Y
F
 
Y

Sites not aligning to the query:

7bgmA Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
42% identity, 72% coverage: 12:102/126 of query aligns to 17:106/213 of 7bgmA

query
sites
7bgmA
G
 
G
L
 
L
L
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
D
 
N
A
 
V
E
 
D
T
 
T
G
 
G
Q
 
A
V
 
I
L
 
L
M
 
M
M
 
Q
A
 
G
Y
 
F
M
 
A
N
 
N
R
 
R
E
 
E
A
 
A
W
 
V
E
 
A
K
 
T
T
 
T
V
 
I
E
 
S
T
 
S
G
 
R
T
 
K
V
 
A
H
 
T
Y
 
F
W
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
R
 
S
K
 
S
L
 
L
W
 
W
L
 
T
K
 
K
G
 
G
E
 
E
T
 
T
S
 
S
G
 
N
H
 
N
V
 
F
Q
 
I
K
 
N
V
 
V
V
 
H
D
 
D
I
 
V
L
 
F
V
 
L
D
|
D
C
 
C
D
|
D
L
 
R
D
|
D
T
 
S
I
 
I
L
 
-
V
 
I
K
 
Y
V
 
L
H
 
G
Q
 
K
L
 
P
G
 
D
G
 
G
A
 
P
A
 
T
C
|
C
H
 
H
E
 
T
G
 
G
Y
 
A
K
 
E
S
 
T
C
|
C
F
 
Y
F
 
Y

Sites not aligning to the query:

Query Sequence

>WP_245795086.1 NCBI__GCF_900129305.1:WP_245795086.1
MTAHPDFSKGDGLLPAIAQDAETGQVLMMAYMNREAWEKTVETGTVHYWSRSRRKLWLKG
ETSGHVQKVVDILVDCDLDTILVKVHQLGGAACHEGYKSCFFRRLKDGAFEITEDKVFDP
EEVYKK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory