SitesBLAST
Comparing WP_281055216.1 NCBI__GCF_000024385.1:WP_281055216.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
46% identity, 93% coverage: 31:594/608 of query aligns to 89:654/664 of P09114
- P191 (≠ T133) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W512) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M287), R292 (= R313), W489 (= W512), S568 (≠ A587)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), G426 (= G449), M428 (= M451), G452 (= G475), D453 (= D476), G454 (= G477), S455 (≠ C478), L483 (= L506), G484 (= G507), M485 (= M508), V486 (= V509)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), M263 (= M284), L264 (≠ P285), M266 (= M287), H267 (= H288), G286 (= G307), R288 (= R309), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446)
- binding magnesium ion: A37 (= A58), T82 (= T103), S83 (= S104), Q122 (= Q143), Y381 (= Y404), D453 (= D476), M458 (= M481), Q461 (= Q484), N480 (= N503), H482 (≠ N505), K533 (≠ A551)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 13:574/582 of 3ea4A
- active site: Y32 (≠ I54), G34 (= G56), G35 (= G57), A36 (= A58), S37 (≠ I59), E58 (= E80), T81 (= T103), F120 (= F142), Q121 (= Q143), E122 (= E144), K170 (= K192), M265 (= M287), V292 (= V314), V399 (= V423), G425 (= G449), M427 (= M451), D452 (= D476), N479 (= N503), H481 (≠ N505), L482 (= L506), M484 (= M508), V485 (= V509), W488 (= W512), H557 (≠ Q577)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D312), R291 (= R313), W488 (= W512), S567 (≠ A587)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R182), G221 (= G241), G222 (= G242), G223 (= G243), T245 (= T267), L246 (= L268), M247 (= M269), L263 (≠ P285), G264 (= G286), M265 (= M287), H266 (= H288), G285 (= G307), R287 (= R309), D289 (= D311), R291 (= R313), D309 (= D331), I310 (= I332), G327 (= G349), D328 (= D350), V329 (≠ A351), M404 (= M428), G422 (= G446)
- binding magnesium ion: D452 (= D476), N479 (= N503), H481 (≠ N505)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V423), G400 (= G424), Q401 (= Q425), H402 (= H426), M427 (= M451), G451 (= G475), D452 (= D476), G453 (= G477), S454 (≠ C478), N479 (= N503), H481 (≠ N505), L482 (= L506), G483 (= G507), M484 (= M508), V485 (= V509)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 13:574/582 of 3e9yA
- active site: Y32 (≠ I54), G34 (= G56), G35 (= G57), A36 (= A58), S37 (≠ I59), E58 (= E80), T81 (= T103), F120 (= F142), Q121 (= Q143), E122 (= E144), K170 (= K192), M265 (= M287), V292 (= V314), V399 (= V423), G425 (= G449), M427 (= M451), D452 (= D476), N479 (= N503), H481 (≠ N505), L482 (= L506), M484 (= M508), V485 (= V509), W488 (= W512), H557 (≠ Q577)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D312), R291 (= R313), W488 (= W512), S567 (≠ A587)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R182), G221 (= G241), G222 (= G242), G223 (= G243), T245 (= T267), L246 (= L268), M247 (= M269), L263 (≠ P285), G285 (= G307), R287 (= R309), D289 (= D311), R291 (= R313), D309 (= D331), I310 (= I332), G327 (= G349), D328 (= D350), V329 (≠ A351), M404 (= M428), G422 (= G446)
- binding magnesium ion: D452 (= D476), N479 (= N503), H481 (≠ N505)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V423), G400 (= G424), Q401 (= Q425), H402 (= H426), M427 (= M451), G451 (= G475), G453 (= G477), S454 (≠ C478), N479 (= N503), H481 (≠ N505), L482 (= L506), G483 (= G507), M484 (= M508), V485 (= V509)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), G426 (= G449), M428 (= M451), G452 (= G475), D453 (= D476), G454 (= G477), S455 (≠ C478), M458 (= M481), N480 (= N503), H482 (≠ N505), L483 (= L506), G484 (= G507), M485 (= M508), V486 (= V509)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), M266 (= M287), H267 (= H288), G286 (= G307), V287 (≠ A308), R288 (= R309), D290 (= D311), R292 (= R313), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446)
- binding magnesium ion: F370 (≠ Y392), D453 (= D476), M458 (= M481), Q461 (= Q484), N480 (= N503), H482 (≠ N505), K533 (≠ A551)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M287), R292 (= R313), M485 (= M508), W489 (= W512), S568 (≠ A587)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 5wj1A
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), M263 (= M284), L264 (≠ P285), G286 (= G307), R288 (= R309), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446), G424 (= G447)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M287), D291 (= D312), R292 (= R313), M485 (= M508), W489 (= W512), S568 (≠ A587)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), M428 (= M451), D453 (= D476), G454 (= G477), S455 (≠ C478), M458 (= M481), N480 (= N503), H482 (≠ N505), L483 (= L506), G484 (= G507), M485 (= M508), V486 (= V509)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 5k6tA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H288), R292 (= R313), M485 (= M508), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), G286 (= G307), R288 (= R309), D290 (= D311), R292 (= R313), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), Q404 (= Q427), M405 (= M428), G423 (= G446)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), G426 (= G449), M428 (= M451), G452 (= G475), G454 (= G477), S455 (≠ C478), N480 (= N503), H482 (≠ N505), L483 (= L506), G484 (= G507)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 5k6rA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R313), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), M266 (= M287), G286 (= G307), R288 (= R309), R292 (= R313), V293 (= V314), D310 (= D331), I311 (= I332), G328 (= G349), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), G426 (= G449), M428 (= M451), D453 (= D476), G454 (= G477), S455 (≠ C478), M458 (= M481), N480 (= N503), H482 (≠ N505), L483 (= L506), G484 (= G507), M485 (= M508), V486 (= V509)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 1z8nA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K156), R161 (= R182), Y191 (= Y212), R194 (= R213), D291 (= D312), R292 (= R313), D312 (= D333), W489 (= W512), G569 (= G588)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), G265 (= G286), M266 (= M287), H267 (= H288), G286 (= G307), V287 (≠ A308), R288 (= R309), D290 (= D311), R292 (= R313), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446), G424 (= G447)
- binding magnesium ion: D453 (= D476), N480 (= N503)
- binding thiamine diphosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), G426 (= G449), M428 (= M451), G452 (= G475), G454 (= G477), S455 (≠ C478), N480 (= N503), H482 (≠ N505), L483 (= L506), G484 (= G507), M485 (= M508), V486 (= V509)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 1yi1A
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D312), R292 (= R313), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), M263 (= M284), L264 (≠ P285), G265 (= G286), M266 (= M287), H267 (= H288), G286 (= G307), V287 (≠ A308), R288 (= R309), D290 (= D311), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446), G424 (= G447)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 1yi0A
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D312), R292 (= R313), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), G265 (= G286), M266 (= M287), H267 (= H288), G286 (= G307), V287 (≠ A308), R288 (= R309), D290 (= D311), R292 (= R313), V293 (= V314), D310 (= D331), I311 (= I332), G328 (= G349), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446), G424 (= G447)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 1yhzA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D312), R292 (= R313), M485 (= M508), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), M266 (= M287), H267 (= H288), G286 (= G307), V287 (≠ A308), R288 (= R309), D290 (= D311), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), Q404 (= Q427), M405 (= M428), G423 (= G446), G424 (= G447)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 1yhyA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D312), R292 (= R313), V486 (= V509), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), G265 (= G286), M266 (= M287), H267 (= H288), G286 (= G307), V287 (≠ A308), R288 (= R309), D290 (= D311), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), Q404 (= Q427), M405 (= M428), G423 (= G446), G424 (= G447)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/582 of 1ybhA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M287), D291 (= D312), R292 (= R313), M485 (= M508), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), M266 (= M287), H267 (= H288), G286 (= G307), V287 (≠ A308), R288 (= R309), D290 (= D311), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), Q404 (= Q427), M405 (= M428), G423 (= G446), G424 (= G447)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
46% identity, 92% coverage: 35:594/608 of query aligns to 99:660/670 of P17597
- A122 (= A58) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L60) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E80) binding thiamine diphosphate
- S186 (= S122) binding FAD
- P197 (≠ T133) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ G135) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q143) binding thiamine diphosphate
- K220 (= K156) binding (R)-imazaquin
- R246 (= R182) binding (R)-imazaquin; binding FAD
- K256 (= K192) binding chlorimuron-ethyl
- G308 (= G242) binding FAD
- TL 331:332 (= TL 267:268) binding FAD
- C340 (≠ D276) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ PGMH 285:288) binding FAD
- GVRFD 371:375 (≠ GARFD 307:311) binding FAD
- DR 376:377 (= DR 312:313) binding chlorimuron-ethyl
- DI 395:396 (= DI 331:332) binding FAD
- DV 414:415 (≠ DA 350:351) binding FAD
- QH 487:488 (= QH 425:426) binding thiamine diphosphate
- GG 508:509 (= GG 446:447) binding FAD
- GAM 511:513 (≠ GTM 449:451) binding thiamine diphosphate
- D538 (= D476) binding Mg(2+)
- DGS 538:540 (≠ DGC 476:478) binding thiamine diphosphate
- N565 (= N503) binding Mg(2+)
- NQHLGM 565:570 (≠ NGNLGM 503:508) binding thiamine diphosphate
- H567 (≠ N505) binding Mg(2+)
- W574 (= W512) binding chlorimuron-ethyl; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ A587) binding chlorimuron-ethyl; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/583 of 5k3sA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R313), M485 (= M508), W489 (= W512), G569 (= G588)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), M266 (= M287), G286 (= G307), R288 (= R309), D290 (= D311), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), M405 (= M428), G423 (= G446)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), G426 (= G449), M428 (= M451), D453 (= D476), G454 (= G477), S455 (≠ C478), N480 (= N503), H482 (≠ N505), L483 (= L506), G484 (= G507), M485 (= M508), V486 (= V509)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
45% identity, 93% coverage: 31:594/608 of query aligns to 92:657/667 of P09342
- C161 (= C100) modified: Disulfide link with 307
- P194 (≠ T133) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V244) modified: Disulfide link with 161
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
46% identity, 92% coverage: 35:594/608 of query aligns to 14:575/585 of 5k2oA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), S38 (≠ I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), M266 (= M287), V293 (= V314), V400 (= V423), G426 (= G449), M428 (= M451), D453 (= D476), N480 (= N503), H482 (≠ N505), L483 (= L506), M485 (= M508), V486 (= V509), W489 (= W512), H558 (≠ Q577)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M287), R292 (= R313), W489 (= W512), S568 (≠ A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G222 (= G241), G223 (= G242), G224 (= G243), T246 (= T267), L247 (= L268), M248 (= M269), L264 (≠ P285), G286 (= G307), R288 (= R309), D290 (= D311), V293 (= V314), D310 (= D331), I311 (= I332), D329 (= D350), V330 (≠ A351), Q404 (= Q427), M405 (= M428), G423 (= G446)
- binding magnesium ion: D453 (= D476), N480 (= N503), H482 (≠ N505)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V423), G401 (= G424), Q402 (= Q425), H403 (= H426), M428 (= M451), D453 (= D476), G454 (= G477), S455 (≠ C478), N480 (= N503), H482 (≠ N505), L483 (= L506), G484 (= G507), M485 (= M508), V486 (= V509)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
44% identity, 92% coverage: 33:594/608 of query aligns to 14:576/599 of 6denA
- active site: Y35 (≠ I54), G37 (= G56), G38 (= G57), A39 (= A58), I40 (= I59), E61 (= E80), T84 (= T103), F123 (= F142), Q124 (= Q143), E125 (= E144), K173 (= K192), K230 (≠ E252), M266 (= M287), V293 (= V314), V409 (= V423), L434 (≠ A448), G435 (= G449), M437 (= M451), D462 (= D476), N489 (= N503), E491 (≠ N505), Q492 (≠ L506), M494 (= M508), V495 (= V509), W498 (= W512), L520 (= L537), N525 (≠ G542), V526 (≠ C543)
- binding flavin-adenine dinucleotide: R163 (= R182), G219 (= G241), A220 (≠ G242), G221 (= G243), N224 (≠ K246), T246 (= T267), L247 (= L268), Q248 (≠ M269), L264 (≠ P285), G286 (= G307), A287 (= A308), R288 (= R309), D290 (= D311), R292 (= R313), V293 (= V314), E319 (≠ D331), I320 (= I332), N324 (≠ E336), D338 (= D350), V339 (≠ A351), M414 (= M428), G432 (= G446)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M287), D291 (= D312), R292 (= R313), W498 (= W512)
- binding magnesium ion: D462 (= D476), N489 (= N503), E491 (≠ N505)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V423), G410 (= G424), Q411 (= Q425), H412 (= H426), G435 (= G449), M437 (= M451), G461 (= G475), D462 (= D476), A463 (≠ G477), S464 (≠ C478), N489 (= N503), E491 (≠ N505), Q492 (≠ L506), G493 (= G507), M494 (= M508), V495 (= V509)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
44% identity, 92% coverage: 33:594/608 of query aligns to 12:574/597 of 6demA
- active site: Y33 (≠ I54), G35 (= G56), G36 (= G57), A37 (= A58), I38 (= I59), E59 (= E80), T82 (= T103), F121 (= F142), Q122 (= Q143), E123 (= E144), K171 (= K192), K228 (≠ E252), M264 (= M287), V291 (= V314), V407 (= V423), L432 (≠ A448), G433 (= G449), M435 (= M451), D460 (= D476), N487 (= N503), E489 (≠ N505), Q490 (≠ L506), M492 (= M508), V493 (= V509), W496 (= W512), L518 (= L537), N523 (≠ G542), V524 (≠ C543)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M287), D289 (= D312), R290 (= R313), M492 (= M508), W496 (= W512), A567 (= A587)
- binding flavin-adenine dinucleotide: R161 (= R182), G217 (= G241), A218 (≠ G242), G219 (= G243), N222 (≠ K246), T244 (= T267), L245 (= L268), Q246 (≠ M269), L262 (≠ P285), G284 (= G307), A285 (= A308), R286 (= R309), D288 (= D311), R290 (= R313), V291 (= V314), E317 (≠ D331), I318 (= I332), N322 (≠ E336), D336 (= D350), V337 (≠ A351), M412 (= M428), G430 (= G446)
- binding magnesium ion: D460 (= D476), N487 (= N503), E489 (≠ N505)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V423), G408 (= G424), Q409 (= Q425), H410 (= H426), M435 (= M451), G459 (= G475), D460 (= D476), A461 (≠ G477), S462 (≠ C478), M465 (= M481), N487 (= N503), E489 (≠ N505), Q490 (≠ L506), G491 (= G507), M492 (= M508), V493 (= V509)
Query Sequence
>WP_281055216.1 NCBI__GCF_000024385.1:WP_281055216.1
MRAPLDRRDRHEGFFVGQDHLSHQGKGMTTEQMTGAQALIRALENVGVDTVFGIPGGAIL
PAYDPLFDSTKVRHILVRHEQGAGHAAQGYAMVTGKVGVCMATSGPGATNLVTPISDAYM
DSVPIVAITGQVTSGAIGTDAFQEADIVGITMPITKHNFLVKDPHDIARTIVEAFHIAST
GRPGPVLVDIAKDALQATFDFTWPESPHLPGYRPVTRPHAKQVREAARLLMEAKRPVLYV
GGGVLKAGAAAELKVLAELTGAPVVTTLMAKGALPDSHPLHVGMPGMHGTVAAVGALQRA
DLLVALGARFDDRVTGKLDSFAPEAKVVHADIDPAEISKNRHADVPIVGDAREVIADLIV
AVQAEHEAGRRGDYAAWWKQLRAWQETYPLGYDHPEDGSLAPQYVIEQIGKIAGPDAYYV
AGVGQHQMWAAQFIKYERPGAFLNSGGAGTMGYAIPAAMGAKVAKPDATVWAIDGDGCFQ
MTNQELATCAVEGIPIKVAIINNGNLGMVRQWQTLFYNERYSNTNLHSKRIPDFVKLAEA
YGCVGMRCDRAEDVEETIRKAMEINDTPVVIDFVVHQDAMVWPMVAAGTSNDDIKIARDL
APEWENGD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory