SitesBLAST
Comparing YP_002826111.1 NCBI__GCF_000018545.1:YP_002826111.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8y83A Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
50% identity, 97% coverage: 8:250/251 of query aligns to 7:248/249 of 8y83A
- binding nicotinamide-adenine-dinucleotide: G13 (= G14), S16 (= S17), G17 (= G18), I18 (= I19), D37 (= D38), I38 (≠ L39), A62 (≠ V63), D63 (= D64), S64 (≠ V65), N90 (= N91), M141 (≠ V142), Y156 (= Y157), K160 (= K161), P186 (= P187), G187 (= G188), Y188 (≠ W189), I189 (= I190), L193 (= L194)
5h5xC Crystal structure of nadh bound carbonyl reductase from streptomyces coelicolor
57% identity, 98% coverage: 5:250/251 of query aligns to 11:256/257 of 5h5xC
- active site: G24 (= G18), S151 (= S144), Y164 (= Y157), K168 (= K161)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G20 (= G14), S23 (= S17), G24 (= G18), I25 (= I19), D44 (= D38), F45 (≠ L39), L69 (≠ V63), D70 (= D64), N97 (= N91), A98 (= A92), Y164 (= Y157), K168 (= K161), P194 (= P187), G195 (= G188), I197 (= I190), T199 (= T192)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
48% identity, 98% coverage: 5:250/251 of query aligns to 3:247/248 of 6ixmC
- active site: G16 (= G18), S142 (= S144), Y155 (= Y157), K159 (= K161)
- binding nicotinamide-adenine-dinucleotide: G12 (= G14), S15 (= S17), G16 (= G18), I17 (= I19), D36 (= D38), I37 (≠ L39), A61 (≠ V63), D62 (= D64), T63 (≠ V65), N89 (= N91), A90 (= A92), M140 (≠ V142), S142 (= S144), Y155 (= Y157), K159 (= K161), P185 (= P187), A186 (≠ G188), Y187 (≠ W189), I188 (= I190), L192 (= L194)
7v1qA Leifsonia alcohol dehydrogenases lnadh (see paper)
51% identity, 97% coverage: 8:251/251 of query aligns to 9:251/251 of 7v1qA
- binding nicotinamide-adenine-dinucleotide: G15 (= G14), S18 (= S17), G19 (= G18), I20 (= I19), D39 (= D38), L40 (= L39), D65 (= D64), V66 (= V65), N91 (= N91), M142 (≠ V142), Y157 (= Y157), K161 (= K161), P187 (= P187), G188 (= G188), F189 (≠ W189), I190 (= I190)
4urfB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
46% identity, 99% coverage: 3:250/251 of query aligns to 1:247/248 of 4urfB
- active site: G16 (= G18), S142 (= S144), I152 (≠ A154), Y155 (= Y157), K159 (= K161)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: L210 (≠ M213), R211 (≠ G214), R212 (= R215)
- binding bicarbonate ion: I92 (= I94), G94 (= G96), R109 (= R111), R179 (= R181), S228 (= S231)
- binding nicotinamide-adenine-dinucleotide: G12 (= G14), G14 (= G16), N15 (≠ S17), G16 (= G18), I17 (= I19), D36 (= D38), I37 (≠ L39), D62 (= D64), T63 (≠ V65), N89 (= N91), A90 (= A92), G91 (= G93), I140 (≠ V142), Y155 (= Y157), K159 (= K161), P185 (= P187), A186 (≠ G188), I188 (= I190), T190 (= T192)
4urfA Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
46% identity, 99% coverage: 3:250/251 of query aligns to 1:247/248 of 4urfA
- active site: G16 (= G18), S142 (= S144), I152 (≠ A154), Y155 (= Y157), K159 (= K161)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: I92 (= I94), S93 (≠ E95), G94 (= G96), E95 (≠ V97), T97 (≠ K99), E101 (≠ D103), T103 (≠ P105), Q106 (≠ N108), R109 (= R111), S175 (≠ R177), G177 (= G179)
- binding magnesium ion: S237 (= S240), Y238 (= Y241)
- binding nicotinamide-adenine-dinucleotide: G12 (= G14), G14 (= G16), N15 (≠ S17), G16 (= G18), I17 (= I19), D36 (= D38), I37 (≠ L39), W41 (≠ A43), D62 (= D64), T63 (≠ V65), N89 (= N91), A90 (= A92), G91 (= G93), I140 (≠ V142), Y155 (= Y157), K159 (= K161), P185 (= P187), I188 (= I190), T190 (= T192)
4ureB Molecular genetic and crystal structural analysis of 1-(4- hydroxyphenyl)-ethanol dehydrogenase from aromatoleum aromaticum ebn1 (see paper)
46% identity, 99% coverage: 3:250/251 of query aligns to 1:247/248 of 4ureB
- active site: G16 (= G18), S142 (= S144), I152 (≠ A154), Y155 (= Y157), K159 (= K161)
- binding 3-pyridinium-1-ylpropane-1-sulfonate: N15 (≠ S17), G16 (= G18), I17 (= I19), N89 (= N91), G91 (= G93), Y155 (= Y157), P185 (= P187), A186 (≠ G188)
4wecA Crystal structure of a short chain dehydrogenase from mycobacterium smegmatis
41% identity, 100% coverage: 1:250/251 of query aligns to 4:252/258 of 4wecA
- active site: G21 (= G18), S143 (= S144), Q154 (≠ S155), Y157 (= Y157), K161 (= K161)
- binding nicotinamide-adenine-dinucleotide: G17 (= G14), A19 (≠ G16), S20 (= S17), G21 (= G18), I22 (= I19), D41 (= D38), I42 (≠ L39), V61 (= V63), D62 (= D64), V63 (= V65), N89 (= N91), T141 (≠ V142), Y157 (= Y157), K161 (= K161), P187 (= P187), P189 (≠ W189), V190 (≠ I190)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
37% identity, 100% coverage: 1:251/251 of query aligns to 1:261/261 of 6zzsD
- active site: G18 (= G18), S143 (= S144), Y156 (= Y157)
- binding nicotinamide-adenine-dinucleotide: G14 (= G14), S17 (= S17), I19 (= I19), D38 (= D38), M39 (≠ L39), D64 (= D64), V65 (= V65), N91 (= N91), A92 (= A92), G93 (= G93), M141 (≠ V142), A142 (≠ T143), S143 (= S144), Y156 (= Y157), K160 (= K161), P186 (= P187), G187 (= G188), V189 (≠ I190), T191 (= T192), L193 (= L194)
- binding 3-oxidanylidenepentanoic acid: Q95 (≠ E95), S143 (= S144), N145 (≠ L146), K153 (≠ A154), Y156 (= Y157), Q197 (≠ E197)
5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
40% identity, 100% coverage: 1:251/251 of query aligns to 1:255/255 of 5itvA
- active site: G18 (= G18), S141 (= S144), Y154 (= Y157), K158 (= K161)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G14), S17 (= S17), G18 (= G18), I19 (= I19), D38 (= D38), I39 (≠ L39), T61 (≠ V63), I63 (≠ V65), N89 (= N91), G91 (= G93), T139 (≠ V142), S141 (= S144), Y154 (= Y157), K158 (= K161), P184 (= P187), G185 (= G188), I186 (≠ W189), I187 (= I190)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
36% identity, 100% coverage: 2:251/251 of query aligns to 1:260/260 of 6zzqA
- active site: G17 (= G18), S142 (= S144), Y155 (= Y157)
- binding acetoacetic acid: Q94 (≠ E95), S142 (= S144), K152 (≠ A154), Y155 (= Y157), Q196 (≠ E197)
- binding nicotinamide-adenine-dinucleotide: G13 (= G14), S16 (= S17), G17 (= G18), I18 (= I19), D37 (= D38), M38 (≠ L39), D63 (= D64), V64 (= V65), N90 (= N91), A91 (= A92), G92 (= G93), M140 (≠ V142), A141 (≠ T143), S142 (= S144), Y155 (= Y157), K159 (= K161), Y187 (≠ W189), V188 (≠ I190), T190 (= T192)
7djsD Crystal structure of isopiperitenol dehydrogenase from pseudomonas aeruginosa complexed with NAD
43% identity, 98% coverage: 5:250/251 of query aligns to 3:250/251 of 7djsD
- binding nicotinamide-adenine-dinucleotide: G12 (= G14), G16 (= G18), I17 (= I19), D36 (= D38), L37 (= L39), C61 (≠ V63), D62 (= D64), V63 (= V65), N89 (= N91), A90 (= A92), T140 (≠ V142), S142 (= S144), Y155 (= Y157), K159 (= K161), A186 (≠ G188), V187 (≠ W189)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
40% identity, 96% coverage: 8:248/251 of query aligns to 5:245/246 of 3osuA
4nbuB Crystal structure of fabg from bacillus sp (see paper)
38% identity, 97% coverage: 4:246/251 of query aligns to 4:240/244 of 4nbuB
- active site: G18 (= G18), N111 (= N116), S139 (= S144), Q149 (≠ A154), Y152 (= Y157), K156 (= K161)
- binding acetoacetyl-coenzyme a: D93 (≠ R98), K98 (≠ D103), S139 (= S144), N146 (≠ L151), V147 (≠ P152), Q149 (≠ A154), Y152 (= Y157), F184 (≠ W189), M189 (≠ L194), K200 (≠ R206)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G14), N17 (≠ S17), G18 (= G18), I19 (= I19), D38 (= D38), F39 (≠ L39), V59 (= V63), D60 (= D64), V61 (= V65), N87 (= N91), A88 (= A92), G89 (= G93), I90 (= I94), T137 (≠ V142), S139 (= S144), Y152 (= Y157), K156 (= K161), P182 (= P187), F184 (≠ W189), T185 (≠ I190), T187 (= T192), M189 (≠ L194)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
40% identity, 96% coverage: 8:248/251 of query aligns to 2:238/239 of 3sj7A
- active site: G12 (= G18), S138 (= S144), Q148 (≠ A154), Y151 (= Y157), K155 (= K161)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G14), S10 (≠ G16), R11 (≠ S17), I13 (= I19), N31 (≠ A37), Y32 (≠ D38), A33 (≠ L39), G34 (vs. gap), S35 (≠ N40), A58 (≠ V63), N59 (≠ D64), V60 (= V65), N86 (= N91), A87 (= A92), T109 (≠ V115), S138 (= S144), Y151 (= Y157), K155 (= K161), P181 (= P187), G182 (= G188)
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
37% identity, 98% coverage: 5:251/251 of query aligns to 2:252/252 of 1vl8B
- active site: G17 (= G18), S143 (= S144), I154 (≠ A154), Y157 (= Y157), K161 (= K161)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G14), R16 (≠ S17), G17 (= G18), L18 (≠ I19), S37 (≠ D38), R38 (≠ L39), C63 (≠ V63), D64 (= D64), V65 (= V65), A91 (≠ N91), A92 (= A92), G93 (= G93), I94 (= I94), V114 (= V115), I141 (≠ V142), S143 (= S144), Y157 (= Y157), K161 (= K161), P187 (= P187), G188 (= G188), Y190 (≠ I190), T192 (= T192), M194 (≠ L194), T195 (≠ L195)
3ay6B Crystal structure of bacillus megaterium glucose dehydrogenase 4 a258f mutant in complex with nadh and d-glucose (see paper)
37% identity, 100% coverage: 1:251/251 of query aligns to 7:259/267 of 3ay6B
- active site: G24 (= G18), S151 (= S144), Y164 (= Y157), K168 (= K161)
- binding beta-D-glucopyranose: E102 (= E95), S151 (= S144), H153 (≠ L146), W158 (≠ L151), Y164 (= Y157), N202 (≠ L195), K205 (vs. gap)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G20 (= G14), T23 (≠ S17), G24 (= G18), L25 (≠ I19), Y45 (≠ L39), D71 (= D64), V72 (= V65), N98 (= N91), A99 (= A92), G100 (= G93), V101 (≠ I94), M149 (≠ V142), S151 (= S144), Y164 (= Y157), K168 (= K161), P194 (= P187), G195 (= G188), M197 (≠ I190), T199 (= T192), P200 (= P193), I201 (≠ L194), N202 (≠ L195)
Q9LBG2 Levodione reductase; (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase; EC 1.1.1.- from Leifsonia aquatica (Corynebacterium aquaticum) (see paper)
36% identity, 99% coverage: 2:250/251 of query aligns to 8:265/267 of Q9LBG2
- 17:42 (vs. 11:36, 46% identical) binding NAD(+)
- E103 (= E95) mutation E->A,D,N,Q: 26-fold increase in Km and a much lower enantiomeric excess of the reaction products.
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
37% identity, 98% coverage: 5:251/251 of query aligns to 2:260/260 of 5b4tA
- active site: G15 (= G18), N114 (= N116), S142 (= S144), Y155 (= Y157), K159 (= K161), I200 (≠ A202)
- binding (3R)-3-hydroxybutanoic acid: Q94 (≠ E95), S142 (= S144), H144 (≠ L146), K152 (≠ A154), Y155 (= Y157), W187 (= W189), Q196 (≠ Y198)
- binding nicotinamide-adenine-dinucleotide: G11 (= G14), T13 (≠ G16), G15 (= G18), I16 (= I19), F36 (≠ L39), D63 (= D64), L64 (≠ V65), N90 (= N91), G92 (= G93), L113 (≠ V115), I140 (≠ V142), Y155 (= Y157), K159 (= K161), P185 (= P187), G186 (= G188), W187 (= W189), V188 (≠ I190), T190 (= T192), L192 (= L194), V193 (≠ L195)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
37% identity, 98% coverage: 5:251/251 of query aligns to 2:260/260 of 3w8dA
- active site: G15 (= G18), N114 (= N116), S142 (= S144), Y155 (= Y157), K159 (= K161), I200 (≠ A202)
- binding methylmalonic acid: Q94 (≠ E95), S142 (= S144), H144 (≠ L146), K152 (≠ A154), Y155 (= Y157), W187 (= W189), Q196 (≠ Y198), W257 (≠ Y248)
- binding nicotinamide-adenine-dinucleotide: G11 (= G14), T13 (≠ G16), S14 (= S17), G15 (= G18), I16 (= I19), F36 (≠ L39), A62 (≠ V63), D63 (= D64), L64 (≠ V65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (≠ V115), S142 (= S144), Y155 (= Y157), K159 (= K161), P185 (= P187), G186 (= G188), W187 (= W189), V188 (≠ I190), T190 (= T192), L192 (= L194), V193 (≠ L195)
Query Sequence
>YP_002826111.1 NCBI__GCF_000018545.1:YP_002826111.1
MTLRFDGKIAIVTGGGSGIGAAISRQLSGEGAEVVVADLNPEAAEGIVDEIRAKGGRARH
FTVDVADAGAVEQLVGFALSECGGLNLAVNNAGIEGVRKPTGDYPLDNWERVIDVNLTGT
FHCMKYEIAAMLGRGGGAIVNVTSILASVGLPTASAYTAAKHGVVGLTKSAAIEYARMGI
RINTVGPGWIETPLLSEYAELAKTRRLEALQPMGRRGTPEEVAALACFLLSDEASFITGS
YHLVDGAYTAH
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory